Shigekuni Hosogi, Atsukazu Kuwahara, Yuko Kuwahara, Saori Tanaka, Chikao Shimamoto, Noriko Tagawa, Ikuo Kato, Kanji Yoshimoto, Wataru Aoi, Kazuyuki Takata, Hiroaki Miyazaki, Naomi Niisato, Yasuhiro Tsubo, Katsumi Yagi, Takashi Nakahari, Yoshinori Marunaka
The present study tried to clarify if mumefural would prevent hyperglycemia, one of the typical symptoms of type 2 diabetes mellitus (T2DM), since mumefural is an extract from Japanese apricots preventing hyperglycemia. To clarify if mumefural would prevent T2DM pathogenesis, we used Otsuka Long-Evans Tokushima fatty (OLETF) rats, T2DM model. Mumefural diminished hyperglycemia, HOMA-IR and plasma triglyceride concentration in OLETF rats under fasting conditions. In addition, mumefural elevated protein expression of sodium-coupled monocarboxylate transporter 1 (SMCT1) in the distal colon participating in absorption of weak organic acids, which behave as bases but not acids after absorption into the body...
2023: Biomedical Research