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Current Eye Research

Enes Uyar, Umit Dogan, Fatih Ulas, Serdal Celebi
PURPOSE: The aim of this study was to assess the effect of the Ramadan fasting on choroidal thickness and its associated diurnal variations using spectral domain-optic coherence tomography. MATERIALS AND METHODS: Ocular measurements were performed on a single eye of 87 healthy individuals. Eyes were evaluated twice a day around 8.00 a.m. and 4.00 p.m. during Ramadan. Evaluations were repeated at the same time of the day one month following the Ramadan on the same subjects...
February 19, 2019: Current Eye Research
Claudio I Perez, Sunee Chansangpetch, Anwell Nguyen, Max Feinstein, Marta Mora, Mai Badr, Marisse Masis, Travis Porco, Shan C Lin
Purpose/Aim: To evaluate the best formula to predict intraocular pressure (IOP) reduction after cataract surgery. MATERIALS AND METHODS: Prospective longitudinal study. We included consecutive patients with or without glaucoma, either with open or narrow angles but without peripheral anterior synechiae, who underwent phacoemulsification. Clinical factors and anterior segment parameters measured with optical biometry and optical coherence tomography were evaluated as preoperative predictors for IOP reduction at 6 months postoperatively...
February 12, 2019: Current Eye Research
Mehdi Shajari, Kim Herrmann, Jens Bühren, Poojita Vunnava, Efstathios Vounotrypidis, Michael Müller, Ghada Al-Khateeb, Thomas Kohnen
PURPOSE: The purpose of the study was to determine the distribution of the anterior chamber angle (ACA) within a population-based study sample in Germany and to find correlations between age, sphere, and biometric parameters of the anterior chamber. PATIENTS AND METHODS: A total of 500 eyes, approximately 100 eyes per decade starting with patient age of 20 years, of 463 patients with an average age of 45.2 ± 14.1 (±values subsequent represent standard deviation) years without any known history of ocular diseases, surgery, or optic nerve head excavation or hypoplasia were included...
February 12, 2019: Current Eye Research
Fang-Fang Bao, Qing-Song Li, Zhen-Yong Zhang, Min-Hong Xiang
OBJECTIVE: To investigate the treatment effects of botulinum toxin-A (BTA) injection and acupuncture on blepharospasm (BP) evaluated by the change in lower eyelid tension (LET). METHODS: A series of 30 patients (male: 8, female: 22) aged between 37 and 83 years (63.80 ± 10.96 yrs) who met the eligibility criteria of BP were recruited in this study, who were randomly assigned to BTA injection group (BTA group, n = 15) and acupuncture treatment group (Acupuncture group, n = 15)...
February 6, 2019: Current Eye Research
Penpe Gül Firat, Ersan Ersin Demirel, Soner Demirel, Seyhan Dikci, Yusuf Turkoz, Fatma Ozyalın
PURPOSE: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls. PATIENTS AND METHODS: 25 primary open angle glaucoma patients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry...
February 1, 2019: Current Eye Research
Janusz Skrzypecki, Tomasz Huc, Karolina Ciepiaszuk, Marcin Ufnal
PURPOSE Trimethylamine oxide (TMAO) is an osmolyte used by saltwater animals to protect their cells from hyperosmotic environment. Here, we studied if TMAO may exert beneficial effect in dry eye disease which results from hyperosmotic tear film. MATERIALS AND METHODS Female, 12-week-old Sprague Dawley rats underwent either removal of extra- and infraorbital lacrimal glands (dry eye group) or sham surgery (sham group). A one-week topical treatment with either 0.9% NaCl (control) or 1% TMAO in 0.9% NaCl solution was started four weeks after the surgery...
January 31, 2019: Current Eye Research
Decai Wang, Yu Jiang, Miao He, Jane Scheetz, Wei Wang
PURPOSE: To evaluate the disparities in burden of disease of age-related macular degeneration (AMD) in terms of disability-adjusted life years (DALYs). METHOD: This is an international, database observational study. The DALY due to AMD were retrieved from the 2015 Global Burden of Disease study. The human development index (HDI) and gross domestic product (GDP) per capita across countries were obtained from the 2016 Human Development Report and the World Bank. Other related data were obtained from the World Health Organization and United Nations...
January 31, 2019: Current Eye Research
Miki Hiraoka, Ei Ohkawa, Akira Abe, Masaki Murata, Shinji Go, Jin-Ichi Inokuchi, Hiroshi Ohguro
PURPOSE: Most complex gangliosides in vertebrates are formed from ganglioside GM3. GM3 deficiency in humans can result in epilepsy and visual impairment. To investigate whether a deficiency of GM3 is involved in visual function, ST3GAL5-/- mice with mutations in the ST3GAL5 gene-coded GM3 synthase were employed. MATERIALS AND METHODS: Sixty mice were employed in this study. The glycosphingolipids of mice retinas were analyzed through high performance thin layer chromatography...
January 27, 2019: Current Eye Research
Philippe Daull, Stefano Barabino, Laurence Feraille, Karima Kessal, Mylene Docquier, Stephane Melik Parsadaniantz, Christophe Baudouin, Jean-Sébastien Garrigue
Purpose/Aim: Inflammation is recognized as playing an etiological role in dry eye disease. This study aimed to assess the efficacy of various topical cyclosporine A (CsA) formulations on cornea inflammatory markers in a mouse model of dry eye. MATERIAL AND METHODS: Six- to 7-week-old mice treated with scopolamine were housed in a controlled environment room to induce dry eye. Following dry eye confirmation by corneal fluorescein staining (CFS), the mice were treated three times a day with: 0...
January 21, 2019: Current Eye Research
Seniz Demiryürek, Ahmet Saracaloglu, Sabit Kimyon, Alper Mete, Omer Eronat, Ebru Temiz, Gülper Nacarkahya, Zeynep Sav Tunca, Betül Düzen, Oguzhan Saygili, Kıvanc Güngör, Metin Karakök, Abdullah T Demiryürek
PURPOSE: Pterygium, one of the most common ocular surface diseases, is characterized by inflammatory infiltrates, proliferation, angiogenesis, fibrosis, and extracellular matrix breakdown. The objective of this study was to elucidate the levels of the intercellular adhesion molecule (ICAM)-2, and ICAM-3 gene and protein expressions in pterygium. METHODS: A total of 59 patients with pterygium were included in this study. mRNA from pterygial and conjunctival autograft tissues were extracted, and real time polymerase chain reaction on the BioMark HD dynamic array system was performed for the ICAM-2 and ICAM-3 gene expressions...
January 18, 2019: Current Eye Research
Ding Xixia, Chang Pingjun, Zhang Hongfang, Savini Giacomo, Huang Jinhai, Chu Feixue, Yu A-Yong, Huang Fang, Huang Shenghai, Lin Lei, Zhao Yun-E
Purpose:To study the capsule morphology in pseudophakic eyes on the three-dimensional level using high-speed swept-source optical coherence tomography (SSOCT). Methods:This study collected patients with age related cataract and divided them into 2 groups according to the anterior capsule and intraocular lens (IOL) optic relationship: total anterior capsule overlap (360°, Group-T) and partial anterior capsule overlap (< 360°, Group-P). One standard SSOCT radial scanning was performed in all eyes at 1 day, 1 week, 1 month, and 3 months postoperatively...
January 17, 2019: Current Eye Research
Samuel Asanad, Jack J Tian, Starleen Frousiakis, Jerry P Jiang, Kaitlin Kogachi, Christian M Felix, Fatemeh Darvizeh, Anne Gority Irvine, Anna Ter-Zakarian, Khalil Ghasemi Falavarjani, Piero Barboni, Rustum Karanjia, Alfredo A Sadun
BACKGROUND: Mitochondrial optic neuropathies such as Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA) have been shown to produce an optic neuropathy secondary to retinal ganglion cell loss with thinning of the retinal ganglion cell complex (RGCC). METHODS: We performed a retrospective analysis assessing the thicknesses of the peripapillary RNFL (pRNFL) along with the macular RGC-IPL using optical coherence tomography (OCT). We compared these changes among acute and chronic LHON, DOA, and normal healthy control patients...
January 16, 2019: Current Eye Research
Yang Yao, Rong Li, Junhui Du, Lihui Long, Xiangnan Li, Na Luo
Backgroud: Interleukin-6 (IL-6) is produced by a variety of cells involved in inflammation and acts as local intensification signals in pathological processes associated with chronic eye inflammation. This meta-analysis was performed to provide a better understanding of the relationship between IL-6 and Diabetic Retinopathy. Methods: The study was started with systematic search for literatures by using the PubMed, Web of Science and Embase online databases. The standard mean difference (SMD) and its 95% confidence intervals (CIs) were was included and then pooled with a random effects model...
January 15, 2019: Current Eye Research
Victoria Eugenia Lledó, Hanan Awad Alkozi, Jesús Pintor
PURPOSE: Melatonin is a neurohormone mainly synthesized in the pineal gland; however, it is also present in the aqueous humor. One of melatonins' functions in the eye is the regulation of intraocular pressure. Melatonin is known to be sensitive to light. Recently, the photopigment which controls melatonin synthesis, melanopsin, was found in the crystalline lens. Therefore, light conditions is an interesting possible way of regulating melatonin levels in the aqueous humor. The current study used yellow-filters, since melanopsin is activated by short-wavelength (blue light)...
January 14, 2019: Current Eye Research
Jerome Ozkan, Mark D Willcox
The ocular surface is continually exposed to bacteria from the environment and traditional culture-based microbiological studies have isolated a low diversity of microorganisms from this region. The use of culture-independent methods to define the ocular microbiome, primarily involving 16S ribosomal RNA gene sequencing, has shown that the microbial communities present on the ocular surface have a greater diversity than previously reported and appear to have an immune modulating function. These molecular techniques have been used to investigate the effect of contact lens wear and disease on the microbiota of the ocular surface and eyelids and these studies have consistently identified bacteria not previously identified in normal eyes...
January 14, 2019: Current Eye Research
Karen Peynshaert, Joke Devoldere, An-Katrien Minnaert, Stefaan C De Smedt, Katrien Remaut
The inner limiting membrane (ILM) represents the structural boundary between the vitreous and the retina, and is suggested to act as a barrier for a wide range of retinal therapies. While it is widely acknowledged that the morphology of the human ILM exhibits regional variations and undergoes age-related changes, insight into its structure in laboratory animals is very limited. Besides presenting a detailed overview of the morphology and composition of the human ILM, this review specifically reflects on the species-specific differences in ILM structure...
January 14, 2019: Current Eye Research
Eleftherios I Paschalis, Elise V Taniguchi, James Chodosh, Louis R Pasquale, Kathryn Colby, Claes H Dohlman, Lucy Q Shen
PURPOSE: Boston keratoprosthesis (KPro) patients are prone to glaucoma even with well-controlled intraocular pressure (IOP). Recent experimental data have shown that soluble tumor necrosis factor alpha (TNF-α) after ocular injury may contribute to progressive retinal damage and subsequent glaucoma. This study evaluates the blood plasma levels of soluble TNF-α, TNF receptors 1 (TNFR1) and 2 (TNFR2), and leptin in patients with Boston type I KPro. METHODS: Venous blood samples were collected from KPro patients with glaucoma (KPro G, n = 19), KPro patients without glaucoma (KPro NoG, n = 12), primary angle closure glaucoma without KPro (PACG n = 13), and narrow angles without glaucoma or KPro (NA, n = 21)...
January 11, 2019: Current Eye Research
Qi Tan, Alex Lk Ng, George Pm Cheng, Victor Cp Woo, Pauline Cho
PURPOSE: To present the study design and one month's preliminary results of a two-year randomized trial, Combined Atropine with Orthokeratology (AOK) for myopia control study. METHODS: Children aged 6-<11 years and with 1.00-4.00 D myopia were randomly assigned to AOK Group or ortho-k alone (OK) group. Subjects are required to attend routine ortho-k aftercare visits (first-overnight, 1-week, 2-week, 3-week, 1-month, and every 3 months after commencement of lens wear)...
January 11, 2019: Current Eye Research
Ujwala A Shinde, Prajakta N Joshi, Divya D Jain, Kavita Singh
PURPOSE: A major challenge in ocular therapeutics is poor bioavailability of drug, 1% or even less of the instilled dose is absorbed and frequent administration of conventional products leads to poor adherence to therapy. Hence the present study is to synthesize N-trimethyl chitosan (TMC), a water-soluble chitosan derivative and to prepare flurbiprofen (FLU):hydroxyl propyl-β-cyclodextrin (HP-β-CD) complex loaded nanoparticles for treatment of bacterial conjunctivitis which aims to increase the residence time in ocular tissue thus enhancing patient compliance and improved efficacy...
January 11, 2019: Current Eye Research
Hyun Jin Shin, Shin-Hyo Lee, Tae-Jun Ha, Wu-Chul Song, Ki-Seok Koh
PURPOSE: The intramuscular nerve distribution in the extraocular muscles may be crucial for understanding their physiological and pathological responses. This study aimed to determine the oculomotor nerve distribution in the medial rectus muscle (MR) using Sihler's staining. METHOD: Thirty-seven MRs from 23 cadavers were investigated. The MR including the oculomotor nerve was finely dissected from its origin to its insertion point into the sclera. The total length of the muscle-belly, tendon length and maximum width of the muscle were measured...
January 9, 2019: Current Eye Research
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