journal
https://read.qxmd.com/read/22519624/subclinical-endothelial-dysfunction-and-low-grade-inflammation-play-roles-in-the-development-of-erectile-dysfunction-in-young-men-with-low-risk-of-coronary-heart-disease
#21
JOURNAL ARTICLE
F Yao, Y Huang, Y Zhang, Y Dong, H Ma, C Deng, H Lin, D Liu, K Lu
The purpose of this study is to investigate the possible underlying pathogenesis of erectile dysfunction(ED) in young men with low risk of coronary heart disease and no well-known aetiology. To conduct this study, 122 patients with ED under the age of 40 were enrolled, along with 33 age-matched normal control subjects. The patients with ED had significantly higher levels of systolic blood pressure (SBP), total cholesterol and triglyceride, high sensitivity C-reactive protein (hs-CRP), greater carotid intima-media thickness (CIMT) and Framingham risk score (FRS) than the control group, though all of these values were within the respective normal range...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22519580/asymmetric-dimethylarginine-adma-symmetric-dimethylarginine-sdma-and-l-arginine-in-patients-with-arteriogenic-and-non-arteriogenic-erectile-dysfunction
#22
JOURNAL ARTICLE
R Paroni, A Barassi, F Ciociola, E Dozio, E Finati, I Fermo, F Ghilardi, G M Colpi, M M Corsi, G V Melzi d'Eril
The plasma concentration of asymmetrical dimethylarginine (ADMA), an inhibitor of nitric oxide synthase, has been linked to endothelial dysfunction. We investigated the relation between ADMA, symmetric dimethylarginine (SDMA) and L-arginine concentrations and erectile dysfunction. We compared plasma levels of ADMA, SDMA and L-arginine in 61 men in good health with erectile dysfunction of arteriogenic and non-arteriogenic origin. Diagnosis of erectile dysfunction was based on the International Index of Erectile Function Score and its aetiology was classified with penile echo-colour-Doppler in basal condition and after intracavernous injection of prostaglandin E1...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22519558/vasectomy-reversal-using-a-microsurgical-three-layer-technique-one-surgeon-s-experience-over-18-years-with-1300-patients
#23
JOURNAL ARTICLE
J U Schwarzer
The technique and the results of microsurgical vasectomy reversal in a single-centre study over 18 years are presented. Both vasovasostomy (VV) and epididymovasostomy (EV) were carried out in a three-layer technique. With strict adherence to the strategy, end-to-end VV was only performed if spermatozoa had been demonstrated at the epididymal stump of the vas. In all other cases, EV was carried out in a preocclusive region of the epididymal tubule. The outpatient procedure of refertilization was associated with a very low complication rate, which underlines its minimal-invasive character...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22519471/glial-cell-line-derived-neurotrophic-factor-promotes-invasive-behaviour-in-testicular-seminoma-cells
#24
JOURNAL ARTICLE
F Ferranti, B Muciaccia, G Ricci, L Dovere, R Canipari, F Magliocca, M Stefanini, A Catizone, E Vicini
The glial cell line-derived neurotrophic factor (GDNF) has multiple functions that promote cell survival, proliferation and migration in different cell types. The experimental over-expression of GDNF in mouse testis leads to infertility and promotes seminomatous germ cell tumours in older animals, which suggests that deregulation of the GDNF pathway may be implicated in germ cell carcinogenesis. GDNF activates downstream pathways upon binding to its specific co-receptor GDNF family receptor-a 1 (GFRA1). This complex then interacts with Ret and other co-receptors to activate several intracellular signalling cascades...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22490376/are-apolipoprotein-e-alleles-correlated-with-semen-quality
#25
JOURNAL ARTICLE
D Paoli, S Zedda, D Grassetti, M Gallo, R M Corbo, F Lombardo, A Lenzi, L Gandini
Apolipoproteins have a unique role in lipoprotein metabolism regulation, aiding lipid transport and acting as a cofactor of the enzymes involved in metabolism. There are three co-dominant alleles, APOE*2, APOE*3 and APOE*4, which encode three protein isoforms, apoE2, apoE3 and apoE4. APOE*3 is the most frequent in all populations thus far investigated, ranging from 50 to 90%. Some studies have tried to resolve a genetic 'dilemma' by evaluating the cause of the frequency and survival of the three alleles. Genetic drift, migration or natural selection could explain the current distribution of APOE gene frequencies worldwide...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22489599/reduced-artery-diameters-in-klinefelter-syndrome
#26
JOURNAL ARTICLE
C Foresta, N Caretta, P Palego, A Ferlin, D Zuccarello, A Lenzi, R Selice
Various epidemiological studies in relatively large cohorts of patients with Klinefelter syndrome (KS) described the increased morbidity and mortality in these subjects. Our aim was to study the structure and function of arteries in different districts to investigate in these subjects possible alterations. A total of 92 patients having non-mosaic KS, diagnosed in Centre for Human Reproduction Pathology at the University of Padova, and 50 age-matched healthy male controls were studied. Klinefelter syndrome subjects and controls evaluation included complete medical history, physical examination, measurement of concentrations of the reproductive hormones, lipidic and glycidic metabolism, AR function and sensitivity, ultrasound examinations (diameters, carotid intima-media thickness and brachial flow-mediated dilation) of brachial, common carotid and common femoral artery and abdominal aorta...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22435752/long-term-use-of-hu210-adversely-affects-spermatogenesis-in-rats-by-modulating-the-endocannabinoid-system
#27
JOURNAL ARTICLE
S E M Lewis, R Paro, L Borriello, L Simon, L Robinson, Z Dincer, G Riedel, N Battista, M Maccarrone
Recent societal acceptance of cannabinoids as recreational and therapeutic drugs has posed a potential hazard to male reproductive health. Mammals have a highly sophisticated endogenous cannabinoid (ECS) system that regulates male (and female) reproduction and exo-cannabinoids may influence it adversely. Therefore it is imperative to determine their effects on male reproduction so that men can make informed choices as to their use. Here, an animal model was used to administer HU210, a synthetic analogue of Δ9-tetrahydrocannabinol (THC) and potent cannabinoid receptor (CB) agonist to determine its effects on reproductive organ weights, spermatogenesis, testicular histology and sperm motility...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22420564/effects-of-inducible-nitric-oxide-synthase-inos-deficiency-in-mice-on-sertoli-cell-proliferation-and-perinatal-testis-development
#28
JOURNAL ARTICLE
S A Auharek, N L M Lara, G F Avelar, R M Sharpe, L R França
Nitric oxide (NO) plays crucial roles in several physiological and pathological conditions. The iNOS isoform produces high levels of NO independent of intracellular calcium and, in the testis, which is expressed in Sertoli (SC), Leydig (LC) and germ cells. The testicular roles of NO are unclear, but it can inhibit LC testosterone production. Our aim was to evaluate the effects of iNOS deficiency on testis development in mice from late fetal life through early puberty. Therefore, testes from wild type (C57BCL/6) and iNOS(-/-) mice (B6...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22420522/differences-in-the-clinical-characteristics-between-young-and-elderly-men-with-varicocoele
#29
JOURNAL ARTICLE
S-S Chen
Information concerning the clinical characteristics in elderly men with varicocoele is relatively limited. This study was assessed to evaluate the differences in clinical characteristics between young and elderly patients with varicocoele by retrospective chart review. Between June 2003 and February 2011, 169 young (18-30 years) men and 156 elderly (45-55 years) men with varicocoele, and 30 age-matched men without varicocoele were recruited for this study. All the patients were divided into six groups. Thirty-one infertile patients were assigned to Group 1, 138 fertile patients to Group 2, 35 infertile patients to Group 3 and 121 fertile patients to Group 4...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22394170/no-effects-of-n-3-fatty-acid-supplementation-on-serum-total-testosterone-levels-in-older-men-the-alpha-omega-trial
#30
RANDOMIZED CONTROLLED TRIAL
E J Giltay, J M Geleijnse, A C Heijboer, J de Goede, L M Oude Griep, M A Blankenstein, D Kromhout
The intake of the n-3 fatty acids alpha-linolenic acid (ALA), acid (EPA) and docosahexaenoic acid (DHA) has been related to testosterone levels in epidemiological analyses. The aim of this study was to assess whether the n-3 fatty acids affects testosterone levels in post-myocardial infarction (MI) patients, who are at risk of testosterone deficiency. In a double-blind, placebo-controlled trial of low-dose supplementation of n-3 fatty acids, we included 1850 male post-MI patients aged 60-80 years who participated in the Alpha Omega Trial...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22394130/serum-from-patients-with-erectile-dysfunction-inhibits-circulating-angiogenic-cells-from-healthy-men-relationship-with-cardiovascular-risk-endothelial-damage-and-circulating-angiogenic-modulators
#31
JOURNAL ARTICLE
F Pelliccione, A D'Angeli, S Filipponi, S Falone, S Necozione, A Barbonetti, F Francavilla, S Francavilla
Erectile dysfunction (ED) is an early manifestation of arteriosclerosis associated with endothelial damage/dysfunction and to a blunted ability of cultured mononuclear circulating cells (MNCs) to differentiate circulating angiogenic cells (CACs), putatively involved in endothelial damage repair. Here we explored effects of human serum (HS) from patients with ED and cardiovascular risk factors (VRFs) but no clinical atherosclerosis, on cultured MNCs of healthy men to differentiate CACs and to form colonies. Effect of HS on number of CACS and of colony forming units (CFUs) was correlated with circulating markers of endothelial damage and with angiogenic modulators...
October 2012: International Journal of Andrology
https://read.qxmd.com/read/22970435/retraction-effects-of-exposure-to-a-mobile-phone-on-testicular-function-and-structure-in-adult-rabbit
#32
(no author information available yet)
No abstract text is available yet for this article.
August 2012: International Journal of Andrology
https://read.qxmd.com/read/22804455/new-era-in-sperm-selection-for-icsi
#33
REVIEW
M H Nasr-Esfahani, M R Deemeh, M Tavalaee
Spermatozoa contribute to approximately half of the genome of future progeny, and therefore, have a profound impact on embryo development post-fertilization. Sperm selection based on viability and normal morphology does not eliminate the chance for DNA damaged spermatozoa to be inseminated and may account for a considerable percentage of failed embryo development post-ICSI (Intra cytoplasmic sperm injection). Therefore, sperm selection based on functional sperm characteristics to preclude insemination of DNA damaged spermatozoa have paved the way for successful ICSI outcomes...
August 2012: International Journal of Andrology
https://read.qxmd.com/read/22458710/investigation-of-the-expression-and-functional-significance-of-the-novel-mouse-sperm-protein-a-disintegrin-and-metalloprotease-with-thrombospondin-type-1-motifs-number-10-adamts10
#34
JOURNAL ARTICLE
M D Dun, A L Anderson, E G Bromfield, K L Asquith, B Emmett, E A McLaughlin, R J Aitken, B Nixon
Fertilization represents the culmination of a series of complex interactions between male and female gametes. Despite advances in our understanding, the precise molecular mechanisms underlying these fundamental interactions remain largely uncharacterized. There is however growing recognition that this process requires the concerted action of multiple sperm receptors that possess affinity for complementary zona pellucida ligands and those that reside on the surface of the oolemma. Among the candidate sperm proteins that have been implicated in fertilization, those belonging to the ADAM (a disintegrin and metalloprotease) family of proteases have received considerable attention...
August 2012: International Journal of Andrology
https://read.qxmd.com/read/22428616/neurotrophic-effect-of-bone-marrow-mesenchymal-stem-cells-for-erectile-dysfunction-in-diabetic-rats
#35
JOURNAL ARTICLE
C Sun, H Lin, W Yu, X Li, Y Chen, X Qiu, R Wang, Y Dai
It has been demonstrated that intracavernous injection of bone marrow-derived mesenchymal stem cells (BM-MSCs) had beneficial effects on improving erectile function in type-1 diabetic rats. This study was designed to investigate the neurotrophic effect of BM-MSCs for type-1 diabetic rats. Streptozocin-induced type-1 diabetic rats were randomly divided into three groups: diabetic group, BM-MSCs-treated group and BM-MSCs-conditioned medium-treated group. At the 3d, 1 and 2w time points after BM-MSCs injection, three randomly selected rats in MSCs group were sacrificed and penile samples were harvested to detect BM-MSCs in penile tissue...
August 2012: International Journal of Andrology
https://read.qxmd.com/read/22420485/relationship-between-conventional-sperm-parameters-and-motile-sperm-organelle-morphology-examination-msome
#36
JOURNAL ARTICLE
A Perdrix, R Saïdi, J F Ménard, E Gruel, J P Milazzo, B Macé, N Rives
With the motile sperm organelle morphology examination (MSOME), spermatozoa morphology may be assessed directly on motile spermatozoa at high magnification (up to 6600×). This procedure describes more precisely spermatozoa abnormalities, especially head vacuoles. However, no consensus has been established concerning normal or abnormal MSOME criteria. The aim of our study was to define MSOME vacuole criteria assessed objectively with a digital imaging system software to establish a potential relationship between conventional semen parameters...
August 2012: International Journal of Andrology
https://read.qxmd.com/read/22413766/high-levels-of-the-extracellular-matrix-proteoglycan-decorin-are-associated-with-inhibition-of-testicular-function
#37
JOURNAL ARTICLE
M Adam, H F Urbanski, V T Garyfallou, U Welsch, F M Köhn, J Ullrich Schwarzer, L Strauss, M Poutanen, A Mayerhofer
Decorin (DCN), a component of the extracellular matrix of the peritubular wall and the interstitial areas of the human testis, can interact with growth factor (GF) signalling, thereby blocking downstream actions of GFs. In the present study the expression and regulation of DCN using both human testes and two experimental animal models, namely the rhesus monkey and mouse, were examined. DCN protein was present in peritubular and interstitial areas of adult human and monkey testes, while it was almost undetectable in adult wild type mice...
August 2012: International Journal of Andrology
https://read.qxmd.com/read/22404291/expression-of-the-vitamin-d-metabolizing-enzyme-cyp24a1-at-the-annulus-of-human-spermatozoa-may-serve-as-a-novel-marker-of-semen-quality
#38
JOURNAL ARTICLE
M Blomberg Jensen, A Jørgensen, J E Nielsen, P J Bjerrum, M Skalkam, J H Petersen, D L Egeberg, S Bangsbøll, A N Andersen, N E Skakkebaek, A Juul, E Rajpert-De Meyts, S Dissing, H Leffers, N Jørgensen
Vitamin D (VD) is important for male reproduction in mammals and the VD receptor (VDR) and VD-metabolizing enzymes are expressed in human spermatozoa. The VD-inactivating enzyme CYP24A1 titrates the cellular responsiveness to VD, is transcriptionally regulated by VD, and has a distinct expression at the sperm annulus. Here, we investigated if CYP24A1 expression serves as a marker for VD metabolism in spermatozoa, and whether CYP24A1 expression was associated with semen quality. We included 130 men (53 healthy young volunteers and 77 subfertile men) for semen analysis and immunocytochemical (ICC) detection of CYP24A1...
August 2012: International Journal of Andrology
https://read.qxmd.com/read/22372587/the-protective-effects-of-quercetin-on-the-cytotoxicity-of-atrazine-on-rat-sertoli-germ-cell-co-culture
#39
JOURNAL ARTICLE
S O Abarikwu, A B Pant, E O Farombi
To evaluate the direct effect of atrazine (ATZ) and the protective effect of quercetin (QT) on testicular cells, we used primary cultures of rat Sertoli-germ cells (SGCs). ATZ (232 μm) up-regulated the mRNA expression of GATA-4, androgen receptor (AR), androgen-binding protein (ABP), steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme (CYP11A1), cyclooxygenase-2 (COX-2) and NF-κappaB (NF-κB) and down-regulated the expression of stem cell factor (SCF) mRNA. There was no change on the mRNA expression of oestrogen receptor-alpha (ER-α)...
August 2012: International Journal of Andrology
https://read.qxmd.com/read/22321000/do-men-with-prostate-abnormalities-prostatitis-benign-prostatic-hyperplasia-prostate-cancer-develop-immunity-to-spermatozoa-or-seminal-plasma
#40
JOURNAL ARTICLE
P Hoover, R K Naz
Prostate is an immunocompetent and not an immunoprivileged organ. It has an active immunologic armamentarium. There are three major prostate abnormalities namely, prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer. In all these abnormalities, infection/inflammation has been implicated. As infection/inflammation of the male genital tract can also be involved in induction of antisperm antibodies (ASA), this study was conducted to examine if these prostate abnormalities lead to the formation of ASA...
August 2012: International Journal of Andrology
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