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Journal of Periodontology

Davide Pietropaoli, Rita Del Pinto, Claudio Ferri, Eleonora Ortu, Annalisa Monaco
BACKGROUND: Increasing evidence links periodontal microbiota to several systemic conditions, including high blood pressure (BP). Antibodies to oral pathogens can be considered an indirect assessment of periodontal bacterial burden. We aimed at assessing the relationship between systemic exposure to periodontal microbiota, expressed in terms of relative antibodies, and BP, using data from NHANES III. METHODS: We analyzed cross-sectional, nationally representative data from 7928 adults aged ≥40 years who underwent determination of BP and serum antibodies to 21 periodontal microorganisms...
May 15, 2019: Journal of Periodontology
Giovanni Zucchelli, Lorenzo Tavelli, Martina Stefanini, Shayan Barootchi, Claudio Mazzotti, Guido Gori, Hom-Lay Wang
BACKGROUND AND AIM: The incidence of a peri-implant soft tissue dehiscence/deficiency (PSTD) is not a rare finding. Despite multiple previous attempts aimed at correcting the PSTDs, a classification of these condition has not yet been proposed. This lack in the literature may also lead to discrepancies in the reported treatment outcomes and thus misinform the clinician or the readers. The aim of the present article was therefore to present a classification of peri-implant PSTD at a single implant site...
May 13, 2019: Journal of Periodontology
Thomas E Van Dyke
No abstract text is available yet for this article.
May 12, 2019: Journal of Periodontology
César A Ossola, Noelia B Balcarcel, Julia I Astrauskas, Clarisa Bozzini, Juan C Elverdin, Javier Fernández-Solari
BACKGROUND: Transient receptor potential vanilloid type-1 (TRPV1) is expressed in oral tissues cells and its activity can be regulated by inflammation products and anandamide. The aim of the present study was to evaluate the effects of blocking TRPV1 or specific cannabinoid receptors 1 (CB1r) and 2 (CB2r) on periodontal status of rats subjected to experimental periodontitis (EP). METHODS: Male rats were distributed in groups 1) control, 2) lipopolysaccharide induced EP (LPS) and 3) LPS plus capsazepine (Capz, TRPV1 antagonist) application (LPS+Capz)...
May 11, 2019: Journal of Periodontology
Liyuan Chen, Shenzheng Mo, Yongmei Hua
BACKGROUND: Autophagy has recently emerged as a protective mechanism in response to compressive force and an important process in maintenance of bone homeostasis. It appears to be involved in the degradation of osteoclasts, osteoblasts and osteocytes. The aim of this study was to investigate the role of compressive force-induced autophagy in periodontal ligament (PDL) cells in regulating osteoclastogenesis of orthodontic tooth movement (OTM). METHODS: An OTM model and compressive force on PDL cells were employed to investigate the expression of autophagy markers in vivo and in vitro, respectively...
May 11, 2019: Journal of Periodontology
Jose Bagan, Judith Murillo-Cortes, Manuel Leopoldo-Rodado, Jose M Sanchis-Bielsa, Leticia Bagan
BACKGROUND: Proliferative verrucous leukoplakia (PVL) and recently coined as Proliferative leukoplakia (PL) is associated with a strong tendency to recur after treatment and an elevated rate of malignant transformation. We compared the clinical characteristics of patients with gingival PL with and without progression to oral squamous cell carcinoma. METHODS: The patients were divided into two groups: group 1 included 33 patients with gingival PL that did not progress to cancer, and group 2 included 30 patients with PL, who developed malignant transformation during follow-up...
May 9, 2019: Journal of Periodontology
Bernardo de Carvalho Dutra, Alcione Maria Soares Dutra Oliveira, Peterson Antônio Dutra Oliveira, Luís Otávio de Miranda Cota, Juliana Oliveira Silveira, Fernando Oliveira Costa
BACKGROUND: Sodium alendronate (ALN) is an aminobisphosphonate and potent inhibitor of bone resorption. It has been suggested that ALN might be a promising carrier of biomolecules for periodontal bone repair. The aim of this randomized split-mouth clinical trial was to evaluate the effects of the topical application of 1% ALN gel in intrabony defects during the surgical treatment of patients with periodontitis. METHODS: Sixty-four intrabony defects from 32 patients with periodontitis were randomly treated with either 1% ALN gel or placebo gel during periodontal surgeries...
May 9, 2019: Journal of Periodontology
Yago Leira, Pablo Ameijeira, Clara Domínguez, Esteban López-Arias, Paulo Ávila, María Pérez-Mato, Tomás Sobrino, Francisco Campos, Francesco D'Aiuto, Rogelio Leira, Juan Blanco
BACKGROUND: Recently, a relationship was found between periodontitis and chronic migraine. Calcitonin gene-related peptide (CGRP) is a key element in migraine pathophysiology. However, no information exists of the potential association between periodontal inflammation and CGRP in chronic migraine. The aim of the study was, therefore, to investigate whether there is a link between periodontitis and peripheral levels of CGRP in a cohort of patients with chronic migraine. METHODS: We included 102 chronic migraineurs and 77 age and gender matched individuals free of headache/migraine...
May 9, 2019: Journal of Periodontology
Dayana D Mendonça, Mariana V Furtado, Roberta A Sarmento, Bruna B Nicoletto, Gabriela C Souza, Tassiane P Wagner, Barbara R Christofoli, Carisi A Polanczyk, Alex N Haas
BACKGROUND: Despite the association between cardiovascular diseases and periodontitis, there are scarce data on the impact of oral health in the dietary intake of patients with coronary artery disease (CAD). The aim of this study was to assess the association between dietary intake with the periodontitis and present teeth in individuals with stable CAD. METHODS: This cross-sectional study included 115 patients with stable CAD (76 males, 61.0±8.3 years-old) who were under cardiovascular care in an outpatient clinic for at least 3 months...
May 3, 2019: Journal of Periodontology
Alice Blufstein, Christian Behm, Johannes Gahn, Oksana Uitz, Ivana Naumovska, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov
BACKGROUND: Although periodontitis is associated with disruption of the host-microbial homeostasis, viruses are currently discussed to influence disease progression. Viral pathogens are recognized by Toll-like receptor (TLR)-3, which engages a different signaling pathway than other TLRs. This study aimed to investigate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expression of inflammatory markers and bone metabolism proteins by human periodontal ligament stem cells (hPDLSCs) compared to TLR-2 agonist Pam3CSK4, which mimics the effect of bacterial lipoproteins...
May 2, 2019: Journal of Periodontology
Yukari Aoki-Nonaka, Koichi Tabeta, Mai Yokoji, Aoi Matsugishi, Yumi Matsuda, Naoki Takahashi, Benso Sulijaya, Hisanori Domon, Yutaka Terao, Masayuki Taniguchi, Kazuhisa Yamazaki
BACKGROUND: Periodontitis is an inflammatory disease that results in alveolar bone resorption due to inflammatory cytokine production induced by bacterial antigens such as lipopolysaccharides (LPS). Here, the preventive effect of the AmyI-1-18 peptide derived from rice in an experimental model of periodontitis and the effect on the anti-inflammatory response were assessed. METHODS: Alveolar bone resorption, gene transcription of pro-inflammatory cytokines in the gingiva, and the endotoxin level in the oral cavity were evaluated after oral administration of the AmyI-1-18 peptide for 14 days using a ligature-induced periodontitis model in mice...
April 29, 2019: Journal of Periodontology
Takanori Shinjo, Atsushi Ishikado, Hatice Hasturk, David M Pober, Samantha M Paniagua, Hetal Shah, I-Hsien Wu, Liane J Tinsley, Motonobu Matsumoto, Hillary A Keenan, Thomas E Van Dyke, Robert J Genco, George L King
BACKGROUND: Periodontitis is more common and severe in people with diabetes than the general population. We have reported in the Joslin Medalist Study that people with type 1 diabetes of ≥50 years (Medalists) may have endogenous protective factors against diabetic nephropathy and retinopathy. METHODS: In this cross-sectional study, the prevalence of periodontitis according to the CDC/AAP classification in a subset (n = 170, mean age = 64.6±6.9 years) of the Medalist cohort and its associations to various criteria of periodontitis and diabetic complications were assessed...
April 26, 2019: Journal of Periodontology
Yang Xu, Chunxiao Lv, Jiawei Zhang, Yuyu Li, Tiancheng Li, Cheng Zhang, Jianwei Chen, Ding Bai, Xing Yin, Shujuan Zou
BACKGROUND: Intermittent parathyroid hormone (PTH) promotes cementogenesis and provides a promising biotherapeutic to rehabilitate resorbed roots. However, the underlying mechanisms remain inconclusive. Cyclic AMP-dependent protein kinases A (PKA) and extracellular signal-regulated MAP kinases 1/2 (ERK1/2) are key regulators of bone remodeling. The present study aims to investigate whether PKA and ERK1/2 are involved in the process of intermittent PTH promoted cementogenesis. METHODS: Sprague Dawley rats in experimental group (n = 30) received a daily subcutaneous injection of PTH and the control (n = 30) received placebo vehicle for 1, 2, 3, 4 and 5 weeks...
April 26, 2019: Journal of Periodontology
Gözde Veyisoğlu, Levent Savran, Figen Narin, Huriye Erbak Yılmaz, Candeğer Avşar, Mehmet Sağlam
BACKGROUND: The aim of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PAD2) and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) in patients with periodontal disease and patients with healthy periodontium and investigate the effects of periodontal treatment on the levels of these molecules. METHODS: GCF samples were collected from periodontally healthy controls (C group, n = 20), gingivitis patients (G group, n = 20) and chronic periodontitis patients (CP group, n = 20)...
April 26, 2019: Journal of Periodontology
K J Nisha, Janam Presanthila, K Harshakumar
BACKGROUND: Though the utilization of salivary miRNAs as potential biomarkers has been reported in few diseases/conditions such as rheumatoid arthritis and oral cancer, there are no reported studies on their utility in periodontal diagnostics. Thus, the aim of the present study was to profile salivary miRNAs and identify the most suitable salivary miRNA biomarker in chronic periodontitis. METHODS: In this study, we have explored the potential application of next generation sequencing (NGS) technology for profiling of miRNAs in two unstimulated saliva samples collected by passive drool method from a patient diagnosed with generalized chronic periodontitis and a healthy control...
April 25, 2019: Journal of Periodontology
Ayşe Tayman, Şivge Kurgan, Canan Önder, Zeliha Güney, Muhittin A Serdar, Alpdoğan Kantarcı, Meral Günhan
BACKGROUND: ADAMTS (A disintegrin-like and metalloproteinase with thrombospondin) are a family of proteinases that are structurally similar to the family of matrix metalloproteinases with critical roles in damage and repair of the extracellular matrix. Their functions are closely related to inflammation, hypoxia, and vascularization. Our aim was to determine levels of ADAMTS-1 in gingival crevicular fluid (GCF) in patients with advanced periodontal diseases and identify their association with hypoxia-inducible factor-1alpha (HIF-1α), vascular endothelial growth factor (VEGF-A), and clinical parameters of periodontitis...
April 25, 2019: Journal of Periodontology
David H Moisa, Julie A Connolly, Bin Cheng, Evanthia Lalla
BACKGROUND: The aim of this study was to compare thick vs. thin connective tissue grafts (CTG) for the treatment of gingival recession, over a 3-month period. METHODS: Forty-two CTG procedures were performed on single tooth Miller Class I or II recession defects at either premolar or anterior sites in 30 individuals. Procedures were randomized (1:1 ratio) to CTG thickness of 1 mm or 2 mm (parallel group design). Primary outcomes were the change in the width of the zone of keratinized tissue and the amount of root coverage achieved 3 months postoperatively at the recipient site...
April 24, 2019: Journal of Periodontology
Koula Asimakopoulou, Matthew Nolan, Claire McCarthy, Jonathan T Newton
BACKGROUND: This study determines the effects of a routine assessment (Treatment as Usual, TAU) versus a risk communication intervention (Risk) versus a Goal-Setting, Planning and Self-Monitoring (GPS) intervention on periodontal disease patients' clinical and psychological outcomes. METHODS: In a three-arm randomized controlled trial (RCT; registration: ISRCTN59696243) adults (N = 97) judged to have moderate oral hygiene attended a primary dental care setting for a standard consultation...
April 17, 2019: Journal of Periodontology
Josefine Hirschfeld, Elisabeth Reichardt, Praveen Sharma, Anna Hilber, Philipp Meyer-Marcotty, Angelika Stellzig-Eisenhauer, Ulrich Schlagenhauf, Franka E Sickel
BACKGROUND: Orthodontic treatment can successfully align pathologically migrated teeth and lead to improvement of periodontal stability in patients with periodontitis. Periodontic-orthodontic approaches have gained increasing attention in the past years. Here, we investigated the interest of adults affected by chronic periodontitis in undergoing orthodontic treatment as well as patient-related and tooth-related influence factors. METHODS: Periodontal and orthodontic measurements/indices were taken from 115 adult patients with moderate to severe periodontitis...
April 4, 2019: Journal of Periodontology
Xinyi Zhou, Peng Zhang, Qian Wang, Ning Ji, Sisi Xia, Yi Ding, Qi Wang
BACKGROUND: Metformin, a classical treatment for diabetes mellitus, has shown sound anti-inflammatory effects. Emerging studies have focused on the mechanism underlying inflammation-related diabetic complications, such as diabetic periodontitis. Herein, we investigated the anti-inflammatory effects of metformin on the NIMA-related kinase 7(Nek7)/NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway both in vivo and in vitro in experimental diabetic periodontitis. METHODS: All procedures were conducted in Porphyromonas gingivalis (P...
April 4, 2019: Journal of Periodontology
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