journal
https://read.qxmd.com/read/38366669/single-centre-analysis-of-factors-influencing-surgical-treatment-of-splenic-trauma-in-children
#1
JOURNAL ARTICLE
Jun Gang Zhao, Chen-Xiang Hao, Yong-Gen Xu, Feng Liu, Guo-Ji Zhu
OBJECTIVE: This study aims to investigate determinants impacting the surgical management of splenic trauma in paediatric patients by scrutinizing age distribution, etiological factors and concomitant injuries. The analysis seeks to establish a foundation for delineating optimal operative timing. METHODS: A cohort of 262 paediatric cases presenting with splenic trauma at our institution from January 2011 to December 2021 underwent categorization into either the conservative or operative group...
February 7, 2024: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38339873/revised-one-bag-iv-fluid-protocol-for-pediatric-dka-a-feasible-approach-and-retrospective-comparative-study
#2
JOURNAL ARTICLE
Durmuş Doğan, Hatice D C Gökalp, Erdal Eren, Halil Sağlam, Ömer Tarım
BACKGROUND: This study compared the effectiveness of the traditional and revised one-bag protocols for pediatric diabetic ketoacidosis (DKA) management. METHODS: This single-center retrospective cohort study included children diagnosed with DKA upon admission between 2012 and 2019. Our institution reevaluated and streamlined the traditional one-bag protocol (revised one-bag protocol). The revised one-bag protocol rehydrated all pediatric DKA patients with dextrose (5 g/100 ml) containing 0...
February 7, 2024: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38332590/efficacy-and-safety-of-short-vs-standard-course-antibiotics-for-culture-negative-neonatal-sepsis-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Risha Devi, Mayank Priyadarshi, Poonam Singh, Suman Chaurasia, Sriparna Basu
OBJECTIVES: To conduct a systematic review and meta-analysis of evidence from randomized controlled trials (RCTs) comparing a short course of antibiotics (2-4 days), to a standard course (5-7 days), for the treatment of culture-negative neonatal sepsis. METHODS: Relevant databases were searched for RCTs comparing short- vs. standard-course of antibiotics for culture-negative sepsis. The primary outcomes were mortality and treatment failure, defined as the reappearance of clinical signs suggestive of sepsis within 7 days of stoppage of antibiotics...
February 7, 2024: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38324898/hemodynamic-effects-of-noradrenaline-in-neonatal-septic-shock-a-prospective-cohort-study
#4
JOURNAL ARTICLE
Aditya Kallimath, Reema Garegrat, Suprabha Patnaik, Yogen Singh, Naharmal B Soni, Pradeep Suryawanshi
BACKGROUND: The incidence of neonatal septic shock in low-income countries is 26.8% with a mortality rate of 35.4%. The evidence of the hemodynamic effects of noradrenaline in neonates remains sparse. This study was carried out to evaluate the effects of noradrenaline in neonates with septic shock. METHODS: This was a single-center prospective cohort study in a tertiary care hospital's level III neonatal intensive care unit. Neonates with septic shock and those who received noradrenaline as a first-line vasoactive agent were included...
February 7, 2024: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38200618/prevalence-and-pattern-of-functional-gastrointestinal-disorders-among-secondary-school-adolescents-in-lagos-nigeria
#5
JOURNAL ARTICLE
Tolulope Kumolu-Johnson, Idowu Odunayo Senbanjo
BACKGROUND: Limited data exist on functional gastrointestinal disorders (FGIDs) among sub-Saharan African children. This study aimed to determine FGID prevalence and pattern among secondary school adolescents in Lagos, Nigeria. METHODS: This descriptive cross-sectional study was conducted among adolescents aged 10-18 years in Isolo, Lagos, Nigeria from December 2020 to March 2021. A multi-stage sampling technique was used to select a total of 696 students from four secondary schools...
December 6, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38150674/sars-cov-2-reinfections-in-the-pediatric-cohort-a-single-center-experience
#6
JOURNAL ARTICLE
Asli Arslan, Zumrut Sahbudak Bal, Ece Erci, Sema Yıldırım Arslan, Nimet Melis Bilen, Gülhadiye Avcu, Candan Çiçek, Ferda Ozkinay, Zafer Kurugol
BACKGROUND: This study focused on timelines of infection episodes and dominant variants and aims to determine disease severity and outcome of pediatric patients with reinfection. MATERIALS AND METHODS: This study retrospectively evaluated the medical records of the hospitalized patients and/or outpatients aged 0-18 with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction between March 2020 and September 2022 at Ege University Children's Hospital...
December 6, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38116810/the-new-xpert-mycobacterium-tuberculosis-rifampicin-mtb-rif-ultra-assay-in-comparison-to-xpert-mtb-rif-assay-for-diagnosis-of-tuberculosis-in-children-and-adolescents
#7
JOURNAL ARTICLE
Harveen Kaur, Vishal Guglani, Lipika Singhal, Shivani Randev, Pankaj Kumar, Varsha Gupta
BACKGROUND: Microbiological diagnosis of pediatric tuberculosis (TB) using conventional microbiological techniques has been challenging due to paucibacillary nature of the disease. Molecular methods using cartridge-based tests like Xpert, have immensely improved diagnosis. A novel next-generation cartridge test, Xpert Ultra, incorporates two additional molecular targets and claims to have much lower detection limit. We attempted to compare the two techniques in presumptive pediatric TB patients...
December 6, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38110745/tumor-necrosis-factor-alpha-gene-polymorphism-affects-the-pattern-of-idiopathic-nephrotic-syndrome-in-kuwaiti-arab-children
#8
JOURNAL ARTICLE
Amal A Al-Eisa, Maysoun Al Rushood, Sumedha Kashyap, Mohammad Z Haider
OBJECTIVES: TNF-α is a pro-inflammatory cytokine that has been implicated in many inflammatory diseases, but its association with idiopathic nephrotic syndrome (INS) is poorly understood. This study looked for an association of TNF-α gene polymorphisms with INS, as well as its effect on steroid responsiveness among Kuwaiti Arab children. METHODS: Genotypes of the TNF-a gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism in 151 INS Kuwaiti Arab patients and 64 age and sex-matched controls...
December 6, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38099863/risk-factors-for-mortality-in-an-african-pediatric-emergency-department-case-of-sour%C3%A3-sanou-hospital-a-prospective-cross-sectional-study
#9
JOURNAL ARTICLE
Makoura Barro, Cheick Ahmed Ouattara, Bintou Sanogo, Abdel Aziz Baby, Ad Bafa Ibrahim Ouattara, Fatimata Sahoura Nacro, Isidore Tiandiogo Traoré, Angèle Kalmogho, Alain Saga Ouermi, Réné Souanguimpari Ouoba, Klangboro Raymond Cessouma, Boubacar Nacro
BACKGROUND: Childhood mortality rates remain high in sub-Saharan Africa. This study aimed to assess the causes and associated factors of pediatric emergency mortality at the Sourô Sanou University Hospital of Bobo-Dioulasso. METHODOLOGY: This was a cross-sectional study with prospective collection from June to August 2020. We documented and analyzed demographic and clinical characteristics by means or proportions. Logistic regression was performed to identify the factors associated with childhood mortality...
December 6, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38085999/antimicrobial-resistance-and-epidemic-clustering-of-late-onset-neonatal-infections-in-a-brazilian-intensive-care-unit
#10
JOURNAL ARTICLE
Felipe Teixeira de Mello Freitas, Marcela Santos Corrêa da Costa, Kaylla Heduarda Rodrigues da Costa, Everton Giovanni Alves
Nosocomial infections in the neonatal intensive care unit (NICU) tend to cluster and multidrug-resistant (MDR) pathogens are rising in developing countries. We did a retrospective cohort study of neonates admitted to a NICU in Brazil with late-onset neonatal sepsis (LOS) confirmed by blood culture from October 2012 to December 2016 and from July 2018 to December 2021. We defined a cluster of infection when at least two cases of LOS occurred within two different time intervals: 15 and 30 days with the same pathogen in different patients...
December 6, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38055837/evaluating-blood-culture-collection-practice-in-children-hospitalized-with-acute-illness-at-a-tertiary-hospital-in-malawi
#11
JOURNAL ARTICLE
Victoria Temwanani Mukhula, Philliness Prisca Harawa, Chisomo Phiri, Stanley Khoswe, Emmie Mbale, Caroline Tigoi, Judd L Walson, James A Berkley, Robert Bandsma, Pui-Ying Iroh Tam, Wieger Voskuijl
BACKGROUND: Blood culture collection practice in low-resource settings where routine blood culture collection is available has not been previously described. METHODOLOGY: We conducted a secondary descriptive analysis of children aged 2-23 months enrolled in the Malawi Childhood Acute Illness and Nutrition (CHAIN) study, stratified by whether an admission blood culture had been undertaken and by nutritional status. Chi-square test was used to compare the differences between groups...
December 6, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38007622/prevalence-and-predictors-of-mortality-among-hospitalized-children-with-severe-acute-malnutrition-in-a-hospital-in-north-cameroon
#12
JOURNAL ARTICLE
Danièle Christiane Kedy Koum, Charlotte Eposse, Loick Pradel Kojom Foko, Ritha Mbono Betoko, Zeinabou Ismaila, Carine Laure Njanseb Nfanleu, Diomède Noukeu Njinkui, Calixte Ida Penda
BACKGROUND: Severe acute malnutrition (SAM) is a major public health concern responsible for paediatric hospitalizations and more than one-third of deaths across the world. In 2013, SAM caused ≥20% of deaths in severely malnourished infants in Douala, the economic capital of Cameroon. There is little data on SAM in economically, sanitary and socially disadvantaged Cameroonian regions including the North region. OBJECTIVES: To determine the prevalence and potential predictors of mortality among children with SAM in a reference health facility in Garoua, North region, Cameroon...
October 5, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38006295/seroprevalence-of-sars-cov-2-antibodies-in-pediatric-hospital-surgical-unit-a-lower-middle-income-country-perspective
#13
JOURNAL ARTICLE
Murad Habib, Noshela Javed, Sadia Asmat Burki, Mansoor Ahmed, Muhammad Amjad Chaudhary
BACKGROUND: The objective of our study was to measure and give insight into the seropositivity of anti-SARS-CoV-2 antibodies in the patients in our pediatric hospital surgical unit in Pakistan. METHODS: A prospective cohort study was conducted at a tertiary care pediatric hospital surgical unit in Pakistan between 1 January 2021 and 1 June 2021 on the enrolled neonates and children aged 1 day to 13 years. All patients from three different pediatric strata [neonates (<1 month), infants (1 to 12 months) and children (>1 year)] were enrolled in the study...
October 5, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/38006294/kangaroo-mother-care-utilization-at-stepdown-ward-of-a-tertiary-care-teaching-hospital-a-quality-improvement-study
#14
JOURNAL ARTICLE
Dipen V Patel, K Sameer, Reshma K Pujara, Somashekhar M Nimbalkar, Paresha Y Patel, Jayshreeben B Makwana, Smita N Patel
PURPOSE: India has the highest burden of preterm/low birth weight newborns. To tackle this, Kangaroo Mother Care (KMC) needs to be scaled up. We did a quality improvement (QI) study to increase KMC coverage to 80% and its utilization to at least 4 h/infant/day. METHODS: This study was conducted at a stepdown ward (KMC ward) of a tertiary care teaching institute over a period of four months. All babies with birth weight <2.5 kg were eligible. The QI team included faculty in-charge, one senior resident and three senior staff nurses...
October 5, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/37997463/anthropometric-measurements-and-body-composition-of-preterm-infants-born-%C3%A2-34-weeks-at-12-13-months-corrected-age-as-compared-to-term-infants
#15
JOURNAL ARTICLE
Apoorva Kutar, Padmasani Venkat Ramanan, Kandathil Eapen Elizabeth, A J Hemamalini
BACKGROUND: Growth in the first year of life depends primarily on nutrition. Currently, the infant feeding practices of term babies are being extrapolated for preterms. While extrapolating, it is not clear if corrected age (CA) or chronological age should be used. In preterm infants, born ≤34 week gestation age, this difference may be more than 6 weeks. We studied the growth parameters and body composition of preterm infants born ≤34 week gestation age as compared to that of term infants at 12-13 months CA...
October 5, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/37994793/assessment-of-interleukin-1-receptor-antagonist-il-1ra-levels-in-children-with-and-without-community-acquired-pneumonia-a-hospital-based-case-control-study
#16
JOURNAL ARTICLE
Neha Verma, Shally Awasthi, Anuj K Pandey, Prashant Gupta
The primary objective was to compare serum interleukin-1 receptor antagonist (IL-1RA) levels in cases of community acquired pneumonia (CAP) and healthy age-gender-matched controls. The secondary objective was to compare serum IL-1RA levels in cases which were positive or negative for Streptococcus pneumoniae in the blood by real-time-polymerase chain reaction (RT-PCR). Hospitalized children with World Health Organization defined CAP, aged 2-59 months, were included as cases. Healthy controls were recruited from the immunization clinic of the hospital...
October 5, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/37991049/antenatal-corticosteroid-therapy-delivery-intervals-and-perinatal-mortality-in-low-resource-settings
#17
JOURNAL ARTICLE
Stanley Mwita, Benjamin Kamala, Eveline Konje, Deogratias Katabalo, Delfina R Msanga, Karol J Marwa, Namanya Basinda, Gilbert Kongola, Mary Jande, Deborah Dewey
BACKGROUND: Uncertainty exists regarding the ideal interval between the administration of antenatal corticosteroids (ACS) and delivery. The study's objective was to assess the risks of perinatal mortality and respiratory distress syndrome (RDS) among preterm neonates whose mothers gave birth within 48 h of the administration of ACS and those whose mothers gave birth between 48 h and 7 days. METHODS: The study design was a secondary analysis of data from an observational prospective chart review study that was carried out in Tanzania in 2020...
October 5, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/37986651/ten-vs-14-day-antibiotic-therapy-for-culture-positive-neonatal-sepsis
#18
RANDOMIZED CONTROLLED TRIAL
Kamirul Islam, Nazima Khatun, Kuntalkanti Das, Sudipto Paul, Taraknath Ghosh, Kaustav Nayek
BACKGROUND: Neonatal sepsis is a major determinant of neonatal mortality. There is a scarcity of evidence-based guidelines for the duration of antibiotics in culture-positive sepsis. OBJECTIVES: The aim of this study was to compare the efficacy of 10- and 14-day antibiotic therapies in the management of culture-positive neonatal sepsis. METHODS: This randomized controlled trial was conducted in the neonatal intensive care unit of a tertiary care center among the neonates suffering from culture-positive sepsis (with signs of clinical remission on day 9 of antibiotic) between January 2023 and May 2023...
October 5, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/37864522/trends-in-clinical-features-and-severity-of-plasmodium-vivax-malaria-among-children-at-tertiary-care-center-in-north-india
#19
JOURNAL ARTICLE
Aditi Arya, Shyam Sundar Meena, Monika Matlani, Shewta Chaudhry, Vineeta Singh
BACKGROUND: Malaria is a significant cause of morbidity and mortality in adults and children. Plasmodium falciparum is the primary cause of severe malaria, but recently Plasmodium vivax is also recognized to cause severe malaria-associated morbidity and mortality. The study focuses on determining the mortality related to severity parameters in individuals under 12 years and their critical presentation in P.vivax malaria-infected children. METHODS: A prospective cross-sectional hospital-based study was conducted at Safdarjung Hospital, New Delhi, and ICMR-NIMR, New Delhi...
October 5, 2023: Journal of Tropical Pediatrics
https://read.qxmd.com/read/37830545/covid-19-lockdown-effect-on-healthcare-utilization-and-in-hospital-mortality-in-children-under-5-years-in-cape-town-south-africa-a-cross-sectional-study
#20
JOURNAL ARTICLE
Noradin Elmi, Liezl Smit, Thandi Wessels, Moleen Zunza, Helena Rabie
BACKGROUND: COVID-19 pandemic measures resulted in the de-escalation of non-COVID-19 healthcare provision. METHODS: A retrospective cross-sectional study of routinely collected data was done to investigate the effect of COVID-19 policies on the healthcare utilization and mortality of children younger than 5 years in Eastern Cape Town, South Africa. We compared visits to primary and urgent care facilities, hospitalization, in-hospital deaths, and vaccine uptake from 1 January to 31 December 2020 to similar periods in 2018 and 2019...
October 5, 2023: Journal of Tropical Pediatrics
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