journal
https://read.qxmd.com/read/39009438/neuroticism-negative-emotionality-is-associated-with-increased-reactivity-to-uncertain-threat-in-the-bed-nucleus-of-the-stria-terminalis-not-the-amygdala
#1
JOURNAL ARTICLE
Shannon E Grogans, Juyoen Hur, Matthew G Barstead, Allegra S Anderson, Samiha Islam, Hyung Cho Kim, Manuel Kuhn, Rachael M Tillman, Andrew S Fox, Jason F Smith, Kathryn A DeYoung, Alexander J Shackman
Neuroticism/Negative Emotionality (N/NE)-the tendency to experience anxiety, fear, and other negative emotions-is a fundamental dimension of temperament with profound consequences for health, wealth, and wellbeing. Elevated N/NE is associated with a panoply of adverse outcomes, from reduced socioeconomic attainment to psychiatric illness. Animal research suggests that N/NE reflects heightened reactivity to uncertain threat in the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce), but the relevance of these discoveries to humans has remained unclear...
July 15, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38997160/synaptic-connectivity-and-electrophysiological-properties-of-the-nucleus-of-the-lateral-olfactory-tract
#2
JOURNAL ARTICLE
Sapir Penker, Naheel Lawabny, Aya Dhamshy, Tamar Licht, Dan Rokni
The sense of smell is tightly linked to emotions, a link that is thought to rely on the direct synaptic connections between the olfactory bulb and nuclei of the amygdala. However, there are multiple pathways projecting olfactory information to the amygdala and their unique functions are unknown. Among them, is the pathway via the nucleus of the lateral olfactory tract (NLOT) that receives input from olfactory regions and projects to the basolateral amygdala. NLOT has been very little studied and consequentially its function is unknown...
July 12, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38997159/dissociable-roles-of-the-dorsolateral-and-ventromedial-prefrontal-cortex-in-human-categorization
#3
JOURNAL ARTICLE
Matthew B Broschard, Brandon M Turner, Daniel Tranel, John H Freeman
Models of human categorization predict the prefrontal cortex (PFC) serves a central role in category learning. The dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC) have been implicated in categorization; however, it is unclear whether both are critical for categorization and whether they support unique functions. We administered three categorization tasks to patients with PFC lesions (mean age = 69.6 years; 5 men, 5 women) to examine how prefrontal subregions contribute to categorization...
July 12, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38997158/the-role-of-the-medial-prefrontal-cortex-in-spatial-margin-of-safety-calculations
#4
JOURNAL ARTICLE
Song Qi, Logan Cross, Toby Wise, Xin Sui, John O'Doherty, Dean Mobbs
Naturalistic observations show that animals pre-empt danger by moving to locations that increase their success in avoiding future threats. To test this in humans, we created a spatial margin of nsafety (MOS) decision task that quantifies pre-emptive avoidance by measuring the distance subjects place themselves to safety when facing different threats whose attack locations vary in predictability. Behavioral results show that human participants place themselves closer to safe locations when facing threats that attack in spatial locations with more outliers...
July 12, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38997157/an-in-vivo-high-resolution-human-brain-atlas-of-synaptic-density
#5
JOURNAL ARTICLE
Annette Johansen, Vincent Beliveau, Emil Colliander, Nakul Ravi Raval, Vibeke Høyrup Dam, Nic Gillings, Susana Aznar, Claus Svarer, Pontus Plavén-Sigray, Gitte Moos Knudsen
Synapses are fundamental to the function of the central nervous system and are implicated in a number of brain disorders. Despite their pivotal role, a comprehensive imaging resource detailing the distribution of synapses in the human brain has been lacking until now. Here, we employ high-resolution PET neuroimaging in healthy humans (17F/16M) to create a 3D atlas of the synaptic marker Synaptic Vesicle glycoprotein 2A (SV2A). Calibration to absolute density values (pmol/mL) was achieved by leveraging postmortem human brain autoradiography data...
July 12, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38991792/erratum-burman-et-al-optogenetic-determination-of-dynamic-and-cell-type-specific-inhibitory-reversal-potentials
#6
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 11, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38991791/perineuronal-nets-in-the-rat-medial-prefrontal-cortex-alter-hippocampal-prefrontal-oscillations-and-reshape-cocaine-self-administration-memories
#7
JOURNAL ARTICLE
Jereme C Wingert, Jonathan D Ramos, Sebastian X Reynolds, Angela E Gonzalez, R Mae Rose, Deborah M Hegarty, Sue A Aicher, Lydia G Bailey, Travis E Brown, Atheir I Abbas, Barbara A Sorg
The medial prefrontal cortex (mPFC) is a major contributor to relapse to cocaine in humans and to reinstatement in rodent models of cocaine use disorder. Output from the mPFC is potently modulated by parvalbumin (PV)-containing fast-spiking interneurons, the majority of which are surrounded by perineuronal nets (PNNs). We previously showed that ABC treatment with chondroitinase ABC (ABC) reduced the consolidation and reconsolidation of a cocaine conditioned place preference (CPP) memory. However, self-administration memories are more difficult to disrupt...
July 11, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38991790/dissociable-representations-of-decision-variables-within-subdivisions-of-macaque-orbitofrontal-and-ventrolateral-frontal-cortex
#8
JOURNAL ARTICLE
Frederic M Stoll, Peter H Rudebeck
Ventral frontal cortex (VFC) in macaques is involved in many affective and cognitive processes and has a key role in flexibly guiding reward-based decision-making. VFC is composed of a set of anatomically distinct subdivisions that are within the orbitofrontal cortex, ventrolateral prefrontal cortex, and anterior insula. In part, because prior studies have lacked the resolution to test for differences, it is unclear if neural representations related to decision-making are dissociable across these subdivisions...
July 11, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38981688/erratum-huang-et-al-phosphoinositide-3-kinase-gamma-contributes-to-neuroinflammation-in-a-rat-model-of-surgical-brain-injury
#9
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 9, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38977303/erratum-gottschalk-et-al-gemfibrozil-protects-dopaminergic-neurons-in-a-mouse-model-of-parkinson-s-disease-via-ppar%C3%AE-dependent-astrocytic-gdnf-pathway
#10
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 8, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38977302/erratum-gokce-and-s%C3%A3-dhof-membrane-tethered-monomeric-neurexin-lns-domain-triggers-synapse-formation
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 8, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38977301/agouti-induced-anxiety-like-behaviour-is-mediated-by-central-serotonergic-pathways-in-zebrafish
#12
JOURNAL ARTICLE
Alejandra Godino-Gimeno, Ana Rocha, Mauro Chivite, Alfonso Saera-Vila, Josep Rotllant, Jesús M Míguez, José Miguel Cerdá-Reverter
Overexpression of the agouti-signalling protein ( asip1 ), an endogenous melanocortin antagonist, under the control of a constitutive promoter in zebrafish [Tg(Xla.Eef1a1:Cau.Asip1]iim4] ( asip1 -Tg) increases food intake by reducing sensitivity of the central satiety systems and abolish circadian activity rhythms. The phenotype also shows increased linear growth and body weight, yet no enhanced aggressiveness in dyadic fights is observed. In fact, asip1 -Tg animals choose to flee to safer areas rather than face a potential threat thus suggesting a potential anxiety-like behaviour (ALB)...
July 8, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38977300/generation-and-characterization-of-a-novel-prkcd-cre-rat-model
#13
JOURNAL ARTICLE
Sanne Toivainen, Michele Petrella, Li Xu, Esther Visser, Tamina Weiss, Sofia Vellere, Zane Zeier, Claes Wahlestedt, Estelle Barbier, Esi Domi, Markus Heilig
Activity of central amygdala (CeA) PKCδ expressing neurons has been linked to appetite regulation, anxiety-like behaviors, pain sensitivity, and addiction-related behaviors. Studies of the role that CeA PKCδ+ neurons play in these behaviors have largely been carried out in mice, and genetic tools that would allow selective manipulation of PKCδ+ cells in rats have been lacking. Here, we used a CRISPR/Cas9 strategy to generate a transgenic Prkcd -cre knock-in rat, and characterized this model using anatomical, electrophysiological and behavioral approaches in both sexes...
July 8, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38969506/electrical-synapses-mediate-embryonic-hyperactivity-in-a-zebrafish-model-of-fragile-x-syndrome
#14
JOURNAL ARTICLE
Kaleb D Miles, Chase M Barker, Kristen P Russell, Bruce H Appel, Caleb A Doll
Although hyperactivity is associated with a wide variety of neurodevelopmental disorders, the early embryonic origins of locomotion have hindered investigation of pathogenesis of these debilitating behaviors. The earliest motor output in vertebrate animals is generated by clusters of early-born motor neurons that occupy distinct regions of the spinal cord, innervating stereotyped muscle groups. Gap junction electrical synapses drive early spontaneous behavior in zebrafish, prior to the emergence of chemical neurotransmitter networks...
July 5, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38969505/neural-representations-of-sensory-uncertainty-and-confidence-are-associated-with-perceptual-curiosity
#15
JOURNAL ARTICLE
Michael Cohanpour, Mariam Aly, Jacqueline Gottlieb
Humans are immensely curious and motivated to reduce uncertainty, but little is known about the neural mechanisms that generate curiosity. Curiosity is inversely associated with confidence, suggesting that it is triggered by states of low confidence (subjective uncertainty). The neural mechanisms of this process, however, have been little investigated. What are the mechanisms through which uncertainty about an event gives rise to curiosity about that event? Inspired by studies of sensory uncertainty, we hypothesized that visual areas provide multivariate representations of uncertainty, which are then read out by higher-order structures to generate signals of confidence and, ultimately, trigger curiosity...
July 5, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38969504/dopamine-release-in-the-nucleus-accumbens-core-encodes-the-general-excitatory-components-of-learning
#16
JOURNAL ARTICLE
Masakazu Taira, Samuel J Millard, Anna Verghese, Lauren E DiFazio, Ivy B Hoang, Ruiting Jia, Ana Sias, Andrew Wikenheiser, Melissa J Sharpe
Dopamine release in the nucleus accumbens core (NAcC) is generally considered to be a proxy for phasic firing of dopamine neurons in the ventral tegmental area (VTADA ). Thus, dopamine release in NAcC is hypothesized to reflect a unitary role in reward prediction error signalling. However, recent studies revealed more diverse roles of dopamine neurons, which support an emerging idea that dopamine regulates learning differently in distinct circuits. To understand whether the NAcC might regulate a unique component of learning, we recorded dopamine release in NAcC while male rats performed a backward conditioning task where a reward is followed by a cue...
July 5, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38960720/integrated-perceptual-decisions-rely-on-parallel-evidence-accumulation
#17
JOURNAL ARTICLE
Dragan Rangelov, Julia Fellrath, Jason B Mattingley
The ability to make accurate and timely decisions, such as judging when it is safe to cross the road, is the foundation of adaptive behaviour. While the computational and neural processes supporting simple decisions on isolated stimuli have been well characterised, decision making in the real world often requires integration of discrete sensory events over time and space. Most previous experimental work on perceptual decision-making has focused on tasks that involve only a single, task-relevant source of sensory input...
July 3, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38960719/human-cervical-epidural-spinal-electrogram-topographically-maps-distinct-volitional-movements
#18
JOURNAL ARTICLE
Poojan D Shukla, John F Burke, Nikhita Kunwar, Kara Presbrey, Jannine Balakid, Maria Yaroshinsky, Kenneth Louie, Line Jacques, Prasad Shirvalkar, Doris D Wang
Little is known about the electrophysiologic activity of the intact human spinal cord during volitional movement. We analyzed epidural spinal recordings from a total of 5 human subjects of both sexes during a variety of upper extremity movements and found that these spinal epidural electrograms contain spectral information distinguishing periods of movement, rest, and sensation. Cervical epidural electrograms also contained spectral changes time-locked with movement. We found that these changes were primarily associated with increased power in the theta (4-8 Hz) band, feature increased theta-gamma phase-amplitude coupling, and that this increase in theta power can be used to topographically map distinct upper extremity movements onto the cervical spinal cord in accordance with established myotome maps of the upper extremity...
July 3, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38955488/conflicting-sensory-information-sharpens-the-neural-representations-of-early-selective-visuospatial-attention
#19
JOURNAL ARTICLE
Panchalee Sookprao, Kanyarat Benjasupawan, Tanagrit Phangwiwat, Itthi Chatnuntawech, Kanda Lertladaluck, Angela Gutchess, Chaipat Chunharas, Sirawaj Itthipuripat
Adaptive behaviors require the ability to resolve conflicting information caused by the processing of incompatible sensory inputs. Prominent theories of attention have posited that early selective attention helps mitigate cognitive interference caused by conflicting sensory information by facilitating the processing of task-relevant sensory inputs and filtering out behaviorally irrelevant information. Surprisingly, many recent studies that investigated the role of early selective attention on conflict mitigation have failed to provide positive evidence...
July 2, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38955487/astrocyte-d1-d5-dopamine-receptors-govern-non-hebbian-long-term-potentiation-at-sensory-synapses-onto-lamina-i-spinoparabrachial-neurons
#20
JOURNAL ARTICLE
Jie Li, Elizabeth K Serafin, Nathan Koorndyk, Mark L Baccei
Recent work demonstrated that activation of spinal D1 and D5 dopamine receptors (D1/D5Rs) facilitates non-Hebbian long-term potentiation (LTP) at primary afferent synapses onto spinal projection neurons. However, the cellular localization of the D1/D5Rs driving non-Hebbian LTP in spinal nociceptive circuits remains unknown, and it is also unclear whether D1/D5R signaling must occur concurrently with sensory input in order to promote non-Hebbian LTP at these synapses. Here we investigate these issues using cell type-selective knockdown of D1Rs or D5Rs from lamina I spinoparabrachial neurons, dorsal root ganglion (DRG) neurons or astrocytes in adult mice of either sex using Cre recombinase-based genetic strategies...
July 2, 2024: Journal of Neuroscience
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