journal
https://read.qxmd.com/read/38761858/right-thalamic-volume-mediates-impact-of-the-dopamine-beta-hydroxylase-gene-on-the-endowment-effect
#41
JOURNAL ARTICLE
Tao Wang, Jianmin Zeng, Weijie Huang, Xiong Xiong, Li Su
The endowment effect is a tendency that individuals overvalue items belonging to them relative to those items that do not. Previous studies showed a strong relation between the dopamine beta-hydroxylase (DBH) gene and the endowment effect (EE), and a link between EE and task-based functional MRI activation in multiple brain regions. However, the role of brain structure on EE remains unclear. In this study, we have explored whether regional brain volume mediate the effect of the DBH gene on EE. Results showed that rs1611115, single-nucleotide polymorphisms (SNPs) at DBH loci, were significantly associated with right thalamus volume and the endowment effect in males but not in female participants...
May 16, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38761857/the-impact-of-high-fat-diet-consumption-and-inulin-fiber-supplementation-on-anxiety-related-behaviors-and-liver-oxidative-status-in-female-wistar-rats
#42
JOURNAL ARTICLE
Lucas Gabriel Vieira, Sylvana Izaura Salyba Rendeiro de Noronha, Máira Tereza Talma Chírico, Ana Beatriz de Souza, Natália Alves de Matos, Deoclécio Alves Chianca Júnior, Frank Silva Bezerra, Rodrigo Cunha Alvim de Menezes
BACKGROUND: Obesity is a worldwide public health problem associated with cognitive and mental health problems in both humans and rats. Studies assessing the effect of fiber supplementation on behavioral deficits and oxidative stress caused by high-fat diet (HFD) consumption in female rats are still scarce. We hypothesized that HFD consumption would lead to anxiety-related behavior and hepatic oxidative stress and that inulin would protect against these changes. We analyzed the impact of HFD-induced obesity combined with fiber supplementation (inulin) on anxiety-related defensive behavior and hepatic oxidative stress...
May 16, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38759799/oxidative-stress-plays-an-important-role-in-the-central-regulatory-mechanism-of-orofacial-hyperalgesia-under-low-estrogen-conditions
#43
JOURNAL ARTICLE
Jiali Lu, Linqian Zhang, Jinglin Zhang, Yanrong Sun, Hanfei Wang, Wenjuan Wang, Ke Wang, Lihua Qin, Jing Jia
Hyperalgesia occurs in the orofacial region of rats when estrogen levels are low, although the specific mechanism needs to be investigated further. Furthermore, oxidative stress plays an important role in the transmission of pain signals. This study aimed to explore the role of oxidative stress in orofacial hyperalgesia under low estrogen conditions. We firstly found an imbalance between oxidative and antioxidant capacity within the spinal trigeminal subnucleus caudalis (SP5C) of rats after ovariectomy (OVX), resulting in oxidative stress and then a decrease in the orofacial pain threshold...
May 15, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38754789/interaction-between-maternal-immune-activation-and-postpartum-immune-stress-in-neuropsychiatric-phenotypes
#44
JOURNAL ARTICLE
Pengsheng You, Jiaping Sui, Zhongman Jin, Lian Huang, Hui Wei, Qi Xu
Epidemiological evidence has shown that maternal infection is a notable risk factor for developmental psychiatric disorders. Animal models have corroborated this link and demonstrated that maternal immune activation (MIA) induces long-term behavioural deficits and neuroimmunological responses to subsequent immune stress in offspring. However, it is unclear whether MIA offspring are more sensitive or more tolerant to immunological challenges from postnatal infections. Pregnant mice were weighed and injected with a single dose of polyinosinic-polycytidylic acid (poly I:C) or saline at gestational day 9...
May 14, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38734034/persistent-fatigue-in-post-acute-covid-syndrome-is-associated-with-altered-t1-mri-texture-in-subcortical-structures-a-preliminary-investigation
#45
JOURNAL ARTICLE
Nathan W Churchill, Eugenie Roudaia, J Jean Chen, Allison Sekuler, Fuqiang Gao, Mario Masellis, Benjamin Lam, Ivy Cheng, Chris Heyn, Sandra E Black, Bradley J MacIntosh, Simon J Graham, Tom A Schweizer
Post-acute COVID syndrome (PACS) is a global health concern and is often associated with debilitating symptoms. Post-COVID fatigue is a particularly frequent and troubling issue, and its underlying mechanisms remain incompletely understood. One potential contributor is micropathological injury of subcortical and brainstem structures, as has been identified in other patient populations. Texture-based analysis (TA) may be used to measure such changes in anatomical MRI data. The present study develops a methodology of voxel-wise TA mapping in subcortical and brainstem regions, which is then applied to T1-weighted MRI data from a cohort of 48 individuals who had PACS (32 with and 16 without ongoing fatigue symptoms) and 15 controls who had cold and flu-like symptoms but tested negative for COVID-19...
May 9, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38734033/social-cognition-in-idiopathic-generalised-epilepsies
#46
REVIEW
Viktoria Ogurcakova, Michaela Kajsova, Petr Marusic, Jana Amlerova
Social cognition is a set of mental skills necessary to create satisfactory interpersonal relationships and feel a sense of belonging to a social group. Its deficits significantly reduce the quality of life in people with epilepsy. Studies on social cognition and its impairments focus predominantly on people with focal epilepsies. Idiopathic generalised epilepsies are a group of diseases that share similar clinical, prognostic and electrographic characteristics. Despite their typically normal intelligence, people with Idiopathic generalised epilepsies can suffer from learning disabilities and executive dysfunctions...
May 9, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38729219/social-hierarchy-differentially-influences-the-anxiety-like-behaviors-and-dendritic-spine-density-in-prefrontal-cortex-and-limbic-areas-in-male-rats
#47
JOURNAL ARTICLE
Zeinab Parvin, Ali Jaafari Suha, Mohammad Reza Afarinesh, Narges Hosseinmardi, Mahyar Janahmadi, Gila Behzadi
Social hierarchy is a fundamental feature of social organization that can influence brain and emotional processing regarding social ranks. Several areas, including the medial prefrontal cortex (mPFC), the hippocampus, and the basolateral nucleus of the amygdala (BLA), are recognized to be involved in the regulation of emotional processing. However, its delicate structural correlates in brain regions are poorly understood. To address this issue, social hierarchy in home-caged sibling Wistar rats (three male rats/cage) was determined by employing a social confrontation tube test (postnatal weeks 9-12)...
May 8, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38723677/programmed-cell-death-factor-4-mediated-hippocampal-synaptic-plasticity-is-involved-in-early-life-stress-and-susceptibility-to-depression
#48
JOURNAL ARTICLE
Jiao Cheng, Lin Yuan, Shuwen Yu, Bing Gu, Qian Luo, Xixi Wang, Yijing Zhao, Chengcheng Gai, Tingting Li, Weiyang Liu, Zhen Wang, Dexiang Liu, Roger C M Ho, Cyrus S H Ho
Early life stress (ELS) increases the risk of depression later in life. Programmed cell death factor 4 (PDCD4), an apoptosis-related molecule, extensively participates in tumorigenesis and inflammatory diseases. However, its involvement in a person's susceptibility to ELS-related depression is unknown. To examine the effects and underlying mechanisms of PDCD4 on ELS vulnerability, we used a "two-hit" stress mouse model: an intraperitoneal injection of lipopolysaccharide (LPS) into neonatal mice was performed on postnatal days 7-9 (P7-P9) and inescapable foot shock (IFS) administration in adolescent was used as a later-life challenge...
May 7, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38723676/effects-of-unilateral-hippocampal-surgical-procedures-needed-for-calcium-imaging-on-mouse-behavior-and-adult-hippocampal-neurogenesis
#49
JOURNAL ARTICLE
Suvi-Maaria Lehtonen, Veera Puumalainen, Miriam S Nokia, Sanna Lensu
Hippocampus is essential for episodic memory formation, lesion studies demonstrating its role especially in processing spatial and temporal information. Further, adult hippocampal neurogenesis (AHN) in the dentate gyrus (DG) has also been linked to learning. To study hippocampal neuronal activity during events like learning, in vivo calcium imaging has become increasingly popular. It relies on the use of adeno-associated viral (AAV) vectors, which seem to lead to a decrease in AHN when applied on the DG. More notably, imaging requires the implantation of a relatively large lens into the tissue...
May 7, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38723675/neuroprotective-effects-of-si-based-hydrogen-producing-agent-on-6-hydroxydopamine-induced-neurotoxicity-in-juvenile-mouse-model
#50
JOURNAL ARTICLE
Shogo Togawa, Noriyoshi Usui, Miyuki Doi, Yuki Kobayashi, Yoshihisa Koyama, Yukiko Nakamura, Koh Shinoda, Hikaru Kobayashi, Shoichi Shimada
Neurotoxins have been extensively investigated, particularly in the field of neuroscience. They induce toxic damage, oxidative stress, and inflammation on neurons, triggering neuronal dysfunction and neurodegenerative diseases. Here we demonstrate the neuroprotective effect of a silicon (Si)-based hydrogen-producing agent (Si-based agent) in a juvenile neurotoxic mouse model induced by 6-hydroxydopamine (6-OHDA). The Si-based agent produces hydrogen in bowels and functions as an antioxidant and anti-inflammatory agent...
May 7, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38723674/arbutin-intervention-ameliorates-memory-impairment-in-a-rat-model-of-lysolecethin-induced-demyelination-neuroprotective-and-anti-inflammatory-effects
#51
JOURNAL ARTICLE
Sahand Ashrafpour, Mohammad-Javad Nasr-Taherabadi, Alie Sabouri-Rad, Soheila Hosseinzadeh, Fereshteh Pourabdolhossein
Cognitive impairment (CI) and memory deficit are prevalent manifestations of multiple sclerosis (MS). This study explores the therapeutic potential of arbutin on memory deficits using a rat hippocampal demyelination model induced by lysophosphatidylcholine (LPC). Demyelination was induced by bilateral injection of 1% LPC into the CA1 area of the hippocampus, and the treated group received daily arbutin injections (50mg/kg, i.p) for two weeks. Arbutin significantly improved memory impairment 14 days post-demyelination as assessed by Morris water maze test...
May 7, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38718877/the-effect-of-olanzapine-on-spatial-memory-impairment-depressive-like-behavior-pain-perception-and-bdnf-and-synaptophysin-expression-following-childhood-chronic-unpredictable-mild-stress-in-adult-male-and-female-rats
#52
JOURNAL ARTICLE
Zahra Tajabadi Farahani, Salar Vaseghi, Elham Rajabbeigi, Batool Ghorbani Yekta
Chronic unpredictable mild stress (CUMS) method has been introduced as a rodent model of depression. On the other hand, olanzapine, as an antipsychotic, can induce antidepressant and antipsychotic effects. Also, olanzapine may improve cognitive functions. Both CUMS and olanzapine can also affect the expression level of brain-derived neurotrophic factor (BDNF) and synaptophysin, the molecular factors involved in synaptic function, and learning and memory. In this study, we investigated the effect of olanzapine on locomotor activity (using open field test), pain threshold (using hot plate), depressive-like behavior (using forced swim test), spatial learning and memory (using Morris water maze), and BDNF and synaptophysin hippocampal expression (using real-time PCR) in both male and female CUMS rats...
May 6, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38710451/prenatal-restraint-stress-affects-early-neurobehavioral-response-and-oxidative-stress-in-mice-pups
#53
JOURNAL ARTICLE
Oumaima Essaidi, Meriem Laaroussi, Hafsa Malqui, Laila Berroug, Hammou Anarghou, Hamadi Fetoui, Fatiha Chigr
Prenatal stress (PS), in both humans and animals, presents a potential risk to the mother and her fetus throughout gestation. PS is always associated with physiological changes that alter embryonic development and predispose the individual to lifelong health problems, including susceptibility to mental illness. This study aims to identify the harmful effects of prenatal restraint stress (PRS), commonly employed to induce stress painlessly and without any lasting debilitation during gestation. This stress is applied to pregnant Swiss albino mice from E7...
May 4, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38705283/spatio-temporal-modulation-of-cortical-activity-during-motor-deadaptation-depends-on-the-feedback-of-task-related-error
#54
JOURNAL ARTICLE
C A Mista, F G Arguissain, A Ranieri, J F Nielsen, H Andersen, J A Biurrun Manresa, O K Andersen
Motor adaptations are responsible for recalibrating actions and facilitating the achievement of goals in an ever-changing environment. Once consolidated, the decay of motor adaptation is a process affected by available sensory information during deadaptation. However, the cortical response to task error feedback during the deadaptation phase has received little attention. Here, we explored changes in brain cortical responses due to feedback of task-related error during deadaptation. Twelve healthy volunteers were recruited for the study...
May 3, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38705282/event-related-prefrontal-activations-during-online-video-game-playing-are-modulated-by-game-mechanics-physiological-arousal-and-the-amount-of-daily-playing
#55
JOURNAL ARTICLE
Kehong Long, Xuzhe Zhang, Ningxin Wang, Hao Lei
There is a trend to study human brain functions in ecological contexts and in relation to human factors. In this study, functional near-infrared spectroscopy (fNIRS) was used to record real-time prefrontal activities in 42 male university student habitual video game players when they played a round of multiplayer online battle arena game, League of Legends. A content-based event coding approach was used to analyze regional activations in relation to event type, physiological arousal indexed by heart rate (HR) change, and individual characteristics of the player...
May 3, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38704247/retraction-notice-to-hypobaric-hypoxia-induces-dendritic-plasticity-in-cortical-and-hippocampal-pyramidal-neurons-in-rat-brain-behav-brain-res-189-2-2008-233-243
#56
JOURNAL ARTICLE
Panchanan Maiti, S Muthuraju, G Ilavazhagan, Shashi B Singh
No abstract text is available yet for this article.
May 3, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38703793/nasal-application-of-kisspeptin-54-mitigates-motor-deficits-by-reducing-nigrostriatal-dopamine-loss-in-hemiparkinsonian-rats
#57
JOURNAL ARTICLE
Osman Sinen, Ayşegül Gemici Sinen, Narin Derin, Mutay Aydın Aslan
Parkinson's Disease is a progressive neurodegenerative disorder characterized by motor symptoms resulting from the loss of nigrostriatal dopaminergic neurons. Kisspeptins (KPs) are a family of neuropeptides that are encoded by the Kiss-1 gene, which exert their physiological effects through interaction with the GPR54 receptor. In the current investigation, we investigated the prospective protective effects of central KP-54 treatments on nigrostriatal dopaminergic neurons and consequent motor performance correlates in 6-hydroxydopamine (6-OHDA)-lesioned rats...
May 2, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38702283/corrigendum-to-task-general-or-specific-the-alertness-modulates-post-error-adjustment-behav-brain-res-volume-466-2024-114990
#58
Na Hu, Quanshan Long, Lijun Wang, Xueping Hu, Xiaoxi Wang, Ruimin Ma, Yuqing Bai, Chen Qian, Antao Chen
No abstract text is available yet for this article.
May 2, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38697302/the-alpha1a-antagonist-tamsulosin-impairs-memory-acquisition-consolidation-and-retrieval-in-a-novel-object-recognition-task-in-mice
#59
JOURNAL ARTICLE
Victor A D Holanda, Matheus C Oliveira, Carina I de Oliveira Torres, Clarissa de Almeida Moura, Hindiael Belchior, Edilson D da Silva Junior, Elaine C Gavioli
Tamsulosin is an α1 -adrenoceptor antagonist used to treat benign prostatic hyperplasia. This drug exhibits high affinity for α1A - and α1D -adrenoceptor subtypes, which are also expressed in the brain. While dementia symptoms have been reported after administration of tamsulosin in humans, studies on its effects on the rodent brain are still rare. The present study investigated the effects of tamsulosin (and biperiden, an amnesic drug) on cognitive performance in the object recognition task (ORT)...
April 30, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38697301/impact-of-abl2-arg-deficiency-on-anxiety-and-depressive-behaviors-in-mice
#60
JOURNAL ARTICLE
Xiaojuan Yao, Ruiying Chen, Hongting Chen, Anthony Koleske, Xiao Xiao
Abl2/Arg (ABL-related gene) is a member of the Abelson family of nonreceptor tyrosine kinases, known for its role in tumor progression, metastasis, tissue injury responses, inflammation, neural degeneration, and other diseases. In this study, we developed Abl2/Arg knockout (arg-/- ) mice to explore its impact on sensory/motor functions and emotion-related behaviors. Our findings show that arg-/- mice exhibit normal growth and phenotypic characteristics, closely resembling their wild-type (WT) counterparts. Behavioral tests, including the elevated plus maze, marble-burying behavior test, and open field test, indicated pronounced anxiety-like behaviors in arg-/- mice compared to WT mice...
April 30, 2024: Behavioural Brain Research
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