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Journals Iranian Journal of Medical Sci...

Iranian Journal of Medical Sciences

https://read.qxmd.com/read/38356490/manipulation-of-sonic-hedgehog-signaling-pathway-in-maintenance-differentiation-and-endocrine-activity-of-insulin-producing-cells-a-systematic-review
#1
REVIEW
Dian Dayer, Vahid Bayati, Mina Ebrahimi
BACKGROUND: Some studies have evaluated the manipulation of the sonic hedgehog (Shh) signaling pathway to generate more efficient insulin-producing cells (IPCs). In a systematic review, we evaluated in vitro and in vivo studies on the effect of inhibition or activation of the Shh pathway on the production, differentiation, maintenance, and endocrine activity of IPCs. METHODS: A systematic review was conducted using all available experimental studies published between January 2000 and November 2022...
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38356489/cytogenetic-clinical-hematologic-demographic-immunohistochemical-and-flow-cytometry-characteristics-of-patients-with-plasma-cell-neoplasm-in-five-years-a-first-report-from-iran
#2
JOURNAL ARTICLE
Mansoureh Shokripour, Seyed Ehsan Hosseini, Navid Omidifar, Maral Mokhtari, Akbar Safaei
BACKGROUND: The aggregation of clonal plasma cells causes plasma cell neoplasms, which vary in severity and clinical outcomes. The present research focused on the epidemiological, clinical, immunologic, and cytogenetic characteristics of plasma cell neoplasms. METHODS: In this five-year retrospective cross-sectional study, demographic information such as age and sex, calcium elevation, renal insufficiency, anemia, and bone lesion (CRAB) characteristics, as well as laboratory data including bone marrow and peripheral blood film results, immunohistochemistry, flow cytometry, and cytogenetic study outcomes were collected at Shiraz University of Medical Sciences, Shiraz, Iran...
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38356488/chlorogenic-acid-inhibits-progressive-pulmonary-fibrosis-in-a-diabetic-rat-model
#3
JOURNAL ARTICLE
Sagita Mega Sekar Kencana, Nur Arfian, Ratih Yuniartha, Ramadhea Laila Afifa An-Nur Willya Saputri, Fauziyatul Munawaroh, Dwi Cahyani Ratna Sari
BACKGROUND: Chlorogenic acid (CGA) is known to have antifibrotic and hypoglycemic effects and may play a role in preventing diabetes-induced pulmonary fibrosis. This study aimed to determine the effect and optimum dose of CGA on diabetes-induced pulmonary fibrosis. METHODS: Thirty Wistar rats (two-month-old, 150-200 grams) were randomly divided into six groups, namely control, six weeks diabetes mellitus (DM1), eight weeks DM (DM2), and three DM2 groups (CGA1, CGA2, and CGA3) who received CGA doses of 12...
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38356487/comparison-of-telogen-effluvium-incidence-in-hospitalized-and-outpatient-settings-after-recovery-from-covid-19
#4
JOURNAL ARTICLE
Ali Asilian, Fariba Iraji, Sayed Mohsen Hosseini, Parisa Mohammadian Dehkordi
No abstract text is available yet for this article.
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38356486/correlation-between-intimate-partner-violence-during-pregnancy-and-parental-acceptance-by-primiparous-mothers
#5
JOURNAL ARTICLE
Masomah Jalili, Shahnaz Kohan, Mohammad Javad Tarrahi, Fatemeh Torabi
BACKGROUND: Pregnancy and the transition to parenthood are periods in parents' lives that require tremendous adjustment. The physical and mental health of mothers during these periods is significantly associated with maternal acceptance. The present study aimed to evaluate the correlation between intimate partner violence (IPV) during pregnancy and parental acceptance by primiparous mothers in Isfahan, Iran. METHODS: A cross-sectional descriptive and correlational study was conducted from September 2021 to February 2022 in Isfahan, Iran...
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38356485/epstein-barr-virus-promotes-tumorigenicity-and-worsens-hodgkin-lymphoma-prognosis-by-activating-jak-stat-and-nf-%C3%AE%C2%BAb-signaling-pathways
#6
JOURNAL ARTICLE
Mohamed Ali Alabiad, Warda M M Said, Rema H Faraj Saad, Rawda Balata, Asmaa A Mahmoud, Elsayed Anany Metwally, Amany Mohamed Shalaby, Walaa Samy, Ahmed M Yehia, Amar Ibrahim Omar Yahia, Mohammed Alorini, Doaa I Abdelrahman
BACKGROUND: Epstein-Barr virus (EBV) is detected in 40% of patients with Hodgkin lymphoma (HL). During latency, EBV induces epigenetic alterations to the host genome and decreases the expression of pro-apoptotic proteins. The present study aimed to evaluate the expression levels of mRNA molecules and the end product of proteins for the JAK/STAT and NF-κB pathways, and their association with clinicopathological and prognostic parameters in patients with EBV-positive and -negative classical Hodgkin lymphoma (CHL)...
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38356484/successful-sealing-of-post-covid-19-bronchopleural-fistula-with-computed-tomography-scan-guided-percutaneous-cyanoacrylate-glue-injection-a-case-series
#7
Alireza Rasekhi, Haleh Bozorgi, Seyed Masoom Masoompour, Parviz Mardani, Mohammad Reza Azimi Aval
Bronchopleural fistula (BPF), a sinus tract between the bronchial system and the pleural space, is associated with COVID-19 and can lead to pneumothorax, which increases the mortality rate. Due to the analytical status of COVID-19 patients, sealing the BPF necessitates the least minimal invasive treatment. Herein, we demonstrated a technique of sealing post-COVID-19 BPF with direct injection of cyanoacrylate glue under the guidance of a computed tomography scan. Following glue injection, the BPF was completely sealed in all four patients...
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38356483/adipose-derived-stem-cells-secretome-attenuates-lesion-size-and-parasite-loading-in-leishmaniasis-caused-by-leishmania-major-in-mice
#8
JOURNAL ARTICLE
Iman Khodkar, Jasem Saki, Reza Arjmand, Ghasem Saki, Layasadat Khorsandi
BACKGROUND: Stem cell-derived secretome (SE) released into the extracellular space contributes to tissue repair. The present study aimed to investigate the impact of isolated secretome (SE) from adipose-derived mesenchymal stem cells (ASCs) on Leishmania major ( L. major ) lesions in BALB/c mice. METHODS: This experimental study was conducted at Ahvaz University of Medical Sciences (Ahvaz, Iran) in 2021. Forty female BALB/c mice were infected with stationary phase promastigotes through intradermal injection in the bottom of their tail and randomly divided into four groups (n=10 per group)...
February 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38322164/expression-and-clinical-significance-of-ire1-xbp1s-p62-and-caspase-3-in-colorectal-cancer-patients
#9
JOURNAL ARTICLE
Mohammadkian Zarafshani, Habibollah Mahmoodzadeh, Vahid Soleimani, Mohammad Amin Moosavi, Marveh Rahmati
BACKGROUND: Three main cell signaling pathways including the endoplasmic reticulum stress (ERS) response, autophagy, and apoptosis play critical roles in both cell survival and death. They were found to crosstalk with one another during tumorigenesis and cancer progression. This study aimed to investigate the expression of the spliced form of X-box binding protein 1 (XBP1s), p62, and caspase-3, as the essential biomarkers of ERS, autophagy, and apoptosis in patients with colorectal cancer (CRC), as well as the correlation between their expression and clinicopathological data...
January 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38322163/clinical-outcome-and-recurrence-of-open-versus-laparoscopic-nissen-fundoplication-in-the-republic-of-kazakhstan-during-2010-2021
#10
JOURNAL ARTICLE
Bolatbek Baimakhanov, Shakir Zhurayev, Adil Shokebaev, Nurbol Orynbassar, Nurmakhan Imammyrzayev, Khozybek Kazakhstan, Kuanysh Kanatov, Yevgene Yenin, Gulziya Ismailova
BACKGROUND: Surgical treatment of recurrent gastroesophageal reflux disease (GERD) negatively affects patients' quality of life (QoL). Determination of risk factors is essential when considering a surgical approach. The present study aimed to evaluate short-term and long-term outcomes of primary laparoscopic Nissen fundoplication (LNF) and open Nissen fundoplication (ONF), as well as the risks of laparoscopic redo fundoplication. METHODS: A retrospective cohort observational study was conducted from 2010 to 2021 at the National Research Center of Surgery (Almaty, Kazakhstan)...
January 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38322162/complication-rate-after-percutaneous-liver-biopsy-using-a-real-time-ultrasound-approach-and-introducing-a-uniform-methodology-a-brief-report
#11
JOURNAL ARTICLE
Mohammad Reza Sasani, Alireza Rasekhi
Following the initial liver biopsy attempts, several techniques using a wide range of methodologies and materials were developed. Many studies on the evaluation of post-liver biopsy complications were conducted. However, their fundamental limitation was significant variance in patient demographics and methodology, which might account for the inconsistent outcomes. Therefore, a uniform methodology to perform percutaneous liver biopsies that result in comparable outcomes around the world is required. This study aimed to determine the precise complication rate following percutaneous liver biopsy using a consistent method in all individuals...
January 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38322161/-in-vitro-comparative-study-on-antineoplastic-effects-of-pinoresinol-and-lariciresinol-on-healthy-cells-and-breast-cancer-derived-human-cells
#12
JOURNAL ARTICLE
Mona Soltani, Reza Fotovat, Mohsen Sharifi, Najmeh Ahmadian Chashmi, Mehrdad Behmanesh
BACKGROUND: Herbal medicines are the preferred anticancer agents due to their lower cytotoxic effects on healthy cells. Plant lignans play an important role in treating various diseases, especially cancer. The present study aimed to evaluate the effect of podophyllotoxin, pinoresinol, and lariciresinol on cellular toxicity and inducing apoptosis in fibroblasts, HEK-293, and SkBr3 cell lines. METHODS: An in vitro study was conducted from 2017 to 2019 at the Faculty of Biological Sciences, Tarbiat Modares University (Tehran, Iran)...
January 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38322160/effect-of-aromatase-inhibitor-letrozole-on-the-placenta-of-adult-albino-rats-a-histopathological-immunohistochemical-and-biochemical-study
#13
JOURNAL ARTICLE
Mohamed Ali Alabiad, Ibtesam Elhasadi, Sulaiman Mohammed Alnasser, Mohammed Alorini, Ahmed Baker A Alshaikh, Fatima A Jaber, Amany Mohamed Shalaby, Walaa Samy, Ahmed Ismail Heraiz, Khalid Mohammed Mohammed Albakoush, Dina Ahmed Khairy
BACKGROUND: Letrozole, an aromatase inhibitor, has recently been introduced as the preferred treatment option for ectopic pregnancy. To date, no study has investigated the effect of letrozole alone on placental tissue. The present study aimed to evaluate the effect of different doses of letrozole on the placenta of rats and to clarify the underlying mechanism. METHODS: Sixty pregnant female rats were equally divided into three groups, namely the control group (GI), low-dose (0...
January 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38322159/pulmonary-function-tests-in-thunderstorm-associated-respiratory-symptoms-a-cross-sectional-study
#14
JOURNAL ARTICLE
Maryam Haddadzadeh Shoushtari, Sakineh Afrakhteh, Seyed Hamid Borsi, Hanieh Raji, Esmail Idani
BACKGROUND: Epidemic thunderstorm asthma is an observed increase in cases of acute bronchospasm following thunderstorms. This study aimed to compare the frequency of obstructive airway disease or bronchial hyperresponsiveness in subjects with thunderstorm-associated respiratory symptoms with subjects with similar symptoms presented at other times. METHODS: A cross-sectional study from June to November of 2013 was conducted on subjects with thunderstorm-associated respiratory symptoms living in Ahvaz City, Iran...
January 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38322158/spatial-proximity-distribution-of-covid-19-in-iran-panel-february-2019-february-2023
#15
JOURNAL ARTICLE
Afshin Mottaghi, Michael Aryan Kya
No abstract text is available yet for this article.
January 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38322157/managing-monkeypox-virus-infections-a-contemporary-review
#16
REVIEW
Fariba Asadi Noghabi, John G Rizk, Dheeraj Makkar, Nasibeh Roozbeh, Soleyman Ghelichpour, Aref Zarei
Monkeypox is an infectious and contagious zoonotic disease caused by the Orthopoxvirus species and was first identified in Africa. Recently, this infectious disease has spread widely in many parts of the world. Fever, fatigue, headache, and rash are common symptoms of monkeypox. The presence of lymphadenopathy is another prominent and key symptom of monkeypox, which distinguishes this disease from other diseases and is useful for diagnosing the disease. This disease is transmitted to humans through contact with or eating infected animals as well as objects infected with the virus...
January 2024: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38094288/genotoxic-and-cytotoxic-effects-of-cone-beam-computed-tomography-and-multidetector-computed-tomography-on-exfoliated-buccal-epithelial-cells
#17
JOURNAL ARTICLE
Zahra Jahanshahiafshar, Hakimeh Ghorbani, Maryam Seyedmajidi, Mehrdad Nabahati, Kourosh Ebrahimnejad Gorji, Seyedali Seyedmajidi, Ehsan Moudi
BACKGROUND: Cone beam computed tomography (CBCT) and multidetector computed tomography (MDCT) are frequently used in dental and maxillofacial problems. This study aimed to assess the genotoxicity and cytotoxicity effects of CBCT and MDCT radiographies on exfoliated buccal epithelial cells during dental examinations. METHODS: This prospective experimental study was conducted at Babol University of Medical Sciences (Babol, Iran) from March 2021 to April 2021. Buccal mucosa smears were collected bilaterally pre-exposure and 12 days after CBCT or MDCT examinations...
November 2023: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38094287/the-ameliorative-impact-of-cichorium-intybus-l-distillate-on-reproductive-parameters-in-male-mice
#18
JOURNAL ARTICLE
Shima Fakher, Saeid Karbalay-Doust, Ali Noorafshan, Atefeh Seghatoleslam
BACKGROUND: Cichorium intybus L. (Kasni) distillate is widely used in Eastern countries as a safe herbal drink to improve male fertility. However, the potential effects on fertility parameters and possible adverse effects have not been studied experimentally. The current study aims to evaluate the impact of Cichorium intybus L. distillate (CD) on male mice fertility. METHODS: In the present study (Shiraz, Iran), 30 male mice (30-35 g) were divided into three groups...
November 2023: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38094286/the-added-on-of-ziziphus-jujube-syrup-in-the-treatment-of-chronic-spontaneous-urticaria-resistant-to-standard-dose-of-secondary-generation-h-1-antihistamine-a-double-blind-randomized-clinical-trial
#19
JOURNAL ARTICLE
Hamid Zare, Seyed Hesamedin Nabavizdeh, Amir Mohamad Jaladat, Mohamad Mehdi Zarshenas, Mozhgan Moghtaderi, Atefeh Basirat, Nahid Nasri
BACKGROUND: Although antihistamines are the first-line treatment for chronic spontaneous urticaria (CSU), 50% of patients don't respond to standard doses. In this study, the effectiveness of Ziziphus jujube fruit syrup in combination with antihistamines was assessed in patients with CSU. METHODS: This double-blind randomized clinical trial was conducted in Shiraz between December 2019 and December 2020. 64 patients with CSU who had experienced hives for at least six weeks and did not respond to the usual treatments were enrolled in the study...
November 2023: Iranian Journal of Medical Sciences
https://read.qxmd.com/read/38094285/potential-role-of-zinc-finger-365-rs10822013-and-rs10995190-in-mammographic-density-sporadic-breast-cancer-risk-and-prognosis
#20
JOURNAL ARTICLE
Seyed Reza Ghadamgahi, Leila Hosseinzadeh, Sahar Ardalan Khales, Mohammadreza Nassiri, Maryam Alidoust, Shirin Etemadrezaei, Asma Khorshid Shamshiri, Fatemeh Homaei Shandiz, Alireza Pasdar, Fahimeh Afzaljavan
BACKGROUND: Despite suggesting many genetic risk markers as the outcome of Genome-wide association studies (GWAS) for breast cancer, replicating the results in different populations has remained the main issue. In this regard, this study assessed the association of two variations in Zinc Finger 365 ( ZNF365 ) in an Iranian population. METHODS: In a case-control study conducted at Mashhad University of Medical Sciences, Mashhad, Iran, between 2017 and 2020, ZNF365 - rs10822013 and rs10995190 were genotyped using Allele-Specific PCR (AS-PCR)...
November 2023: Iranian Journal of Medical Sciences
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