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Neuro Endocrinology Letters

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https://read.qxmd.com/read/30664348/evaluation-of-the-effectiveness-of-treatment-of-vulvar-lichen-sclerosus-et-atrophicus-analysis-of-own-material-and-review-of-the-literature
#1
Malgorzata Gajewska, Aleksandra Jagodzinska, Miroslaw Wielgos
MATERIAL AND METHODS: The study group included eleven female patients aged 18-77 years with a diagnosis of lichen sclerosus. Basic therapy consisted in the application of clobetasol in the first month and then once a day for the following two months. Then, clobetasol was recommended once a week until full resolution of the symptoms. RESULTS: In nine patients with three-month basic therapy with clobetasol we observed a reduction of symptoms. Improvement of skin lesions was obtained in seven patients...
December 22, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664347/selected-bisphenols-and-phthalates-screened-for-estrogen-and-androgen-disruption-by-in-silico-and-in-vitro-methods
#2
Marketa Dvorakova, Kristina Kejlová, Marian Rucki, Dagmar Jírová
OBJECTIVES: The aim of this study was to detect endocrine disruption potential of selected bisphenols and phthalates, compare in silico prediction with results from two in vitro methods and bring up-to-date information on development of EU legislation, available in vitro methods and biomechanisms involved in endocrine disruption. MATERIAL AND METHODS: In silico approach based on the OECD QSAR Toolbox was used for prediction of estrogen receptor α binding. OECD TG 455 assay and a yeast-based YES/YAS assay was used to determine the interactions with human estrogen (ERα) and androgen receptors...
December 22, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664345/mathematical-evaluation-of-melatonin-secretion-in-hypoxic-ischemic-encephalopathy
#3
Justyna Paprocka, Marek Kijonka, Damian Borys, Ewa Emich-Widera, Piotr Wojcieszek, Maria Sokół
OBJECTIVES: The aims of the study were to assess the kinematics of the lower limbs and pelvis during normal walking in professional ballet dancers and to investigate relationships between movements of segments of the lower limbs and pelvis. METHODS: Thirty one professional ballet dancers and twenty eight controls completed five walking trials at their preferred speed. Kinematic data in the basic anatomical planes for ankle, knee, and hip joints as well as for the pelvis were collected with an optoelectronic motion system...
December 22, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664344/comparison-of-gait-kinematics-between-professional-ballet-dancers-and-non-dancers
#4
Miroslav Janura, Lucie Tepla, Pavla Strakova, Eliska Kubonova, Zdenek Svoboda, Filip Javurek
OBJECTIVES: The aims of the study were to assess the kinematics of the lower limbs and pelvis during normal walking in professional ballet dancers and to investigate relationships between movements of segments of the lower limbs and pelvis. METHODS: Thirty one professional ballet dancers and twenty eight controls completed five walking trials at their preferred speed. Kinematic data in the basic anatomical planes for ankle, knee, and hip joints as well as for the pelvis were collected with an optoelectronic motion system...
December 22, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664340/insulin-resistance-the-good-or-the-bad-and-ugly
#5
Konrad Szosland, Andrzej Lewinski
Insulin resistance (IR) is a state of decreased sensitivity or responsiveness of target tissues to metabolic actions of circulating insulin. IR can be selective, involving only certain aspects of insulin action, i.e. only its impact on hepatic glucose disposal. Plasma insulin concentration is a continuous variable, dependent upon several physiological stimuli, thus the thresholds used to diagnose IR are arbitrary. Insulin resistance (impaired insulin action) may occur due to derangements on three levels: pre-receptor (antibodies against insulin, defected insulin molecule), receptor (defects of insulin receptor, anti-receptor antibodies) and post-receptor (disregulated intracellular pathways)...
December 22, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664339/encephalitis-with-anti-nmda-receptor-antibodies-paraneoplastic-or-non-paraneoplastic
#6
Jiri Masopust, Aleš Tvaroh, Zbyšek Pavelek, Martin Valis
We report the case of an encephalitis patient with anti-N-methyl-D-aspartate receptor (NMDAR) antibody positivity. Anti-NMDAR encephalitis is a relatively rare autoimmune disease. In our patient, the diagnosis of anti-NMDAR encephalitis was established as late as several months after the first manifestations of the condition. Further development demonstrated that the patient probably suffered from a paraneoplastic form of the disease, although the presence of an underlying tumour was not detected by the available imaging methods at the time of diagnosis...
December 22, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664346/assessing-the-awareness-of-czechs-age-40-on-the-link-between-lifestyle-choices-and-risk-factors-for-cardiovascular-diseases
#7
(no author information available yet)
OBJECTIVES: Cardiovascular diseases constitute the main cause of disability and premature death worldwide. Those diseases will continue to endanger health unless the public understands clearly and completely which risk factors contribute to the development of these diseases and what they can do to avoid these risks. This article assesses the understanding of risk factors that can lead to the development of heart and vessel diseases. METHODS: A non-standardized questionnaire was used for data collection...
December 21, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664343/accumulation-of-selected-metals-pollution-in-aquatic-ecosystems-in-the-smeda-river-czech-republic
#8
(no author information available yet)
OBJECTIVES: Biomonitoring of some slelected heavy metals in the Smeda river (Czech Republic) was carried out during 2015-2016 to assess the extent of environmental pollution. Attempts were also made to map the intensity of bioaccumulation in brown trout which was used as an indicator species. Monitoring of the environmental pollution of the Smeda river was carried in 2016. DESIGN: Concentrations of some heavy metals i.e. Mercury (Hg), Lead (Pb), Cadmium (Cd) and Cobalt (Co) were quantified in the fish muscles...
December 21, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664342/sequencing-of-the-insulin-receptor-insr-gene-reveals-association-between-gene-variants-in-exon-and-intron-13-and-schizoaffective-disorder
#9
Kristina Melkersson
OBJECTIVES: From the hypothesis that an impaired insulin and insulin-like growth factor cellular signalling in brain and body might result in the development of schizophrenia or related psychoses, I in this study chose to thoroughly investigate the insulin receptor gene in patients with schizophrenia or schizoaffective disorder and controls. METHODS: For identification of single nucleotide polymorphisms (SNPs) of interest in the insulin receptor gene, targeted whole gene sequencing of DNA using the SOLiD technology was first carried out in two subgroups of the study population: 1) 49 schizophrenia or schizoaffective disorder patients with heredity for schizophrenia or related psychoses, and 2) 25 controls...
December 21, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30664341/mu-opioid-receptor-regulation-of-gonadotropin-releasing-hormone-luteinizing-hormone-axis-during-short-term-food-deprivation-role-of-alpha1-adrenoreceptor-signaling
#10
Karen P Briski, Manita Shakya
OBJECTIVES: Brain bio-energetic stability is required for optimal gonadal steroid positive-feedback activation of the gonadotropin-releasing hormone-I (GnRH-I)-pituitary luteinizing hormone (LH) neuroendocrine axis. Caudal hindbrain metabolic-sensory noradrenergic neurons counter energy deficiency by curtailing the mid-cycle LH surge. Central mu opioid receptors (mu-R) impose inhibitory effects of diverse physiological stimuli, including stress, on LH. DESIGN/MATERIAL AND METHODS: To address the premise that mu-R attenuate the LH surge due to metabolic stress of food deprivation (FD), this study examined impacts of lateral ventricular administration of the selective mu-R antagonist CTOP on FD-associated patterns of GnRH-I protein expression and LH release in estradiol-primed ovariectomized female rats...
December 21, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531707/the-assessment-of-retina-in-pregnant-women-with-myopia
#11
Joanna Moneta-Wielgos, Joanna Brydak-Godowska, Joanna Golebiewska, Michal Lipa, Marek Rekas
OBJECTIVES: Myopia is associated with increased frequency of retinal degenerative changes which are the risk factors of intra- and postpartal ophthalmological complications. Aim of this study was to analyze the degenerative lesions detected in opthalmological examination (including peripheral retinal lesions) as a potential risk factors for eyes' status in terms of delivery in myopic women. MATERIAL AND METHODS: 254 pregnant women affected with myopia underwent opthalmological examination as a screening method to examine retina...
October 12, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531706/regional-differences-in-somatostatin-receptor-2-sstr2-immunoreactivity-is-coupled-to-level-of-bowel-invasion-in-small-intestinal-neuroendocrine-tumors
#12
Omid Fotouhi, Jan Zedenius, Anders Höög, Carl Christofer Juhlin
OBJECTIVE: Somatostatin receptor (SSTR) expression constitutes a pivotal cornerstone for accurate radiological detection and medical treatment of small intestinal neuroendocrine tumors (SI-NETs), and the development of somatostatin analogues for these purposes have revolutionized the clinical work-up. Previous assessments of SSTR isoform expression in SI-NETs have found correlations to overall prognosis and treatment response, however these analyses usually report overall tumoral immunoreactivity, and little is reported regarding histo-regional differences in expressional patterns...
October 12, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531700/endocrine-response-to-high-intensity-barbell-squats-performed-with-constant-movement-tempo-and-variable-training-volume
#13
Michal Wilk, Miroslav Petr, Michal Krzysztofik, Adam Zajac, Petr Stastny
OBJECTIVE: Research indicates that among the many elements of resistance exercise protocols, training volume and total training load are the key factors for post-exercise increase in the secretion of testosterone (T), growth hormone (GH), insulin-like growth factor (IGF-1) and cortisol (C). The aim of this study was to determine the effects of resistance exercises with variable volume and constant intensity and movement tempo on post-exercise concentrations of selected anabolic and catabolic hormones...
October 12, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531699/depressive-symptoms-are-associated-with-higher-morning-plasma-cortisol-in-primary-care-subjects
#14
Valentina Capponi, Carmen Carrasco, Stefano Macchiavello, Juan Undurraga, Carmen Campino, Cristian Carvajal, Teresita Gomez, Cristian Weiss, Igor Aedo, Andrea Vecchiola, Fidel Allende, Sandra Solari, Carlos Fardella, René Baudrand
BACKGROUND: Cortisol dysregulation has a potential role in depression. AIM AND METHODS: We evaluated depressive symptoms using the Hamilton Rating Scale for Depression in 48 primary care subjects without history of previous or current depression and its association with cortisol dysregulation (morning plasma cortisol, 24-hour urinary free cortisol and cortisol metabolites). Presence of metabolic syndrome and inflammatory parameters were also assessed. RESULTS: Hamilton Rating Scale for Depression correlated significantly with morning cortisol, but not with urinary free cortisol or metabolites...
October 12, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531708/the-effect-of-silver-nanoparticles-and-silver-ions-on-zebrafish-embryos-danio-rerio
#15
(no author information available yet)
OBJECTIVES: The aim of this study was to establish and evaluate the mortality rate, hatching rate and observe the presence of sublethal changes in zebrafish embryos after exposure to silver ions and nanoparticles. METHODS: Tests were conducted on newly fertilized zebrafish embryos, according to the modified OECD guideline 236, using a semistatic method and 96 hour incubation time. Silver nitrate and two different silver nanoparticles, stabilized with 0.01% solution of maltose and gelatine in the first case, and stabilized with polyvinylpyrrolidone, in the latter, were tested...
October 10, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531705/locomotion-in-young-rats-with-induced-brain-cellular-edema-effects-of-recombinant-human-erythropoietin
#16
(no author information available yet)
OBJECTIVES: Effect of recombinant human erythropoietin (rhEPO) on spontaneous motor activity was tested in young rats after intraperitoneal (i.p.) administration of rhEPO, followed by induction of cellular brain edema (CE). Induced changes in the spontaneous horizontal locomotor activity was studied by open field test (OFT). METHODS: CE was induced by water intoxication (WI) using standard method of fractional hyperhydration accompanied with desmopressin administration...
October 10, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531704/light-dark-influence-on-enkephalinase-activity-in-hypothalamus-and-pituitary
#17
(no author information available yet)
OBJECTIVES: Enkephalins functions are partly modulated by enkephalinases especially membrane-bound alanyl aminopeptidase (EC-3.4.11.2) considered as the major enkephalin-degrading enzyme in brain. The analysis of its activity in standard and non-standard light/dark conditions may help the understanding of the regulatory mechanisms of enkephalins. METHODS: Enkephalinase activity was determined fluorometrically, using an arylamide derivative as substrate, in hypothalamus and pituitary of adult male rats, in a standard 12:12 h light/dark cycle; samples were collected at 10:00 h, 13:00 h and 16:00 h of the light period (light on from 7:00 to 19:00 h) and at 22:00 h, 01:00 h and 04:00 h of the dark one (light off from 19:00 h to 07:00 h)...
October 10, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531703/levels-of-selected-contaminants-in-fish-muscle-from-upper-nitra-river
#18
(no author information available yet)
OBJECTIVES: This study determines the levels of selected contaminants in the muscle of three common fish species from the upper course of the Nitra River. DESIGN: Were detected levels of Zn, Cu, Ni, Cr, Pb, Cd and Hg in the muscle and correlations among selected metals as well as standard length and total weight in brown trout (Salmo trutta morpha fario), Alpine bullhead (Cottus poecilopus) and grayling (Thymallus thymallus). RESULTS: The content of analysed metals (mg...
October 10, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531702/human-mature-milk-zearalenone-and-deoxynivalenol-levels-in-turkey
#19
(no author information available yet)
INTRODUCTION: Zearalenone (ZEA) and deoxynivalenol (DON) are toxic fungal secondary metabolites, found mainly in contaminated food, that are associated with serious health problems. It is important to identify undesirable toxins and metabolites that may be present in human milk. The aim of this study was to evaluate human milk ZEA and DON levels, total daily intake of ZEA and DON; and their possible relationship with maternal dietary habits. METHODS: We enrolled 90 lactating mothers who had 7- to 90-day-old babies...
October 10, 2018: Neuro Endocrinology Letters
https://read.qxmd.com/read/30531701/gamma-knife-radiosurgery-for-local-recurrence-of-glioblastoma
#20
(no author information available yet)
OBJECTIVE: Local recurrence of glioblastoma is observed in most patients after standard oncologic treatment (surgery, chemotherapy and radiotherapy). Stereotactic radiosurgery with the Leksell Gamma Knife (SRS with LGK) was used to treat recurrent tumors in selected cases, and retrospective analysis of treatment outcome was performed. METHODS: Altogether 126 patients were treated for glioblastoma at our center from 1992-2014. Sixty-nine patients (55%) were male and 57 (45%) female, with a median age of 56 years (range 17-80 years)...
October 10, 2018: Neuro Endocrinology Letters
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