Nikolaus Luft, Niklas Mohr, Elmar Spiegel, Hannah Marchi, Jakob Siedlecki, Lisa Harrant, Wolfgang J Mayer, Martin Dirisamer, Siegfried G Priglinger
PURPOSE: AI (artificial intelligence)-based methodologies have become established tools for researchers and physicians in the entire field of ophthalmology. However, the potential of AI to optimize the refractive outcome of keratorefractive surgery by means of machine learning (ML)-based nomograms has not been exhausted yet. In this study, we wanted to comprehensively compare state-of-the-art conventional nomograms for Small-Incision-Lenticule-Extraction (SMILE) with a novel ML-based nomogram regarding both their spherical and astigmatic predictability...
November 30, 2023: Current Eye Research
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November 30, 2023: Current Eye Research
Lina Yang, Zheming Li, Jian Fang
PURPOSE: Diabetic retinopathy, a prevalent complication of diabetes, represents the leading cause of vision loss and blindness among middle-aged and elderly populations. Recent research has demonstrated the ameliorating effects of scutellarin on diabetes-associated complications such as diabetic retinopathy and type 2 diabetic cardiomyopathy. However, investigations into its protective impact and underlying mechanisms on diabetic retinopathy are scant. This study aims to explore the therapeutic potential of scutellarin in diabetic retinopathy treatment...
November 28, 2023: Current Eye Research
Andrew J Swampillai, Chandni Nigam, Emily Dowse, Kin Sheng Lim
PURPOSE: To review the application of laser flare photometry (LFP) in the objective quantification of aqueous flare (anterior chamber inflammation) post laser and surgical procedures for glaucoma. METHODS: A search was undertaken using the following: PubMed (all years), the Web of Science (all years), Ovid MEDLINE (R) (1980 to 30 March 2023), Ovid MEDLINE (R) Daily Update 30 March 2023, MEDLINE and MEDLINE non-indexed items, Embase (1980-2021, week 52), Ovid MEDLINE (R) and Epub Ahead of Print, in-Process & Other Non-Indexed Citations and Daily (1980 to 30 March 2023), CENTRAL (including Cochrane Eyes and Vision Trials Register), metaRegister of Controlled Trials (mRCT) (www...
November 23, 2023: Current Eye Research
Shuxian Xu, Hanyan Mao
PURPOSE: To investigate the role of Crocin on proliferation, fibrosis, and migration of orbital fibroblasts, as well as the possible signaling pathway. METHODS: Immunofluorescence assay was performed to detect the expression of fibroblast marker proteins vimentin cytokeratin, desmin, and S-100. The quantity of 5‑ethynyl‑2'‑deoxyuridine-positive cells in orbital fibroblast was analyzed. Quantitative real-time PCR and western blots were performed to evaluate the expression level of fibrosis-related marker including alpha-smooth muscle actin, connective-tissue growth factor, collagen 1A1, and fibronectin...
November 20, 2023: Current Eye Research
Minna Karesvuo, Timo Sorsa, Raimo Tuuminen
PURPOSE: Periodontitis causes low-grade systemic inflammation and has been associated with elevated active-matrix metalloproteinase (aMMP-8) levels, blood-ocular barrier breakdown and a risk of wet age-related macular degeneration. To assess the association between aMMP-8 levels and macular status among patients with wet age-related macular degeneration (AMD). METHODS: Patients on anti-VEGF treatment for wet AMD were enrolled for oral aMMP-8 rinse test in Mehiläinen Private Hospital, Helsinki, Finland...
November 17, 2023: Current Eye Research
Jing Zhang, Zhulin Zhang, Lin Jiang, Shu He, Xin Long, Xiao Zheng
PURPOSE: N -acetylserotonin (NAS) can reduce retinal ischemia-reperfusion injury (RIRI) by inhibiting the TLR4/NF-κB/NLRP3 signaling pathway. Aflibercept is an anti-VEGF drug used to treat a variety of eye diseases. This study was performed to investigate the effect of combination therapy with N -acetylserotonin and aflibercept on RIRI and its mechanism. METHODS: The RIRI model was established by elevating the intraocular pressure. H&E staining was used to observe the pathological changes in the retinal tissue...
November 16, 2023: Current Eye Research
Chris Zajner, Bernice Leung, Tom Sheidow, Monali S Malvankar-Mehta
PURPOSE: Comparisons of the surgical and anatomic results of rhegmatogenous retinal detachment surgery have been investigated previously. A systematic evaluation of the available evidence comparing quality of life outcomes of either pars plana vitrectomy, scleral buckling, or pneumatic retinopexy has not been evaluated to date. This article analyzes whether pars plana vitrectomy, scleral buckling, or pneumatic retinopexy for the treatment of rhegmatogenous retinal detachment results in differing quality of life outcomes...
November 8, 2023: Current Eye Research
Mehdi Emamverdi, Abbas Habibi, Maryam Ashrafkhorasani, Muneeswar G Nittala, Shin Kadomoto, SriniVas R Sadda
PURPOSE: To evaluate the optical coherence tomography (OCT) features of hyperpigmented lesions in the absence of intraretinal hyperreflective foci (IHRF) on OCT in eyes with age-related macular degeneration (AMD). METHODS: We retrospectively analyzed OCT images of eyes with intermediate AMD (iAMD) and macular hyperpigmentation (HP) on color fundus photograph (CFP) but without IHRF on OCT in the corresponding location. The most prominent or definite HP was selected for analysis...
November 8, 2023: Current Eye Research
Behzod Tashbayev, Xiangjun Chen, Tor Paaske Utheim
A chalazion is one of the most common eye conditions presenting as a mass lesion of the eyelids. It is seen in all age groups. Chalazion is a non-inflammatory process and develops due to retained secretion of the meibomian or Zeis glands. Treatment of choice differs among clinicians and may include application of warm compress onto eyelids, lid hygiene, using local antibiotic ointment with or without steroids, injecting steroid solution (triamcinolone acetonide) into the lesion and surgical removal of the lesion by incision and curettage...
November 8, 2023: Current Eye Research
Hakan Kaymak, Kai Neller, Birte Graff, Achim Langenbucher, Berthold Seitz, Hartmut Schwahn, Karsten Klabe
PURPOSE: To learn whether contrast adaptation, induced by positive spherical defocus, is compromised by macular disorders such as age-related macular degeneration (AMD) or epiretinal membranes (ERM) and to gain further insight in the functionality of the pathological macula and the level of "functional reserve" often postulated for the indication of presbyopia correcting IOLs. METHODS: In a pilot study, patients with macular disorders, AMD and ERM, ( n  = 10) and healthy volunteers ( n  = 10) were tested to quantify contrast adaption after +4 D defocus for 10 min, by performing an interocular contrast matching task...
November 7, 2023: Current Eye Research
Ofira Zloto, Prachi Shah, Victor Paiusco, Bharpoor Singh, Swan Kang, David Verity, Murta Fabiola
PURPOSE: To report the surgical outcome of anterior approach primary ptosis surgery in a tertiary center and to compare redo surgical rates between different grades of surgeons. METHODS: This is a Retrospective review of series of annual audits. All involutional/aponeurosis-disinsertion ptosis surgeries performed at Moorfields Eye-hospital (MEH) between January 01, 2016 and December 31, 2019 were included. Only primary surgery was included. The following data were collected; number of surgeries per year, number of patients, demographics data, grades of surgeons, success rate, redo surgery rate from different grades of surgeons, complications rate and patients' satisfaction...
November 3, 2023: Current Eye Research
Ning Chai, Tanja Stachon, Tim Berger, Zhen Li, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry
PURPOSE: To investigate collagen I, collagen V, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), lysyl oxidase (LOX), transforming growth factor β1 (TGF-β1) and interleukin-6 (IL-6) expression in healthy and keratoconus human corneal fibroblasts (HCFs and KC-HCFs), 24 h after Rose Bengal photodynamic therapy (RB-PDT). METHODS: HCFs were isolated from healthy human corneal donors ( n  = 5) and KC-HCFs from elective penetrating keratoplasties ( n  = 5)...
November 3, 2023: Current Eye Research
Chengfang Zhu, Xianwen Xiao, Xie Fang, Lei Yan, Shunrong Luo, Xumin Shang, Zhiwen Xie, Nuo Dong, Huan He, Rongrong Zong, Lan Gong, Huping Wu, Zhirong Lin
Purpose To clarify the ocular surface features of patients with recent history of epidemic keratoconjunctivitis (EKC) and the relation between corneal dendritic cells (DCs) and ocular discomfort. Methods Normal controls (NC) and dry eye (DE) patients without EKC were recruited. Patients with recent EKC history (onset >4 weeks, but <20 weeks) were recruited as EKC + DE group (with dry eye) or EKC-DE group (without dry eye). Ocular Surface Disease Index (OSDI) questionnaire, tear film parameters including lipid layer thickness, first tear break-up time (fBUT), average tear break-up time (aBUT), tear meniscus height and Schirmer I test, meibomian gland parameters, and in vivo corneal confocal microscopy were evaluated...
October 26, 2023: Current Eye Research
Wenyi Zhang, Jing Yao, Chen Chen, Jianming Wang, Aiyi Zhou
Purpose To investigate the expression, source, role, and mechanism of Fetuin-B (FETUB) in diabetic retinopathy (DR). Methods ELISA and immunofluorescence were used to analyze the concentration of FETUB in plasma, aqueous fluid, and tissue specimens of patients with DR and healthy controls. Immunofluorescence, q-PCR, and western blotting were used to examine the expression of FETUB in DR mice and cells cultured with different concentrations of glucose. BV2 microglia cell line and DR mice were treated using FETUB recombination protein and FETUB shRNA to explore the function of FETUB in DR by q-PCR, western blotting, and immunofluorescence...
October 26, 2023: Current Eye Research
Bin Liu, Xumin Shang, Xiuxian Tan, Shunrong Luo, Xie Fang, Zhiwen Xie, Xianwen Xiao, Huan He, Lan Gong, Huping Wu, Zhirong Lin
Purpose To compare the refractive efficacy and morphological changes in the cornea following a novel biphasic higher fluence transepithelial corneal crosslinking (BI-TE-CXL) and transepithelial corneal crosslinking (TE-CXL) in adults keratoconus. Methods Patients with progressive keratoconus who required corneal crosslinking were assigned to the BI-TE-CXL group (32 eyes, phase 1: 7.2 J/cm2 for 5 minutes and 20 seconds of pulsed-light exposure, KXL, Glaukos-Avedro; phase 2: 3.6 J/cm2 for 6 minutes and 40 seconds of continuous light exposure at the front curvature apex with a 6 mm diameter light spot, UVX-2000, IROC) or the TE-CXL group (32 eyes, uniform 7...
October 26, 2023: Current Eye Research
Yasmine Meqdad, Mohamed El-Basty, Ahmed Awadein, Jylan Gouda, Dina Hassanein
PURPOSE: To compare the outcomes of patching to dichoptic stimulation using virtual reality (VR) in moderate and severe amblyopia. METHODS: This randomized controlled trial (RCT) was conducted on 86 subjects with unilateral anisometropic and mixed amblyopia. The subjects were randomized to the VR or patching group. The VR group received treatment using a VR dichoptic digital therapeutic. Each subject received weekly 2 hour-sessions for 10 weeks. The patching group was prescribed patching for 10 weeks...
October 25, 2023: Current Eye Research
Mayank A Nanavaty, Zahra Ashena, Ingrid Bekono-Nessah, Jennie Harding
PURPOSE: To propose an algorithm to facilitate lens-based surgery in keratoconus. METHODS: A literature review was performed to prepare a software algorithm based on cone location, stability, best spectacle-corrected distance visual acuity (BSCVA) level and whether there is a clear or cataractous lens. The software usability was assessed through a 10-question questionnaire and two hypothetical keratoconus case histories (moderately simple and moderately complex) given to 15 trainees...
October 23, 2023: Current Eye Research
Dianjun Jiang, Ning Guo, Xiaotong Lv, Yu Li, Yu Han, Mingzhen Yuan, Changbin Zhai, Wei Zhang, Fengju Zhang
PURPOSE: To assess the association of fundus tessellation with contrast sensitivity, Quality of Vision questionnaire, and other factors at five years postcorneal refractive surgery. METHODS: This is a cross-sectional study. Both eyes of 98 subjects (196 eyes) who received femtosecond laser in situ keratomileusis (FS-LASIK) or small incision lenticular extraction (SMILE) five years prior were enrolled in this study. Fundus tessellation was imaged using wide-angle fundus photographs and graded into four categories with the assistance of the ETDRS grid...
October 16, 2023: Current Eye Research
Jing Wang, Li Lu, Gaocheng Zou, Ziyang Ye, Feiyu Jin, Lin Wang, Genjie Ke, Kai Dong, Liming Tao
PURPOSE: To screen for the differentially expressed genes in experimental retinal detachment rats, and to explore the expression of S100 calcium-binding protein A9 and Toll-like receptor 4 in the vitreous of rhegmatogenous retinal detachment patients. METHODS: Three rats of experimental retinal detachment and three normal rats were enrolled in the study. Transcriptomics (RNAseq) sequencing technology was used to screen differentially expressed genes in the retinas of the experimental retinal detachment group and the normal group...
October 16, 2023: Current Eye Research
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