journal
https://read.qxmd.com/read/38374518/calcium-hydroxide-loaded-nanoparticles-dispersed-in-thermosensitive-gel-as-a-novel-intracanal-medicament
#21
JOURNAL ARTICLE
Xavier Roig, Lyda Halbaut, Firas Elmsmari, Rubén Pareja, Aizea Arrien, Fernando Duran-Sindreu, Luis María Delgado, Marta Espina, María Luisa García, José Antonio González Sánchez, Elena Sánchez-López
AIM: Design, produce and assess the viability of a novel nanotechnological antibacterial thermo-sensible intracanal medicament This involves encapsulating calcium hydroxide (Ca(OH)2 ) within polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) and dispersing them in a thermosensitive gel (Ca(OH)2 -NPs-gel). In addition, perform in vitro and ex vivo assessments to evaluate tissue irritation and penetration capacity into dentinal tubules in comparison to free Ca(OH)2 . METHODOLOGY: Reproducibility of Ca(OH)₂-NPs was confirmed by obtaining the average size of the NPs, their polydispersity index, zeta potential and entrapment efficiency...
February 19, 2024: International Endodontic Journal
https://read.qxmd.com/read/38374488/efficacy-of-the-gentlewave-system-in-the-removal-of-biofilm-from-the-mesial-roots-of-mandibular-molars-before-and-after-minimal-instrumentation-an-ex%C3%A2-vivo-study
#22
JOURNAL ARTICLE
Kwang Ho Kim, Céline Lévesque, Gevik Malkhassian, Bettina Basrani
AIM: To compare the efficacy of Enterococcus faecalis biofilm removal using the GentleWave System (GWS) (Sonendo Inc, CA) on non-instrumented versus minimally instrumented root canal systems. METHODOLOGY: Thirty-four mandibular molars were autoclaved and allocated to four groups: Negative control (n = 5); positive control (n = 5); Group 1: non-instrumentation + GWS (NI + GWS) (n = 12); and Group 2: minimal instrumentation + GWS (MI + GWS) (n = 12)...
February 19, 2024: International Endodontic Journal
https://read.qxmd.com/read/38357799/identification-of-keystone-taxa-in-root-canals-and-periapical-lesions-of-post-treatment-endodontic-infections-next-generation-microbiome-research
#23
JOURNAL ARTICLE
Maria Teresa Arias-Moliz, Virginia Pérez-Carrasco, David Uroz-Torres, Jose Domingo Santana Ramos, Jose Antonio García-Salcedo, Miguel Soriano
AIM: The aim of this study was to analyse and compare the microbiome present in root canals and periapical lesions of teeth with post-treatment infections, and to identify the presence of keystone taxa in both habitats using next-generation sequencing analysis. METHODOLOGY: Apices and periapical lesions of patients with post-treatment apical periodontitis were surgically extracted. Specimens were cryo-pulverized, bacterial DNA was extracted, and the V3-V4 hypervariable regions of the 16S rRNA gene were sequenced using the Illumina Miseq platform...
February 15, 2024: International Endodontic Journal
https://read.qxmd.com/read/38340038/next-generation-antibacterial-nanopolymers-for-treating-oral-chronic-inflammatory-diseases-of-bacterial-origin
#24
REVIEW
Manuel Toledano-Osorio, Raquel Osorio, Jaime Bueno, Cristina Vallecillo, Marta Vallecillo-Rivas, Mariano Sanz
BACKGROUND: 'Periodontitis' refers to periodontal destruction of connective tissue attachment and bone, in response to microorganisms forming subgingival biofilms on the root surface, while 'apical periodontitis' refers to periapical inflammatory processes occurring in response to microorganisms within the root canal system. The treatment of both diseases is based on the elimination of the bacterial challenge, though its predictability depends on the ability of disrupting these biofilms, what may need adjunctive antibacterial strategies, such as the next-generation antibacterial strategies (NGAS)...
February 10, 2024: International Endodontic Journal
https://read.qxmd.com/read/38340037/principle-and-antimicrobial-efficacy-of-laser-activated-irrigation-a-narrative-review
#25
REVIEW
Maarten Meire, Roeland J G De Moor
In the last two decades, the activation of root canal irrigants with pulsed lasers as an adjunct in root canal treatment has become increasingly popular. This narrative review explains the physical basics and the working mechanism of laser-activated irrigation (LAI), explores the parameters influencing LAI efficacy, considers historical evolutions in the field and summarizes laboratory and clinical evidence with emphasis on the antimicrobial action of LAI. Cavitation is the driving force behind LAI, with growing and imploding vapour bubbles around the laser tip causing various secondary phenomena in the irrigant, leading to intense liquid dynamics throughout the underlying root canal...
February 10, 2024: International Endodontic Journal
https://read.qxmd.com/read/38332717/pdgf-aa-guides-cell-crosstalk-between-human-dental-pulp-stem-cells-in%C3%A2-vitro-via-the-pdgfr-%C3%AE-pi3k-akt-axis
#26
JOURNAL ARTICLE
Siqun Xu, Jieya Wei, Yang Liu, Li Zhang, Mengmeng Duan, Jiazhou Li, Zhixing Niu, Xiaohua Pu, Minglei Huang, Hao Chen, Xuedong Zhou, Jing Xie
AIM: To explore the influence of PDGF-AA on cell communication between human dental pulp stem cells (DPSCs) by characterizing gap junction intercellular communication (GJIC) and its potential biomechanical mechanism. METHODOLOGY: Quantitative real-time PCR was used to measure connexin family member expression in DPSCs. Cell migration and CCK-8 assays were utilized to examine the influence of PDGF-AA on DPSC migration and proliferation. A scrape loading/dye transfer assay was applied to evaluate GJIC triggered by PDGF-AA, a PI3K/Akt signalling pathway blocker (LY294002) and a PDGFR-α blocker (AG1296)...
February 9, 2024: International Endodontic Journal
https://read.qxmd.com/read/38326290/vital-pulp-therapy-factors-influencing-decision-making-for-permanent-mature-teeth-with-irreversible-pulpitis-a-systematic-review
#27
REVIEW
Yasmen Alfaisal, Ghassan Idris, Ove A Peters, Sobia Zafar, Venkateshbabu Nagendrababu, Christine I Peters
BACKGROUND: There is an increased tendency towards adopting minimally invasive interventions in dentistry, supported by advancement in materials and techniques. However, the decision-making process in choosing conservative or invasive treatments is influenced by several factors, particularly in permanent teeth with irreversible pulpitis. OBJECTIVES: The objective of the study was to systematically review the literature regarding factors that influence decision-making for vital pulp therapy (VPT) as definitive treatment option in permanent mature teeth diagnosed with irreversible pulpitis...
February 7, 2024: International Endodontic Journal
https://read.qxmd.com/read/38323923/final-irrigation-with-bioglass-solution-in-regenerative-endodontic-procedure-induces-tissue-formation-inside-the-root-canals-collagen-maturation-proliferation-cell-and-presence-of-osteocalcin
#28
JOURNAL ARTICLE
Kiani Dos Santos de Paula, Alexandre Henrique Dos Reis-Prado, Witalo Pereira de Jesus, Juliana Goto, Lara Cancella de Arantes, Marina Verçosa, Luciano Tavares Angelo Cintra, Edilson Ervolino, Raphael Escorsim Szawka, Murilo Camuri Crovace, Ricardo Alves de Mesquita, Francine Benetti
AIM: To evaluate the influence of an experimental solution of cobalt-doped F18 bioactive glass (F18Co) on tissue repair following regenerative endodontic procedure (REP) in rat molars. METHODOLOGY: The F18Co solution was prepared at a ratio of 1:5 F18Co powder to distilled water. The right or left upper first molars of 12 Wistar rats were used, where the pulps were exposed, removed, and irrigated with 2.5% sodium hypochlorite (NaOCl), followed by 17% ethylenediaminetetraacetic acid (EDTA) (5 min each)...
February 7, 2024: International Endodontic Journal
https://read.qxmd.com/read/38314902/a-22-year-follow-up-cross-sectional-study-on-periapical-health-in-relation-to-the-quality-of-root-canal-treatment-in-a-belgian-population
#29
JOURNAL ARTICLE
Georgios Keratiotis, Loukia Spineli, Mieke A A De Bruyne, Roeland J G De Moor, Maarten A Meire
AIM: To investigate the prevalence of apical periodontitis (AP) and the technical standard of root canal treatment in a Belgian population, assess the association of different variables with periapical status, and compare the results to a similar study conducted 22 years previously. METHODOLOGY: In this cross-sectional study, 614 panoramic radiographs of first-time adult attendees at the Dental School of the University Hospital of Ghent were examined. Recorded patient-level parameters included gender, age, number of teeth, number of root filled teeth, presence of any AP lesion, and number of implants...
February 5, 2024: International Endodontic Journal
https://read.qxmd.com/read/38306111/vital-root-resection-with-radicular-retrograde-partial-pulpotomy-in-furcation-involved-maxillary-molars-in-patients-with-periodontitis-technique-description-and-case-series-considering-clinical-and-economic-aspects
#30
Antonio Ciardo, Sarah Rampf, Ti-Sun Kim
AIM: Conventional root resection in periodontally compromised furcation-involved maxillary molars requires preceding endodontic treatment and is therefore associated with loss of tooth vitality, higher invasiveness, treatment time and costs, and the risk of endodontic complications. Vital root resection (VRR) could overcome these disadvantages while establishing stable periodontal and endodontic conditions. This case series aimed to introduce the concept of one-stage VRR with radicular retrograde partial pulpotomy (VRRretro)...
February 2, 2024: International Endodontic Journal
https://read.qxmd.com/read/38294105/substance-p-calcitonin-gene-related-peptide-and-their-receptors-expression-in-human-periodontal-ligament-after-root-canal-preparation-with-five-different-systems
#31
JOURNAL ARTICLE
Javier Caviedes-Bucheli, Hernan Dario Muñoz-Alvear, Luis Fernando Lopez-Moncayo, Kranthi Raja Kacharaju, Adriana Carolina Velasquez-Rivera, Luis Alberto Carlosama-Recalde, Juan Camilo Pazmiño, Jose Francisco Gomez-Sosa, Luis Eduardo Diaz-Barrera, Hugo Roberto Munoz
AIM: The purpose of this study was to quantify the effect of five different root canal preparation instruments on Substance P (SP), Calcitonin gene-related peptide (CGRP) and their receptors expression in healthy human periodontal ligament. METHODOLOGY: STROBE guidelines were used to design a study using 60 periodontal ligament samples obtained from healthy lower premolars where extraction was indicated for orthodontic reasons. Prior to extraction 40 of these premolars were equally divided into four groups and root canals were prepared using different systems: Mtwo, Reciproc Blue, HyFlex EDM and Plex-V...
January 31, 2024: International Endodontic Journal
https://read.qxmd.com/read/38279778/effect-of-preemptive-use-of-a-nonsteroidal-anti-inflammatory-drug-and-a-corticosteroid-on-the-efficacy-of-inferior-alveolar-nerve-blockade-and-postoperative-pain-control-in-endodontic-treatment-of-molars-with-symptomatic-pulpitis-a-randomized-double-blind-placebo
#32
JOURNAL ARTICLE
Guilherme Araujo Rodrigues, Ruy Hizatugu, Juliana Delatorre Bronzato, Adriana de-Jesus-Soares, Marcos Frozoni
AIM: The anaesthetic success rate of an inferior alveolar nerve block (IANB) in mandibular molars with irreversible symptomatic pulpitis can be low, and postoperative pain control in teeth with this diagnosis can be challenging. This study aimed to evaluate the influence of preemptive use of dexamethasone and oral potassium diclofenac on the success of IANB. The influence of these drugs on the intensity of postoperative pain was assessed as a secondary outcome. METHODOLOGY: Eighty-four patients with mandibular molars diagnosed with irreversible symptomatic pulpitis recorded preoperative pain intensity using a cold thermal test and a modified Numerical Rating Scale (mNRS)...
January 27, 2024: International Endodontic Journal
https://read.qxmd.com/read/38279773/osteopontin-interacts-with-dendritic-cells-and-macrophages-in-pulp-inflammation-comprehensive-transcriptomic-analysis-and-laboratory-investigations
#33
JOURNAL ARTICLE
Leyi Chen, Mingqi Zhu, Chuhan Zhang, Ziting Wang, Xiaolin Lyu, Wenan Xu, Buling Wu
AIM: To investigate novel diagnostic markers for pulpitis and validate by clinical samples from normal and inflamed pulp. To explore the relationship between diagnostic markers and immune cells or their phenotypes during pulp inflammation. METHODOLOGY: Two microarray datasets, GSE77459 and GSE92681, and identified differential expression genes were integrated. To understand immune features, gene functions, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Disease Ontology (DO) and ImmuneSigDB Gene Set Enrichment Analysis (GSEA) were analysed...
January 27, 2024: International Endodontic Journal
https://read.qxmd.com/read/38279698/rev-erb%C3%AE-attenuates-refractory-periapical-periodontitis-via-m1-polarization-an-in-vitro-and-in-vivo-study
#34
JOURNAL ARTICLE
W Song, L Ye, Q Tang, X Lu, X Huang, M Xie, S Yu, Z Yuan, L Chen
AIM: Rev-erbα has been reported to regulate the healing of inflammatory lesions through its effect on the immune system in a variety of inflammatory disease. Moreover, the balance of macrophages polarization plays a crucial role in immune response and inflammatory progression. However, in refractory periapical periodontitis (RAP), the role of Rev-erbα in inflammatory response and bone resorption by regulating macrophage polarization remains unclarified. The aims of the present study were to investigate the expression of Rev-erbα in experimental RAP and to explore the relationship between Rev-erbα and macrophage polarization through the application of its pharmacological agonist SR9009 into the in vivo and in vitro experiments...
January 27, 2024: International Endodontic Journal
https://read.qxmd.com/read/38251804/a-video-based-decision-aid-improved-knowledge-and-decreased-decisional-conflict-for-asymptomatic-persistent-endodontic-lesions
#35
JOURNAL ARTICLE
Mingrun Wei, Shaoyong Tan, Peter Tsao Pan Yu, Thomas Kvist, Victoria Soo Hoon Yu
AIM: This prospective cohort study aimed to (i) evaluate patients' treatment decisions, decisional conflict and knowledge levels before and after use of a video-based decision aid (DA) on asymptomatic persistent endodontic lesions (APEL) and to (ii) elicit important decision factors for patients in the decision-making process. METHODOLOGY: A video DA modelled after the International Patient Decision Aids Standards (IPDAS) was designed. The video was pilot-tested, revised and used on 50 patients referred to the graduate endodontic clinic and presenting with an incidental finding of APEL detected on radiographs, with informed consent (DSRB 2020/00133)...
January 22, 2024: International Endodontic Journal
https://read.qxmd.com/read/38243920/dynamically-guided-transantral-piezoelectric-endodontic-microsurgery-a-case-report-with-technical-considerations
#36
Paula Andrea Villa-Machado, Felipe Augusto Restrepo-Restrepo, Sergio Iván Tobón-Arroyave
AIM: Endodontic microsurgery (EMS) of maxillary molars may represent a complex challenge to the clinician due to the location of the roots and the proximity of the maxillary sinus floor. This report aimed to describe the simultaneous use of a computer-assisted dynamic navigation (C-ADN) system and piezoelectric bony-window osteotomy for the transantral microsurgical approach of a maxillary left first molar with adequate root canal filling and symptomatic apical periodontitis. SUMMARY: This case report highlights the importance of C-ADN to carry out a minimally invasive buccal surgical access to palatal roots affected by apical periodontitis and provides a practical example to help clinicians make treatment decisions based on the available evidence...
January 20, 2024: International Endodontic Journal
https://read.qxmd.com/read/38243912/factors-associated-with-the-outcome-of-root-canal-treatment-a-cohort-study-conducted-in-a-private-practice
#37
JOURNAL ARTICLE
Rok Jurič, G Vidmar, R Blagus, Janja Jan
AIM: To investigate the association of various pre-, intra- and post-operative factors on root canal treatment outcome. METHODOLOGY: In this cohort study, primary or secondary root canal treatment of mature permanent teeth was performed by a single endodontist in a private practice over 13 years, and followed 1-4 years after treatment. Treatment details and clinical and radiographic data were collected. The proportion of successfully treated teeth and roots based on strict radiographic (periapical index (PAI) ≤2) and clinical criteria (absence of pain, swelling or sinus tract) was estimated...
January 20, 2024: International Endodontic Journal
https://read.qxmd.com/read/38243897/reduced-c-reactive-protein-levels-after-root-canal-treatment-in-clinically-healthy-young-apical-periodontitis-individuals-at-cardiovascular-risk-a-prospective-study
#38
JOURNAL ARTICLE
Mauricio Garrido, María José Bordagaray, Catalina Schweitzer, Joaquín Lucero-Mora, Montserrat Reyes, Elizabeth Pellegrini, Patricia Hernández-Ríos, Alejandra Fernández, Marcela Hernández
AIM: To determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated with root canal treatment (RCT). METHODOLOGY: Prospective pre-/post-study. Apical periodontitis (AP) individuals aged 16-40 were included (N = 29). Individuals received RCT and were followed at 1 and 6 months. Fasting blood samples were obtained. Apical lesions of endodontic origin (ALEO) diameter (mm), and periapical index (PAI), were recorded...
January 20, 2024: International Endodontic Journal
https://read.qxmd.com/read/38240378/effect-of-final-irrigation-protocols-with-chitosan-nanoparticle-and-genipin-on-dentine-against-collagenase-degradation-an-ex-vivo-study
#39
JOURNAL ARTICLE
S N Şengül, S Ozturk, K Ulubayram, N Pekel Bayramgil, S Kucukkaya Eren
AIM: Endodontic irrigants may affect the mechanical and chemical properties of dentine. This study evaluated the effects of various final irrigation protocols including the use of chitosan nanoparticle (CSnp) and cross-linking with genipin on the (1) mechanical and (2) chemical properties of dentine against enzymatic degradation. METHODOLOGY: CSnp was synthesized and characterized considering physiochemical parameters and stability. The root canals of 90 single-rooted teeth were prepared and irrigated with NaOCl...
January 19, 2024: International Endodontic Journal
https://read.qxmd.com/read/38240345/circ-znf236-mediates-stem-cells-from-apical-papilla-differentiation-by-regulating-lgr4-induced-autophagy
#40
JOURNAL ARTICLE
Ya Xiao, Luyao Chen, Yunlong Xu, Ruiyang Yu, Jiamin Lu, Yue Ke, Rong Guo, Tingjie Gu, Haowen Yu, Yuxin Fang, Zehan Li, Jinhua Yu
AIM: Human stem cells from the apical papilla (SCAPs) are an appealing stem cell source for tissue regeneration engineering. Circular RNAs (circRNAs) are known to exert pivotal regulatory functions in various cell differentiation processes, including osteogenesis of mesenchymal stem cells. However, few studies have shown the potential mechanism of circRNAs in the odonto/osteogenic differentiation of SCAPs. Herein, we identified a novel circRNA, circ-ZNF236 (hsa_circ_0000857) and found that it was remarkably upregulated during the SCAPs committed differentiation...
January 19, 2024: International Endodontic Journal
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