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Biological Trace Element Research

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https://read.qxmd.com/read/30783921/effect-of-the-zn-supplementation-on-immuno-modulatory-activities-of-bovine-lactoferrin-in-the-murine-splenocytes-and-raw264-7-macrophages
#1
Hui-Juan Zhao, Xin-Huai Zhao
Lactoferrin (LF) has important bio-functions including immuno-modulation, while essential trace metals may interact with LF and thereby induce property especially bio-activity changes. Bovine LF was thus supplemented with Zn2+ at 0.16, 0.32, and 0.64 mg/g LF to yield 10%, 20%, and 40% Zn-saturation, respectively. Afterwards, bovine LF and the Zn-supplemented LF products at 10-40-μg/mL doses were compared for their immuno-modulatory activities in two immune cells (murine splenocytes and RAW264.7 macrophages), using the stimulation index of the splenocytes, T lymphocyte subpopulations, macrophage phagocytosis, and cytokine production as evaluation reflectors...
February 19, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30783920/the-toxicological-analysis-of-ni-and-cr-in-prescription-food-for-special-medical-purposes-and-modified-milk-products-for-babies-in-infancy-available-in-pharmacies-in-poland
#2
Kamil Jurowski, Mirosław Krośniak, Maria Fołta, Barbara Tatar, Michael Cole, Wojciech Piekoszewski
Prescription food for special medical purposes (FSMPs) and modified milk products (MMPs) for babies in the infancy period available in pharmacies are increasingly frequently used for newborns and infants-especially in cases where allergies and food-borne diseases are diagnosed. However, there is a lack of scientific study around the safety assessment of the elemental impurities in these products. Importantly, the allergen Ni and the problematic metal Cr are little considered. Hence, the aim of this article was the toxicological analysis of Ni and Cr impurities in prescription FSMPs (n = 6) and MMPs (n = 6) for newborns and infants available in Polish pharmacies...
February 19, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30783919/propolis-and-its-combination-with-boric-acid-protect-against-ischemia-reperfusion-induced-acute-kidney-injury-by-inhibiting-oxidative-stress-inflammation-dna-damage-and-apoptosis-in-rats
#3
Fatime Geyikoglu, Kubra Koc, Suat Colak, Huseyin Serkan Erol, Salim Cerig, Berna Kavakcioglu Yardimci, Ozge Cakmak, Muhammed Bahaeddin Dortbudak, Gizem Eser, Ferhunde Aysin, Nihal Simsek Ozek, Serkan Yildirim
Ischemia reperfusion (I/R) injury which causes kidney dysfunction is one of the most studied diseases directly linked to oxidative stress. In this regard, it is important to protect cells against damage by inducing antioxidant response. Herein, we aimed to evaluate the therapeutic roles and possible mechanisms of propolis and boric acid in kidney I/R injury based on relevant basic research and clinical studies. Sprague-Dawley rats were subjected to 50 min of ischemia followed by 3 h of reperfusion. Animals were randomly divided into a control group (the abdominal wall was just opened and closed), an I/R injury group, the propolis intervention group (200 mg/kg, intragastric administration, 1 h before ischemia), boric acid intervention group (14 mg/kg, intragastric administration 1 h before ischemia), and the propolis + boric acid intervention group (intragastric administration 1 h before ischemia)...
February 19, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30778755/comparative-response-of-cardiomyocyte-zips-and-znts-to-extracellular-zinc-and-tpen
#4
Sandhya Thokala, Vijaya Lakshmi Bodiga, Madhukar Rao Kudle, Sreedhar Bodiga
Intracellular zinc concentrations are tightly regulated by the coordinated regulation of ZIPs and ZnTs. Very little is known about the regulation of these transporters in cardiomyocytes, in response to extracellular zinc. Adult rat cardiomyocytes express ZnTs 1, 2, 5, and 9, in addition to ZIPs 1, 2, 3, 6, 7, 9, 10, 11, 13, and 14. We have determined the intracellular free zinc levels using Zinpyr-1 fluorescence and studied response of ZIP and ZnT mRNA by real-time PCR to the changes in extracellular zinc and TPEN in adult rat ventricular myocytes...
February 18, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30771140/the-alterations-of-copper-and-zinc-homeostasis-in-acute-appendicitis-and-the-clinical-significance
#5
Wenhao Lin, Wei Han, Ke Wen, Sunhua Huang, Yao Tang, Zhexuan Lin, Ming Han
Copper (Cu) and zinc (Zn) are involved in inflammatory process. This study was to investigate the clinical significance of Cu and Zn homeostasis alterations in acute appendicitis (AA). One hundred twenty-two AA patients and 102 healthy controls were enrolled in this study. Of which, 85 patients' appendixes were collected after appendectomy. Another six appendixes from colon cancer patients were collected as tissue controls. The contents of Cu and Zn in serum or appendix were detected, and the Cu to Zn ratio (CZr) was calculated...
February 15, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30767181/the-role-of-zinc-in-poultry-breeder-and-hen-nutrition-an-update
#6
REVIEW
Liang Huang, Xi Li, Wence Wang, Lin Yang, Yongwen Zhu
Zinc (Zn) is an essential trace mineral in breeder hen diets and functions in diverse physiological processes, including reproduction, immunity, antioxidant ability, and epigenetic processes. In this paper, five main aspects of Zn nutrition in poultry breeder birds and hens, including semen quality, molting, egg production and egg quality, hatchability and embryonic development, and offspring performance, are reviewed. Zn deficiency in poultry breeder birds led to lower semen quality (reducing around 10% sperm motility) and egg production (lowering 3-10 g/day/bird egg mass) as well as poor offspring development and growth performance (increasing 9-10% weak chick ratio and 10% mortality of progeny)...
February 14, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30761462/dose-dependent-absorption-profile-of-different-magnesium-compounds
#7
Mehmet Ates, Servet Kizildag, Oguz Yuksel, Ferda Hosgorler, Zeynep Yuce, Guven Guvendi, Sevim Kandis, Aslı Karakilic, Basar Koc, Nazan Uysal
Magnesium, one of the basic elements for the human body, is necessary for many physiological functions. Magnesium deficiency is widely observed as a result of the reduced nutrient content of foods, over-cooking, diseases, drugs, alcohol, and caffeine consumption. Taking a dietary supplement is necessary magnesium deficiency. It has been demonstrated that absorption of organic magnesium compounds is better than absorption of inorganic compounds. The aim of this study is to investigate transitions to tissues of different organic magnesium compounds in different doses and whether there is a difference in the organic acid-bounded compounds (magnesium citrate and magnesium malate) and the amino acid-bounded compounds (magnesium acetyl taurate and magnesium glycinate), associated with transition and bioavailability...
February 13, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30756291/se-regulates-the-contractile-ability-of-uterine-smooth-musclevia-selenoprotein-n-selenoprotein-t-and-selenoprotein-win-mice
#8
Fu-Han Wang, Xiao Peng, Yu Chen, Ying Wang, Mei Yang, Meng-Yao Guo
Selenium (Se) is an essential micronutrient that maintains normal physiological functions in humans and animals. Se plays a vital role in regulating smooth muscle contractions, and selenoprotein N (SelN), selenoprotein T (SelT), and selenoprotein W (SelW) are closely related to the release of Ca2+ . The present study analyzed the effects and mechanisms of SelN, SelT, and SelW in uterine smooth muscle contractions in a mouse model fed Se. The mRNA and protein levels in the uterine smooth muscle of mice were detected by qPCR, Western blot, and immunohistochemical analysis...
February 12, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30746586/the-effect-of-multispecies-probiotic-supplementation-on-iron-status-in-rats
#9
Katarzyna Skrypnik, Paweł Bogdański, Marcin Schmidt, Joanna Suliburska
A range of interactions between gut microbiota and iron (Fe) metabolism is described. Oral probiotics ameliorate host's iron status. However, this has been proven for single-strain probiotic supplements. Dose-dependence of beneficial probiotic supplementation effect on iron turnover remains unexplored. Our study aimed to investigate the effects of oral multispecies probiotic supplementation in two doses on iron status in rats. Thirty rats were randomized into three groups receiving multispecies probiotic supplement at a daily dose of 2...
February 12, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30737629/the-effects-of-low-selenium-on-dna-methylation-in-the-tissues-of-chickens
#10
Qiaojian Zhang, Shufang Zheng, Shengchen Wang, Zhihui Jiang, Shiwen Xu
DNA methylation is involved in epigenetic mechanisms associated with gene suppression, and its abnormalities lead to gene instability and disease development. As an essential trace element in humans and animals, selenium (Se) is also associated with abnormal changes in DNA methylation. However, the effect of low Se on DNA methylation in avian tissues has not been reported. In the current study, chickens were fed a low-Se diet (0.033 mg Se/kg) or supplemented with 0.15 mg Se/kg as selenite for up to 55 days...
February 8, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30734198/cadmium-in-groundwater-consumed-in-the-rural-areas-of-gonabad-and-bajestan-iran-occurrence-and-health-risk-assessment
#11
Mehdi Qasemi, Mahmoud Shams, Seyed Ali Sajjadi, Mansoureh Farhang, Saeed Erfanpoor, Mahmood Yousefi, Ahmad Zarei, Mojtaba Afsharnia
Evidences show that high levels of cadmium intake may be contributing to a wide range of deleterious health effects. This study was performed to estimate the concentration of cadmium and the health risk to human by cadmium through the ingestion of groundwater in 39 rural areas of Gonabad and Bajestan, eastern Iran. The mean cadmium concentrations in groundwater in the studied rural areas of Gonabad and Bajestan ranged from 0.087 to 14.32 μg/L and from 0.417 to 18.36 μg/L, respectively. Health risk quotient for cadmium contamination for 16 and 38% of children and infants in rural areas of Gonabad and Bajestan, respectively, was more than 1 which causes non-carcinogenic risk to the local population...
February 8, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30734197/genomic-characterization-of-the-zinc-transcriptional-regulatory-element-reveals-potential-functional-roles-of-znf658
#12
Michael Francis, Huimin Cheng, Ping Ma, Arthur Grider
The zinc transcriptional regulatory element (ZTRE) is a newly reported binding motif for human zinc finger protein ZNF658, which alters gene expression in response to cellular zinc. The ZTRE has two nucleotide components-the palindromic flanking pairs and the bridging "N" bases between these flanks that range in number from 0 to 100. There are 12 pairs of ZTRE flanks (designated A-L). Three thousand five hundred twenty-five genes contain one or more ZTREs - 1000 to + 200 bp from their transcriptional start site (TSS)...
February 7, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30729389/dietary-intake-of-cadmium-chromium-copper-nickel-and-lead-through-the-consumption-of-meat-liver-and-kidney-and-assessment-of-human-health-risk-in-birjand-southeast-of-iran
#13
Tayebeh Zeinali, Fatemeh Salmani, Kobra Naseri
This study aimed to evaluate the mean concentration of cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni), and lead (Pb) in the meat and offal of cow and sheep. Also, the estimated daily intake (EDI) and health risk of these metals were calculated. Analysis of metals was undertaken by the use of an inductively coupled plasma-optic emission spectroscopy (ICP-OES). All samples were contaminated with all metals. Principal component analysis (PCA) showed a clear differentiation of cow and sheep in both the kidney and liver samples...
February 6, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30725267/selenium-levels-in-community-dwellers-with-type-2-diabetes-mellitus
#14
Qianqian Zhang, Wenxia Li, Jian Wang, Biyue Hu, Hang Yun, Renmei Guo, Li Wang
Selenium (Se) is an essential micronutrient required by the human body and exerts biological functions through selenoproteins. The relationship between Se and diabetes remains ambiguous. This study aimed at, through measurements of serum selenoprotein P (SelP), glutathione peroxidase (GPx3), and Se content in serum and hair, evaluating Se levels in community dwellers with type 2 diabetes mellitus (T2DM). A total of 336 subjects, including 176 T2DM patients (65.5 ± 8.7 years old) and 160 healthy residents (63...
February 6, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30723882/high-protein-diet-ameliorates-arsenic-induced-oxidative-stress-and-antagonizes-uterine-apoptosis-in-rats
#15
Prerona Biswas, Aparna Mukhopadhyay, Syed Nazrul Kabir, Prabir Kumar Mukhopadhyay
Arsenic toxicity purportedly threats a broad spectrum of female reproductive functions. We investigated the remedial role of a casein- and pea protein-enriched high-protein diet (HPD) in combating the arsenic insult. Cyclic female rats maintained on standard diet (n = 6) or an isocaloric HPD (n = 6) were gavaged with As2 O3 at 3 mg/kg BW/rat/day (n = 12) for 28 days. Vehicle-fed rats (n = 6) maintained on the standard diet served as the control. We monitored the estrus cycles and performed the histomorphometric analyses of the uterus and ovary...
February 5, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30723881/parenteral-zinc-supplementation-increases-pregnancy-rates-in-beef-cows
#16
J M Anchordoquy, J P Anchordoquy, E M Galarza, N A Farnetano, M J Giuliodori, N Nikoloff, L E Fazzio, C C Furnus
Zinc (Zn) is required for normal reproductive performance in cattle. The aim of this study was to evaluate the effect of subcutaneous injection of 400 mg Zn at the beginning of fixed-time artificial insemination (FTAI) on preovulatory follicle and corpus luteum (CL) size, plasma estradiol (E2) and progesterone (P4) concentrations, and pregnancy rates in beef cows. Copper (Cu) concentration and alkaline phosphatase (ALP) activity in plasma were also evaluated. Zinc supplementation at the beginning of the FTAI protocol (day 0) increased the area of preovulatory follicle (APF, day 9; P = 0...
February 5, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30721397/is-the-cooking-salt-safe-in-china-assessment-of-chemical-contaminants-in-cooking-salt
#17
Zhengyuan Wang, Jingzhe Zhou, Xiaodong Jia
Global environmental pollution is becoming more serious, and most dietary salts come from nature. We postulated that chemical pollutants could affect the quality of salt. Forty-five different types of salt were collected from supermarkets, convenience stores, and online retailers in Shanghai, 2015. These comprised more than 90% of all cooking salts consumed in Shanghai, China. We measured and analyzed heavy metal elements, fluoride, potassium ferrocyanide, and 16 phthalate plasticizers. Lead was detected in only two types of salt at concentrations recorded of 0...
February 5, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30721396/cadmium-exposure-and-blood-telomere-length-in-female-university-students-in-japan
#18
Yuki Mizuno, Shoko Konishi, Hideki Imai, Eiji Fujimori, Nobuhiko Kojima, Jun Yoshinaga
Cadmium is a toxic metal found ubiquitously throughout the world. Our study evaluated whether cadmium exposure was associated with telomere length in 73 female university students. Determination of telomere length was performed by quantitative polymerase chain reaction using DNA in blood. Urinary cadmium concentration was measured by inductively coupled plasma mass spectrometry. The students' physiological attributes and lifestyle were surveyed by means of a self-administered questionnaire. The geometric mean of urinary cadmium concentration was 0...
February 5, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30715684/association-between-trace-element-status-and-depression-in-htlv-1-infected-patients-a-retrospective-cohort-study
#19
Susan Darroudi, Samaneh Abolbashari, Najmeh Ahangari, Maryam Tayefi, Zahra Khashyarmanesh, Parvin Zamani, Hamideh Moalemzadeh Haghighi, Amir Hooshang Mohammadpour, Shima Tavalaei, Habibollah Esmaily, Gordon A Ferns, Zahra Meshkat, Batool Tayefi, Majid Ghayour-Mobarhan
Depression and Anxiety are two important public health problems that are known to be associated with viral infections. The association between the intake of nutrients such as zinc and copper with symptoms of depression has been studied previously. The aim of the current study was to investigate the association between depression with human T cell lymphotropic virus type 1 (HTLV-1) infection and serum content of zinc and copper in a large Iranian population cohort. The study population consisted of 279 HTLV-1-positive patients who were identified after recruitment as part of a large cohort study: the Mashhad Stroke and Heart Association Disorder (MASHAD) study...
February 4, 2019: Biological Trace Element Research
https://read.qxmd.com/read/30715683/glutathione-might-attenuate-cadmium-induced-liver-oxidative-stress-and-hepatic-stellate-cell-activation
#20
Longfei Ren, Kuo Qi, Lei Zhang, Zhongtian Bai, Chenghui Ren, Xianyun Xu, Zeliang Zhang, Xun Li
The liver is a major organ involved in cadmium (Cd)-induced oxidative damage. Following liver injury, hepatic stellate cells (HSCs) are activated to participate in the wound healing process, but also facilitate liver fibrosis. Previous studies have observed fibrogenic effects of Cd on liver. However, the oxidative stress mechanisms of Cd-induced HSC activation as well as whether administration of glutathione (GSH) alleviates this activation, remain unclear. In this study, 24 rats were divided randomly into four experimental groups: control, GSH-treated, Cd-treated, and Cd + GSH-treated...
February 4, 2019: Biological Trace Element Research
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