Colm J McElwain, Andrea Musumeci, Samprikta Manna, Fergus P McCarthy, Cathal M McCarthy
BACKGROUND: Maternal hyperglycaemia has a significant impact on placental metabolism and mitochondrial function. The NLRP3 inflammasome is responsive to endogenous signals of mitochondrial dysfunction. We tested our hypothesis that mitochondrial dysfunction orchestrates activation of the NLRP3 inflammasome and contributes to inflammation in gestational diabetes mellitus (GDM). METHODS: Fasting blood, omental and placental tissue were collected on the day of caesarean section from nulliparous women with normal glucose tolerant (NGT) (n = 30) and GDM (n = 27) pregnancies...
November 24, 2023: Journal of Reproductive Immunology
Yalong Yang, Vishnu Kumar, Wei Peng, Monika Fijak, Michel Gabriela, Wei Cai, Andreas Meinhardt, Sudhanshu Bhushan
Testicular macrophages (TM) are critical for the function of the testis by regulating homeostasis and inflammatory responses. However, the mechanisms by which TM fulfil these roles remain elusive. In this study, we explored the impact of two key testicular microenvironmental factors, namely 25-hydroxycholesterol (25HC), an oxysterol related to sex hormones and macrophage colony-stimulating factor (M-CSF), a factor crucial for macrophage survival and differentiation, on the regulation of the TM phenotype. Specifically, we examined their role in controlling the expression of the transcription factor interferon regulatory factor 7 (Irf7), a factor critical for maintaining the alternative macrophage phenotype...
November 21, 2023: Journal of Reproductive Immunology
Aikaterini Berdiaki, Eleni Vergadi, Fanourios Makrygiannakis, Thomas Vrekoussis, Antonios Makrigiannakis
Repeated implantation failure (RIF) is a significant limiting factor in assisted reproduction. Chronic endometrial inflammation has been noted in RIF women, therefore we sought to investigate the potential association of endometrial Th17/Treg ratio and endometrial inflammation in these cases. Endometrial pipelle biopsies were obtained from volunteers, 29 women with RIF (failure to achieve pregnancy following at least 3 transfers of high-grade embryos in IVF-cycles) and 27 fertile women (at least one child) in total, at the secretory phase of the menstrual cycle...
November 19, 2023: Journal of Reproductive Immunology
Tina Coucheron, Malgorzata Uhrynowska, Katarzyna Guz, Agnieszka Orzińska, Marzena Debska, Agnieszka Gierszon, Maria Therese Ahlen, Eirin Listau Bertelsen, Gerd Berge, Anne Husebekk, Ewa Brojer, Heidi Tiller
Fetomaternal incompatibility in human platelet antigens (HPAs) can cause maternal alloimmunization, which in turn may lead to thrombocytopenia with or without intracranial hemorrhage (ICH) in the fetus or newborn. Retrospective studies suggest that boys from alloimmunized mothers may have higher risk of ICH and lower birth weight than girls. The objective of this study was to assess how maternal HPA-1a alloimmunization, sex of the neonate and birth weight relates in a large prospective cohort. Through a national screening study in Poland (PREVFNAIT) involving HPA-1 typing of 24,259 pregnant women during 2013-2017, 606 HPA-1a negative pregnant women and their offspring were identified and included...
November 7, 2023: Journal of Reproductive Immunology
Min Chu, Shunzhi He, Huishan Zhao, Shuyuan Yin, Zhenteng Liu, Wei Zhang, Xuemei Liu, Hongchu Bao
Chronic endometritis has a high incidence in infertile women, which is caused by endometrial microbiome infection. In response to microbial infection, the role of defensins during chronic endometritis need explored. Besides, the expression of estrogen and its receptors vary in different menstrual cycles, but their roles in chronic endometritis are still unclear. In this study, we used the human endometrial tissues to examine the expression of antimicrobial peptides (AMPs) α-defensin hNP-1 and β-defensins hBD-1, hBD-2, hBD-3, hBD-4 and LCN2...
November 7, 2023: Journal of Reproductive Immunology
Jinzhi Li, Xiuhua Peng, Hequan Zhong, Songping Liu, Jimin Shi, Xiaohui Zhou, Bing Li
Sleep deprivation is a common problem during pregnancy, but its impact on the fetus remains unclear. We aimed to investigate the effect of sleep deprivation during pregnancy on fetal outcomes and its mechanism in Sprague-Dawley rats. Sleep deprivation was performed from gestational day(GD) 1-19 using a multiplatform method for 18 h/day. Rats were sacrificed on GD20, and their blood and placentas were collected. Fetal and placental parameters were ascertained. Melatonin, adrenocorticotropic hormone (ACTH) and corticosterone were also measured in serum...
November 2, 2023: Journal of Reproductive Immunology
Jaya Bharati, Satish Kumar, N H Mohan, Bikash Chandra Das, Salam Jayachitra Devi, Vivek Kumar Gupta
Ovarian follicular development is a critical determinant of reproductive performance in litter bearing species like pigs, wherein economic gains depend on litter size. The study aimed to gain insight into the differentially expressed genes (DEGs) and signalling pathways regulating follicular growth and maturation in Ghoongroo pigs. Transcriptome profiling of porcine small follicles (SF) and large follicles (LF) was conducted using NovaSeq600 sequencing platform and DEGs were identified using DESeq2 with threshold of Padj...
October 24, 2023: Journal of Reproductive Immunology
Hiba Iraqi Møller, Gry Persson, Freja Bluhme Klok, Fie Juhl Vojdeman, Morten Lebech, Thomas Vauvert F Hviid
OBJECTIVES: Preeclampsia is a frequent and potentially fatal pregnancy complication. It can be challenging to make a timely diagnosis. Identifying clinically useful biochemical markers would be a remedying tool to support the diagnosis of preeclampsia. The aim was to investigate differential cell counts and acute phase reactants as diagnostic markers of preeclamptic third-trimester pregnancies and in relation to pregnancy term, gravidity and the severity of hypertension. METHODS: Based on a cohort of 421 pregnant women, we included 174 participants (case n = 84, control n = 90) during the third trimester...
October 9, 2023: Journal of Reproductive Immunology
J Garratt, M Rahmati
A cyclical evolvement of the endometrium into a transient state of receptivity is crucial for acceptance of the semi-allogeneic foetus, conducive to pregnancy. Despite documentation of aberrances in this process within patients experiencing repeated embryo implantation failures and miscarriages, the endometrium is often overlooked in IVF clinics as the cause for failure. Focus instead is usually given to embryo-derived factors, such as aneuploidy. Nevertheless, failure of approximately 30 % of euploid embryos to implant demonstrates that other factors such as the endometrium require clinical exploration...
October 7, 2023: Journal of Reproductive Immunology
Marco Scioscia, Monika Siwetz, Pierre-Yves Robillard, Agostino Brizzi, Berthold Huppertz
The etiology of the pregnancy syndrome preeclampsia is still unclear, while most hypotheses center on the placenta as the major contributor of the syndrome. Especially changes of the placental metabolism, including the use of glucose to produce energy, are important features. As an example, inositol phosphoglycan P-type molecules, second messengers involved in the glucose metabolism of all cells, can be retrieved from maternal urine of preeclamptic women, even before the onset of clinical symptoms. Alterations in the placental metabolism may subsequently lead to negative effects on the plasma membrane of the placental syncytiotrophoblast...
October 5, 2023: Journal of Reproductive Immunology
Mengting Zhang, Nana Huang, Yue Gao, Zhanqi Feng, Bing Kang, Han Guo, Jincheng Jiang, Shixiu Liao, Hongdan Wang
N6 -methyladenosine methylated modification has been shown to play roles in recurrent spontaneous abortion. We aimed to explore role of heterogeneous nuclear ribonucleoprotein C in the occurrence of recurrent spontaneous abortion. We collected embryonic villous tissues from 3 patients with recurrent spontaneous abortion (RSA group) and 3 normal control pregnancy patients. Methylated RNA immunoprecipitation sequencing, RNA sequencing, methylated RNA immunoprecipitation quantitative PCR were conducted to detect the differentially expressed m6 A methylation modification gene and regulatory gene in patients with recurrent spontaneous abortion...
October 4, 2023: Journal of Reproductive Immunology
Mohamed J Saadh, Renzon Daniel Cosme Pecho, Azfar Jamal, Abdulaziz S Alothaim, Mohammad Azhar Kamal, Mohiuddin Khan Warsi, Fuzail Ahmad, Mohammed Obaid, Hani Moslem, H A Zainab, Ali H Amin, José Luis Arias-Gonzáles, Ria Margiana, Reza Akhavan-Sigari
Oligospermia and asthenozoospermia, both frequent, can lead to male infertility. Oligospermia might be viewed as a milder form of azoospermia because the same mutations that produce azoospermia in some individuals also create oligospermia in other individuals. In this, we looked at different characteristics of oligospermia men, counting the level of apoptosis and a few related apoptotic and oxidative stress components, and compared them to solid controls. In this study, semen samples from healthy fertile men (n = 35) and oligospermia (n = 35) were collected, and sperm death rates in both groups were examined using flow cytometry...
October 3, 2023: Journal of Reproductive Immunology
Marcelo Borges Cavalcante, Ana Clara Muniz Tavares, Camila Alves Rocha, Giselle Ferreira de Souza, Eduarda Maia Lima, Júlia Machado Luz Simões, Larissa Cruz de Souza, Maria Yzadora Moura Martins, Nicole Oliveira de Araújo, Ricardo Barini
Recurrent miscarriage (RM) affects up to 2.5% of couples of reproductive age. Up to 10% of couples using assisted reproductive technology experience recurrent implantation failure (RIF). Immunosuppressive drugs, such as calcineurin inhibitors (CNIs), has been proposed for RM and RIF management. This systematic review and meta-analysis (SRMA) aimed to evaluate the efficacy and safety of CNIs in RM and RIF treatment. We searched in the three databases. Review Manager 5.4.1 was used for statistical analysis. This review included 8 studies involving 1042 women (485 women in the CNIs group and 557 women in the control group)...
September 30, 2023: Journal of Reproductive Immunology
Leqian Lin, Kunfeng Bai, Jianlin Li, Philip C N Chiu, Cheuk-Lun Lee
The human endometrial gland plays a vital role in maternal immune tolerance and placental development. Decidual macrophages are the major phagocytic cells that regulate tissue remodeling during pregnancy. This study examines the regulatory effect of endometrial gland secretome on macrophage polarization and functions using endometrial organoid. We demonstrated that endometrial organoids treated with hormones mimicking the environment of the secretory phase/early pregnancy polarize macrophages to acquire a decidua-like macrophage phenotype, including higher expressions of decidual macrophage markers, reduced phagocytic capacity and altered cytokine secretion...
September 30, 2023: Journal of Reproductive Immunology
Xiaohong Zhu, Sijia Chen, Peipei Zhang, Yana Ma, Xiu Liu, Haiyi Fei, Jingjing Qian, Yanqing Hao, Lingling Jiang, Xiaona Lin
Intrauterine adhesion (IUA) caused by endometrial injury is a common cause of female infertility and is challenging to treat. Macrophages play a critical role in tissue repair and cyclical endometrial regeneration. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has significant reparative and anti-fibrotic effects in various tissues. However, there is limited research on the role of GM-CSF in the repair of endometrial injury and the involvement of macrophages in GM-CSF-mediated endometrial repair...
September 23, 2023: Journal of Reproductive Immunology
Shinobu Goto, Yasuhiko Ozaki, Fumiko Ozawa, Hiroyuki Yoshihara, Dorina Ujvari, Tamao Kitaori, Mayumi Sugiura-Ogasawara
A recent meta-analysis revealed that patients with unexplained recurrent pregnancy loss (RPL) show higher insulin resistance compared to healthy controls. However, the etiology of RPL remains unknown. Prokineticin (PROK1), a pleiotropic uterine endometrial protein, is important for implantation and decidualization and is regulated by hypoxia and insulin. In this study, we investigated the decidualization status and the role of PROK1 in the decidua of patients with unexplained RPL showing insulin resistance...
September 22, 2023: Journal of Reproductive Immunology
Rui Wang, Xiu-Qin Li, Meng-Ru Wang, Xiu-Mei Wu, Yu-Sheng Xu, Ahunova Hilola, Xue-Chang Wang, Heng Liu
Pelvic inflammatory disease (PID) is commonly encountered in gynecological practice. Kangfuxiaomi suppository, made from the compound extract of Periplaneta Americana, is a Traditional Chinese Medicine remedy widely used for the treatment of gynecological disorders. This study aimed to preliminarily explore the therapeutic effect of Kangfuxiaomi suppository in a rat model of PID established by chemical injury and pathogen infection. The key parameters assessed were vulvar inflammation score, vaginal + uterine organ index, and serum levels of interleukin (IL)- 8; tumor necrosis factor (TNF)-α; C-reactive protein (CRP); superoxide dismutase (SOD); and malondialdehyde (MDA)...
September 20, 2023: Journal of Reproductive Immunology
Manami Yanagisawa, Takeshi Nagamatsu, Makoto Kurano, Fumi Misumi, Ayumi Taguchi, Naoya Akiba, Mari Ichinose, Keiichi Kumasawa, Takayuki Iriyama, Tomoyuki Fujii, Yutaka Yatomi, Yutaka Osuga
The response of autotaxin (ATX)-lysophosphatidic acid (LPA) signaling system to placental oxidative stress (OS) and its significance to preeclampsia were investigated. For this purpose, oxidative stress index (OSI) and ATX levels were measured in the serum of pregnant women with preeclampsia. The expression levels of ATX and LPA receptors were assessed in trophoblast cells under high OS and glucose deprivation/re-oxygenation (OGD/R) conditions, with particular emphasis on the antioxidative nuclear factor erythroid 2-related factor 2 (NRF2) pathway...
September 17, 2023: Journal of Reproductive Immunology
Changsheng Huang, Lujain AlSubki, Ayano Yamaya, Nayoung Sung, Joanne Kwak-Kim
Anti-ovarian antibody (AOA) could be considered an independent marker for autoimmune ovarian disease and predicting future premature ovarian failure (POF). This study aims to investigate if AOA is associated with poor ovarian response (POR) and pro-inflammatory immune responses in women undergoing assisted reproductive technology (ART) cycles. Two hundred forty-eight women undergoing ART cycles were divided into four groups based on AOA test results and the presence of POR: POR(-)/AOA(-) group (N = 148), POR(+)/AOA(-) group (N = 34), POR (-)/AOA(+) group (N = 44), POR(+)/AOA(+) group (N = 22)...
September 15, 2023: Journal of Reproductive Immunology
K L Milan, R Jayasuriya, K Harithpriya, M Anuradha, K M Ramkumar
Increasing evidence suggests that vitamin D (Vit-D) could be pivotal in maintaining normal glucose homeostasis. Low levels of Vit-D in early pregnancy are associated with a higher risk of gestational diabetes mellitus (GDM). Though several reports have highlighted the prevalence of vit-D deficiency among pregnant women, its underlying cause has not yet been fully elucidated. In this connection, a few studies have found the development of resistance to Vit-D, including the levels of Vitamin D receptor (VDR) and transcription regulators that modify VDR action, as well as the bioavailability of Vit-D...
September 9, 2023: Journal of Reproductive Immunology
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