journal
https://read.qxmd.com/read/38581767/contemporaneous-and-temporal-network-analysis-of-complex-posttraumatic-stress-disorder-among-chinese-college-students-with-childhood-adversity-a-longitudinal-study
#21
JOURNAL ARTICLE
Aiyi Liu, Yizhen Ren, Shuhan Yang, Zimi Li, Zibin Zhu, Lake Mozi Zhang, Yu Peng
OBJECTIVE: To enhance understanding of the longitudinal progression of complex posttraumatic stress disorder (CPTSD) symptoms, this longitudinal study examined how CPTSD symptoms interact over time in Chinese college students with childhood trauma. METHODS: From 18,933 college students who took part in two surveys 12 months apart, 4,006 participants who reported adverse childhood experiences were screened. Cross-sectional network comparisons and cross-lagged panel network (CLPN) analysis characterized interactions among CPTSD symptoms...
March 24, 2024: Psychiatry Research
https://read.qxmd.com/read/38547600/evidence-for-cytokine-dysregulation-in-schizophrenia-spectrum-disorders-a-comparison-of-cerebrospinal-fluid-and-blood-samples
#22
JOURNAL ARTICLE
Juan A Gallego, Robert K McNamara, Emily A Blanco, Santiago Castaneda, Laura D Jimenez, Santiago Alvarez-Lesmes, Todd Lencz, Anil K Malhotra
Abnormalities in immune function have been described in schizophrenia but few studies have investigated cytokines in cerebrospinal fluid (CSF) and their correlation with blood levels. In this cross-sectional study, cytokines were measured in CSF and plasma of 30 subjects with schizophrenia spectrum disorder (SSD) diagnosis and 23 healthy volunteers (HV). Results showed that CSF TNFα was increased in SSD subjects compared to HV and there were no correlations between CSF and plasma cytokine levels. The present findings provide evidence of dysregulation of TNFα in CSF of schizophrenia...
March 22, 2024: Psychiatry Research
https://read.qxmd.com/read/38537595/psychosis-spectrum-symptoms-among-individuals-with-schizophrenia-associated-copy-number-variants-and-evidence-of-cerebellar-correlates-of-symptom-severity
#23
JOURNAL ARTICLE
Esra Sefik, Ryan M Guest, Katrina Aberizk, Roberto Espana, Katrina Goines, Derek M Novacek, Melissa M Murphy, Adam E Goldman-Yassen, Joseph F Cubells, Opal Ousley, Longchuan Li, Sarah Shultz, Elaine F Walker, Jennifer G Mulle
The 3q29 deletion (3q29Del) is a copy number variant (CNV) with one of the highest effect sizes for psychosis-risk (>40-fold). Systematic research offers avenues for elucidating mechanism; however, compared to CNVs like 22q11.2Del, 3q29Del remains understudied. Emerging findings indicate that posterior fossa abnormalities are common among carriers, but their clinical relevance is unclear. We report the first in-depth evaluation of psychotic symptoms in participants with 3q29Del (N=23), using the Structured Interview for Psychosis-Risk Syndromes, and compare this profile to 22q11...
March 21, 2024: Psychiatry Research
https://read.qxmd.com/read/38547602/erroneous-conclusions-about-the-long-term-cognitive-effects-of-electroconvulsive-therapy
#24
LETTER
Abhinav Pandey, Rini Joseph, Shyam Sundar Arumugham, Jagadisha Thirthalli
No abstract text is available yet for this article.
March 20, 2024: Psychiatry Research
https://read.qxmd.com/read/38547601/ketogenic-diet-intervention-on-metabolic-and-psychiatric-health-in-bipolar-and-schizophrenia-a-pilot-trial
#25
JOURNAL ARTICLE
Shebani Sethi, Diane Wakeham, Terrance Ketter, Farnaz Hooshmand, Julia Bjornstad, Blair Richards, Eric Westman, Ronald M Krauss, Laura Saslow
The ketogenic diet (KD, also known as metabolic therapy) has been successful in the treatment of obesity, type 2 diabetes, and epilepsy. More recently, this treatment has shown promise in the treatment of psychiatric illness. We conducted a 4-month pilot study to investigate the effects of a KD on individuals with schizophrenia or bipolar disorder with existing metabolic abnormalities. Twenty-three participants were enrolled in a single-arm trial. Results showcased improvements in metabolic health, with no participants meeting metabolic syndrome criteria by study conclusion...
March 20, 2024: Psychiatry Research
https://read.qxmd.com/read/38574700/the-utility-of-measuring-daily-hassles-and-uplifts-in-understanding-outcomes-to-treatments-for-major-depressive-disorder
#26
JOURNAL ARTICLE
Benjamin W Furman, W Edward Craighead, Helen S Mayberg, Tanja Mletzko, Charles B Nemeroff, Boadie W Dunlop
Little is known about the effects of common daily experiences in patients with major depressive disorder (MDD). The Daily Hassles and Uplifts Scale (HUPS) was assessed in 142 treatment-naïve adult MDD outpatients randomized to 12 weeks of treatment with either antidepressant medication (ADM) or Cognitive Behavior Therapy (CBT). Three HUPS measures were analyzed: hassle frequency (HF), uplift frequency (UF), and the mean hassle intensity to mean uplift intensity ratio (MHI:MUI). Remission after treatment was not predicted by these baseline HUPS measures and did not moderate outcomes by treatment type...
March 19, 2024: Psychiatry Research
https://read.qxmd.com/read/38518518/iv-low-dose-ketamine-infusions-for-treatment-resistant-depression-results-from-a-five-year-study-at-a-free-public-clinic-in-an-academic-hospital
#27
JOURNAL ARTICLE
Gilmar Gutierrez, Melody J Y Kang, Gustavo Vazquez
Individuals with major depressive disorder and treatment resistant depression (MDD-TRD) have limited and sometimes poorly tolerated therapeutic options. Low dose ketamine has presented promising and potent antidepressant effects in this population. To support the existent literature, we conducted a longitudinal study examining five years of real-world clinical data on the use of IV low-dose ketamine alongside standard care for MDD-TRD outpatients. For this study we collected demographic information, clinical scale scores, side effects and dropout data...
March 19, 2024: Psychiatry Research
https://read.qxmd.com/read/38522151/group-differences-in-oxt-methylation-between-patients-with-major-depressive-disorder-and-healthy-controls-a-pre-registered-replication-study
#28
JOURNAL ARTICLE
Simon Sanwald, Christian Montag, Markus Kiefer
Depression is linked to stress which leaves traces in the epigenetic signature of genes. The oxytocin system is implicated in allostatic processes promoting adaption to environmental stressors. Interactions of the oxytocin system with the environment, e.g., methylation of the gene coding for oxytocin (OXT), are candidates for the investigation of the biological underpinnings of depression. Recently, we found hypomethylation of OXT in patients with Major Depressive Disorder (MDD) compared to healthy controls (HC)...
March 16, 2024: Psychiatry Research
https://read.qxmd.com/read/38554493/validation-of-the-structured-interview-section-of-the-penn-computerized-adaptive-test-for-neurocognitive-and-clinical-psychopathology-assessment-cat-goassess
#29
JOURNAL ARTICLE
Eirini Zoupou, Tyler M Moore, Kelly P Kennedy, Monica E Calkins, Alesandra Gorgone, Akira Di Sandro, Sage Rush, Katherine C Lopez, Kosha Ruparel, Tarlan Daryoush, Paul Okoyeh, Andrew Savino, Scott Troyan, Daniel H Wolf, J Cobb Scott, Raquel E Gur, Ruben C Gur
Large-scale studies and burdened clinical settings require precise, efficient measures that assess multiple domains of psychopathology. Computerized adaptive tests (CATs) can reduce administration time without compromising data quality. We examined feasibility and validity of an adaptive psychopathology measure, GOASSESS, in a clinical community-based sample (N = 315; ages 18-35) comprising three groups: healthy controls, psychosis, mood/anxiety disorders. Assessment duration was compared between the Full and CAT GOASSESS...
March 15, 2024: Psychiatry Research
https://read.qxmd.com/read/38503007/association-of-longitudinal-trajectories-of-general-and-abdominal-adiposity-during-middle-age-with-mental-health-and-well-being-in-late-life-a-prospective-analysis
#30
JOURNAL ARTICLE
Huibo Qin, Gang Hu, Zhengting Liang, Xin Jin, Xiaodong Chen, Binbin Su, Yanping Bao, Jing Ouyang, Yunhe Wang
Single measures of adiposity markers, such as body mass index (BMI) and waist circumference (WC), are associated with adverse mental health outcomes; however, long-term patterns of adiposity and their health effects remain unclear. The current study assessed adiposity trajectories during a 14-year span beyond middle age and their relevance to mental well-being in late life, and the contribution of genetic and lifestyle factors to the trajectories. Based on a nationally representative sample with longitudinal anthropometric measures, adiposity trajectories were identified by latent mixture modeling, and logistic regression model was used to estimate their associations with mental well-being, with adjustment for confounders...
March 15, 2024: Psychiatry Research
https://read.qxmd.com/read/38554496/social-determinants-of-mental-health-in-major-depressive-disorder-umbrella-review-of-26-meta-analyses-and-systematic-reviews
#31
JOURNAL ARTICLE
Noy Alon, Natalia Macrynikola, Dylan J Jester, Matcheri Keshavan, Charles F Reynolds, Shekhar Saxena, Michael L Thomas, John Torous, Dilip V Jeste
There is a growing recognition of the impact of social determinants of mental health (SDoMHs) on people with, or at risk of, developing serious mental illnesses. Yet it is not known how associations of individual SDoMHs with risk for major depressive disorder (MDD) vary and roughly compare with one another. Following PRISMA guidelines, this umbrella review included 26 meta-analyses and systematic reviews that reported odds ratios, effect sizes, and/or pooled prevalence rates of MDD in samples with versus without specified SDoMHs...
March 11, 2024: Psychiatry Research
https://read.qxmd.com/read/38547599/predicting-non-response-to-ketamine-for-depression-an-exploratory-symptom-level-analysis-of-real-world-data-among-military-veterans
#32
JOURNAL ARTICLE
Eric A Miller, Houtan Totonchi Afshar, Jyoti Mishra, Roger S McIntyre, Dhakshin Ramanathan
Ketamine helps some patients with treatment resistant depression (TRD), but reliable methods for predicting which patients will, or will not, respond to treatment are lacking. Herein, we aim to inform prediction models of non-response to ketamine/esketamine in adults with TRD. This is a retrospective analysis of PHQ-9 item response data from 120 patients with TRD who received repeated doses of intravenous racemic ketamine or intranasal eskatamine in a real-world clinic. Regression models were fit to patients' symptom trajectories, showing that all symptoms improved on average, but depressed mood improved relatively faster than low energy...
March 11, 2024: Psychiatry Research
https://read.qxmd.com/read/38522150/employing-graph-attention-networks-to-decode-psycho-metabolic-interactions-in-schizophrenia
#33
JOURNAL ARTICLE
Hongyi Yang, Dian Zhu, YanLi Liu, Zhiqi Xu, Zhao Liu, Weibo Zhang, Jun Cai
Schizophrenia is a severe mental disorder characterized by intricate and underexplored interactions between psychological symptoms and metabolic health, presenting challenges in understanding the disease mechanisms and designing effective treatment strategies. To delve deeply into the complex interactions between mental and metabolic health in patients with schizophrenia, this study constructed a psycho-metabolic interaction network and optimized the Graph Attention Network (GAT). This approach reveals complex data patterns that traditional statistical analyses fail to capture...
March 11, 2024: Psychiatry Research
https://read.qxmd.com/read/38493738/risk-of-suicide-attempts-and-intentional-self-harm-on-alprazolam
#34
JOURNAL ARTICLE
Robert D Gibbons, Kwan Hur, Jill E Lavigne, J John Mann
BACKGROUND: From 2000-2021, U.S. suicide deaths have risen 36 %. Identification of pharmacological agents associated with increased suicide risk and safer alternatives may help reduce this trend. METHODS: An exposure-only within-subject time-to-event pharmacoepidemiologic study of the dynamic association between alprazolam treatment and suicide attempts over 2-years. Parallel analyses were conducted for diazepam, lorazepam and buspirone. Data for 2,495,520 patients were obtained from U...
March 11, 2024: Psychiatry Research
https://read.qxmd.com/read/38484607/non-fatal-self-harm-and-suicide-following-postpartum-psychiatric-emergency-department-visits-a-population-based-retrospective-cohort-study
#35
JOURNAL ARTICLE
Lucy C Barker, Hilary K Brown, Susan E Bronskill, Kinwah Fung, Paul Kurdyak, Juveria Zaheer, Simone N Vigod
In a population-based cohort of postpartum individuals in Ontario, Canada, this study aimed to determine the risk of non-fatal self-harm and suicide within one year of an initial postpartum psychiatric emergency department (ED) visit (2008-2020), and the key associated factors. Of 16,475 postpartum individuals with psychiatric ED visits, 714 (4.3 %) had non-fatal self-harm within one year, and 23 (0.15 %) died by suicide. Risk was substantially higher for those with self-harm at the initial presentation. Further efforts to connect individuals with postpartum psychiatric ED visits with needed inpatient care and outpatient follow-up are required to reduce non-fatal self-harm and suicide risk...
March 11, 2024: Psychiatry Research
https://read.qxmd.com/read/38518519/burnout-and-depression-in-college-students
#36
JOURNAL ARTICLE
Xianyang Wang, Mengyuan Yang, Lei Ren, Qingyi Wang, Shuyi Liang, Yahong Li, Yu Li, Qingchen Zhan, Shen Huang, Kangning Xie, Jianjun Liu, Xinhong Li, Shengjun Wu
Research on burnout has garnered considerable attention since its inception. However, the ongoing debate persists regarding the conceptual model of burnout and its relationship with depression. Thus, we conducted a network analysis to determine the dimensional structure of burnout and the burnout-depression overlap. The Maslach Burnout Inventory-Student Survey and Patient Health Questionnaire-9 were used to measure burnout and depression among 1096 college students. We constructed networks for burnout, depression, and a burnout-depression co-occurrence network...
March 8, 2024: Psychiatry Research
https://read.qxmd.com/read/38484606/obesity-in-latinx-and-white-u-s-military-veterans-mental-health-psychosocial-burden-non-suicidal-self-injury-and-suicidal-behavior
#37
JOURNAL ARTICLE
Elina A Stefanovics, Carlos M Grilo, Marc N Potenza, Robert H Pietrzak
Obesity disproportionately affects Latinx communities and is linked to an increased risk of mental health problems. Military veterans are more likely to develop mental health problems, but the role of Latinx ethnicity in moderating the association between obesity and these problems is unclear. To address this gap, this study examined psychiatric and psychosocial correlates of obesity in a nationally representative sample of Latinx and White U.S. military veterans. Data were analyzed from the 2019-2020 National Health and Resilience in Veterans Study, which surveyed 3524 Latinx and White veterans...
March 8, 2024: Psychiatry Research
https://read.qxmd.com/read/38503006/development-validation-and-clinical-utility-of-short-term-adverse-effects-of-electroconvulsive-therapy-save-checklist
#38
JOURNAL ARTICLE
Chithra Uppinkudru, Harsh Pathak, Raj Kumar K, Bridgit S, Kiran Bagali, Makarand Pantoji, Nathiya Ezhumalai, Rujuta Parlikar, Vyoma Shah, Srinivas Balachander, Vanteemar S Sreeraj, Urvakhsh Meherwan Mehta, Preeti Sinha, Shyam Sundar Arumugham, Ganesan Venkatasubramanian, Jagadisha Thirthalli
Electroconvulsive therapy (ECT) is one of the most effective treatments in psychiatry. However, it has many cognitive and non-cognitive adverse effects (AEs). There are lacunae in the literature on systematic assessment of non-cognitive AEs. There is a need for a standard, comprehensive and specific clinical tool to evaluate this. Hence, a checklist of short-term AEs of ECT (SAVE) with a 2-phase assessment was developed. Content validation was done using 15 experts' ratings and predefined content validity ratio and index (CVR and CVI) in a two-stage modified Delphi method...
March 7, 2024: Psychiatry Research
https://read.qxmd.com/read/38461645/clinical-efficacy-of-adjunctive-esketamine-anesthesia-in-electroconvulsive-therapy-for-major-depressive-disorders-a-pragmatic-randomized-controlled-trial
#39
JOURNAL ARTICLE
Li Ren, Qibin Chen, Jin Gao, Yuanyuan Liu, Yi Tao, Xiao Li, Qinghua Luo, Feng Lv, Su Min
Electroconvulsive therapy (ECT) is an effective treatment for depression, and esketamine has been shown to have antidepressant effects. However, it is currently unclear whether adjunctive esketamine can enhance the clinical efficacy of ECT in real-world clinical practice. In this pragmatic clinical trial, patients with major depression were randomly assigned into two groups: patients received 0.25 mg/kg esketamine plus propofol (esketamine group) or the same volume of saline (control group) plus propofol. Results indicated that there was no difference in response and remission rates between the two groups...
March 6, 2024: Psychiatry Research
https://read.qxmd.com/read/38460352/using-transcranial-alternating-current-stimulation-to-enhance-working-memory-skills-in-youths-with-22q11-2-deletion-syndrome-a-randomized-double-blind-sham-controlled-study
#40
JOURNAL ARTICLE
Caren Latrèche, Valentina Mancini, Vincent Rochas, Johanna Maeder, Lucia M Cantonas, Victor Férat, Maude Schneider, Christoph M Michel, Stephan Eliez
Abnormal cognitive development, particularly working memory (WM) deficits, is among the first apparent manifestations of psychosis. Yet, cognitive impairment only shows limited response to current pharmacological treatment. Alternative interventions to target cognition are highly needed in individuals at high risk for psychosis, like carriers of 22q11.2 deletion syndrome (22q11.2DS). Here we applied theta-tuned transcranial alternating current stimulation (tACS) between frontal and temporal regions during a visual WM task in 34 deletion carriers...
March 6, 2024: Psychiatry Research
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