Can Fenerci, Roni Setton, Giulia Baracchini, Jamie Snytte, R Nathan Spreng, Signy Sheldon
Age-related episodic memory decline is attributed to functional alternations in the hippocampus. Less clear is how aging affects the functional connections of the hippocampus to the rest of the brain during episodic memory processing. We examined fMRI data from the CamCAN dataset, in which a large cohort of participants watched a movie (N = 643; 18-88 years), a proxy for naturalistic episodic memory encoding. We examined connectivity profiles across the lifespan both within the hippocampus (anterior, posterior), and between the hippocampal subregions and cortical networks...
June 30, 2024: Neurobiology of Aging
Camila de Ávila, Crystal Suazo, Jennifer Nolz, J Nicholas Cochran, Qi Wang, Ramon Velazquez, Eric Dammer, Benjamin Readhead, Diego Mastroeni
Women have a higher incidence of Alzheimer's disease (AD), even after adjusting for increased longevity. Thus, there is an urgent need to identify genes that underpin sex-associated risk of AD. PIN1 is a key regulator of the tau phosphorylation signaling pathway; however, potential differences in PIN1 expression, in males and females, are still unknown. We analyzed brain transcriptomic datasets focusing on sex differences in PIN1 mRNA levels in an aging and AD cohort, which revealed reduced PIN1 levels primarily within females...
June 29, 2024: Neurobiology of Aging
Pei Ying Lee, Bang V Bui
Age-related neuronal adaptations are known to help maintain function. This study aims to examine gross age-related in vivo retinal functional adaptations (using electroretinography) in young and middle aged C57BL/6J and Thy1-YFPh mice and to relate this to in vivo retinal structure (using optical coherence tomography). Electroretinography responses were generally larger in Thy1-YFPh mice than in C57BL/6J mice, with similar in vivo retinal layer thicknesses except for longer inner/outer photoreceptor segment in Thy1-YFPh mice...
June 26, 2024: Neurobiology of Aging
Suzan van Amerongen, Shreyasee Das, Suzie Kamps, Julie Goossens, Bram Bongers, Yolande A L Pijnenburg, Eugeen Vanmechelen, Everard G B Vijverberg, Charlotte E Teunissen, Inge M W Verberk
Traumatic brain injury (TBI) and Alzheimer's disease (AD) have overlapping mechanisms but it remains unknown if pathophysiological characteristics and cognitive trajectories in AD patients are influenced by TBI history. Here, we studied AD patients (stage MCI or dementia) with TBI history (ADTBI+, n=110), or without (ADTBI- , n=110) and compared baseline CSF concentrations of amyloid beta 1-42 (Aβ42), phosphorylated tau181 (pTau181), total tau, neurofilament light chain (NfL), synaptosomal associated protein-25kDa (SNAP25), neurogranin (Ng), neuronal pentraxin-2 (NPTX2) and glutamate receptor-4 (GluR4), as well as differences in cognitive trajectories using linear mixed models...
September 2024: Neurobiology of Aging
Rikki Lissaman, Sricharana Rajagopal, Julia Kearley, Stamatoula Pasvanis, Maria Natasha Rajah
Decline in spatial context memory emerges in midlife, the time when most females transition from pre- to post-menopause. Recent evidence suggests that, among post-menopausal females, advanced age is associated with functional brain alterations and lower spatial context memory. However, it is unknown whether similar effects are evident for white matter (WM) and, moreover, whether such effects contribute to sex differences at midlife. To address this, we conducted a study on 96 cognitively unimpaired middle-aged adults (30 males, 32 pre-menopausal females, 34 post-menopausal females)...
June 8, 2024: Neurobiology of Aging
Sandra Aleksic, Roman Fleysher, Erica F Weiss, Noa Tal, Timothy Darby, Helena M Blumen, Juan Vazquez, Kenny Q Ye, Tina Gao, Shira M Siegel, Nir Barzilai, Michael L Lipton, Sofiya Milman
The hypothalamus regulates homeostasis across the lifespan and is emerging as a regulator of aging. In murine models, aging-related changes in the hypothalamus, including microinflammation and gliosis, promote accelerated neurocognitive decline. We investigated relationships between hypothalamic microstructure and features of neurocognitive aging, including cortical thickness and cognition, in a cohort of community-dwelling older adults (age range 65-97 years, n=124). Hypothalamic microstructure was evaluated with two magnetic resonance imaging diffusion metrics: mean diffusivity (MD) and fractional anisotropy (FA), using a novel image processing pipeline...
June 3, 2024: Neurobiology of Aging
Blanca Rodríguez-Fernández, Gonzalo Sánchez-Benavides, Patricia Genius, Carolina Minguillon, Karine Fauria, Immaculata De Vivo, Arcadi Navarro, Jose Luis Molinuevo, Juan Domingo Gispert, Aleix Sala-Vila, Natalia Vilor-Tejedor, Marta Crous-Bou
INTRODUCTION: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. METHODS: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR...
June 1, 2024: Neurobiology of Aging
Joan Jiménez-Balado, Christian Habeck, Yaakov Stern, Teal Eich
White matter hyperintensities (WMH) are associated with cortical thinning. Although they are primarily detected in older participants, these lesions can appear in younger and midlife individuals. Here, we tested whether WMH are associated with cortical thinning in relatively younger (26-50 years) and relatively older (58-84) participants who were free of dementia, and how these associations are moderated by WMH localization. WMH were automatically quantified and categorized according to the localization of three classes of white matter tracts: association, commissural and projection fibers...
May 29, 2024: Neurobiology of Aging
Stephanie Lindgård Knudtzon, Kaja Nordengen, Gøril Rolfseng Grøntvedt, Jonas Jarholm, Ingvild Vøllo Eliassen, Per Selnes, Lene Pålhaugen, Jacob Espenes, Berglind Gísladóttir, Knut Waterloo, Tormod Fladby, Bjørn-Eivind Kirsebom
Cerebrospinal fluid total-tau (t-tau) and neurofilament light chain (NfL) are biomarkers of neurodegeneration and are increased in Alzheimer's disease (AD). In order to adjust for age-related increases in t-tau and NfL, cross-sectional age-adjusted norms were developed based on amyloid negative cognitively normal (CN) adults aged 41-78 years (CN, n = 137). The age-adjusted norms for t-tau and NfL did not improve receiver operating curve based diagnostic accuracies in individuals with mild cognitive impairment (MCI) due to AD (AD-MCI, n = 144)...
May 29, 2024: Neurobiology of Aging
Helmet T Karim, Soyoung Lee, Andrew Gerlach, Mark Stinley, Rachel Berta, Rebecca Mahbubani, Dana L Tudorascu, Meryl A Butters, James J Gross, Carmen Andreescu
Studies have confirmed that anxiety, especially worry and rumination, are associated with increased risk for cognitive decline, including Alzheimer's disease and related dementias (ADRD). Hippocampal atrophy is a hallmark of ADRD. We investigated the association between hippocampus and its subfield volumes and late-life global anxiety, worry, and rumination, and emotion regulation strategies. We recruited 110 participants with varying worry severity who underwent magnetic resonance imaging and clinical interviews...
May 28, 2024: Neurobiology of Aging
Helena M Blumen, Oshadi Jayakody, Emmeline Ayers, Nir Barzilai, Christian Habeck, Sofiya Milman, Yaakov Stern, Erica F Weiss, Joe Verghese
Cognition and gait share brain substrates in aging and dementia. Cognitive reserve (CR) allows individuals to cope with brain pathology and delay cognitive impairment and dementia. Yet, evidence for that CR is associated with age-related cognitive decline is mixed, and evidence for that CR is associated with age-related gait decline is limited. In 1,079 older (M Age = 75.4 years; 56.0% women) LonGenity study participants without dementia at baseline and up to 12 years of annual follow-up (M follow-up = 3.9 years, SD = 2...
May 27, 2024: Neurobiology of Aging
Wei-Yeh Liao, George M Opie, Ulf Ziemann, John G Semmler
The communication between dorsal premotor cortex (PMd) and primary motor cortex (M1) is important for visuomotor adaptation, but it is unclear how this relationship changes with advancing age. The present study recruited 21 young and 23 older participants for two experimental sessions during which intermittent theta burst stimulation (iTBS) or sham was applied over PMd. We assessed the effects of PMd iTBS on M1 excitability using motor evoked potentials (MEP) recorded from right first dorsal interosseous when single-pulse transcranial magnetic stimulation (TMS) was applied with posterior-anterior (PA) or anterior-posterior (AP) currents; and adaptation by quantifying error recorded during a visuomotor adaptation task (VAT)...
May 25, 2024: Neurobiology of Aging
Andrea Mendez Colmenares, Michael L Thomas, Charles Anderson, David B Arciniegas, Vince Calhoun, In-Young Choi, Arthur F Kramer, Kaigang Li, Jongho Lee, Phil Lee, Agnieszka Z Burzynska
INTRODUCTION: The "structural disconnection" hypothesis of cognitive aging suggests that deterioration of white matter (WM), especially myelin, results in cognitive decline, yet in vivo evidence is inconclusive. METHODS: We examined age differences in WM microstructure using Myelin Water Imaging and Diffusion Tensor Imaging in 141 healthy participants (age 20-79). We used the Virginia Cognitive Aging Project and the NIH Toolbox® to generate composites for memory, processing speed, and executive function...
May 23, 2024: Neurobiology of Aging
Rui Liu, Jin-Ze Li, Jun-Ke Song, Dan Zhou, Chao Huang, Xiao-Yu Bai, Tao Xie, Xue Zhang, Yong-Jie Li, Cai-Xia Wu, Lan Zhang, Lin Li, Tian-Tai Zhang, Guan-Hua Du
No abstract text is available yet for this article.
May 22, 2024: Neurobiology of Aging
Yuji Suzuki, Yukimi Nakamura, Hironaka Igarashi
Physiological age-related alterations in the interstitial flow in the brain, which plays an important role in waste product removal, remain unclear. Using [15 O]H2 O positron emission tomography (PET), water dynamics were evaluated in 63 healthy adult participants aged between 20 and 80 years. Interstitial flow was assessed by influx ratio (IR) and drain rate (DR), using time-activity concentration data. Participants were divided into four age groups with 15-year ranges, to evaluate age-related functional alterations...
May 19, 2024: Neurobiology of Aging
Daniel E Gustavson, Jeremy A Elman, Chandra A Reynolds, Lisa T Eyler, Christine Fennema-Notestine, Olivia K Puckett, Matthew S Panizzon, Nathan A Gillespie, Michael C Neale, Michael J Lyons, Carol E Franz, William S Kremen
We examined how brain reserve in midlife, measured by brain-predicted age difference scores (Brain-PADs), predicted executive function concurrently and longitudinally into early old age, and whether these associations were moderated by young adult cognitive reserve or APOE genotype. 508 men in the Vietnam Era Twin Study of Aging (VETSA) completed neuroimaging assessments at mean age 56 and six executive function tasks at mean ages 56, 62, and 68 years. Results indicated that greater brain reserve at age 56 was associated with better concurrent executive function (r=...
May 16, 2024: Neurobiology of Aging
Ana T Vitantonio, Christina Dimovasili, Farzad Mortazavi, Kelli L Vaughan, Julie A Mattison, Douglas L Rosene
Calorie restriction (CR) is a robust intervention that can slow biological aging and extend lifespan. In the brain, terminally differentiated neurons and glia accumulate oxidative damage with age, reducing their optimal function. We investigated if CR could reduce oxidative DNA damage to white matter oligodendrocytes and microglia. This study utilized post-mortem brain tissue from rhesus monkeys that died after decades on a 30 % reduced calorie diet. We found that CR subjects had significantly fewer cells with oxidative damage within the corpus callosum and the cingulum bundle...
May 16, 2024: Neurobiology of Aging
Qian Yang, Xueyan Zhou, Tao Ma
Synaptic dysfunction is highly correlated with cognitive impairments in Alzheimer's disease (AD), the most common dementia syndrome in the elderly. Long-term potentiation (LTP) and long-term depression (LTD) are two primary forms of synaptic plasticity with opposite direction of synaptic efficiency change. Both LTD and LTD are considered to mediate the cellular process of learning and memory. Substantial studies demonstrate AD-associated deficiency of both LTP and LTD. Meanwhile, the molecular signaling mechanisms underlying impairment of synaptic plasticity, particularly LTD, are poorly understood...
May 15, 2024: Neurobiology of Aging
Francesca Bernocchi, Chiara Giuseppina Bonomi, Martina Assogna, Alessandra Moreschini, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Astrocytes in Alzheimer's disease (AD) exert a pivotal role in the maintenance of blood-brain barrier (BBB) integrity essentially through structural support and release of soluble factors. This study provides new insights into the vascular remodeling processes occurring in AD, and reveals, in vivo, a pathological profile of astrocytic secretion involving Vascular Endothelial Growth Factor (VEGF), Matrix Metalloproteinases (MMP)-9, MMP-2 and Endothelin-1 (ET-1). Cerebrospinal fluid (CSF) levels of VEGF, MMP-2/-9 were lower in patients belonging to the AD continuum, compared to aged-matched controls...
May 14, 2024: Neurobiology of Aging
Yueh-Sheng Chen, Chen-Yuan Kuo, Cheng-Hsien Lu, Yuan-Wei Wang, Kun-Hsien Chou, Wei-Che Lin
Brain biological age, which measures the aging process in the brain using neuroimaging data, has been used to assess advanced brain aging in neurodegenerative diseases, including Parkinson disease (PD). However, assuming that whole brain degeneration is uniform may not be sufficient for assessing the complex neurodegenerative processes in PD. In this study we constructed a multiscale brain age prediction models based on structural MRI of 1240 healthy participants. To assess the brain aging patterns using the brain age prediction model, 93 PD patients and 91 healthy controls matching for sex and age were included...
May 14, 2024: Neurobiology of Aging
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.