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Journal of Muscle Research and Cell Motility

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https://read.qxmd.com/read/30903453/obituary-sumiko-kimura-1947-2018
#1
Akira Hanashima
No abstract text is available yet for this article.
March 22, 2019: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30900059/a-mechanical-model-of-the-half-sarcomere-which-includes-the-contribution-of-titin
#2
Irene Pertici, Marco Caremani, Massimo Reconditi
The evidence, in both resting and active muscle, for the presence of an I-band spring element like titin that anchors the Z line to the end of the thick filament did not yet produce a proper theoretical treatment in a complete model of the half-sarcomere. The textbook model developed by A. F. Huxley and his collaborators in 1981, which provides that the half-sarcomere (hs) compliance is due to the contribution of the compliances of the thin and thick filaments and actin-attached myosin motors, predicts that at any sarcomere length (SL) the absence of attached motors results in an infinite half-sarcomere compliance, in contrast with the observations...
March 21, 2019: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30895442/baboon-papio-ursinus-single-fibre-contractile-properties-are-similar-to-that-of-trained-humans
#3
Suhail Dada, Franclo Henning, Daneil Caroline Feldmann, Tertius Abraham Kohn
This study investigated the contractile properties of single skeletal muscle fibres from the Vastus lateralis (VL) of two male adult chachma baboons (Papio ursinus) and compared it to that from five male human cyclists. Species comparisons are observational and statistical analyses were not performed due to the low sample size. The histological analyses revealed that the baboon muscles contained more type II fibres than their human counterparts. Cross-sectional areas of type I and type II fibres from human VL were similar in size, whereas baboon type I and type II fibres appeared smaller and larger compared to humans, respectively...
March 20, 2019: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30888583/proteomic-profiling-of-the-mouse-diaphragm-and-refined-mass-spectrometric-analysis-of-the-dystrophic-phenotype
#4
Sandra Murphy, Margit Zweyer, Maren Raucamp, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
The diaphragm is a crucial muscle involved in active inspiration and whole body homeostasis. Previous biochemical, immunochemical and cell biological investigations have established the distribution and fibre type-specific expression of key diaphragm proteins. Building on these findings, it was of interest to establish the entire experimentally assessable diaphragm proteome and verify the presence of specific protein isoforms within this specialized subtype of skeletal muscle. A highly sensitive Orbitrap Fusion Tribrid mass spectrometer was used for the systematic identification of the mouse diaphragm-associated protein population...
March 19, 2019: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30850933/comparative-analysis-of-widely-used-methods-to-remove-nonfunctional-myosin-heads-for-the-in-vitro-motility-assay
#5
Mohammad A Rahman, Aseem Salhotra, Alf Månsson
The in vitro motility assay allows studies of muscle contraction through observation of actin filament propulsion by surface-adsorbed myosin motors or motor fragments isolated from muscle. A possible problem is that motility may be compromised by nonfunctional, "dead", motors, obtained in the isolation process. Here we investigate the effects on motile function of two approaches designed to eliminate the effects of these dead motors. We first tested the removal of heavy meromyosin (HMM) molecules with ATP-insensitive "dead" heads by pelleting them with actin filaments, using ultracentrifugation in the presence of 1 mM MgATP ("affinity purification")...
March 8, 2019: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30810926/a-brief-history-of-m-c-schaub-s-legacies-a-life-dedicated-to-heart-and-muscle-research-in-memoriam-marcus-c-schaub-1936-2018
#6
Michael Zaugg, Eliana Lucchinetti
No abstract text is available yet for this article.
February 27, 2019: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30806861/increase-in-phospholamban-content-in-mouse-skeletal-muscle-after-denervation
#7
Masatoshi Komatsu, Tsutomu Nakada, Hiroyuki Kawagishi, Hiroyuki Kato, Mitsuhiko Yamada
It is well-known that denervation of motor nerves induces atrophy and decreases contractile force of the skeletal muscle. However, it is not completely understood how denervation alters calcium handling in the skeletal muscle. We investigated the effect of denervation on the expression and function of proteins involved in calcium handling. Two weeks after denervation of the right sciatic nerve in mice, we observed a significant decrease in mass and cross-sectional area of the ipsilateral tibialis anterior (TA) and flexor digitorum brevis (FDB) muscles...
February 26, 2019: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30771202/a-new-twist-on-tropomyosin-binding-to-actin-filaments-perspectives-on-thin-filament-function-assembly-and-biomechanics
#8
William Lehman, Michael J Rynkiewicz, Jeffrey R Moore
Tropomyosin, best known for its role in the steric regulation of muscle contraction, polymerizes head-to-tail to form cables localized along the length of both muscle and non-muscle actin-based thin filaments. In skeletal and cardiac muscles, tropomyosin, under the control of troponin and myosin, moves in a cooperative manner between blocked, closed and open positions on filaments, thereby masking and exposing actin-binding sites necessary for myosin crossbridge head interactions. While the coiled-coil signature of tropomyosin appears to be simple, closer inspection reveals surprising structural complexity required to perform its role in steric regulation...
February 15, 2019: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30569432/47th-european-muscle-conference-in-budapest-hungary
#9
(no author information available yet)
No abstract text is available yet for this article.
December 19, 2018: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30382520/acidosis-affects-muscle-contraction-by-slowing-the-rates-myosin-attaches-to-and-detaches-from-actin
#10
Katelyn Jarvis, Mike Woodward, Edward P Debold, Sam Walcott
The loss of muscle force and power during fatigue from intense contractile activity is associated with, and likely caused by, elevated levels of phosphate ([Formula: see text]) and hydrogen ions (decreased pH). To understand how these deficits in muscle performance occur at the molecular level, we used direct measurements of mini-ensembles of myosin generating force in the laser trap assay at pH 7.4 and 6.5. The data are consistent with a mechanochemical model in which a decrease in pH reduces myosin's detachment from actin (by slowing ADP release), increases non-productive myosin binding (by detached myosin rebinding without a powerstroke), and reduces myosin's attachment to actin (by slowing the weak-to-strong binding transition)...
October 31, 2018: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30209718/specific-effects-of-neuregulin-1%C3%AE-on-the-communication-between-drg-neurons-and-skeletal-muscle-cells-in-vitro
#11
Menglin Cong, Jianmin Li, Yuan Qiao, Rui Jing, Hao Li, Zhenzhong Li
The communication between primary afferent neuron and skeletal muscle (SKM) is one of the important factors on maintaining the structure and function of SKM cells. Neuregulin-1β (NRG-1β) signaling is essential for regulating synaptic neurotransmission. Here, we established a neuromuscular coculture model of dorsal root ganglion (DRG) sensory neurons and SKM cells to explore the nerve-muscle communication in the presence of exogenous NRG-1β. The expression of three distinct subtypes (TrkA, TrkB, and TrkC) of tyrosine kinase receptors was monitored for the phenotypical alterations of the neurons...
September 12, 2018: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30143958/a-study-of-the-mechanisms-of-excitation-contraction-coupling-in-frog-skeletal-muscle-based-on-measurements-of-ca-2-transients-inside-the-sarcoplasmic-reticulum
#12
J Fernando Olivera, Gonzalo Pizarro
[Ca2+ ] transients inside the sarcoplasmic reticulum (SR) were recorded in frog skeletal muscle twitch fibers under voltage clamp using the low affinity indicator Mag Fluo 4 (loaded in its AM form) with the purpose of studying the effect on Ca2+ release of extrinsic Ca2+ buffers (i.e. BAPTA) added at high concentration to the myoplasm. When the extrinsic Ca2+ buffer is added to the myoplasm, part of the released Ca2+ binds to it, reducing the Ca2+ signal reported by a myoplasmic indicator. This, in turn, hinders the quantification of the amount of Ca2+ released...
April 2018: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/30051360/cold-shock-protein-rbm3-attenuates-atrophy-and-induces-hypertrophy-in-skeletal-muscle
#13
Douglas W Van Pelt, Amy L Confides, Andrew R Judge, Peter W Vanderklish, Esther E Dupont-Versteegden
RNA-binding motif protein 3 (RBM3), a stress-inducible RNA-binding protein that increases protein synthesis and confers cell protection in multiple cell types, has been identified as a possible regulator of skeletal muscle mass. Therefore, the primary aim of this study was to examine the impact of elevated RBM3 on skeletal muscle hypertrophy and resistance to atrophy. Plasmid-mediated overexpression of RBM3 in vitro and in vivo was used to assess the role of RBM3 in muscle. C2 C12 myotubes overexpressing RBM3 were approximately 1...
April 2018: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/29948664/physiological-and-biochemical-characteristics-of-skeletal-muscles-in-sedentary-and-active-rats
#14
Hongyang Xu, Xiaoyu Ren, Graham D Lamb, Robyn M Murphy
Laboratory rats are sedentary if housed in conditions where activity is limited. Changes in muscle characteristics with chronic inactivity were investigated by comparing sedentary rats with rats undertaking voluntary wheel running for either 6 or 12 weeks. EDL (type II fibers) and soleus (SOL) muscles (predominantly type I fibers) were examined. When measured within 1-2 h post-running, calcium sensitivity of the contractile apparatus was increased, but only in type II fibers. This increase disappeared when fibers were treated with DTT, indicative of oxidative regulation of the contractile apparatus, and was absent in fibers from rats that had ceased running 24 h prior to experiments...
April 2018: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/29948663/bgp-15-improves-contractile-function-of-regenerating-soleus-muscle
#15
Tábata L Nascimento, Meiricris T Silva, Elen H Miyabara
This study investigated the effect of the heat shock protein inducer O-[3-piperidino-2-hydroxy-1-propyl]-nicotinic amidoxime (BGP-15) on the morphology and contractile function of regenerating soleus muscles from mice. Cryolesioned soleus muscles from young mice treated daily with BGP-15 (15 mg/Kg) were evaluated on post-cryolesion day 10. At this time point, there was a significant decrease in the cross-sectional area of regenerating myofibers, maximal force, specific tetanic force, and fatigue resistance of regenerating soleus muscles...
April 2018: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/29869011/the-expression-of-aquaporin-4-is-regulated-based-on-innervation-in-skeletal-muscles
#16
Minenori Ishido, Tomohiro Nakamura
Aquaporin-4 (AQP4) is a selective water channel, which expresses on the plasma membrane of myofibers and regulates the osmotic pressure, energy metabolism and morphological changes in myofibers by modulating water transport across sarcolemma in skeletal muscles. Although the physiological roles of AQP4 have been gradually clarified in skeletal muscles, the regulatory mechanisms of AQP4 expression have been poorly understood in skeletal muscles. Recently, it was reported that the expression of AQP4 decreased in atrophied skeletal muscles following sciatic nerve transection, but not tail-suspension...
April 2018: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/29218609/abstracts-of-emc2017
#17
(no author information available yet)
No abstract text is available yet for this article.
December 7, 2017: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/29582353/development-of-apical-hypertrophic-cardiomyopathy-with-age-in-a-transgenic-mouse-model-carrying-the-cardiac-actin-e99k-mutation
#18
Li Wang, Fan Bai, Qing Zhang, Weihua Song, Andrew Messer, Masataka Kawai
In both humans and mice, the Glu-99-Lys (E99K) mutation in the cardiac actin gene (ACTC) results in little understood apical hypertrophic cardiomyopathy (AHCM). To determine how cross-bridge kinetics change with AHCM development, we applied sinusoidal length perturbations to skinned papillary muscle fibres from 2- and 5-month old E99K transgenic (Tg) and non-transgenic (NTg) mice, and studied tension and its transients. These age groups were chosen because our preliminary studies indicated that AHCM develops with age...
December 2017: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/29546606/hans-christoph-l%C3%A3-ttgau-20-july-1926-5-november-2017
#19
D George Stephenson, David J Miller
No abstract text is available yet for this article.
December 2017: Journal of Muscle Research and Cell Motility
https://read.qxmd.com/read/29185184/changes-in-contractile-and-metabolic-parameters-of-skeletal-muscle-as-rats-age-from-3-to-12-months
#20
Hongyang Xu, Graham D Lamb, Robyn M Murphy
Laboratory rats are considered mature at 3 months despite that musculoskeletal growth is still occurring. Changes in muscle physiological and biochemical characteristics during development from 3 months, however, are not well understood. Whole muscles and single skinned fibres from fast-twitch extensor digitorum longus (EDL) and predominantly slow-twitch soleus (SOL) muscles were examined from male Sprague-Dawley rats (3, 6, 9, 12 months). Ca2+ sensitivity of contractile apparatus decreased with age in both fast- (~ 0...
December 2017: Journal of Muscle Research and Cell Motility
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