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Guangle Niu, Ruoyao Zhang, Yuan Gu, Jianguo Wang, Chao Ma, Ryan T K Kwok, Jacky W Y Lam, Herman H-Y Sung, Ian D Williams, Kam Sing Wong, Xiaoqiang Yu, Ben Zhong Tang
Photostability is a particularly important parameter for fluorescence imaging especially long-term dynamic tracking in live samples. However, many organic fluorophores show poor photostability under one-photon and two-photon continuous irradiation. In addition, these traditional fluorophores also suffer from aggregation-caused quenching (ACQ) in aggregate state in insolvable water environment. Therefore, it remains challenging to develop photostable and ACQ-free fluorophores for biological imaging. In this work, we developed two highly photostable aggregation-induced emission luminogens (AIEgens) based on the cyanostilbene core for in vitro and ex vivo bioimaging...
April 9, 2019: Biomaterials
Sheema Khan, Saini Setua, Sonam Kumari, Nirnoy Dan, Andrew Massey, Bilal Bin Hafeez, Murali M Yallapu, Zachary Edwar Stiles, Anas Alabkaa, Junming Yue, Aditya Ganju, Stephen Behrman, Meena Jaggi, Subhash C Chauhan
Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops chemoresistance leading to poor patient outcome. We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. In this study, we demonstrate that SP-CUR effectively delivers bioactive curcumin to pancreatic tumors, simultaneously enhances GEM uptake and its efficacy...
April 8, 2019: Biomaterials
Wei Liu, Jinhua Li, Mengqi Cheng, Qiaojie Wang, Yebin Qian, Kelvin W K Yeung, Paul K Chu, Xianlong Zhang
Metal ions or nanoparticles are believed to be promising additives in developing antibacterial biomaterials, owing to possessing favorable bactericidal effects against antibiotic-resistant bacteria. However, the immunomodulatory antibacterial activity of metal ions has seldom been reported. Herein, a porous microstructure designed to trap methicillin-resistant Staphylococcus aureus (MRSA) is fabricated on polyetheretherketone biomaterial surface through sulfonation (SPEEK), following which copper (Cu) nanoparticles, which can kill the trapped MRSA, are immobilized on SPEEK surface using a customized magnetron sputtering technique...
April 8, 2019: Biomaterials
Jiarui Chen, Kun Yan, Shijie Xiong, Tingting Wei, Xinglong Wu, Paul K Chu
Artificial synthesis and manipulation of functional amyloid-like fibrils with both positive and negative biological roles in living organisms are still major challenges. As a kind of typical building sequences, diphenylalanine and its derivatives have attracted substantial interests due to their outstanding self-assembly ability and unique combinations of biological, physical, and chemical properties. Herein, inspired by the thermodynamic behavior of cellular fiberization, we describe a novel approach which utilizes a phase merging process in the water/hexafluoroisopropanol binary solutions to initiate and modulate self-assembly of diphenylalanine monomers...
April 8, 2019: Biomaterials
Zhengwei Liu, Faming Wang, Jinsong Ren, Xiaogang Qu
Notorious bacterial biofilms are becoming severe threats to public health worldwide. As the important component in biofilm extracellular polymeric substances (EPS), extracellular DNA (eDNA) has been manifested to connect different EPS components and bacteria together, leading biofilms hard to eliminate. Herein a series of MOF/Ce-based nanozymes with deoxyribonuclease (DNase) and peroxidase mimetic activities have been designed and synthesized for combating biofilms. The cerium (IV) complexes (DNase mimics) are capable of hydrolyzing eDNA and disrupting established biofilms, while the MOF with peroxidase-like activity can kill bacteria exposed in dispersed biofilms in the presence of H2 O2 ...
April 7, 2019: Biomaterials
Ramkumar T Annamalai, Xiaowei Hong, Nicholas G Schott, Gopinath Tiruchinapally, Benjamin Levi, Jan P Stegemann
Repair of complex fractures with bone loss requires a potent, space-filling intervention to promote regeneration of bone. We present a biomaterials-based strategy combining mesenchymal stromal cells (MSC) with a chitosan-collagen matrix to form modular microtissues designed for delivery through a needle to conformally fill cavital defects. Implantation of microtissues into a calvarial defect in the mouse showed that osteogenically pre-differentiated MSC resulted in complete bridging of the cavity, while undifferentiated MSC produced mineralized tissue only in apposition to native bone...
April 4, 2019: Biomaterials
Jing-Jing Hu, Miao-Deng Liu, Ying Chen, Fan Gao, Si-Yuan Peng, Bo-Ru Xie, Chu-Xin Li, Xuan Zeng, Xian-Zheng Zhang
Various negative effects accompanying with the instability of bare liquid metal (LM) nanoparticles, including undesirable spontaneous coalescence, continuous photothermal performance deterioration and difficult multi-step functionalization, severely hinder its applications in biomedical area. In this study, we proposed a new concept of immobilized liquid metal nanoparticles based on a surface mesoporous silica coating strategy (LM@MSN). Strikingly, it was found that unsteady and vulnerable LM nanoparticles after immobilization exhibited enhanced stabilization and sustainable photothermal performance even with a long and repeated light irradiation in acidic environments...
April 1, 2019: Biomaterials
Qin Zeng, Ruijing Zhang, Tao Zhang, Da Xing
A tumor-related stimuli-activatable and biodegradable nanoplatform for tumor-selective imaging and effective photodynamic therapy (PDT) towards precision medicine is highly desirable but still greatly challenging. Here, we developed a novel H2 O2 -activatable and biodegradable nanomedicine (BSA-MBPB) by encapsulation of a single newly synthesized pro-photosensitizer (MBPB) with its photoactivity completely annihilated within bovine serum albumin (BSA) to achieve imaging-guided tumor-targeted effective PDT. BSA-MBPB can be decomposed and activated by H2 O2 to not only produce the clinical photosensitizer methylene blue to recover its fluorescent, photoacoustic and photosensitizing properties for dual-modal imaging and cytotoxic singlet oxygen (1 O2 ) generation, but also to simultaneously produce a GSH-depleting adjuvant quinone methide to boost the 1 O2 yield, thus strengthening the efficacy of PDT...
March 30, 2019: Biomaterials
Shuang Yang, Xiaoxiu Shi, Xiaoming Li, Jinfeng Wang, Yuanliang Wang, Yanfeng Luo
Well-aligned collagen fiber scaffolds are considered promising candidates for tendon tissue engineering in terms of their biomimetic chemical composition and topographic structure. Insoluble collagen fibers are more suitable for the preparation of scaffolds than soluble collagens due to their more approximate self-assembly and mechanical properties to native collagen ECMs. In this work, we employed counter-rotating extrusion technology for the first time to fabricate an aligned (CMa , orientation angle 0°-15°) and a randomly-oriented (CMr , orientation angle -60°-60°) collagen membrane from insoluble collagens...
March 29, 2019: Biomaterials
Zhongyu Cai, Yong Wan, Matthew L Becker, Yun-Ze Long, David Dean
Poly(propylene fumarate) (PPF) is a biodegradable polymer that has been investigated extensively over the last three decades. It has led many scientists to synthesize and fabricate a variety of PPF-based materials for biomedical applications due to its controllable mechanical properties, tunable degradation and biocompatibility. This review provides a comprehensive overview of the progress made in improving PPF synthesis, resin formulation, crosslinking, device fabrication and post polymerization modification...
March 28, 2019: Biomaterials
Qi Quan, Haoye Meng, Biao Chang, Lei Hong, Rui Li, GuangBo Liu, XiaoQing Cheng, He Tang, Ping Liu, Yi Sun, Jiang Peng, Qing Zhao, Yu Wang, ShiBi Lu
Flexible nerve guide conduits (NGCs) are desired in peripheral nerve reconstruction near the joints. Inspired by the engineered structure of the helical tube, we addressed the problems of conventional NGCs often mentioned in clinical feedback. We developed a type of helix-flexible NGC (HF-NGC) and evaluated its mechanical properties as well as its flexibility, and it performed excellently during in vitro tests. During the in vivo tests, HF-NGCs and conventional nonflexible NGCs (NF-NGCs) were implanted in a rat sciatic nerve defect model...
March 28, 2019: Biomaterials
Tae-Hyun Kim, Min Sil Kang, Nandin Mandakhbayar, Ahmed El-Fiqi, Hae-Won Kim
Inflammation prevailing conditions delay healing processes of damaged tissues, leading to a functional impairment. Although anti-inflammatory drugs are clinically available, they often cause unwanted side effects thus being considered suboptimal. Here we report drug-free synthetic nanoparticles that target and internalize pro-inflammatory cells and release ions, ultimately demonstrating profound anti-inflammatory functions. We introduce folate-functionalized bioactive glass nanoparticle BGN(F) that can bind to pro-inflammatory cells to endocytose and release ions...
March 27, 2019: Biomaterials
Yeong-Jin Choi, Young-Joon Jun, Dong Yeon Kim, Hee-Gyeong Yi, Su-Hun Chae, Junsu Kang, Juyong Lee, Ge Gao, Jeong-Sik Kong, Jinah Jang, Wan Kyun Chung, Jong-Won Rhie, Dong-Woo Cho
Volumetric muscle loss (VML) is an irrecoverable injury associated with muscle loss greater than 20%. Although hydrogel-based 3D engineered muscles and the decellularized extracellular matrix (dECM) have been considered for VML treatment, they have shown limited efficacy. We established a novel VML treatment with dECM bioink using 3D cell printing technology. Volumetric muscle constructs composed of cell-laden dECM bioinks were generated with a granule-based printing reservoir. The 3D cell printed muscle constructs exhibited high cell viability without generating hypoxia and enhanced de novo muscle formation in a VML rat model...
March 27, 2019: Biomaterials
Hua Qiu, Pengkai Qi, Jingxia Liu, Ying Yang, Xing Tan, Yu Xiao, Manfred F Maitz, Nan Huang, Zhilu Yang
Co-immobilization of two or more molecules with different and complementary functions to prevent thrombosis, suppress smooth muscle cell (SMC) proliferation, and support endothelial cell (EC) growth is generally considered to be promising for the re-endothelialization on cardiovascular stents. However, integration of molecules with distinct therapeutic effects does not necessarily result in synergistic physiological functions due to the lack of interactions among them, limiting their practical efficacy. Herein, we apply heparin and nitric oxide (NO), two key molecules of the physiological functions of endothelium, to develop an endothelium-mimetic coating...
March 26, 2019: Biomaterials
Jun Xu, Hui Wang, Ligeng Xu, Yu Chao, Chenya Wang, Xiao Han, Ziliang Dong, Hong Chang, Rui Peng, Yiyun Cheng, Zhuang Liu
Cancer vaccines for prevention and treatment of tumors have attracted tremendous interests as a type of cancer immunotherapy strategy. A major challenge in achieving robust T-cell responses to destruct tumor cells after vaccination is the abilities of antigen cross-presentation for antigen-presenting cells (APCs) such as dendritic cells (DCs). Herein, we demonstrate that a polyamidoamine dendrimer modified with guanidinobenzoic acid (DGBA) could serve as an effective protein carrier to enable delivery of protein antigen, thereby leading to effective antigen cross-presentation by DCs...
March 25, 2019: Biomaterials
Can Ni, Jing Zhou, Na Kong, Tianying Bian, Yangheng Zhang, Xiaofeng Huang, Yin Xiao, Wenrong Yang, Fuhua Yan
The regeneration of lost periodontal apparatus in periodontitis treatment remains a clinical challenge due to the limited regenerative capacity of cementum, periodontal ligament and alveolar bone in periodontitis condition. For periodontal tissue regeneration, it is essential to regulate the inflammatory response and the subsequent differentiation of periodontal cells under the condition due to the infectious nature of the disease. In this study, it was noted that 45 nm gold nanoparticles (AuNPs) could exhibit significant anti-inflammatory effect and improve the periodontal inflammatory microenvironment via regulating inflammatory and regenerative cytokine production and modulating macrophage polarization, subsequently affect the differentiation of human periodontal ligament cells (hPDLCs)...
March 25, 2019: Biomaterials
Rameshwar Patil, Anna Galstyan, Tao Sun, Ekaterina S Shatalova, Pramod Butte, Adam N Mamelak, Christine Carico, David S Kittle, Zachary B Grodzinski, Antonella Chiechi, Hui Ding, Keith L Black, Julia Y Ljubimova, Eggehard Holler
Maximal surgical resection of glioma remains the single most effective treatment. Tools to guide the resection while avoiding removal of normal brain tissues can aid surgeons in achieving optimal results. One strategy to achieve this goal is to rely upon interoperative fluorescence staining of tumor cells in vivo, that can be visualized by the surgeon during resection. Towards this goal we have designed a biodegradable fluorescent mini nano imaging agent (NIA) with high specificity for U87MG glioma cells and previously unmet high light emission...
March 23, 2019: Biomaterials
Shun Deng, Ailing Fu, Muhammad Junaid, Yan Wang, Qian Yin, Chen Fu, Li Liu, Dong-Sheng Su, Wan-Ping Bian, De-Sheng Pei
Graphene quantum dots (GQDs) are well-known for its potential applications for bioimaging, biosensor, and drug carrier in biomedicine. GQDs are well characteristic of intrinsic peroxidase-like catalytic activity, which is proven effective in scavenging the free radicals, such assuperoxide anion, hydrogen peroxide, and hydroxyl radical. GQDs are also well praised for its low in vivo and in vitro toxicity. Here, we found that nitrogen-doped GQDs (N-GQDs) can strongly disturb redox-sensitive system via the selective inhibition of endogenous antioxidant enzyme activities in zebrafish...
March 23, 2019: Biomaterials
Lei Xing, Jia-Hui Gong, Yi Wang, Yong Zhu, Zhang-Jian Huang, Jun Zhao, Fei Li, Jian-Hua Wang, Hao Wen, Hu-Lin Jiang
Photodynamic therapy (PDT) has attracted growing attention in the field of cancer therapy due to its non-invasive intervention and initiation of antitumor immune responses by use of non-toxic photosensitizers (PS) and topical light irradiation. However, inherent hypoxia and immunosuppression mediated by checkpoints in tumors severally impair the efficacy of PDT and PDT-induced immunity. Herein, a multi-functional nanoplatform is rationally constructed by fluorinated polymer nanoparticle saturated with oxygen in advance, which simultaneously encapsulated PS (Ce6) and an indoleamine 2,3-dioxygenase (IDO) inhibitor (NLG919)...
March 22, 2019: Biomaterials
Can Ergen, Patricia Maria Niemietz, Felix Heymann, Maike Baues, Felix Gremse, Robert Pola, Louis van Bloois, Gert Storm, Fabian Kiessling, Christian Trautwein, Tom Luedde, Twan Lammers, Frank Tacke
Myeloid immune cells promote inflammation and fibrosis in chronic liver diseases. Drug delivery systems, such as polymers, liposomes and microbubbles, efficiently target myeloid cells in healthy liver, but their targeting properties in hepatic fibrosis remain elusive. We therefore studied the biodistribution of three intravenously injected carrier material, i.e. 10 nm poly(N-(2-hydroxypropyl)methacrylamide) polymers, 100 nm PEGylated liposomes and 2000 nm poly(butyl cyanoacrylate) microbubbles, in two fibrosis models in immunocompetent mice...
March 22, 2019: Biomaterials
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