Yu Han, Xu Zhang, Qing Wang, Xiaoyue Cui, Hesuiyuan Wang, Xiang Zhang, Qian Wang, Jianbin Ji, Yuebing Wang, Shusen Wang, Xiuming Zhang, Haijin Xu, Mingqiang Qiao, Zhenzhou Wu
Antigen-presenting cells (APCs) constantly express major histocompatibility complex II (MHC II), including macrophages and dendritic cells (DCs) which deliver antigens to CD4+ T cells and play an important role in adaptive immunity. The expression of MHC II is controlled by the transcriptional coactivator CIITA. Interleukin-27 (IL-27), a newly discovered IL-12 family cytokine, is composed of p28 and EBI3 subunits. In this study, we used IL-27p28 conditional knock-out mice to investigate the regulatory effects of IL-27p28 on macrophage polarization and the expression of MHC II in macrophages...
November 1, 2023: Immunobiology