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Immunobiology | Page 2

Lin Cheng, Xian Tang, Liumei Xu, Lukun Zhang, Huichun Shi, Qiaoli Peng, Fang Zhao, Yang Zhou, Yun He, Hui Wang, Boping Zhou, Zhiliang Gao, Zhiwei Chen
BACKGROUND: We recently identified a novel alternatively spliced isoform of human programmed cell death 1 (PD-1), named Δ42PD1, which contains a 42-base-pair in-frame deletion compared with the full-length PD-1. Δ42PD1 is likely constitutively expressed on human monocytes and down-regulated in patients infected with human immunodeficiency virus type 1 (HIV-1). The mechanism underlying the regulation of Δ42PD-1 expression in monocytes remains unknown. METHODS: By flow cytometry, we investigated the effect of Interferon-gamma (INF-γ) on the expression of Δ42PD1 in primary human monocytes as well as monocytic cell lines THP-1 and U937 cells...
February 21, 2019: Immunobiology
Goro Matsuzaki, Masatoshi Yamasaki, Toshiki Tamura, Masayuki Umemura
Mycobacterial antigen-specific CD4+ Th1 cells have pivotal role in protective immunity against mycobacterial infections including pulmonary tuberculosis. In the course of the infection, Th1 cells differentiate in the lung-draining lymph nodes and migrate into the infected lung. Chemokine receptors on T cells are involved in T cell migration into the intestine and skin. However, role of chemokine receptors in the migration of CD4+ T cells into the lung is not yet established. To address the issue, the role of chemokine receptors in T cell migration into the mycobacteria-infected lung was analyzed using mycobacterial Ag85B peptide 25-specific T cell receptor-transgenic (P25) CD4+ T cells...
February 16, 2019: Immunobiology
B Groen, T P Links, P P van den Berg, P de Vos, M M Faas
The incidence of pregnancy complications in women with type 1 Diabetes Mellitus (T1D) is greater than in healthy pregnant women. This has mostly been attributed to hyperglycemia. However, despite the implementation of stricter guidelines regarding glycemic control, pregnancy complications remain more common in women with T1D. This may suggest that other etiological factors are involved. We suggest that the immune response may play a role, since the immune response has to adapt during pregnancy in order to facilitate implantation, placental and fetal development, and aberrant immunological adaptations to pregnancy are involved in various pregnancy complications...
February 15, 2019: Immunobiology
Shahrzad Talebian, Jalal Gharesouran, Soudeh Ghafouri-Fard, Behnaz Salek Esfahani, Shahram Arsang-Jang, Mir Davood Omrani, Mohammad Taheri, Maryam Rezazadeh
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Nearly 85% of MS patients are recognized with relapsing-remitting MS (RRMS), a typical clinical course of disease which is distinguished by several episodes of relapses, separated by remissions of neurological impairment. Failure of repair mechanisms is a main factor in progression of neurological dysfunction in MS. Several lines of evidence suggest that Reelin (RELN) signaling pathway can contribute in the regulation of repair mechanisms in MS patients...
February 12, 2019: Immunobiology
Ahmed A Al-Qahtani, Valarmathy Murugaiah, Hani A Bashir, Ansar A Pathan, Suhair M Abozaid, Evgeny Makarov, Beatrice Nal-Rogier, Uday Kishore, Mohammed N Al-Ahdal
Hydrophilic lung surfactant proteins have emerged as key immunomodulators which are potent at the recognition and clearance of pulmonary pathogens. Surfactant protein A (SP-A) is a surfactant-associated innate immune molecule, which is known to interact with a variety of pathogens, and display anti-microbial effects. SP-A, being a carbohydrate pattern recognition molecule, has a wide range of innate immune functions against respiratory pathogens, including influenza A virus (IAV). Some pandemic pH1N1 strains resist neutralization by SP-A due to differences in the N-glycosylation of viral hemagglutinin (HA)...
February 11, 2019: Immunobiology
Rui-Jie Ma, Ya-Qin Tan, Gang Zhou
OBJECTIVES: Oral lichen planus (OLP) is a T cell-mediated immune-related chronic disease, featured by accumulation of T cells and apoptosis of keratinocytes. Insulin-like growth factors 1 (IGF1) signaling, in combination with its downstream PI3K/AKT/MTOR cascade, plays pivotal roles in the regulation of inflammation and immune response. Meanwhile, TRB3 acts as a connective protein in the pathway. This study investigated the possible function of IGF1-PI3K/AKT/MTOR pathway in the local immunity of OLP...
February 10, 2019: Immunobiology
Sumayya Shahzad, Somaiya Mateen, Asif Hasan, Shagufta Moin
BACKGROUND: Etiopathogenesis of myocardial infarction (MI) is contributed by oxidative injury and inflammatory response. The interplay of these processes determines outcomes in MI patients. However, studies showing the relationship of oxidative stress and inflammatory cytokines with prognosis and severity of MI are lacking. OBJECTIVE: The present study was designed to assess the degree of oxidative stress and inflammation in correlation with GRACE (Global Registry of Acute Coronary Events) risk score in patients of MI...
February 10, 2019: Immunobiology
Lara Vargas Becker, Daniela Ferreira Passos, Daniela Bitencourt Rosa Leal, Vera Maria Morsch, Maria Rosa Chitolina Schetinger
Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease with periods of exacerbation and remission. SLE is characterized by the irreversible breakdown of immunological self-tolerance, where there is deregulation of multiple aspects of the immune system. SLE immune dysfunction is characterized by activation of autoreactive T lymphocytes, and hyperactivity of B lymphocytes with consequent production of several autoantibodies. ATP is a purinergic mediator released into the extracellular space in response to cell and tissue damage which operates as a danger signal to modulate immune and inflammatory responses...
February 8, 2019: Immunobiology
Adrian Y S Lee, Heinrich Körner
Traditionally, chemokine immunobiology has focused on chemotaxis and the positioning of cells at sites of inflammation and within lymphoid organs. More recently, however, regulation of intricate immune responses has emerged as a function attributed to chemokines and their receptors. One such pair, CCR6 and its chemokine ligand CCL20, has been receiving interest for its potential role in the coordination and regulation of humoral immune responses and in particular, memory responses, at the cellular level. B cells up-regulate CCR6 after activation in secondary lymphoid organs; however, its function is still unclear...
February 8, 2019: Immunobiology
Somkiat Ud-Naen, Tunsuda Tansit, Duangjit Kanistanon, Angkana Chaiprasert, Wanchai Wanachiwanawin, Yuttana Srinoulprasert
BACKGROUND: Pythium insidiosum has been mainly reported to cause morbidity and mortality in thalassemia patients. P. insidiosum zoospores can germinate to be hyphae within a few hours; therefore, it is difficult to study the initial immune response that P. insidiosum zoospores induce. The present study aims to compare immune responses against P. insidiosum zoospore infection by comparing monocytes/macrophages from thalassemia patients with those from non-thalassemia controls. METHODS: In order to keepP...
February 8, 2019: Immunobiology
Neda Djedovic, Bojan Jevtić, M José Mansilla, Filip Petković, Jana Blaževski, Gordana Timotijević, Juan Navarro-Barriuso, Eva Martinez-Caceres, Marija Mostarica Stojković, Đorđe Miljković
Dendritic cells (DC) are responsible for the initiation and shaping of the adaptive immune response and are in the focus of autoimmunity research. We were interested in comparison of DC obtained from autoimmunity-prone Dark Agouti (DA) rats and autoimmunity-resistant Albino Oxford (AO) rats. DC were generated from bone marrow precursors and matured (mDC) by lipopolysaccharide. Tolerogenic DC (tolDC) obtained by vitamin D3 treatment were studied in parallel. Profile of cytokine production was different in AO and DA mDC and tolDC...
February 8, 2019: Immunobiology
Mateusz Michalski, Anna S Świerzko, Sambor Sawicki, Andrzej Kałużyński, Jolanta Łukasiewicz, Anna Maciejewska, Dariusz Wydra, Maciej Cedzyński
BACKGROUND: Ficolin-3 is a pattern-recognition molecule with the ability to activate the lectin pathway of complement. It is found in lung, liver and blood, but its physiological role is unclear. We have investigated interaction of recombinant ficolin-3 with malignant cells and tissues. MATERIAL AND METHODS: Cells of various lines of human origin as well as ovarian tissue sections have been studied with the use of flow cytometry and immunohistochemistry. RESULTS: Recombinant (but not serum-derived) ficolin-3 was found to bind strongly to the ovarian cancer cell lines, SKOV-3, OVCAR-3 and ES-2, at concentrations of 2...
January 30, 2019: Immunobiology
Dhanapal Govindaraj, Swati Sharma, Naresh Singh, Naveen Arora
Peptide immunotherapy (PIT) represents a safe and efficacious therapeutic modality for allergic diseases. Present study evaluates immunotherapeutic potential of T cell peptides of major cockroach allergen, Per a 10 in murine model of airway allergy. Treatment with peptides T-P8 and T-P10 demonstrated maximal resolution of pathophysiological features such as reduced recruitment of inflammatory cells to airways, lowered specific IgE, induction of IgG2a antibodies in serum, immune deviation towards Th1 cytokine milieu, suppression of Th2 cytokines in BALF and splenocyte culture supernatant and resolution of lung inflammation...
January 30, 2019: Immunobiology
Borivoj Bijelić, Ivana Z Matić, Irina Besu, Ljiljana Janković, Zorica Juranić, Senka Marušić, Sladjana Andrejević
The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Antibodies against tissue transglutaminase (anti-tTG), deaminated gliadin peptides (DGP), deaminated gliadin-analogous fragments (anti-GAF-3X) and Saccharomyces cerevisiae (ASCA) were determined by ELISA and antineutrophil cytoplasmic antibodies (ANCA) by indirect immunoflurescence (IIF) in 57 patients with RAS and 60 control subjects...
January 2019: Immunobiology
Xining Yang, Ning Kang, Wendy M Toyofuku, Mark D Scott
T lymphocytes play a critical role in the pro-inflammatory anti-cancer response; hence, significant pharmacologic efforts have been made to enhance the endogenous T cell response. Unfortunately, significant toxicity arises consequent to pan T cell activation. In contrast, the less robust T cell alloresponse has also demonstrated an anti-cancer effect, but poses an inherent risk of GvHD. To overcome the GvHD risk, an acellular pro-inflammatory agent (IA1) has been biomanufactured from the secretome of the allorecognition response...
December 28, 2018: Immunobiology
Saibo Cheng, Fenghua Zhou, Yuling Xu, Xiaoyu Liu, Yu Zhang, Minhua Gu, Zhijie Su, Dandan Zhao, Lei Zhang, Yuhua Jia
Atherosclerosis (AS) is the common pathological basis of chronic cardiovascular diseases and is associated with inflammation and lipid metabolism dysfunction. Geniposide, the main active ingredient of Gardenia jasminoides Ellis fruit, exhibits a variety of anti-inflammatory and anti-oxidative functions; however, its role in AS remains unclear. The aim of this study was to investigate the mechanisms of geniposide in alleviating inflammation and thereby attenuating the development of AS. ApoE-/- mice were fed a high fat diet to induce AS and were treated with geniposide (50 mg/kg) for 12 weeks...
December 27, 2018: Immunobiology
Ramóna Pap, Emese Ugor, Tímea Litvai, Lilla Prenek, József Najbauer, Péter Németh, Tímea Berki
OBJECTIVE: Functional disturbances in regulatory T cells (Treg) have been described in autoimmune diseases, and their potential therapeutic use is intensively studied. Our goal was to investigate the influence of glucocorticoid hormone on the in vitro differentiation of Treg cells from thymic and splenic CD4+ T cells under different conditions to establish methods for generating stable and functionally suppressive iTregs for future use in adoptive transfer experiments. METHODS: Thymic and splenic CD4+ T lymphocytes were isolated from 3 to 4 week-old control and in vivo dexamethasone (DX) pretreated BALB/c mice using magnetic bead negative selection, followed by CD25 positive selection...
December 27, 2018: Immunobiology
Cecilie Bo Hansen, Anton Willer, Rafael Bayarri-Olmos, Claudia Kemper, Peter Garred
Complement activation is traditionally thought to occur in the extracellular space. However, it has been suggested that complement proteins are activated and function at additional locations. T cells contain intracellular stores of C3 and C5 that can be cleaved into C3a and C5a and bind to intracellular receptors, which have been shown to be of vital importance for the differentiation and function of these cells. However, whether the origin of the complement proteins located within T cells is derived from endogenous produced complement or from an uptake dependent mechanism is unknown...
December 27, 2018: Immunobiology
Fatemeh Shojaei Jeshvaghani, Jafar Amani, Rouhollah Kazemi, Ahmad Karimi Rahjerdi, Mahyat Jafari, Shahsanam Abbasi, Ali Hatef Salmanian
The most bacterial cause of infectious diseases associated with diarrhea are enterotoxigenic and enterohemorrhagic Escherichia coli (ETEC and EHEC, respectively). These strains use colonization factors for the attachment to the human intestinal mucosa, followed by enterotoxins production that could induce more host damage. The Heat-labile enterotoxin (LT) and colonization factors (CFs) are momentous factors for the pathogenesis of ETEC. Also, Intimin and Shiga like toxin (STX) are the main pathogenic factors expressed by EHEC...
December 11, 2018: Immunobiology
Sonja E van Roeden, Mirjam H A Hermans, Peet T G A Nooijen, Alexandra Herbers, Chantal P Bleeker-Rovers, Andy I M Hoepelman, Jan Jelrik Oosterheert, Peter C Wever
PURPOSE: Coxiella burnetii has been suggested as a potential cause of B-cell non-Hodgkin lymphoma (B-NHL), as C. burnetii was detected in B-NHL tissues. To further investigate this potential relationship, we hypothesized that among subjects previously exposed to C. burnetii, the bacterium is more frequently detectable in tissues of patients with B-NHL (cases) compared to patients without B-NHL (controls). METHODS: We aimed to evaluate this hypothesis by assessing the presence of C...
December 5, 2018: Immunobiology
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