journal
https://read.qxmd.com/read/39018697/in-situ-customized-apolipoprotein-b48-enriched-protein-corona-enhances-oral-gene-delivery-of-chitosan-based-nanoparticles
#1
JOURNAL ARTICLE
Ziyun Lin, Shengqi Li, Qiuji Wu, Hongfei Qu, Xiliang Shi, Ke Wang, Cui Tang, Chunhua Yin
The formation of protein corona (PC) is important for promoting the in vivo delivery of nanoparticles (NPs). However, PC formed in the physiological environment of oral delivery is poorly understood. Here, we engineered seven types of trimethyl chitosan-cysteine (TC) NPs, with distinct molecular weights, quaternization degrees, and thiolation degrees, to deeply investigate the influence of various PC formed in the physiological environment of oral delivery on in vivo gene delivery of polymeric NPs, further constructing the relationship between the surface characteristics of NPs and the efficacy of oral gene delivery...
July 14, 2024: Biomaterials
https://read.qxmd.com/read/39008916/camouflaging-nanoreactor-traverse-the-blood-brain-barrier-to-catalyze-redox-cascade-for-synergistic-therapy-of-glioblastoma
#2
JOURNAL ARTICLE
WeiYi Cheng, WeiYe Ren, Peng Ye, Li He, Dandan Bao, Tianxiang Yue, Jianjun Lai, Yajun Wu, YingHui Wei, Zhibing Wu, Ji-Gang Piao
The blood-brain barrier (BBB) is a complex and highly restrictive barrier that prevents most biomolecules and drugs from entering the brain. However, effective strategies for delivering drugs to the brain are urgently needed for the treatment of glioblastoma. Based on the efficient BBB penetration properties of exosomes derived from brain metastatic breast cancer cells (EB), this work prepared a nanoreactor (denoted as MAG@EB), which was constructed by self-assembly of Mn2+ , arsenate and glucose oxidase (GOx) into nanoparticles wrapped with EB...
July 14, 2024: Biomaterials
https://read.qxmd.com/read/39002516/hydrogel-activation-of-mincle-receptors-for-tumor-cell-processing-a-novel-approach-in-cancer-immunotherapy
#3
JOURNAL ARTICLE
Jiake Lin, Yuemin Zhou, Chen Li, Benke Li, Haibin Hao, Fengchao Tian, Huixin Li, Zhenyu Liu, Guangchuan Wang, Xing-Can Shen, Ruikang Tang, Xiaoyu Wang
An obstacle in current tumor immunotherapies lies in the challenge of achieving sustained and tumor-targeting T cell immunity, impeded by the limited antigen processing and cross-presentation of tumor antigens. Here, we propose a hydrogel-based multicellular immune factory within the body that autonomously converts tumor cells into an antitumor vaccine. Within the body, the scaffold, formed by a calcium-containing chitosan hydrogel complex (ChitoCa) entraps tumor cells and attracts immune cells to establish a durable and multicellular microenvironment...
July 8, 2024: Biomaterials
https://read.qxmd.com/read/38981153/3d-printed-bone-regeneration-scaffolds-modulate-bone-metabolic-homeostasis-through-vascularization-for-osteoporotic-bone-defects
#4
JOURNAL ARTICLE
Caiping Yan, Pengrui Zhang, Qiwei Qin, Ke Jiang, Yue Luo, Chao Xiang, Jiangtao He, Lu Chen, Dianming Jiang, Wenguo Cui, Yuling Li
The treatment of osteoporotic bone defects poses a challenge due to the degradation of the skeletal vascular system and the disruption of local bone metabolism within the osteoporotic microenvironment. However, it is feasible to modulate the disrupted local bone metabolism imbalance through enhanced vascularization, a theory termed "vascularization-bone metabolic balance". This study developed a 3D-printed polycaprolactone (PCL) scaffold modified with EPLQLKM and SVVYGLR peptides (PCL-SE). The EPLQLKM peptide attracts bone marrow-derived mesenchymal stem cells (BMSCs), while the SVVYGLR peptide enhances endothelial progenitor cells (EPCs) vascular differentiation, thus regulating bone metabolism and fostering bone regeneration through the paracrine effects of EPCs...
July 6, 2024: Biomaterials
https://read.qxmd.com/read/38981152/a-strategy-of-adding-fuel-to-the-flames-enables-a-self-accelerating-cycle-of-ferroptosis-cuproptosis-for-potent-antitumor-therapy
#5
JOURNAL ARTICLE
Lin Huang, Jiaoyang Zhu, Guochao Wu, Wei Xiong, Jie Feng, Chenggong Yan, Jing Yang, Zongheng Li, Qingdeng Fan, Bin Ren, Yan Li, Chaomin Chen, Xiangrong Yu, Zheyu Shen
Cuproptosis in antitumor therapy faces challenges from copper homeostasis efflux mechanisms and high glutathione (GSH) levels in tumor cells, hindering copper accumulation and treatment efficacy. Herein, we propose a strategy of "adding fuel to the flames" for potent antitumor therapy through a self-accelerating cycle of ferroptosis-cuproptosis. Disulfiram (DSF) loaded hollow mesoporous copper-iron sulfide (HMCIS) nanoparticle with conjugation of polyethylene glycol (PEG) and folic acid (FA) (i.e., DSF@HMCIS-PEG-FA) was developed to swiftly release DSF, H2 S, Cu2+ , and Fe2+ in the acidic tumor microenvironment (TME)...
July 6, 2024: Biomaterials
https://read.qxmd.com/read/38996671/bioactive-sucralfate-based-microneedles-promote-wound-healing-through-reprogramming-macrophages-and-protecting-endogenous-growth-factors
#6
JOURNAL ARTICLE
Zhicheng Le, Mayk Caldas Ramos, Yufeng Shou, Renee R Li, Hong Sheng Cheng, Clarisse Jm Jang, Ling Liu, Chencheng Xue, Xianlei Li, Hong Liu, Chwee Teck Lim, Nguan Soon Tan, Andrew D White, Christopher John Charles, Yongming Chen, Zhijia Liu, Andy Tay
Impaired wound healing due to insufficient cell proliferation and angiogenesis is a significant physical and psychological burden to patients worldwide. Therapeutic delivery of exogenous growth factors (GFs) at high doses for wound repair is non-ideal as GFs have poor stability in proteolytic wound environments. Here, we present a two-stage strategy using bioactive sucralfate-based microneedle (SUC-MN) for delivering interleukin-4 (IL-4) to accelerate wound healing. In the first stage, SUC-MN synergistically enhanced the effect of IL-4 through more potent reprogramming of pro-regenerative M2-like macrophages via the JAK-STAT pathway to increase endogenous GF production...
July 4, 2024: Biomaterials
https://read.qxmd.com/read/38971121/bifunctional-black-phosphorus-quantum-dots-platform-delivery-and-remarkable-immunotherapy-enhancement-of-sting-agonist
#7
JOURNAL ARTICLE
Yujun Zhang, Shijing Wang, Hyeonji Rha, Chang Xu, Yue Pei, Xiaoyuan Ji, Junmin Zhang, Ruitao Lu, Shaochong Zhang, Zhongjian Xie, Jong Seung Kim
Cancer immunotherapy has been developed to improve therapeutic effects for patients by activating the innate immune stimulator of interferon gene (STING) pathway. However, most patients cannot benefit from this therapy, mainly due to the problems of excessively low immune responses and lack of tumor specificity. Herein, we report a solution to these two problems by developing a bifunctional platform of black phosphorus quantum dots (BPQDs) for STING agonists. Specifically, BPQDs could connect targeted functional groups and regulate surface zeta potential by coordinating metal ions to increase loading (over 5 times) while maintaining high universality (7 STING agonists)...
July 2, 2024: Biomaterials
https://read.qxmd.com/read/38968688/ecm-derivatized-alginate-augmenting-bio-functionalities-of-lyophilized-mat-for-skin-and-liver-wound-treatment
#8
JOURNAL ARTICLE
Md Sohanur Rahaman, Asuva Arin, Ume Farwa, Myeongki Park, Sang Ho Bae, Byong-Taek Lee
Peptides and molecular residues sourced from the fragmentation of the extracellular matrix (ECM) can exacerbate a plethora of cellular functions. We selected a natural ECM-derived complex peptide mixture to functionalize sodium alginate. Three alginate derivatives (sodium alginate conjugated with ECM) SALE-1, SALE-2, and SALE-3 were synthesized using the lowest (10 % w/w), moderate (50 % w/w), and highest (100 % w/w) concentrations of ECM. Thereafter, they were used to fabricate three groups of mat scaffolds EMAT-1 (ECM derivatized alginate thrombin-mat), EMAT-2, and EMAT-3, respectively by the freeze-drying process...
July 2, 2024: Biomaterials
https://read.qxmd.com/read/38968687/dictating-the-spatial-temporal-delivery-of-molecular-adjuvant-and-antigen-for-the-enhanced-vaccination
#9
JOURNAL ARTICLE
Yumeng Yan, Xiaonan Huang, Lili Yuan, To Ngai, Guanghui Ma, Yufei Xia
The incorporation of molecular adjuvants has revolutionized vaccine by boosting overall immune efficacy. While traditional efforts have been concentrated on the quality and quantity of vaccine components, the impact of adjuvant and antigen delivery kinetics on immunity remains to be fully understood. Here, we employed poly (lactic-co-glycolic acid) nanoparticle (PLGA NP) -stabilized Pickering emulsion (PPE) to refine the delivery kinetics of molecular adjuvant CpG and antigen, aiming to optimize immune responses...
July 2, 2024: Biomaterials
https://read.qxmd.com/read/38996673/acoustic-holography-patterned-primary-hepatocytes-possess-liver-functions
#10
JOURNAL ARTICLE
Changcan Li, Gang Xu, Yinhan Wang, Laixin Huang, Feiyan Cai, Long Meng, Bao Jin, Zhuoran Jiang, Hang Sun, Haitao Zhao, Xin Lu, Xingting Sang, Pengyu Huang, Fei Li, Huayu Yang, Yilei Mao, Hairong Zheng
Acoustic holography (AH), a promising approach for cell patterning, emerges as a powerful tool for constructing novel invitro 3D models that mimic organs and cancers features. However, understanding changes in cell function post-AH remains limited. Furthermore, replicating complex physiological and pathological processes solely with cell lines proves challenging. Here, we employed acoustical holographic lattice to assemble primary hepatocytes directly isolated from mice into a cell cluster matrix to construct a liver-shaped tissue sample...
July 1, 2024: Biomaterials
https://read.qxmd.com/read/38954960/integration-of-sting-activation-and-cox-2-inhibition-via-steric-hindrance-effect-tuned-nanoreactors-for-cancer-chemoimmunotherapy
#11
JOURNAL ARTICLE
Pengfei Zhang, Di Zhong, Yongbo Yu, Lupeng Wang, Yifan Li, Ye Liang, Yanfeng Shi, Meilin Duan, Bing Li, Haitao Niu, Yuanhong Xu
Integrating immunotherapy with nanomaterials-based chemotherapy presents a promising avenue for amplifying antitumor outcomes. Nevertheless, the suppressive tumor immune microenvironment (TIME) and the upregulation of cyclooxygenase-2 (COX-2) induced by chemotherapy can hinder the efficacy of the chemoimmunotherapy. This study presents a TIME-reshaping strategy by developing a steric-hindrance effect tuned zinc-based metal-organic framework (MOF), designated as CZFNPs. This nanoreactor is engineered by in situ loading of the COX-2 inhibitor, C-phycocyanin (CPC), into the framework building blocks, while simultaneously weakening the stability of the MOF...
June 29, 2024: Biomaterials
https://read.qxmd.com/read/38976935/intrinsic-antimicrobial-resistance-molecular-biomaterials-to-combat-microbial-biofilms-and-bacterial-persisters
#12
REVIEW
Swagatam Barman, Leman Buzoglu Kurnaz, Ryan Leighton, Md Waliullah Hossain, Alan W Decho, Chuanbing Tang
The escalating rise in antimicrobial resistance (AMR) coupled with a declining arsenal of new antibiotics is imposing serious threats to global public health. A pervasive aspect of many acquired AMR infections is that the pathogenic microorganisms exist as biofilms, which are equipped with superior survival strategies. In addition, persistent and recalcitrant infections are seeded with bacterial persister cells at infection sites. Together, conventional antibiotic therapeutics often fail in the complete treatment of infections associated with bacterial persisters and biofilms...
June 28, 2024: Biomaterials
https://read.qxmd.com/read/38959533/recent-advances-in-biomimetic-strategies-for-the-immunotherapy-of-glioblastoma
#13
REVIEW
Haoyu You, Shuo Geng, Shangkuo Li, Mohammad Imani, Davide Brambilla, Tao Sun, Chen Jiang
Immunotherapy is regarded as one of the most promising approaches for treating tumors, with a multitude of immunotherapeutic thoughts currently under consideration for the lethal glioblastoma (GBM). However, issues with immunotherapeutic agents, such as limited in vivo stability, poor blood-brain barrier (BBB) penetration, insufficient GBM targeting, and represented monotherapy, have hindered the success of immunotherapeutic interventions. Moreover, even with the aid of conventional drug delivery systems, outcomes remain suboptimal...
June 28, 2024: Biomaterials
https://read.qxmd.com/read/38954959/multifunctional-scaffolds-for-bone-repair-following-age-related-biological-decline-promising-prospects-for-smart-biomaterial-driven-technologies
#14
REVIEW
Jonathan D Schwartzman, Max McCall, Yasmine Ghattas, Abinaya Sindu Pugazhendhi, Fei Wei, Christopher Ngo, Jonathan Ruiz, Sudipta Seal, Melanie J Coathup
The repair of large bone defects due to trauma, disease, and infection can be exceptionally challenging in the elderly. Despite best clinical practice, bone regeneration within contemporary, surgically implanted synthetic scaffolds is often problematic, inconsistent, and insufficient where additional osteobiological support is required to restore bone. Emergent smart multifunctional biomaterials may drive important and dynamic cellular crosstalk that directly targets, signals, stimulates, and promotes an innate bone repair response following age-related biological decline and when in the presence of disease or infection...
June 28, 2024: Biomaterials
https://read.qxmd.com/read/38996672/co-delivery-of-glutamic-acid-extended-peptide-antigen-and-imidazoquinoline-tlr7-8-agonist-via-ionizable-lipid-nanoparticles-induces-protective-anti-tumor-immunity
#15
JOURNAL ARTICLE
Tingting Ye, Zifu Zhong, Federica Cappellesso, Kim Deswarte, Yong Chen, Heleen Lauwers, Emily De Lombaerde, Mark Gontsarik, Stefan Lienenklaus, Dorien Van Lysebetten, Niek N Sanders, Bart N Lambrecht, Stefaan De Koker, Damya Laoui, Bruno G De Geest
Cancer vaccines aim at generating cytotoxic CD8+ T cells that kill cancer cells and confer durable tumor regression. Hereto, CD8+ peptide epitopes should be presented by antigen presenting cells to CD8+ T cells in lymphoid tissue. Unfortunately, in unformulated soluble form, peptide antigens are poorly taken up by antigen presenting cells and do not efficiently reach lymph nodes. Hence, the lack of efficient delivery remains a major limitation for successful clinical translation of cancer vaccination using peptide antigens...
June 27, 2024: Biomaterials
https://read.qxmd.com/read/38986360/branching-in-poly-amine-co-ester-polyplexes-impacts-mrna-transfection
#16
JOURNAL ARTICLE
Kwangsoo Shin, Hee-Won Suh, Alexandra Suberi, Chang-Hee Whang, Madalina Ene, Julian Grundler, Molly K Grun, W Mark Saltzman
Branching is a key structural parameter of polymers, which can have profound impacts on physicochemical properties. It has been demonstrated that branching is a modulating factor for mRNA delivery and transfection using delivery vehicles built from cationic polymers, but the influence of polymer branching on mRNA delivery remains relatively underexplored compared to other polymer features such as monomer composition, hydrophobicity, pKa, or the type of terminal group. In this study, we examined the impact of branching on the physicochemical properties of poly(amine-co-esters) (PACE) and their efficiency in mRNA transfection in vivo and in vitro under various conditions...
June 27, 2024: Biomaterials
https://read.qxmd.com/read/38959534/intranasal-delivery-of-liposome-encapsulated-flavonoids-ameliorates-l-dopa-induced-dyskinesia-in-hemiparkinsonian-mice
#17
JOURNAL ARTICLE
Mohamed Rafiuddin Ahmed, Mohammed Inayathullah, Mithya Morton, Venkata Raveendra Pothineni, Kwangmin Kim, Mohamed Sohail Ahmed, Mustafeez Mujtaba Babar, Jayakumar Rajadas
In the present study, we explored the development of a novel noninvasive liposomal drug delivery material for use in intranasal drug delivery applications in human diseases. We used drug entrapment into liposomal nanoparticle assembly to efficiently deliver the drugs to the nasal mucosa to be delivered to the brain. The naturally occurring flavonoid 7,8-dihydroxyflavone (7,8-DHF) has previously been shown to have beneficial effects in ameliorating Parkinson's disease (PD). We used both naturally occurring 7,8-DHF and the chemically modified form of DHF, the DHF-ME, to be used as a drug candidate for the treatment of PD and l-DOPA induced dyskinesia (LID), which is the debilitating side effect of l-DOPA therapy in PD...
June 27, 2024: Biomaterials
https://read.qxmd.com/read/38944969/integrated-omics-profiling-unveils-the-disparities-of-host-defense-to-ecm-scaffolds-during-wound-healing-in-aged-individuals
#18
JOURNAL ARTICLE
Shuai-Dong Chen, Chen-Yu Chu, Chen-Bing Wang, Yang Yang, Zhao-Yu Xu, Yi-Li Qu, Yi Man
Extracellular matrix (ECM) scaffold membranes have exhibited promising potential to better the outcomes of wound healing by creating a regenerative microenvironment around. However, when compared to the application in younger individuals, the performance of the same scaffold membrane in promoting re-epithelialization and collagen deposition was observed dissatisfying in aged mice. To comprehensively explore the mechanisms underlying this age-related disparity, we conducted the integrated analysis, combing single-cell RNA sequencing (scRNA-Seq) with spatial transcriptomics, and elucidated six functionally and spatially distinctive macrophage groups and lymphocytes surrounding the ECM scaffolds...
June 27, 2024: Biomaterials
https://read.qxmd.com/read/38943823/mechanistic-insights-into-zinc-oxide-nanoparticles-induced-embryotoxicity-via-h3k9me3-modulation
#19
JOURNAL ARTICLE
Xuemei Liu, Jie Li, Ling Zhu, Jiayu Huang, Qi Zhang, Jianwu Wang, Juan Xie, Qiang Dong, Zhen Zou, Guoning Huang, Qi Gu, Jianyu Wang, Jingyu Li
The widespread application of nanoparticles (NPs) in various fields has raised health concerns, especially in reproductive health. Our research has shown zinc oxide nanoparticles (ZnONPs) exhibit the most significant toxicity to pre-implantation embryos in mice compared to other common NPs. In patients undergoing assisted reproduction technology (ART), a significant negative correlation was observed between Zn concentration and clinical outcomes. Therefore, this study explores the impact of ZnONPs exposure on pre-implantation embryonic development and its underlying mechanisms...
June 27, 2024: Biomaterials
https://read.qxmd.com/read/38971120/a-3d-micro-printed-single-cell-micro-niche-with-asymmetric-niche-signals-an-in-vitro-model-for-asymmetric-cell-division-study
#20
JOURNAL ARTICLE
Nan Huang, Barbara Pui Chan
Intricate microenvironment signals orchestrate to affect cell behavior and fate during tissue morphogenesis. However, the underlying mechanisms on how specific local niche signals influence cell behavior and fate are not fully understood, owing to the lack of in vitro platform able to precisely, quantitatively, spatially, and independently manipulate individual niche signals. Here, microarrays of protein-based 3D single cell micro-niche (3D-SCμN), with precisely engineered biophysical and biochemical niche signals, are micro-printed by a multiphoton microfabrication and micropatterning technology...
June 26, 2024: Biomaterials
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