Maya Fujii, Yukiko Tanaka, Hiroyuki Okimura, Eiko Maeda, Masahide Hamaguchi, Michiaki Fukui, Jo Kitawaki, Taisuke Mori
Endometriosis is a serious disorder that can lead to infertility. The immune system, particularly regulatory T cells (Tregs), is involved in endometriosis and infertility; however, endometriosis-associated infertility is poorly understood. Tregs, which have an immunosuppressive function, fluctuate during the menstrual cycle. They are functionally heterogeneous and can be divided into subsets, with only activated Tregs (aTregs) having a true immunosuppressive function. The purpose of this study is to investigate the role of aTregs in endometriosis and how they contribute to endometriosis-associated infertility...
February 1, 2023: Journal of Reproductive Immunology