Isaac Acheampong, Difery Minadzi, Ernest Adankwah, Wilfred Aniagyei, Monika M Vivekanandan, Augustine Yeboah, Joseph F Arthur, Millicent Lamptey, Mohammed K Abass, Francis Kumbel, Francis Osei-Yeboah, Amidu Gawusu, Edwin F Laing, Linda Batsa Debrah, Dorcas O Owusu, Alexander Debrah, Ertan Mayatepek, Julia Seyfarth, Richard O Phillips, Marc Jacobsen
Immunopathology in human tuberculosis affects T-cell phenotype and functions. Previous studies identified impaired T-cell sensitivity to Interleukin (IL)-7 accompanied by lower IL-7 receptor α-chain (IL-7Rα) expression in patients with acute tuberculosis. In the present study, we characterized affected T-cell subsets and determined the influence of tuberculosis disease severity and treatment response. Tuberculosis patients (n = 89) as well as age- and gender-matched asymptomatic contacts (controls, n = 47) were recruited in Ghana...
August 12, 2023: Human Immunology