Alenka Višnić, Gordana Čanadi Jurešić, Robert Domitrović, Marko Klarić, Tina Sušanj Šepić, Dubravko Barišić
In the pathogenesis of endometriosis, a number of pathological reactions occur. Proteins secreted in the urine are thought to interact with each other and stimulate the pathological processes in endometriosis. Identifying one or more proteins that are specific enough and could serve as biomarkers for endometriosis is both a challenge and a necessity that would facilitate diagnosis. The urine of patients treated in a tertiary university hospital between July 1, 2020 and June 30, 2021 was analyzed. The studied group consists of patients who were treated surgically for endometriosis and in whom the diagnosis was confirmed by pathohistological analysis...
March 17, 2023: Journal of Reproductive Immunology
Yuekun Chen, Akiko Hasegawa, Haruka Honda, Yu Wakimoto, Hiroaki Shibahara
We previously established a spontaneously occurring monoclonal antibody, namely Ts3, that was reactive to sperm from an aged male mouse. The present study investigated the characteristic properties and reproductive functions of Ts3. Immunofluorescent staining revealed that Ts3 reacted to epididymal sperm, and the corresponding antigen was located in the midpiece and principal piece. Immunohistochemistry revealed positive reactions in the germ cells and Sertoli cells in the testis, the epithelial cells in the epididymis and vas deferens...
March 9, 2023: Journal of Reproductive Immunology
Yanxian Guo, Menghui Ma, Ziyu Liu, Linyan Lv, Xinyi Pan, Qianru Liu, Guihua Liu, Xing Yang
Cesarean section (CS) scar diverticula (CSD) is an important cause impede further fecundity, with rather complicated pathophysiologic mechanisms and unclear etiopathogenesis. In this study, we detect the influences of CSD on the pregnancy outcomes in in-vitro fertilization (IVF) or intra-cytoplasmic sperm injection (ICSI) embryo transfer (ET) cycles, and further explore the mechanisms involved based on histopathology and immunology differences in endometrium between CSD and vaginal birth (VB) women. The CS group had significantly lower CLBR compared to NCS group...
March 7, 2023: Journal of Reproductive Immunology
Qun Zhou, Xin Jin, Jiaxi Wang, Huifang Li, Lijuan Yang, Weibo Wu, Wenjun Chen
This research explored the pathological and molecular mechanisms of 4-vinylcyclohexene diepoxide (VCD)-induced POI model. QRT-PCR was exploited to detect miR-144 expression in the peripheral blood of POI patients. Rat and KGN cells were treated with VCD to construct POI rat or cell model, respectively. After miR-144 agomir or MK-2206 treatment, miR-144 level, follicle damage, autophagy level and expressions of key pathway-related proteins in rats were detected, and cell viability and autophagy in KGN cells were detected...
March 5, 2023: Journal of Reproductive Immunology
Manuel S Vidal, Ramkumar Menon
Mechanisms of fetal immune system development in utero remain incompletely elucidated. Protective immunity, the arm of reproductive immunology concerned with the progressive education of the fetal immune system as pregnancy advances, allows for programming of the immune system and immune maturation in utero and provides a responsive system to respond to rapid microbial and other antigenic exposure ex utero. Challenges in studying fetal tissues, immune system development, and the contributions of various endogenous and exogenous factors to this process are difficult to study as a progressive sampling of fetal biological samples is impractical during pregnancy, and animal models are limited...
March 2, 2023: Journal of Reproductive Immunology
Alison Maclean, Vanya Barzilova, Simran Patel, Faith Bates, Dharani K Hapangama
Inflammation is implicated in the symptomatology and the pathogenesis of adenomyosis. Injury at the endo-myometrial interface causes inflammation and may facilitate the invasion of endometrium into the myometrium, forming adenomyosis lesions. Their presence causes local inflammation, resulting in heavy menstrual bleeding, chronic pelvic pain, and subfertility. Immunological differences have been described in the eutopic endometrium from women with adenomyosis compared to healthy endometrium, and differences are also expected in the adenomyotic lesions compared with the correctly sited eutopic endometrium...
March 1, 2023: Journal of Reproductive Immunology
Hedia Zitouni, Vera Chayeb, Marwa Ben Ali Gannoun, Nozha Raguema, Sameh Bendhaher, Ines Zouari, Hassen Ben Abdennebi, Jean Guibourdenche, Touhami Mahjoub, Kamel Gaddour, Wassim Y Almawi
We investigated the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with preeclampsia (PE) in Tunisian women. ACE I/D genotyping was done by PCR in 342 pregnant women with PE and 289 healthy pregnant women. The association between ACE I/D and PE and associated features were also evaluated. Decreased active renin concentration, plasma aldosterone concentration, and placental growth factor (PlGF) were observed in PE cases, while soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio was significantly higher in the PE group...
February 28, 2023: Journal of Reproductive Immunology
O O Obembe, A A Ojetola, T G Atere, T A Abayomi, B J Dare, D H Adeyemi, I P Oyeyipo
Buchholzia coriacea has been reported to possess antifertility activities but little is known of the mechanisms responsible. This study was therefore designed to examine the mechanism responsible for the action of Buchholzia coriacea. Eighteen male Wistar rats (180-200 g) were used for this study. They were grouped into 3 (n = 6) namely, Control, Methanolic fraction of Buchholzia coriacea (MFBC) 50 mg/kg, and MFBC 100 mg/kg administered orally with respective dosage. After 6 weeks of administration, rats were euthanized, serum collected, while testes, epididymis and prostate were excised and homogenized...
February 28, 2023: Journal of Reproductive Immunology
R Yokote, Y Kuwabara, S Kasano, M Yonezawa, N Ouchi, T Ichikawa, S Suzuki, T Takeshita
Antiphospholipid syndrome (APS) is an established cause of recurrent pregnancy loss (RPL). It is necessary to detect persistently positive antiphospholipid antibodies to diagnose APS. This study aimed to explore risk factors for persistent anticardiolipin (aCL) positivity. Women with a history of RPL or with a history of one or more intrauterine fetal deaths after 10 weeks underwent examinations to determine the causes of RPL, including antiphospholipid antibodies. If aCL-IgG or aCL-IgM antibodies were positive, retests were performed at least 12 weeks apart...
February 25, 2023: Journal of Reproductive Immunology
Fangxiang Mu, Jiumei Huang, Xianghui Zeng, Ling Liu, Fang Wang
INTRODUCTION: Published data regarding efficacy of intrauterine perfusion of recombinant human granulocyte colony-stimulating factor for patients with unexplained recurrent spontaneous abortion (URSA) is inconclusive. This study aims at evaluating the efficacy and safety of G-CSF in URSA. MATERIALS AND METHODS: Electronic databases were searched including Cochrane Library, PubMed, Embase, China Biology Medicine disc, China Science and Technology Journal Database, Wanfang Database and China National Knowledge Infrastructure Database (last search was performed on Sep 10th, 2022)...
February 16, 2023: Journal of Reproductive Immunology
Zahra Salehpoor, Bahia Namavar Jahromi, Nader Tanideh, Javad Nemati, Mojgan Akbarzade-Jahromi, Maryam Koushkie Jahromi
This study investigated the effects of pentoxifylline (PTX), high intensity interval training (HIIT) and moderate intensity continuous training (MICT) separately and in combination, on inflammatory and apoptotic pathways in the rat model of induced endometriosis. Endometriosis was induced through surgery on female Sprague-Dawley rats. Six weeks after the first surgery, the second look laparotomy was performed. After induction of endometriosis in rats, they were divided into control, MICT, PTX, MICT+ PTX, HIIT, HIIT+PTX groups...
February 16, 2023: Journal of Reproductive Immunology
Yalda Jahanbani, Tabassom Beiranvand, Parisa Yazdi Mamaghani, Leili Aghebati-Maleki, Mehdi Yousefi
Nowadays, infertility related diseases become one of the basic challenges in societies. Human fertilization and fetal development are one of the most complex biological process, influenced by various factors, such as exosomes. Exosomes are Nano-sized bilayer-lipid membrane vesicles that play a role in mediating cell to cell communication in the reproductive system by serving as carriers of different biomolecules. Alterations in exosomes number and contents also can be seen in different male and female reproductive diseases in animals and human cases...
February 15, 2023: Journal of Reproductive Immunology
Ae Ra Han, Suehyun Lee, Jaehun Cha, Jong-Yeup Kim, Dong-Kyu Kim, Jae Won Han, Chul Jung Kim, Sung Ki Lee
Endometriosis is a multifactorial disease, and inflammation is considered a core pathology. Inflammation related to genital tract infection (GTI) and surgical injury may cause endometriosis. Therefore, we investigated the incidence of endometriosis in women with a recent history of GTI, pelvic surgery, or both. Using the Korean National Health Insurance Service-National Sample Cohort, 20- to 49-year-old women diagnosed with GTI or who underwent pelvic surgeries between 2002 and 2008 were collected and followed up for five years...
February 12, 2023: Journal of Reproductive Immunology
Dongyong Yang, Fangfang Dai, Linlin Wang, Songchen Cai, Yuwei Zhang, Lianghui Diao, Yanxiang Cheng
Dysfunction of decidual macrophages (dMs) are closely associated with recurrent pregnancy loss (RPL) which brings great suffering to patients. Metabolism is essential for regulating macrophage function. Identifying molecules that regulate metabolism and function of dMs is important to revealing the pathogenesis of RPL. Single-cell sequencing data of decidual immune cells from control and RPL patients were downloaded from the GSA database and converted into feature-barcode matrices by Cell Ranger. After quality control, removal of double cell and clustering of all cells, 3579 macrophages were extracted for normalisation, scaling and re-clustering...
February 10, 2023: Journal of Reproductive Immunology
Ayse Citil Dogan, Murat Dogan, Cihan Togrul, Nazli Topfedaisi Ozkan
AIM: Endometriosis is a common, chronic benign gynecologic disease and distresses women in their reproductive age. Yet the pathogenesis of endometriosis is not clear, multifactorial mechanisms have been characterized for the initiation, progression, and regression of this disease. It has been suggested that immune cells in the lymphoid lineage play essential roles in accepting or rejecting the survival, implantation, and proliferation of endometrial and endometriotic cells and, dysfunction of B-lymphocytes (B-cells) are one of the major causes for the progression of endometriosis...
February 7, 2023: Journal of Reproductive Immunology
Yousef Nami, Babak Haghshenas, Arash Javanmard, Mahya Samari, Nahid Mohammadi, Fatemeh Oroojalian, Ahad Mokhtarzadeh
The microbiome in the female reproductive tract plays an essential role in immune modulation and reproductive health. However, various microbes become established during pregnancy, the balance of which plays a crucial role in embryonic development and healthy births. The contribution of disturbances in the microbiome profile to embryo health is poorly understood. A better understanding of the relationship between reproductive outcomes and the vaginal microbiota is needed to optimize the chances of healthy births...
February 3, 2023: Journal of Reproductive Immunology
J L Coloma, Martínez-Zamora, D Tàssies, J C Reverter, G Espinosa, R Cervera, F Carmona
OBJECTIVE: Several studies have reported a high prevalence of autoimmune diseases such as systemic lupus erythematosus (SLE) in endometriosis patients. The aim of this study was to evaluate the SLE autoimmune antibody profile in patients with deep (DE) and non-deep endometriosis (Non-DE). MATERIALS AND METHODS: Four groups of premenopausal patients were evaluated: patients with DE (n = 50); patients with ovarian endometriomas (Non-DE; n = 50); healthy patients without endometriosis (C group; n = 45); and SLE patients without endometriosis (SLE group; N = 46)...
February 3, 2023: Journal of Reproductive Immunology
Takato Goto, Shinobu Goto, Fumiko Ozawa, Hiroyuki Yoshihara, Tamao Kitaori, Masayuki Komura, Satoru Takahashi, Yasuhiko Ozaki, Mayumi Sugiura-Ogasawara
Chronic deciduitis (CD) is defined as the presence of lymphocytes or plasma cells in decidual tissue. CD suggests the presence of chronic endometritis (CE) which is associated with recurrent pregnancy loss (RPL). In this study, we examined the role CD plays in RPL patients with aneuploid and euploid miscarriage. The frequency of CD in 49 RPL patients (22 euploid and 27 aneuploid miscarriages) and 17 control women was assessed and the subsequent live birth rate (LBR) in the presence and absence of CD were compared...
February 2, 2023: Journal of Reproductive Immunology
Xinliang Kong, Guodong Tang, Yanfeng Liu, Zhibo Zheng, Ying Li, Fei Yan
Previous studies of intrauterine infusion therapy in recurrent implantation failure (RIF) patients have shown conflicting results, and there is a lack of head-to-head horizontal comparisons between different drugs. This study aimed to assess the effectiveness of four intrauterine infusion drugs, including human chorionic gonadotropin (HCG), granulocyte colony-stimulating factor (G-CSF), peripheral blood mononuclear cells (PBMCs) and autologous platelet-rich plasma (PRP), in improving pregnancy outcomes in RIF patients through the network meta-analysis...
February 1, 2023: Journal of Reproductive Immunology
Maya Fujii, Yukiko Tanaka, Hiroyuki Okimura, Eiko Maeda, Masahide Hamaguchi, Michiaki Fukui, Jo Kitawaki, Taisuke Mori
Endometriosis is a serious disorder that can lead to infertility. The immune system, particularly regulatory T cells (Tregs), is involved in endometriosis and infertility; however, endometriosis-associated infertility is poorly understood. Tregs, which have an immunosuppressive function, fluctuate during the menstrual cycle. They are functionally heterogeneous and can be divided into subsets, with only activated Tregs (aTregs) having a true immunosuppressive function. The purpose of this study is to investigate the role of aTregs in endometriosis and how they contribute to endometriosis-associated infertility...
February 1, 2023: Journal of Reproductive Immunology
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