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Psychiatry Research

Philip R Szeszko, Rachel Yehuda
The earliest neuroimaging studies in post-traumatic stress disorder (PTSD) utilized positron emission tomography (PET) to examine the brain's response to glucocorticoid administration given predominant neurobiological models of the stress response focusing on that neuroendocrine system. This work revealed that the anterior cingulate cortex and amygdala, which is now considered part of the salience network, play a role in treatment response, and set the stage for subsequent magnetic resonance (MR) imaging studies focused on understanding the role of the salience network in the neurobiology of treatment response in PTSD...
February 2, 2019: Psychiatry Research
Muzi Li, Carl D'Arcy, Xiangfei Meng
Children's mental health problems substantially impact their functioning. For clinically treated children and adolescents, we explored the impact of mental health treatment on functioning and identified predictors of functional improvement. Outpatient clinical data from a regional publicly funded specialist outpatient treatment clinic were analyzed. The Child and Adolescent Functional Assessment Scale (CAFAS) was used to assess outcomes. Non-parametric tests were used to compare baseline and exit scores. Logistic regression analysis was used separately for children and adolescents to examine predictors of improvement...
January 30, 2019: Psychiatry Research
Sarah Abu-Kaf, Orna Braun-Lewensohn
This study aimed to examine coping resources (sense of coherence and hope) and stress reactions among Bedouin Arab adolescents in southern Israel during three periods of escalated political violence. Two main questions were examined: 1) Did adolescents report different coping resources and levels of stress reactions during these three different periods? 2) Were there any differences in the pattern of the associations between coping resources and stress reactions across those periods? Data were gathered from 81, 91, and 192 Bedouin Arab adolescents, who were 14-18 years old, during three periods...
January 30, 2019: Psychiatry Research
Lynn E DeLisi
Authors often are frustrated by responses they receive from editors when their manuscripts are rejected and do not understand from an editor's view what is needed to successfully publish their work. Editors receive sometimes several manuscripts a day and have to develop methods to screen out the ones that are likely not to pass the review process. They also want papers to be able to be written in such a way that it is clear why the studies of which they report are important and novel and worth publishing. Thus, advice is given in the following article that begins with how to choose an appropriate journal, to the surprising importance of a title and ends with how one should conclude the manuscript...
January 29, 2019: Psychiatry Research
Marit Hauschildt, Reuven Dar, Johanna Schröder, Steffen Moritz
The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is the most common measure of Obsessive-Compulsive symptom severity. The Y-BOCS interview is considered gold standard, but its self-rating format is increasingly used in clinical trials. Few studies investigated congruency and potential changes over treatment. This question is highly relevant, as a systematic bias might obscure results of clinical trials. We examined the relationship of self- and clinician-rated Y-BOCS scores in participants with obsessive-compulsive disorder in pre (N = 128), post, (4 weeks, n = 104) and follow-up (6 months, n = 98) assessments of a randomized-controlled clinical trial...
January 29, 2019: Psychiatry Research
Carolina Muniz Carvalho, Pedro M Pan, Vanessa K Ota, Letícia M Spindola, Gabriela Xavier, Marcos L Santoro, Diego R Mazzotti, Renata Pellegrino, Hakon Hakonarson, Luis Augusto Rohde, Euripedes Constantino Miguel, Ary Gadelha, Rodrigo A Bressan, Sintia I Belangero
We evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on development of mental disorders (MD) and psychopathology. We genotyped 720 individuals from a Brazilian community school-based prospective study, focusing on SNPs in 21 genes known to be associated with mental disorders. CM was assessed via a multi-informant-measure, which was previously validated. To test G × CM, we used linear or logistic models depending on variable evaluated (MD or dimensional psychopathology)...
January 29, 2019: Psychiatry Research
Joo Eun Lee, Seong Wu Yang, Yeong Jun Ju, Seung Kuk Ki, Ki Hong Chun
Sleep-disordered breathing (SDB) is common and can lead to significant cognitive decline, such as Alzheimer's disease (AD). Therefore, the present study was conducted to investigate whether SDB is associated with AD onset. This study used the nationwide health check-up cohort data between 2002 and 2015. The study population comprised individuals who were diagnosed with SDB and those without SDB who were matched by using propensity score. The matched cohort was followed up until the onset of AD, death, or end of 2015...
January 28, 2019: Psychiatry Research
C Palma, N Farriols, A Frías, J Cañete, O Gomis, M Fernández, I Alonso, S Signo
AIM: The main goal of this study was to evaluate the effectiveness of a cognitive motivational treatment program. METHOD: A randomized, controlled, single-blind clinical trial was carried out. A total of 104 patients were recruited to take part in the trial, of whom ultimately 62 patients were allocated into two groups and finished the study. An initial assessment was carried out before patients were randomly placed in one of two groups for the clinical trial: (a) PIPE program plus routine care; and (b) routine care only...
January 28, 2019: Psychiatry Research
Virginie Doré-Gauthier, Hubert Côté, Didier Jutras-Aswad, Clairélaine Ouellet-Plamondon, Amal Abdel-Baki
In Canada, about 6,000 youth are homeless every night, many of whom suffer from addiction and psychotic disorders. To facilitate the exit out of homelessness, access to care and to improve psychosis and addiction outcomes, a new intensive outreach intervention team (EQIIP SOL) was created in Montreal (2012). It offers intensive outreach services dedicated to homeless youth suffering from first episode psychosis and addiction (HYFEPA) in addition to an early psychosis intervention service (EIS) in collaboration with the Addiction Psychiatry Unit...
January 27, 2019: Psychiatry Research
Ilanit Hasson-Ohayon, Michal Mashiach-Eizenberg, Adi Lavi-Rotenberg, Martin Brüne, David Roe
No abstract text is available yet for this article.
January 27, 2019: Psychiatry Research
Lynn E DeLisi
No abstract text is available yet for this article.
January 27, 2019: Psychiatry Research
Monte S Buchsbaum
The astonishing 20 fold growth of the yearly published psychiatric research literature over the past four decades has been paralleled and facilitated by the internet application of electronic publishing. This personal history highlights the decade by decade 1978-2018 augmentation and erosion of this interelationship from the founding of Psychiatry Research to the present day.
January 26, 2019: Psychiatry Research
Ágnes Fehér, Anna Juhász, Magdolna Pákáski, Zoltán Janka, János Kálmán
The ATP-binding cassette, sub-family A, member 7 (ABCA7) gene has been identified as a strong genetic risk locus for Alzheimer's disease (AD). Our case-control study (416 AD patients and 302 controls) provides further data on the rs3752246 polymorphism in AD in the Hungarian population that has not been investigated so far regarding the ABCA7 gene variants. A modest, marginally significant association of the G allele containing genotypes with AD was observed (p = 0.054). In line with the previous results in other populations, the G allele carriers had an increased risk for developing AD considering C/C genotype as reference category...
January 26, 2019: Psychiatry Research
Andrew M Subica, Nia Aitaoto, J Greer Sullivan, Benjamin F Henwood, Ann Marie Yamada, Bruce G Link
Native Hawaiians and other Pacific Islanders (NHPI) rarely seek mental health treatment for reasons that are minimally understood. To assess the mental illness stigma context in NHPI communities that may be contributing to low help-seeking, this study collected novel stigma data from two large U.S. NHPI communities from October 2017 to January 2018, then compared this data to national stigma data from the U.S. public. Survey data were collected from 222 community-dwelling NHPI participants recruited by research-trained NHPI staff...
January 26, 2019: Psychiatry Research
Tomoko Nishida, Haruka Tamura, Hisataka Sakakibara
The aim of this study is to assess the association between smartphone usage and depression in each gender of senior high school students. A cross-sectional study with self-administered questionnaires for 295 high school students, aged 15-19 was conducted in Japan. Depression was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). Female adolescents used smartphones more hours a day than males. Students who used the smartphones for three hours a day accounted for 44.3% of female students and 22...
January 26, 2019: Psychiatry Research
Zhang Cheng, Yanbo Yuan, Xue Han, Lei Yang, Xin Zeng, Fude Yang, Zheng Lu, Chuanyue Wang, Hong Deng, Jingping Zhao, Yu-Tao Xiang, Christoph U Correll, Xin Yu
Antipsychotic treatment discontinuation is a major challenge in the treatment of first-episode schizophrenia (FES) patients. However, the rate and predictors remain unclear. Five hundred and sixty-nine FES patients were randomized to risperidone (n = 190), olanzapine (n = 185) or aripiprazole (n = 194) in a six-site study in China with 1-year follow-up. Patients failing the initially assigned antipsychotic were switched to one of the other 2 antipsychotics. By 52 weeks, 47.1% of FES patients discontinued all antipsychotics...
January 24, 2019: Psychiatry Research
Alessandra Minelli, Elisa Zampieri, Chiara Sacco, Roberta Bazzanella, Nicoletta Mezzetti, Elisabetta Tessari, Stefano Barlati, Marco Bortolomasi
In major depressive disorder (MDD) patients, life stress events represent a risk factor for a severe, early-onset, treatment-resistant and chronic endophenotype. Treatment-resistant depression (TRD) patients who have experienced traumatic events could benefit from evidence-based trauma-focused psychotherapies. Because this topic has never been investigated, the aim of this pilot trial was to evaluate whether trauma-focused cognitive-behavioural therapy (TF-CBT) and/or eye movement desensitization and reprocessing (EMDR) can help achieve depressive symptom remission in TRD patients...
January 24, 2019: Psychiatry Research
Takako Miki, Masafumi Eguchi, Keisuke Kuwahara, Takeshi Kochi, Shamima Akter, Ikuko Kashino, Huanhuan Hu, Kayo Kurotani, Isamu Kabe, Norito Kawakami, Akiko Nanri, Tetsuya Mizoue
Breakfast consumption has been suggested to influence mood, but prospective evidence on this issue is limited. We prospectively investigated the association between the frequency of breakfast consumption and the risk of depressive symptoms in Japanese employees. Participants were 716 employees aged 19-68 years who were free from depressive symptoms and mental disorders at baseline and who attended the 3-year follow-up survey. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale...
January 24, 2019: Psychiatry Research
Anne C Knorr, Brooke A Ammerman, Alexander J Hamilton, Michael S McCloskey
Nonsuicidal self-injury (NSSI) and suicidal thoughts and behavior often co-occur, representing a growing public health concern. Despite extensive research examining suicidal thoughts and behavior among those who engage in NSSI, there is a lack of research investigating factors that, when considered together, can differentiate individuals along the continuum of suicidal thoughts and behavior (no history, suicidal ideation, suicide plan, suicide attempt). This study sought to address this question using a sample of 1178 college students with NSSI history (68...
January 24, 2019: Psychiatry Research
Mark Zimmerman, Lucille B Mehring, Sydney Moon, Carolina Guzman Holst
As part of Maintenance of Certification (MOC) for physicians, the American Board of Psychiatry and Neurology (APBN) developed a patient satisfaction form. We are not aware of any studies of the ABPN satisfaction survey. The goal of the present study was to examine the psychometric characteristics of the ABPN survey, and to compare it to a satisfaction measure that was designed to assess satisfaction with the initial evaluation. Two hundred seven patients completed the APBN measure and the Clinically Useful Patient Satisfaction Scale (CUPSS) after their initial meeting with the psychiatrist...
January 24, 2019: Psychiatry Research
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