Nick Corriveau-Lecavalier, Nirubol Tosakulwong, Timothy G Lesnick, Angela J Fought, Robert I Reid, Christopher G Schwarz, Matthew L Senjem, Clifford R Jack, David T Jones, Prashanthi Vemuri, Rosa Rademakers, Eliana Marisa Ramos, Daniel H Geschwind, David S Knopman, Hugo Botha, Rodolfo Savica, Jonathan Graff-Radford, Vijay K Ramanan, Julie A Fields, Neill Graff-Radford, Zbigniew Wszolek, Leah K Forsberg, Ronald C Petersen, Hilary W Heuer, Adam L Boxer, Howard J Rosen, Bradley F Boeve, Kejal Kantarci
We assessed white matter (WM) integrity in MAPT mutation carriers (16 asymptomatic, 5 symptomatic) compared to 31 non-carrier family controls using diffusion tensor imaging (DTI) (fractional anisotropy; FA, mean diffusivity; MD) and neurite orientation dispersion and density imaging (NODDI) (neurite density index; NDI, orientation and dispersion index; ODI). Linear mixed-effects models accounting for age and family relatedness revealed alterations across DTI and NODDI metrics in all mutation carriers and in symptomatic carriers, with the most significant differences involving fronto-temporal WM tracts...
December 10, 2023: Neurobiology of Aging
Jasmin M Kizilirmak, Joram Soch, Anni Richter, Björn H Schott
Episodic memory performance declines with increasing age, and older adults typically show reduced activation of inferior temporo-parietal cortices in functional magnetic resonance imaging (fMRI) studies of episodic memory formation. Given the age-related cortical volume loss, it is conceivable that age-related reduction of memory-related fMRI activity may be partially attributable to reduced grey matter volume (GMV). We performed a voxel-wise multimodal neuroimaging analysis of fMRI correlates of successful memory encoding, using regional GMV as covariate...
December 5, 2023: Neurobiology of Aging
Xiaomin Tang, Haoyue Zhong, Chenyu Xu, Yuxuan Sun, Yuxiang Lou, Yi Zhao, Yue Liang, Xiaotao Guo, Chunchen Pan, Jiaqiang Sun, Jingwu Sun
KCNMA1 encodes the K+ potassium channel α-subunit that plays a significant role in the auditory system. Our previous studies indicated that KCNMA1 is associated with age-related hearing loss(AHL). However, the detailed mechanism of KCNMA1 involvement in auditory age-related degradation has not been fully clarified. Therefore, we explored the expression of KCNMA1 in the peripheral auditory of 2-month-old and 12-month-old mice by Western blotting and immunofluorescence. The results of animal experiments showed that KCNMA1 expression was decreased in 12-month-old mice compared with 2-month-old mice, whereas the ferroptosis level was increased...
December 2, 2023: Neurobiology of Aging
Claudio Babiloni, Giuseppe Noce, Federico Tucci, Dharmendra Jakhar, Raffaele Ferri, Simonetta Panerai, Valentina Catania, Andrea Soricelli, Marco Salvatore, Flavio Nobili, Dario Arnaldi, Francesco Famà, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Fabiana Radicati, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Lucilla Parnetti, Moira Marizzoni, Fabrizia D'Antonio, Giuseppe Bruno, Carlo De Lena, Bahar Güntekin, Ebru Yıldırım, Lutfu Hanoğlu, Görsev Yener, Duygu Hünerli, John-Paul Taylor, Julia Schumacher, Ian McKeith, Giovanni B Frisoni, Angelo Antonini, Florinda Ferreri, Laura Bonanni, Maria Francesca De Pandis, Claudio Del Percio
Here, we hypothesized that the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms during the transition from eyes-closed to -open condition might be lower in patients with Parkinson's disease dementia (PDD) than in patients with Alzheimer's disease dementia (ADD). A Eurasian database provided clinical-demographic-rsEEG datasets in 73 PDD patients, 35 ADD patients, and 25 matched cognitively unimpaired (Healthy) persons. The eLORETA freeware was used to estimate cortical rsEEG sources...
November 28, 2023: Neurobiology of Aging
Adam H Dyer, Helene McNulty, Aoife Caffrey, Shane Gordon, Eamon Laird, Leane Hoey, Catherine F Hughes, Mary Ward, J J Strain, Maurice O'Kane, Fergal Tracey, Anne M Molloy, Conal Cunningham, Kevin McCarroll
Studies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific cognitive performance (Repeatable Battery for Assessment of Neuropsychological Status [RBANS])...
November 28, 2023: Neurobiology of Aging
Bing Xin Song, Laiba Azhar, Grace Ka Yi Koo, Susan Marzolini, Damien Gallagher, Walter Swardfager, Clara Chen, Joycelyn Ba, Nathan Herrmann, Krista L Lanctôt
Impaired angiogenesis is associated with cognitive decline in older adults. While exercise has been broadly associated with increased angiogenesis, the relevant mechanisms in older adults are not clear. Here, we present a systematic review and meta-analysis on the relationship between exercise and specific blood angiogenesis markers in older adults to better understand the relevant mechanisms. MEDLINE, Embase, and Cochrane CENTRAL were searched for original reports of angiogenesis markers' concentrations in blood before and after exercise in older adults (≥50 years)...
March 2024: Neurobiology of Aging
Rachel Twitto-Greenberg, Sigal Liraz-Zaltsman, Daniel M Michaelson, Ori Liraz, Irit Lubitz, Dana Atrakchi-Baranes, Chen Shemesh, Uri Ashery, Itzik Cooper, Ayelet Harari, Dror Harats, Michal Schnaider-Beeri, Aviv Shaish
A significant progressive decline in beta-carotene (βC) levels in the brain is associated with cognitive impairment and a higher prevalence of Alzheimer's disease (AD). In this study, we investigated whether the administration of 9-cis beta-carotene (9CBC)-rich powder of the alga Dunaliella bardawil, the best-known source of βC in nature, inhibits the development of AD-like neuropathology and cognitive deficits. We demonstrated that in 3 AD mouse models, Tg2576, 5xFAD, and apoE4, 9CBC treatment improved long- and short-term memory, decreased neuroinflammation, and reduced the prevalence of β-amyloid plaques and tau hyperphosphorylation...
January 2024: Neurobiology of Aging
Kathleen Margaret Hagen, Paul Gordon, Ariana Frederick, Alexandra Louise Palmer, Pariya Edalat, Yohan Ricci Zonta, Lucas Scott, Melissa Flancia, Jacqueline Kelsey Reid, Matthew Joel, Shalina Sheryl Ousman
Evidence indicates that dysfunction of older Schwann cells and macrophages contributes to poor regeneration of more mature peripheral nervous system (PNS) neurons after damage. Since the underlying molecular factors are largely unknown, we investigated if CRYAB, a small heat shock protein that is expressed by Schwann cells and axons and whose expression declines with age, impacts prominent deficits in the injured, older PNS including down-regulation of cholesterol biosynthesis enzyme genes, Schwann cell dysfunction, and macrophage persistence...
January 2024: Neurobiology of Aging
Sharon Sanz Simon, Eleanna Varangis, Seonjoo Lee, Yian Gu, Yunglin Gazes, Qolamreza R Razlighi, Christian Habeck, Yaakov Stern
The relationship between tau deposition and cognitive decline in cognitively healthy older adults is still unclear. The tau PET tracer 18 F-MK-6240 has shown favorable imaging characteristics to identify early tau deposition in aging. We evaluated the relationship between in vivo tau levels (18 F-MK-6240) and retrospective cognitive change over 5 years in episodic memory, processing speed, and reasoning. For tau quantification, a set of regions of interest (ROIs) was selected a priori based on previous literature: (1) total-ROI comprising selected areas, (2) medial temporal lobe-ROI, and (3) lateral temporal lobe-ROI and cingulate/parietal lobe-ROI...
January 2024: Neurobiology of Aging
Yuanjing Li, Grégoria Kalpouzos, Lars Bäckman, Chengxuan Qiu, Erika J Laukka
We investigated the association of load and accumulation of white matter hyperintensities (WMHs) with rate of cognitive decline. This population-based study included 510 dementia-free people (age ≥60 years) who had repeated measures of global and regional (lobar, deep, periventricular) WMHs up to 6 years (from 2001-2003 to 2007-2010) and repeated measures of cognitive function (episodic memory, semantic memory, category fluency, letter fluency, executive function, perceptual speed) up to 15 years (from 2001-2004 to 2016-2019)...
December 2023: Neurobiology of Aging
Natalie Busby, Sarah Wilson, Janina Wilmskoetter, Roger Newman-Norlund, Sara Sayers, Sarah Newman-Norlund, Rebecca Roth, Chris Rorden, Julius Fridriksson, Leonardo Bonilha
To elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship between age and cognitive decline. Healthy participants (N = 166, 20-80 years) completed the Montreal Cognitive Assessment (MoCA). WMHs were manually delineated on FLAIR scans. Mediation analysis was conducted to determine if WMH load mediates the relationship between age and cognition...
December 2023: Neurobiology of Aging
Soodeh Moallemian, Eric Salmon, Mohamed Ali Bahri, Nikita Beliy, Emma Delhaye, Evelyne Balteau, Christian Degueldre, Christophe Phillips, Christine Bastin
Multiple neuropathological events are involved in Alzheimer's disease (AD). The current study investigated the concurrence of neurodegeneration, increased iron content, atrophy, and demyelination in AD. Quantitative multiparameter magnetic resonance imaging (MRI) maps providing neuroimaging biomarkers for myelination and iron content along with synaptic density measurements using [18F] UCB-H PET were acquired in 24 AD and 19 Healthy controls (19 males). The whole brain voxel-wise group comparison revealed demyelination in the right hippocampus, while no significant iron content difference was detected...
December 2023: Neurobiology of Aging
Kate E Hoy, Melanie R L Emonson, Neil W Bailey, Caitlyn Rogers, Hannah Coyle, Freya Stockman, Paul B Fitzgerald
There is growing evidence that neural network dysfunction is a likely proximate cause of cognitive impairment in Alzheimer's disease and may represent a promising therapeutic target. Here, we investigated whether a course of intermittent theta burst stimulation (iTBS) could modulate functional connectivity and cognition in mild to moderate Alzheimer's. In a double-blind parallel randomized sham-controlled trial, 58 participants were randomized to either active or sham iTBS. Stimulation was applied to the left dorsolateral prefrontal cortex, right dorsolateral prefrontal cortex, left posterior parietal cortex, and right posterior parietal cortex in every treatment session...
December 2023: Neurobiology of Aging
Meral A Tubi, Koral Wheeler, Elizabeth Matsiyevskiy, Matthew Hapenney, Wendy J Mack, Helena C Chui, Kevin King, Paul M Thompson, Meredith N Braskie
In older adults with abnormal levels of Alzheimer's disease neuropathology, lower cerebrospinal fluid (CSF) vascular endothelial growth factor (VEGF) levels are associated with lower [¹⁸F]-fluorodeoxyglucose positron emission tomography (FDG-PET) signal, but whether this association is (1) specific to VEGF or broadly driven by vascular inflammation, or (2) modified by vascular risk (e.g., white matter hyperintensities [WMHs]) remains unknown. To address this and build upon our past work, we evaluated whether 5 CSF vascular inflammation biomarkers (vascular cell adhesion molecule 1, VEGF, C-reactive protein, fibrinogen, and von Willebrand factor)-previously associated with CSF amyloid levels-were related to FDG-PET signal and whether WMH volume modified these associations in 158 Alzheimer's Disease Neuroimaging Initiative participants (55-90 years old, 39 cognitively normal, 80 mild cognitive impairment, 39 Alzheimer's disease)...
December 2023: Neurobiology of Aging
Petar P Raykov, Ethan Knights, Cam-Can, Richard N Henson
Healthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work activities during midlife can have a protective effect on cognition several decades later, rendering it less dependent on brain structural health; the definition of "cognitive reserve". Other work has shown that increasing age is associated with reduced segregation of large-scale brain functional networks. Here we tested the hypothesis that functional segregation (SyS) mediates this effect of middle-aged lifestyle on late-life cognition...
November 25, 2023: Neurobiology of Aging
Ryan A Panela, Francesca Copelli, Björn Herrmann
Neural tracking of spoken speech is considered a potential clinical biomarker for speech-processing difficulties, but the reliability of neural speech tracking is unclear. Here, younger and older adults listened to stories in two sessions while electroencephalography was recorded to investigate the reliability and generalizability of neural speech tracking. Speech tracking amplitude was larger for older than younger adults, consistent with an age-related loss of inhibition. The reliability of neural speech tracking was moderate (ICC ∼0...
November 21, 2023: Neurobiology of Aging
Kai Sin Chin, Sarah Holper, Paula Loveland, Leonid Churilov, Nawaf Yassi, Rosie Watson
Cerebral microbleeds (CMB) are often associated with vascular risk factors and/or cerebral amyloid angiopathy and are frequently identified in people with dementia. The present study therefore aimed to estimate the pooled prevalence and associations of CMB in Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), using meta-analytic methods. Sixty-five MRI studies were included after a systematic search on major electronic databases. We found that the prevalence of CMB was comparable across the three dementia subtypes (31-36%) and was highly influenced by the MRI techniques used...
November 19, 2023: Neurobiology of Aging
John Woulfe, David G Munoz, Douglas A Gray, Hyder A Jinnah, Alyona Ivanova
We explored mechanisms involved in the age-dependent degeneration of human substantia nigra (SN) dopamine (DA) neurons. Owing to its important metabolic functions in post-mitotic neurons, we investigated the developmental and age-associated changes in the purine biosynthetic enzyme inosine monophosphate dehydrogenase (IMPDH). Tissue microarrays prepared from post-mortem samples of SN from 85 neurologically intact participants humans spanning the age spectrum were immunostained for IMPDH combined with other proteins...
November 17, 2023: Neurobiology of Aging
Meishan Ai, Timothy P Morris, Adrián Noriega de la Colina, Nagashree Thovinakere, Jennifer Tremblay-Mercier, Sylvia Villeneuve, Charles H Hillman, Arthur F Kramer, Maiya R Geddes
The relationship between midlife physical activity (PA), and cognition and brain health in later life is poorly understood with conflicting results from previous research. Investigating the contribution of midlife PA to later-life cognition and brain health in high-risk populations will propel the development of health guidance for those most in need. The current study examined the association between midlife PA engagement and later-life cognition, grey matter characteristics and resting-state functional connectivity in older individuals at high-risk for Alzheimer's disease...
November 11, 2023: Neurobiology of Aging
Anni Moore, Peter Wild Crea, Mary Makarious, Sara Bandres-Ciga, Cornelis Blauwendraat, Monica Diez-Fairen
Parkinson's disease (PD) is a progressive neurological disorder caused by both genetic and environmental factors. An association has been described between KTN1 genetic variants and changes in its expression in the putamen and substantia nigra brain regions and an increased risk for PD. Here, we examine the link between PD susceptibility and KTN1 using individual-level genotyping data and summary statistics from the most recent genome-wide association studies (GWAS) for PD risk and age at onset from the International Parkinson's Disease Genomics Consortium (IPDGC), as well as whole-genome sequencing data from the Accelerating Medicines Partnership Parkinson's disease (AMP-PD) initiative...
November 10, 2023: Neurobiology of Aging
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