journal
https://read.qxmd.com/read/38954892/face-brain-correlates-as-potential-sex-specific-biomarkers-for-schizophrenia-and-bipolar-disorder
#41
JOURNAL ARTICLE
Noemí Hostalet, Alejandro González, Pilar Salgado-Pineda, Rubèn Gonzàlez-Colom, Erick J Canales-Rodríguez, Candibel Aguirre, Amalia Guerrero-Pedraza, María Llanos-Torres, Raymond Salvador, Edith Pomarol-Clotet, Xavier Sevillano, Neus Martínez-Abadías, Mar Fatjó-Vilas
Given the shared ectodermal origin and integrated development of the face and the brain, facial biomarkers emerge as potential candidates to assess vulnerability for disorders in which neurodevelopment is compromised, such as schizophrenia (SZ) and bipolar disorder (BD). The sample comprised 188 individuals (67 SZ patients, 46 BD patients and 75 healthy controls (HC)). Using a landmark-based approach on 3D facial reconstructions, we quantified global and local facial shape differences between SZ/BD patients and HC using geometric morphometrics...
June 13, 2024: Psychiatry Research
https://read.qxmd.com/read/38941862/looking-beyond-psychosocial-adversity-and-sex-clinical-factors-associated-with-adhd-and-other-psychiatric-disorders-in-a-non-caucasian-sample-of-high-risk-siblings
#42
JOURNAL ARTICLE
Juan David Palacio-Ortiz, Lino Palacios-Cruz, Marta Martínez-Zamora, Johanna Valencia-Echeverry, Jesus Macias-Duran, Carlos Alberto López-Jaramillo
This study examined the association of clinical factors, independent of sex and high psychosocial adversity (HPAd), with the presence of ADHD or other mental disorders, specifically within a middle-income country with a non-Caucasian population. A multi-centric cross-sectional study was conducted in three sites in Colombia. Our study recruited trios of an ADHD proband, one sibling, and one parent. We used valid instruments for assessing parents and siblings. The sample included 223 siblings, an average age of 12...
June 13, 2024: Psychiatry Research
https://read.qxmd.com/read/38909414/neurodevelopmental-signature-of-a-transcriptome-based-polygenic-risk-score-for-depression
#43
JOURNAL ARTICLE
Amy E Miles, Sarah S Rashid, Fernanda C Dos Santos, Kevan P Clifford, Etienne Sibille, Yuliya S Nikolova
Disentangling the molecular underpinnings of major depressive disorder (MDD) is necessary for identifying new treatment and prevention targets. The functional impact of depression-related transcriptomic changes on the brain remains relatively unexplored. We recently developed a novel transcriptome-based polygenic risk score (tPRS) composed of genes transcriptionally altered in MDD. Here, we sought to investigate effects of tPRS on brain structure in a developmental cohort (Adolescent Brain Cognitive Development study; n = 5124; 2387 female) at baseline (9-10 years) and 2-year follow-up (11-12 years)...
June 13, 2024: Psychiatry Research
https://read.qxmd.com/read/38909413/impact-of-hcv-cure-on-subsequent-hospitalizations-in-people-with-mental-disorders-results-from-the-french-claims-database
#44
JOURNAL ARTICLE
Benjamin Rolland, Nabil Hallouche, Olivier Lada, Pascaline Rabiéga, Fayssoil Fouad, Elias Benabadji, Stanislas Pol
BACKGROUND AND AIMS: Although HCV cure after direct-acting antiviral (DAA) treatment is associated with hepatic and extrahepatic benefits, few studies have assessed the impact of HCV treatment in people with mental disorders (PWMDs). Using quasi-exhaustive national data from the French administrative health care databases (SNDS), we explored whether DAA treatment in PWMDs affected hospitalizations in both psychiatric and non-psychiatric settings. METHODS: All adult PWMDs identified in the SNDS with DAA treatment initiation between 2015 and 2018 and 12 months of data pre- and post-treatment were included...
June 13, 2024: Psychiatry Research
https://read.qxmd.com/read/38917674/risk-of-drug-related-death-associated-with-co-prescribing-of-gabapentinoids-and-z-drugs-among-people-receiving-opioid-agonist-treatment-a-national-retrospective-cohort-study
#45
JOURNAL ARTICLE
Megan Glancy, Norah Palmateer, Alan Yeung, Matthew Hickman, John Macleod, Jen Bishop, Lee Barnsdale, Kirsten Ma Trayner, Saket Priyadarshi, Jason Wallace, Sharon Hutchinson, Andrew McAuley
BACKGROUND: Prescribing of gabapentinoids and Z-drug-hypnotics has increased in the population and among people receiving opioid-agonist treatment (OAT) for opioid dependence. Evidence is mixed on whether co-prescribing of sedatives such as gabapentinoids and Z-drugs during OAT increases risk of drug-related death (DRD). METHODS: We conducted a retrospective cohort study of individuals prescribed OAT between 2011 and 2020 in Scotland. Prescribing records were linked to mortality data and other healthcare datasets (sociodemographic, comorbidity)...
June 12, 2024: Psychiatry Research
https://read.qxmd.com/read/38909412/large-language-models-in-psychiatry-opportunities-and-challenges
#46
JOURNAL ARTICLE
Sebastian Volkmer, Andreas Meyer-Lindenberg, Emanuel Schwarz
The ability of Large Language Models (LLMs) to analyze and respond to freely written text is causing increasing excitement in the field of psychiatry; the application of such models presents unique opportunities and challenges for psychiatric applications. This review article seeks to offer a comprehensive overview of LLMs in psychiatry, their model architecture, potential use cases, and clinical considerations. LLM frameworks such as ChatGPT/GPT-4 are trained on huge amounts of text data that are sometimes fine-tuned for specific tasks...
June 11, 2024: Psychiatry Research
https://read.qxmd.com/read/38875917/addressing-challenges-in-functional-and-clinical-recovery-outcomes-the-critical-role-of-personal-recovery
#47
LETTER
Alessandra Martinelli
No abstract text is available yet for this article.
June 11, 2024: Psychiatry Research
https://read.qxmd.com/read/38870774/effects-of-actissist-a-digital-health-intervention-for-early-psychosis-a-randomized-clinical-trial
#48
JOURNAL ARTICLE
Sandra Bucci, Natalie Berry, John Ainsworth, Katherine Berry, Dawn Edge, Emily Eisner, Richard Emsley, Gordon Forbes, Lamiece Hassan, Shôn Lewis, Matthew Machin, Gillian Haddock
Schizophrenia affects 24 million people worldwide. Digital health interventions drawing on psychological principles have been developed, but their effectiveness remains unclear. This parallel, assessor-blinded, randomized clinical trial aimed to investigate whether a cognitive behaviour therapy-informed digital health intervention (Actissist app) confers added benefit on psychotic symptoms over and above remote symptom monitoring (ClinTouch app). Participants recruited from UK community health services were randomized 1:1 to receive either Actissist plus treatment as usual (TAU) or ClinTouch plus TAU...
June 11, 2024: Psychiatry Research
https://read.qxmd.com/read/38875918/clinical-effectiveness-and-safety-of-adding-a-self-harm-prevention-app-blueice-to-specialist-mental-health-care-for-adolescents-who-repeatedly-self-harm-a-single-blind-randomised-controlled-trial-the-bash-study
#49
JOURNAL ARTICLE
Paul Stallard, Kathryn Whittle, Emma Moore, Antonieta Medina-Lara, Nia Morrish, Bethany Cliffe, Shelley Rhodes, Gordon Taylor
No randomised controlled trials have evaluated whether the addition of a smartphone app to usual child and adolescent mental health care (CAMHS) can reduce self-harm in adolescents (<18 years) with repeated self-harm. We enrolled 170 participants aged 12-17, receiving CAMHS treatment who had self-harmed ≥2 in the past 12 months. Participants were randomised via an independent web-based system (1:1, minimised for gender, age, self-harm frequency, and depression severity) to treatment as usual (TAU) or treatment as usual plus BlueIce (TAU+BI)...
June 10, 2024: Psychiatry Research
https://read.qxmd.com/read/38908264/feasibility-and-acceptability-of-an-online-group-dialectical-behavioural-therapy-skills-training-in-a-transdiagnostic-group-with-anxiety-and-depression
#50
JOURNAL ARTICLE
Joshin George Abraham, Nitha Thomas, Dr Sonia Shenoy, Dr Sebastian Padickaparambil
Transdiagnostic approaches offers a paradigm shift in managing psychiatric disorders. Emotion regulation difficulties are a transdiagnostic prevalent across various mood and personality disorders. Dialectical Behavioural Therapy Skills Training (DBT-ST), initially designed as part of treatment for borderline personality disorder, targets emotion regulation and has shown promise in diverse psychiatric conditions. In lower middle-income countries with resource-constrained settings, online delivery of evidence-based interventions holds potential to bridge treatment gaps...
June 9, 2024: Psychiatry Research
https://read.qxmd.com/read/38950483/alterations-to-sphingolipid-metabolism-from-antipsychotic-administration-in-healthy-volunteers-are-restored-following-the-use-of-cannabidiol
#51
JOURNAL ARTICLE
Beverly Jieu, Eliska B Sykorova, Cathrin Rohleder, Elisabeth Marcolini, Anna E Hoffmann, Dagmar Koethe, F Markus Leweke, Timothy A Couttas
Randomized clinical trials substantiate cannabidiol (CBD) as a next-generation antipsychotic, effective in alleviating positive and negative symptoms associated with psychosis, while minimising the adverse effects seen with established treatments. Although the mechanisms remain debated, CBD is known to induce drug-responsive changes in lipid-based retrograde neurotransmitters. Lipid aberrations are also frequently observed with antipsychotics, which may contribute to their efficacy or increase the risk of undesirables, including metabolic dysfunction, obesity and dyslipidaemia...
June 4, 2024: Psychiatry Research
https://read.qxmd.com/read/38924902/a-systematic-review-of-visual-processing-in-body-dysmorphic-disorder-bdd
#52
REVIEW
Gemma Virgili, Erica Neill, Peter Enticott, David Castle, Susan Lee Rossell
To understand the visual preponderance of perceived flaws in appearance in body dysmorphic disorder (BDD), the study of visual processing has been growing. Studies have focused on facial and other basic visual stimuli. The current literature does not provide evidence of consistent behavioural patterns, lacking an overarching body of work describing visual processing in BDD. This systematic review aims to characterise behavioural outcomes of visual processing anomalies and/or deficits in BDD. Articles were collected through online databases MEDLINE and PubMed, and were included if they comprised a clinical BDD group, and were published after 1990...
June 4, 2024: Psychiatry Research
https://read.qxmd.com/read/38906050/sex-differences-in-trauma-exposure-and-ptsd-symptomatology-among-refugees-internally-displaced-people-and-asylum-seekers-a-systematic-literature-review
#53
REVIEW
Klára Hanáková, Laura Glahder Lindberg, Jessica Carlsson
This systematic review aimed to explore sex differences in exposure to traumatic events and posttraumatic stress disorder (PTSD) symptomatology among refugees, internally displaced persons (IDPs), and asylum seekers. A comprehensive search was conducted across three databases (PubMed, PsychInfo, and Embase), which yielded 2,255 studies. A total of 15 studies were included for trauma exposure assessment, and 8 studies for PTSD symptomatology assessment. The review revealed significant sex differences in trauma exposure, with women experiencing higher rates of sexual violence, while men faced greater risks of imprisonment and torture...
June 4, 2024: Psychiatry Research
https://read.qxmd.com/read/38901365/dopamine-d2-receptor-antagonism-of-antipsychotics-and-the-risk-of-death-due-to-choking
#54
JOURNAL ARTICLE
Jurjen J Luykx, Antti Tanskanen, Markku Lähteenvuo, Peter Manu, Christoph U Correll, Alkomiet Hasan, Johannes Lieslehto, Heidi Taipale, Jari Tiihonen
The risk of fatal choking for people with schizophrenia and associations with antipsychotic medication are largely unknown. Therefore, we calculated the choking-related standardized mortality ratio for schizophrenia relative to the general population (SMRchoking ). We also computed adjusted hazard ratios (aHR) of choking-related mortality for antipsychotics in a nationwide cohort of patients with schizophrenia (N = 59,916). SMRchoking was 20.5 (95 % confidence interval (CI)=17.1-23.9). The aHR was 1.74 (95 %CI=1...
June 3, 2024: Psychiatry Research
https://read.qxmd.com/read/38833937/sleep-disturbances-and-incident-risk-of-major-depressive-disorder-in-a-population-based-cohort
#55
JOURNAL ARTICLE
Geoffroy Solelhac, Théo Imler, Marie-Pierre F Strippoli, Nicola Andrea Marchi, Mathieu Berger, Jose Haba-Rubio, Tifenn Raffray, Virginie Bayon, Anne Sophie Lombardi, Setareh Ranjbar, Francesca Siclari, Peter Vollenweider, Pedro Marques-Vidal, Pierre-Alexis Geoffroy, Damien Léger, Aurélie Stephan, Martin Preisig, Raphaël Heinzer
Sleep disturbances are well-known symptoms of major depressive disorder (MDD). However, the prospective risk of MDD in the presence of sleep disturbances in a general population-based cohort is not well known. This study investigated associations between both polysomnography (PSG)-based or subjective sleep features and incident MDD. Participants representative of the general population who had never had MDD completed sleep questionnaires (n = 2000) and/or underwent PSG (n = 717). Over 8 years' follow-up, participants completed psychiatric interviews enabling the diagnosis of MDD...
June 3, 2024: Psychiatry Research
https://read.qxmd.com/read/38896929/impact-of-traumatic-brain-injury-on-risk-for-schizophrenia-and-bipolar-disorder
#56
JOURNAL ARTICLE
Kai-Yuan Cheng, Natassia Robinson, Alexander Ploner, Ralf Kuja-Halkola, Yasmina Molero, Paul Lichtenstein, Sarah E Bergen
The impact of traumatic brain injury (TBI) on subsequent risk of schizophrenia (SCZ) or bipolar disorder (BD) remains contested. Possible genetic and environmental confounding effects have also been understudied. Therefore, we aim to investigate the impact of TBI on the risk of SCZ and BD and whether the effect varies by injury severity, age at injury, and sex. We identified 4,184 SCZ and 18,681 BD cases born between 1973 and 1998 in the Swedish National Registers. Case-control samples matched (1:5) on birth year, sex, and birthplace were created along with a family design study, with cases matched to non-case full siblings...
June 2, 2024: Psychiatry Research
https://read.qxmd.com/read/38865905/stepped-evidence-based-and-integrated-care-service-model-vs-usual-care-for-mental-disorders-a-randomized-controlled-trial-recover
#57
JOURNAL ARTICLE
Martin Lambert, Hannah König, Anne Karow, Hans-Helmut König, Anja Rohenkohl, Daniel Luedecke, Romy Schröter, Constanze Finter, Lisa Tlach, Andreas Schindler, Helmut Peter, Martin Scherer, Claudia Mews, Martin Härter, Carola Bindt, Bernd Löwe, Peer Briken, Heike Peper, Michael Schweiger, Mike Mösko, Thomas Bock, Arno Deister, Christoph U Correll, Ann-Kathrin Ozga, Amra Pepić, Antonia Zapf, Jürgen Gallinat, Judith Peth, Alexander Konnopka, Holger Schulz
Stepped, evidence-based and integrated care service models have the potential to be used as a reference for mental health services. RECOVER aimed to evaluate cost savings, effectiveness, and cost-effectiveness of such a model within a two arm, assessor- and data analysist-blinded RCT in Hamburg, Germany. Participants aged 16-79 years with mental disorders were randomly assigned either to RECOVER or treatment as usual (TAU). Primary outcomes comprised costs, effectiveness (combined symptoms, functioning, quality of life), and cost-effectiveness, hierarchically ordered...
June 2, 2024: Psychiatry Research
https://read.qxmd.com/read/38850890/diurnal-variation-in-anxiety-and-activity-is-influenced-by-chronotype-and-probable-anxiety-related-disorder-status
#58
JOURNAL ARTICLE
Rebecca C Cox, Kenneth P Wright, John Axelsson, Leonie J T Balter
Anxiety symptoms vary moment-to-moment within a day. One factor that may influence these variations is chronotype. Evening chronotypes prefer to engage in activities (e.g., sleep, physical and social activity) later in the day, and evening chronotype is implicated in psychopathology, including anxiety-related disorders. However, it is unknown whether chronotype influences diurnal variation in anxiety symptoms and whether these effects are amplified in individuals with a probable anxiety-related disorder. We examined the diurnal variation in anxiety symptoms and daily activities in morning and evening chronotypes with and without probable generalized anxiety disorder (GAD) or obsessive-compulsive disorder (OCD) in a community sample of adults (N = 410)...
June 2, 2024: Psychiatry Research
https://read.qxmd.com/read/38850892/associations-between-life-s-essential-8-and-depression-among-us-adults
#59
JOURNAL ARTICLE
Songfeng Zhao, Ying Tang, Yifan Li, Hongxian Shen, Aihua Liu
Few studies have examined the association of Life's Essential 8 (LE8) with depression among US adults. This is a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2020. LE8 score was measured as the mean score of eight metrics (diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipid, blood glucose, and blood pressure). CVH was categorized into low, moderate, and high according to tertiles of LE8 score. Depression was defined based on the 9-Item Patient Health Questionnaire (PHQ-9)...
June 1, 2024: Psychiatry Research
https://read.qxmd.com/read/38875916/use-of-service-and-treatment-adequacy-in-medical-students-and-residents-suffering-from-depression-in-france-a-nationwide-study
#60
JOURNAL ARTICLE
Laure Vergeron, Yannick Morvan, Nawale Hadouiri, Adrien Haas-Jordache, Evan Gouy, Loona Mathieu, Anne Goulard, Franck Rolland, Ariel Frajerman
Depression was already a public health issue before the Covid-19 pandemic. Use of service and treatment adequacy in medical students was poorly known. A 2021 French national study found the prevalence of 12-month major depressive disorder (MDD) was 25 % in medical school students and residents (MSSR). The main objective of our study was to measure the prevalence of service use and adequate treatment (therapy and/or recommended pharmacotherapy) and their associated factors. A national online survey was conducted in 2021...
May 31, 2024: Psychiatry Research
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