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Sohei Matsumoto, Tomoyoshi Takayama, Kohei Wakatsuki, Tetsuya Tanaka, Kazuhiro Migita, Masahiro Ito, Yoshiyuki Nakajima
BACKGROUND/AIMS: The aim of this study was to evaluate the surgical outcomes after palliative surgery for patients with incurable gastric cancer. METHODOLOGY: This retrospective study included 45 patients with gastric outlet obstruction (GOO) who needed parental nutrition and 33 patients with anemia due to tumor bleeding who required blood transfusions. We compared the surgical outcomes of palliative gastrectomy (PG) and bypass surgery (BS) in each group. RESULTS: In the GOO patients, the clinical success rate, as indicated by a resumption of an oral diet, was similar in the PG and BS groups...
June 2015: Hepato-gastroenterology
Yuichi Nagakawa, Yuichi Hosokawa, Yatsuka Sahara, Chie Takishita, Tetsushi Nakajima, Yosuke Hijikata, Tomoya Tago, Kazuhiko Kasuya, Akihiko Tsuchida
BACKGROUND/AIMS: Laparoscopic pancreaticoduodenectomy (LPD) is still a challenging operation, particularly because the dissection around the superior mesenteric artery (SMA) and bleeding control are difficult. Although it has been reported that early ligation of the origin of the inferior pancreaticoduodenal artery (IPDA) reduces blood loss, it is difficult to laparoscopically expose the origin of the IPDA. We sought to develop a novel approach to simplify the dissection of the IPDA and reduce bleeding...
June 2015: Hepato-gastroenterology
Shin Kobayashi, Goro Honda, Masanao Kurata, Yukihiro Okuda, Katsunori Sakamoto, Katsuyuki Karasawa, Tachen Chang, Naoto Egawa, Terumi Kamisawa, Yasushi Omuro, Koji Tsuruta
BACKGROUND/AIMS: To determine the recommended dose (RD) for full-dose S-1 and low-dose gemcitabine combined with radiotherapy in patients with non-metastatic advanced pancreatic cancer. METHODOLOGY: Adult patients with non-metastatic advanced pancreatic cancer (Union for International Cancer Control T stage 3 or 4) were eligible. The weekly intravenous gemcitabine (level 0-1: 200 mg/ml,level 2: 300 mg/m on Days 1, 8, 15, 22, 29, 36) dose was escalated starting from level 1 in a 3+3 design along with full dose twice-daily oral S-1 (level 0: 60 mg/m2/day, level 1-2: 80 mg/ml/day), and was administered on the same days as radiotherapy (1...
June 2015: Hepato-gastroenterology
Kazunari Nakahara, Chiaki Okuse, Keigo Suetani, Yosuke Michikawa, Shinjiro Kobayasi, Takehito Otsubo, Fumio Itoh
BACKGROUND/AIMS: Endoscopic papillary balloon dilation (EPBD) was reported to be superior for preserving the function of the sphincter of Oddi and to cause fewer late complications than endoscopic sphincterotomy. If the early complication of post-EPBD pancreatitis can be prevented, EPBD might be useful as long-term outcomes. This study assessed the feasibility of a novel EPBD for the purpose of reliable post-EPBD pancreatic stenting. METHODOLOGY: Among 1814 ER-CPs, in 17 patients undergoing biliary cannulation with pancreatic duct guidewire placement method, we performed EPBD with the guidewire left in the pancreatic duct by the two-devices-in-one-channel method...
June 2015: Hepato-gastroenterology
Ihsan Uslan, Serdar Olt, Ahmet T Eminler
BACKGROUND/AIMS: Cirrhotic patients admitted to the hospital have a high mortality rate. The aim of this study was to evaluate predictors of mortality in patients hospitalized for specific complications of cirrhosis. METHODOLOGY: All patients admitted to the gastroenterology service with cirrhosis during a 2-year period were retrospectively identified. We compared the clinical characteristics of patients who died and those who survived. Multivariable analysis was performed to determine predictors of mortality...
June 2015: Hepato-gastroenterology
Meng Wang, Hongyu Zhou, Yaozhen Huang, Piyun Gong, Bing Peng, Shichun Zhou
In cirrhotic patients, portal hypertension is often associated with a hyperdynamic changes. Transjugular Intrahepatic Portosystemic Shunt (TIPS) and Laparoscopic splenectomy are both treatments for liver cirrhosis due to portal hypertension. While, the two different interventions have different effects on hemodynamics after operation and the possibilities of triggering PVT are different. How hemodynamics of portal vein system evolving with two different operations remain unknown. Based on ultrasound and established numerical methods, CFD technique is applied to analyze hemodynamic changes after TIPS and Laparoscopic splenectomy...
June 2015: Hepato-gastroenterology
Yueh-shih Chang, Jen-seng Huang, Cho-li Yen, Cheng-hsu Wang, Chien-hong Lai, Tsung-han Wu, Yii-jeng Lan, Pei-hung Chang, Kun-yun Yeh
BACKGROUND/AIMS: This study aimed to investigate the association between comorbidity, anti-cancer treatment, and overall survival in patients with hepatocellular carcinoma (HCC) with extrahepatic metastases. METHODOLOGY: We retrospectively analyzed data from 57 patients diagnosed as having treatment-naïve stage IV HCC with extrahepatic metastases between 2007 and 2010. Comorbidity was assessed using two scoring systems, the Charlson comorbidity index (CCI) and the Kaplan-Feinstein index...
June 2015: Hepato-gastroenterology
Mingshi Yin, Longren Wu
BACKGROUND/AIMS: This work aims to observe the effects of mast cell (MC) chymase on activation, proliferation and transdifferentiation of hepatic stellate cells (HSCs) and to discuss the role of chymase in development of liver fibrosis. METHODOLOGY: Rat HSCs were isolated by in situ perfusion using collagenase IV and proteinase E and density gradient centrifugation (Percoll method), followed by culture. After intervention by chymase with series of concentration (1, 10 and 100 ng/mL), MTT assay was performed to determine HSC proliferation...
June 2015: Hepato-gastroenterology
Yang Hui, Tang Ruihua, Li Jing, Liu Yaxiong, Li Ji, Ye Linjie, Shao Dongyan, Jin Mingliang, Huang Qingsheng, Shi Junling
BACKGROUND/AIMS: To evaluate the efficacy and safety of doxorubicin-eluting beads combined with transcatheter arterial chemoembolization (DEB-TACE) compared with conventional TACE (cTACE). METHODOLOGY: PubMed, EMBASE, MEDLINE and Cochrane Controlled Trials Register were searched for articles published to identify randomized controlled trials evaluating efficacy and side effects between DEB-TACE and cTACE. The RR (relative risk) with a 95% confidence interval (CI) was calculated by the Revman 5...
June 2015: Hepato-gastroenterology
Zhijun Zhao, Jingtao Chen, Xiaoxiang Yin, Huayong Song, Xinchun Wang
BACKGROUND/AIMS: To explore the cause of functional changes of TNF-α in removing hepatitis B virus (HBV) through the structural changes of each site in TNF-α before and after mutation. METHODOLOGY: Three typical mutant sites (TNF-α-308G/A, 857C/T and 863C/A of TNF-α) were chosen and methods like ab initio modeling was adopted for 3D modeling of TNF-α before and after mutation. The structural changes were also analyzed. Then structural changes and functional changes were brought together for comparison to infer the root cause of the changes...
June 2015: Hepato-gastroenterology
Jian-Rong Guo, Hua-Chun Shen, Yang Liu, Feng Xu, Yi-Wei Zhang, Yi Shao, Yong-Jun Su
BACKGROUND/AIMS: This paper aims to investigate the effect of acute normovolemic hemodilution (ANH) used with controlled low central venous pressure (LCVP) technology on perioperative bleeding and coagulation in hepatocellular carcinoma operation patients. METHODOLOGY: A total of 60 cases undergoing hepatic resection operation were randomly divided into the control group, LCVP group (Group II), and ANH + LCVP group (Group III). The changes of hemodynamic indexes at different time points in each group were observed and recorded, along with the volume of allogenous blood transfusion and the number of patients undergoing allogenous blood transfusion...
June 2015: Hepato-gastroenterology
Ivo A Meyer, Riccardo E Vandoni, Mario Alerci, Dimitri A Raptis, Philippe Gertsch
BACKGROUND/AIMS: Portal vein embolization (PVE) is an accepted procedure, which, by redirecting portal vein flow toward specific hepatic segments, is able to pre-operatively increase the volume of the future liver remnant (FLR). The consequent reduction of liver dysfunction risk enables to extend the number of pa tients eligible for major hepatic resection. This study aims at comparing liver regeneration dynamics and long-term volumetric recovery after major hepatic re section preceded by PVE versus major hepatic resec tion not preceded by PVE...
June 2015: Hepato-gastroenterology
(no author information available yet)
BACKGROUND/AIMS: Entecavir and tenofovir are generally accepted as first-line therapeutic options in chronic hepatitis B. Both of them are potent and have high genetic barrier to viral resistance. Aim of this study was to compare the two-year efficacy of entecavir and tenofovir in treatment-naive chronic hepatitis B patients. METHODOLOGY: Study was comprised 164 patients with treatment naïve chronic hepatitis or compensated liver cirrhosis. At least twenty four mouths of entecavir or tenofovir were given to all patients...
June 2015: Hepato-gastroenterology
Hua Shao, Wen Cheng, Lijuan Yu, Yingci Li, Hui Jing
BACKGROUND/AIMS: PET is a highly specific tool in liver cancer diagnosis. However, in small hepatic lesions, typical imaging characteristics are lacking. The aim of this study was to investigate the accuracy of PET-CT and ultrasound-guided biopsy for diagnosis of liver carcinomas. METHODOLOGY: Clinical data of 58 patients who were diagnosed and treated in our hospital from January 2008 to December 2012 were retrospectively reviewed. Before surgery, patients received PET-CT assessment, ultrasound examination, and ultrasound-guided biopsy of liver tissues...
June 2015: Hepato-gastroenterology
C Loinaz Segurola, J L LIedó Navarro, R de la Cruz Burgos, D Martín Ríos, F Ochando Cerdán, S Alonso López, J Martel Villagrán, M L Gutiérrez Garcia, J M Fernandez Cebrián, C Fernández Rodríguez
BACKGROUND/AIMS: Mean survival in hepatocellular carcinoma remains low. Many efforts have been done during the last years through screening, diagnosis and treatment to improve the results. The aim of this work is to present the experience of our hospital multidisciplinary group during the first decade of this century. METHODOLOGY: The patients with hepatocellullar carcinoma presented at the multidisciplinary meeting from 1999 to 2009 were prospectively studied. According to the tumor and functional status they were treated through the current available guidelines by transplant, partial hepatectomy, local/regional procedures, systemic or symptomatic treatment...
June 2015: Hepato-gastroenterology
Akiyoshi Kinoshita, Hiroshi Onoda, Nami Imai, Hirokazu Nishino, Hisao Tajiri
C-reactive protein (CRP) is an acute phase reactant synthesized by hepatocytes that is regulated by pro-inflammatory cytokines, particulary interleukin-6 (IL-6). Over the last decade, CRP has been reported to be associated with a poor prognosis in patients with various types of cancer. Although the mechanisms by which the systemic inflammatory response reflected by an elevated serum CRP level influences survival in patients with cancer have not been fully elucidated, several possibilities involving the activation of IL-6, thereby elevating the CRP level, in cancer patients have been proposed...
June 2015: Hepato-gastroenterology
Cemil Göya, Cihad Hamidi, Hakan Önder, Ali Inal, Güven Tekbaş, Uğur Firat, Mehmet Güli Çetinçakmak
BACKGROUND/AIMS: To determine the utility of the quantitative apparent diffusion coefficient (ADC) values at various b values, in the differentiation of malignant hepatic masses on 3.0 Tesla (T) MRI. METHODOLOGY: We evaluated 81 consecutive patients presenting with 529 malignant masses in the liver. Of those patients 27 had a primary hepatic malignancy while the other 54 patients had metastases in the liver. Quantitative ADC values of malignant hepatic masses was measured at four b values (b 400, b 800, b 1600, b 2000 mm2/s) on MR-DWI...
June 2015: Hepato-gastroenterology
Alessandro Giacomoni, Stefano Di Sandro, Matteo Donadon, Andrea Lauterio, Luca Belli, Iacopo Mangoni, Plamen Mihaylov, Giacomo Concone, Luciano De Carlis
BACKGROUND/AIMS: Selection of patients with hepa- to-cellular carcinoma for liver transplantation is gen- erally performed according to the so-called Milan cri- teria. The aim of this study was to learn whether, after down-staging loco-regional therapies, patients origi- nally non-fulfilling the MC (Milan-OUT) meet these criteria (Milan-IN). METHODOLOGY: Between January 2000 and December 2008, 172 patients with HCC re- ceived LT at our Department. Of these, 142 were sub- jected to DS before LT...
June 2015: Hepato-gastroenterology
Zheng Wang, Bo-Yi Liao, Shuang-Jian Qiu, Hui-Chuan Sun, Xing-Rong Yang, Jian Zhou, Jia Fan
BACKGROUND/AIMS: Oxidized regenerated cellulose (ORC) has been registered as adjuncts to stimulate hemostasis in liver surgery. However, most previous studies were primarily designed to study the intra-operative hemostatic efficacy, and the effect on prophylactic application was never studied as a primary endpoint. This randomized prospective clinical trial was undertaken to evaluate whether ORC is safe and effective when used as a prophylactic agent covering the raw cut surface during the hepatectomy to reduce the volume and duration of drainage...
June 2015: Hepato-gastroenterology
Mahmoud El-Bendary, Mustafa A Neamatallah, Mohamed Abd El-Maksoud, Maha Amin
BACKGROUND/AIMS: Egypt has the highest prevalence of HCV worldwide (15%) with a high morbidity and mortality from chronic liver disease, cirrhosis, and hepatocellular carcinoma. The Aim of this study was to investigate the associations between IL-28B single nucleotide polymorphisms (SNP rs12979860) and treatment outcome among Egyptian patients infected with HCV genotype 4. METHODOLOGY: HCV patients were genotyped as CC, CT, or TT at the polymorphic site, rs12979860 in unrelated case control of Egyptian population with HCV...
June 2015: Hepato-gastroenterology
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