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Journal of Reproductive Immunology

Jing Wang, Qing-Wen Zhu, Xiao-Yan Cheng, Jiang-Yue Liu, Lin-Li Zhang, Yu-Mei Tao, Yu-Bao Cui, Ye Wei
OBJECTIVE: Abnormal changes in immune-mediated inflammation contribute to the pathogenesis of preeclampsia (PE). We aim to investigate the value of systemic immune inflammation indices-neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR)-to identify and evaluate the prognosis of patients with PE. METHODS: This study reviewed clinical records of 367 PE patients (162 with mild PE and 205 with severe PE), in addition to a control group of 172 normal pregnancies...
March 6, 2019: Journal of Reproductive Immunology
Zoltan Bognar, Timea Judit Csabai, Eva Pallinger, Timea Balassa, Nelli Farkas, Janos Schmidt, Eva Görgey, Gergely Berta, Julia Szekeres-Bartho, Jozsef Bodis
During assisted reproduction the embryos are subjected to light. We investigated the relationship between light exposure and the developmental- and implantation capacity of mouse embryos. In vitro cultured embryos were exposed to white or red filtered light, then transferred to the uteri of pseudo-pregnant females. The mice were sacrificed on day 8.5 and implantation sites were counted. The number of nucleic acid containing (PI+) extracellular vesicles (EVs) in culture media of light-exposed and control embryos, as well as, the effect of the EVs on IL-10 production of CD8+ spleen cells was determined by flow cytometry...
March 4, 2019: Journal of Reproductive Immunology
Sandra Andorf, Sanchita Bhattacharya, Brice Gaudilliere, Gary M Shaw, David K Stevenson, Atul J Butte, Marina Sirota
PROBLEM: Preterm birth (PTB), or the delivery of an infant prior to 37 weeks of gestation, is a major health concern. Although a variety of social, environmental, and maternal factors have been implicated in PTB, causes of preterm labor have remained largely unknown. There is evidence of effectiveness and safety of influenza vaccination during pregnancy, however fewer studies have looked at vaccination response as an indicator of an innate host response that may be associated with adverse pregnancy outcomes...
February 27, 2019: Journal of Reproductive Immunology
L Salinas-Muñoz, R Campos-Fernández, I Olivera-Valle, E Mercader, C Fernandez-Pacheco, S Lasarte, L Pérez-Martín, M T Navarro-González, P Sánchez-Mateos, R Samaniego, M Relloso
Female reproductive mucosa must allow allogenic sperm survival whereas at the same time, avoid pathogen infection. To preserve sperm from neutrophil attack, neutrophils disappear from the vagina during the ovulatory phase (high estradiol); although the mechanisms that regulate neutrophil influx to the vagina during insemination remain controversial. We investigated the sex hormone regulation of the neutrophil migration through the cervix during insemination and revealed that ovulatory estradiol dose fades the CXCL1 epithelial expression in the ectocervix and fornix; hence, retarding neutrophil migration and retaining them in the epithelium...
February 18, 2019: Journal of Reproductive Immunology
Mohammad Zahied Johan, Wendy V Ingman, Sarah A Robertson, M Louise Hull
Endometriotic lesion development involves complex interactions between endometrial tissue, the peritoneum and immune cells. Macrophages are essential in this process; however their precise roles are not defined. To investigate whether infiltrating macrophages acquire functionally different phenotypes during lesion development, human endometrial tissues were grafted into immunodeficient mice expressing macrophage-specific green fluorescent protein (GFP). Although the numbers of GFP-positive macrophages were similar in lesions 4, 7, 10 and 14 days after grafting, their surface markers changed over time...
January 25, 2019: Journal of Reproductive Immunology
Theresa Maria Kolben, Elisabeth Rogatsch, Anna Hester, Christina Kuhn, Elisa Schmoeckel, Bastian Czogalla, Sven Mahner, Udo Jeschke, Thomas Kolben
BACKGROUND: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy. PATIENTS AND METHODS: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR...
January 8, 2019: Journal of Reproductive Immunology
Yuko Arita, Hyeon Jeong Park, Aisling Cantillon, Kavita Verma, Ramkumar Menon, Darios Getahun, Morgan R Peltier
Placental inflammation increases the risk of adverse pregnancy outcomes and possibly neurodevelopmental disorders in the offspring. Previous research suggests it may be possible to modulate the placental immune response to bacteria to favor an anti-inflammatory phenotype with dietary factors. Sulforaphane (SFN) is a dietary supplement with known anti-inflammatory activities, however, its effects on placental cytokine production are unclear. Therefore, we evaluated the effects of SFN on biomarkers of inflammation and neurodevelopment under basal conditions and a setting of mild infection...
December 29, 2018: Journal of Reproductive Immunology
Jian Wang, Jing Yang, Yuqing Yan, Zhuangyan Zhu, Yaqin Mu, Xiying Wang, Jinhua Zhang, Lihua Liu, Fuxi Zhao, Yuling Chi
OBJECTIVE: To investigate whether epigenetic modification of CD4+ CD25- T-cells in vitro can make up for the inadequacy of CD4+ CD25+ Foxp3+ Treg in animal model of spontaneous abortion and prevent immune response-mediated spontaneous abortion. METHODS: Trichostatin A (TSA) was applied to inhibit histone deacetylases (HDACs) and thereby to epigenetically modify the special location of Foxp3 gene in CD4+ CD25- T-cells of CBA/J mice. The expressions of CD25, Foxp3, CTLA-4 and PD-1 of CD4+ T cells isolated from spleen of mice were characterized by flow cytometric analysis...
December 26, 2018: Journal of Reproductive Immunology
Dongli Cai, Yunhui Tang, Xiaoying Yao
A successful pregnancy is a complicated process that involves the precisely timed regulation of endocrine as well as immune system. Despite increasing knowledge about immunology in gestation, the studies of immune cells in endometrium and decidua are still fragmented. Dynamic data is lacking on the transition of pre-pregnancy endometrial lymphocytes to initial pregnancy states as well as to second/third-trimester status. Here, we determined the composition of Gamma delta (γδ) T cells in endometrium and decidua from women with normal pregnancy and unexplained spontaneous abortion...
February 2019: Journal of Reproductive Immunology
Arezoo Maleki-Hajiagha, Maryam Razavi, Mahroo Rezaeinejad, Safoura Rouholamin, Amir Almasi-Hashiani, Reihaneh Pirjani, Mahdi Sepidarkish
Intrauterine administration of autologous peripheral blood mononuclear cells (PBMC) has been proposed to improve implantation rates in women with recurrent implantation failure (RIF). The objective of this study was to evaluate whether intrauterine administration of PBMC improves clinical pregnancy and live birth in couples with RIF. Various databases were searched including Medline, Embase, Scopus, Web of Science and Cochrane Central Register of Controlled Trials up to April 2018. This review included all studies that compared intervention of PBMC in infertile women undergoing any form of assisted reproductive technology (ART)...
February 2019: Journal of Reproductive Immunology
Mahnaz Ghaebi, Samaneh Abdolmohammadi-Vahid, Majid Ahmadi, Shadi Eghbal-Fard, Sanam Dolati, Mohammad Nouri, Mehdi Talebi, Kobra Hamdi, Faroogh Marofi, Leili Aghebati-Maleki, Farhad Jadidi-Niaragh, Masoume Dopour, Mehdi Yousefi
The objective of this study was to determine whether there are any differences in the T cell composition and the expression of specific factors (i.e., IRF4, TBX21, GATA3, and GITR) of T cells between women with Repeated Implantation Failure (RIF) and fertile women. We observed a decrease in circulating Tregs and exhausted CD8 + T cells in RIF patients when compared to the controls whereas exhausted Treg and Th17 cells were more frequent. Using real-time PCR, we determined that the expression of IRF-4 and TBX21 was significantly elevated in the cases...
November 8, 2018: Journal of Reproductive Immunology
Martin Schulze, Gábor Á Czirják, Karin Müller, Ralf Bortfeldt, Markus Jung, Ulrike Jakop
The aim of the present study was to characterize the lysozyme concentration and the bacterial killing activity (BKA) of boar seminal plasma against E. coli and S. aureus in 119 fertile Pietrain boars (aged: 18.1 ± 10.5 months). Lysozyme concentration was 2.4 ± 1.2 μg/ml in seminal plasma. More than 80% of the samples (97 of 119) showed BKA against E. coli or S. aureus or both bacterial strains: Group 1 (BKA against E. coli and S. aureus, n = 38), Group 2 (BKA against E. coli, n = 13), Group 3 (BKA against S...
November 3, 2018: Journal of Reproductive Immunology
Mark Hedger, Nicolette A Hodyl, Timothy J Moss
No abstract text is available yet for this article.
November 2018: Journal of Reproductive Immunology
Nathalie Lédée, Claudine Vasseur, Marie Petitbarat, Lucie Chevrier, Katia Vezmar, Geraldine Dray, Sandra Chenière, Annina Lobersztajn, Dominique Vitoux, Guy Nino Cassuto, Gérard Chaouat
PROBLEM: Continuous failures to achieve a pregnancy despite effective embryo transfers is extremely distressing for couples. In consequence, many adjuvant therapies to IVF have been proposed to achieve an "ideal" immune environment. We here focus on Intralipid® therapy (IL) reported to have immunosuppressive properties on NK cells. METHOD OF STUDY: 94 patients exhibited an immune profile of endometrial over-immune activation and an history of repeated implantation failures despite multiple embryos transfers (RIF)...
November 2018: Journal of Reproductive Immunology
Ola Gutzeit, Linoy Segal, Rivka Hertz, Yechiel Burke, Gili Paz, Shay Hantisteanu, Yuval Ginsberg, Mordechai Hallak, Niv Pencovich, Ron Beloosesky, Zeev Weiner, Ofer Fainaru
INTRODUCTION: immature-myeloid cells (IMCs) are proangiogenic bone marrow (BM)-derived cells that normally differentiate into inflammatory cells such as neutrophils, monocytes and dendritic cells (DCs). We characterized placental IMCs comparing their gene expression and subpopulations to tumor IMCs, and tested our hypothesis that progesterone that inhibits preterm labor, may affect their abundance and differentiation. METHODS: differences between IMC-subpopulations in subcutaneous tumors versus placentas in C57BL/6 or ICR (CD-1) mice were analyzed by flow cytometry and gene expression was detected by microarrays...
October 26, 2018: Journal of Reproductive Immunology
Sophie Cooper, Susan M Laird, Najat Mariee, Tin Chiu Li, Mostafa Metwally
This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment. 136 women diagnosed with RRF who had a timed midluteal endometrial biopsy taken for uNK cell analysis were included. Women with high uNK cell concentrations (n = 45) were treated with prednisolone (10 mg/day) for one month, after which a second biopsy was taken for repeat uNK cell analysis...
October 25, 2018: Journal of Reproductive Immunology
Akrem Abdulsid, Fiona Lyall
No abstract text is available yet for this article.
September 2018: Journal of Reproductive Immunology
K B Ziegler, D O Muzzio, F Matzner, I Bommer, M S Ventimiglia, K Malinowsky, J Ehrhardt, M Zygmunt, F Jensen
Though human pregnancy success has been classically linked with a shift into a Th2 immunoglobulin producing cell response, a clear picture concerning B cell development and immunoglobulin profile during human pregnancy is missing. We analyzed in this work the dynamic of different B cell populations in peripheral blood of pregnant women on the first, second and third trimester of pregnancy. As control, age-matched non-pregnant fertile women were included. Additionally, we quantified the levels of immunoglobulin (IgG1, IgG2, IgG3, IgG4, IgM, IgA and IgE) in the serum of pregnant and non-pregnant women...
September 2018: Journal of Reproductive Immunology
Magdalena Palacz, Kelton Tremellen
Obesity is associated with implantation failure, miscarriage, low-grade inflammation and a reduction in peripheral immune-suppressive T regulatory (Treg) cells. Therefore, we postulated that this reduction may also extend to the endometrium and cause embryonic loss. In a cohort of 40 infertile women, without implantation failure or recurrent miscarriage, we examined the density of Treg cells, macrophages and natural killer (NK) cells in mid-luteal endometrial biopsies. Significant positive correlations were observed between BMI and endometrial Treg cells and macrophages, but no relationship with NK cells...
September 2018: Journal of Reproductive Immunology
Lia Karina Volpato, Verônica Vargas Horewicz, Franciane Bobinski, Daniel Fernandes Martins, Anna Paula Piovezan
To characterize Annexin A1 (ANXA1), FPR2/ALX and cytokines expression in peritoneal endometriosis and to clarify their role in its etiology, a cross-sectional study was performed with forty women in reproductive age (22 patients with endometriosis and 18 control women) that had undergone laparoscopic surgery. Peritoneal biopsy and fluid aspirations from endometriosis and control samples were analyzed for the expression of ANXA1, FPR2/ALX and cytokines. ANXA1 and FPR2 / ALX levels were measured by Western blotting and interleukin 1ß (IL-1β), interleukin 4 (IL-4), interleukin 6 (IL-6), and interleukin 10 (IL-10) levels were quantified by enzyme-linked immunosorbent assay (ELISA)...
September 2018: Journal of Reproductive Immunology
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