Daryl M Okamura, Elizabeth D Nguyen, Sarah J Collins, Kevin Yoon, Joshua B Gere, Mary C M Weiser-Evans, David R Beier, Mark W Majesky
Fibrosis-driven solid organ failure is a major world-wide health burden with few therapeutic options. Spiny mice (genus: Acomys) are terrestrial mammals that regenerate severe skin wounds without fibrotic scars to evade predators. Recent studies have shown that spiny mice also regenerate acute ischemic and traumatic injuries to kidney, heart, spinal cord, and skeletal muscle. A common feature of this evolved wound healing response is a lack of formation of fibrotic scar tissue that degrades organ function, inhibits regeneration, and leads to organ failure...
September 21, 2022: Journal of Muscle Research and Cell Motility