V Peters, E Riedl, M Braunagel, S Höger, S Hauske, F Pfister, J Zschocke, B Lanthaler, U Benck, H-P Hammes, B K Krämer, C P Schmitt, B A Yard, H Köppel
In humans, we reported an association of a certain allele of carnosinase gene with reduced carnosinase activity and absence of nephropathy in diabetic patients. CN1 degrades histidine dipeptides such as carnosine and anserine. Further, we and others showed that treatment with carnosine improves renal function and wound healing in diabetic mice and rats. We now investigated the effects of carnosine treatment alone and in combination with ACE inhibition, a clinically established nephroprotective drug in diabetic nephropathy...
November 2014: Regulatory Peptides