Annals of Nutrition & Metabolism

INTRODUCTION: Home parenteral nutrition (HPN) is a rare but challenging therapy and care for patients with mostly severe underlying diseases. We aimed to investigate patient-reported health-related quality of life (QOL) of patients receiving HPN and its development over time in particular. METHODS: We assessed QOL of HPN patients in a prospective multicenter observational study (SWISSHPN II study). We designed a questionnaire to record symptoms and negative impacts of HPN and completed the validated Optum® SF-36v2® Health Survey with the patients...

INTRODUCTION: A high intake of sugar, in particular from sugar-sweetened soft drinks, increases the risk for obesity, type 2 diabetes mellitus and dental caries. Germany has pursued a national strategy for sugar reduction in soft drinks based on voluntary commitments by industry since 2015, but its effects are unclear. METHODS: We use aggregated annual sales data from Euromonitor International to assess trends in mean sales-weighted sugar content of soft drinks and per capita sugar sales from soft drinks in Germany from 2015-2021...

INTRODUCTION: Low dietary intake of vitamin E is a global public health issue. RRR-α-tocopherol (RRR-αT) is the only naturally occurring vitamin E stereoisomer, but the equimolecular mixture of all eight stereoisomers, synthetic vitamin E (S-αT), is commonly consumed. The objective of this study was to evaluate bioavailability and antioxidant activity of RRR-αT vs. S-αT, in both mother and fetus, after maternal supplementation during pregnancy. METHODS: Female rats (7 weeks of age) received a modified AIN-93G diet supplemented with 75 IU/kg of RRR-αT (NVE, n=20) or S-αT (SVE, n=17)...

INTRODUCTION: To increase the total carnitine (TC) content in muscles, LC should be co-ingested with carbohydrates to induce an insulin response. Leucine has an insulin secretagogue effect. Therefore, the primary aim of this study was to examine the effects of 24 weeks of LC and leucine supplementation on the skeletal muscle TC content, muscle mass, and strength in active college-aged subjects. The secondary aim was to determine the activation of the Akt/mTOR signaling pathway in skeletal muscles after supplementation...

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INTRODUCTION: Several researchers focused on the role of skeletal muscle in metabolic problems in recent years. We aimed to evaluate influence of sleeve gastrectomy on skeletal muscular fat infiltration determined by magnetic resonance imaging in patients with metabolic syndrome (MetS). METHODS: 65 MetS patients (male/female 20/45; mean age, 35.3 years ± 6.7 [standard deviation]; age range, 22 - 59 years) enrolled in our study. Prior to and one year after sleeve gastrectomy, patients underwent routine measurement of skeletal muscular fat concentration (denoted by proton density fat fraction, PDFF) and chemical indexes...

INTRODUCTION: The life expectancy of older adults continue to increase, however knowledge regarding their total energy requirements are lacking. This study aims to compare the total energy expenditure (TEE) of older adults ≥ 80 years measured using doubly labelled water (DLW), with estimated TEE. The hypothesis was that the Mifflin, Ikeda and Livingston equations will more closely estimate energy requirements than the commonly used Schofield equation. METHODS: Resting metabolic rate (RMR) and TEE were measured using the reference methods of indirect calorimetry and doubly labelled water (DLW) respectively...

INTRODUCTION: It has been well recognized that sarcopenia is closely related with osteoporosis, while the relationship between bone mass at different sites and muscle mass remains largely unexplored. This study aims to explore the relationship between bone mass at different sites and skeletal muscle mass in older adults. METHODS: A total of 228 patients over 65 years old were enrolled in this study, then 180 valid participants with accessible Dual-energy X-ray Absorptiometry (DXA) scanning data and absence of malignant tumors, mobility disorders, serious liver and kidney disease, and cardiac insufficiency, were selected (138 male and 42 female)...

ECOG's congress aims to bring together childhood obesity experts and young scientists from across Europe. The scientific programme will approach the multidisciplinary nature of childhood obesity prevention and treatment, giving the floor to some of the finest experts in policies and management strategies, dietary interventions, appetite and eating behaviors, pharmacological strategies as well and family programs and general physiology and metabolism. In addition, international associations such as the World Health Organization and the European Association for the Study of Obesity will animate and lead specific sessions...

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OBJECTIVE: Thrombospondin 1 (THBS1) is a highly expressed adipokine in adults with obesity. In the present study, we aimed to investigate the clinical significance of THBS1in children with obesity and non-alcoholic fatty liver disease (NAFLD), and determine the effect of metformin on THBS1 expression in dietary-induced obese (DIO) mice. METHODS: A cross-sectional study was conducted among 78 obese children and 35 ono-obese children. Anthropometric parameters, clinical data and circulating THBS1 levels were measured...

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BACKGROUND: Emerging evidence suggests that dietary one-carbon metabolism-related B-vitamins are associated with the reduced risk of cardiovascular disease (CVD) in general populations. However, only a few studies have assessed their associations in patients with type 2 diabetes (T2D). OBJECTIVE: This study aims to assess the associations between the intake of three one-carbon metabolism-related B-vitamins (folate, vitamin B6 and vitamin B12) and CVD risk in Chinese patients with T2D...

BACKGROUND: Recently, the triglyceride-glucose (TyG) index has been suggested as a surrogate insulin resistance marker. This index could act as an early screening marker in individuals with high risk of Metabolic Syndrome (MS) such as obesity subjects. AIMS: The objective of this work was to detect the cut-off point of the TyG index for the diagnosis of MS according to ATPIII criteria on obese subjects and to compare with HOMA-IR. METHODS: We conducted a cross sectional study in 1494 obese subjects...

The following document is dedicated to compiling the abstracts of the communications and lectures of the FINUT 2022 Conference. The document comprises 111 abstracts of the guest speakers participating in the scientific symposia and special lectures and more than 230 abstracts for oral and poster communications, representing more than 20 countries. FINUT Conferences seek to open a place for contrasted science shared by the Ibero-American region, a necessary space to open opportunities and to display the research work done in Food and Nutrition...

This letter is a commenting on the article recently published in Annals of Nutrition and Metabolism entitled "Association of nutritional support with survival-time in hospitalized older patients with dysphagia: a retrospective study" by Manabe and colleagues published in your esteemed journal. As the benefits of clinically assisted hydration (CAH) were not mentioned in this study, we would like to add some thoughts that may open the debate about the possible fatal cardiovascular events mediated by dehydration in PD patients with dysphagia...

No abstract text is available yet for this article.

OBJECTIVES: To determine the impact of computed tomography (CT)-based body composition and radiomics nomogram on the prediction of postoperative complications in gastric cancer. METHODS: The clinical data of 457 individuals with surgically confirmed gastric cancer, 320 patients in the training cohort (TC) and 137 patients in the validation cohort (VC), were retrospectively analyzed. Body composition data were measured using CT. Postoperative complications were graded using the Clavien-Dindo system...

AIM: We aimed to evaluate the difference between computed tomography (CT) and bioelectrical impedance analysis (BIA) -based assessment of sarcopenia in patients with chronic liver disease (CLD). METHODS: We enrolled a total of 257 patients who was diagnosed with sarcopenia by CT and BIA based on the Japan Society of Hepatology. To evaluate whether or not the different methods influence the diagnosis of sarcopenia for the patients with CLD, we assessed the number and characteristics of mismatch between the low SMI using BIA and CT...

INTRODUCTION: Remote delivery of behavioral and lifestyle interventions has shown great potential for achieving weight loss comparable to in-person treatment. However, little is known about its effects on adherence and efficacy in a real-world setting. During the COVID-19 pandemic, our usual care, a 12-months treatment program for morbid obesity, had to be transitioned to remote delivery. We evaluated whether this had adverse effects on weight loss or adherence. METHODS: We report retrospective data of 234 patients who either belonged to a cohort affected by the transition of treatment delivery (N=117, mean age = 44...