journal
https://read.qxmd.com/read/38996631/polygenic-scores-for-psychiatric-disorders-associate-with-year-of-first-bipolar-disorder-diagnosis-a-register-based-study-between-1972-and-2016
#1
JOURNAL ARTICLE
Lina Jonsson, Jie Song, Erik Joas, Erik Pålsson, Mikael Landén
The diagnostic criteria of bipolar disorder (BD) have changed over time. To test if these changes are reflected in the polygenic profile in BD, we studied the association between first BD diagnosis year (during 1972-2016) and polygenic scores (PGS) for psychiatric disorders in BD patients (N = 3,818). We found significant associations between diagnosis year and PGS for BD, depression, and attention deficit hyperactivity disorder (ADHD). The PGS remained largely stable over time in BD type 1, while changes were observed in BD type 2...
July 7, 2024: Psychiatry Research
https://read.qxmd.com/read/38996632/psychotic-disorders-and-exosomes-an-overview-of-current-evidence-and-future-directions
#2
REVIEW
Charles Desmeules, Olivier Corbeil, Maxime Huot-Lavoie, Laurent Béchard, Sébastien Brodeur, Marie-France Demers, Marc-André Roy, Jessica Deslauriers
Due to its reliance on heterogeneous symptomatology, the accurate diagnosis of psychotic disorders remains a challenging task in clinical practice. Precise and early diagnosis of psychotic disorders facilitates early intervention, which has been shown to have substantial benefits for long-term outcomes. Still, the lack of specific biomarkers is an important limitation in early diagnosis and intervention. Exosomes, which act as messengers between cells, including brain cells, contain a vast array of molecules that hold promise for unveiling disorder-specific abnormalities...
July 6, 2024: Psychiatry Research
https://read.qxmd.com/read/38986178/the-role-of-control-groups-in-non-pharmacological-randomised-controlled-trials-of-treatment-resistant-schizophrenia-a-systematic-review-and-meta-analysis
#3
REVIEW
Alexandra Schütz, Nurul Husna Salahuddin, Josef Priller, Irene Bighelli, Stefan Leucht
Control groups used in randomised controlled trials investigating psychological interventions for depression and anxiety disorders have effects of their own. This has never been investigated for schizophrenia, in particular treatment-resistant schizophrenia. This systematic review and meta-analysis aimed to examine how control groups in randomised controlled trials on psychological interventions for treatment-resistant schizophrenia behave in their effects on general symptomatology. In a search of various databases until July 2023, 31 eligible studies with 3125 participants were found whose control groups were assigned to four categories: active, inactive, treatment as usual and waitlist...
July 6, 2024: Psychiatry Research
https://read.qxmd.com/read/38986177/the-effect-of-physical-exercise-therapy-on-autism-spectrum-disorder-a-systematic-review-and-meta-analysis
#4
REVIEW
Yifan Wu, Lu Ding, Qiao Zhang, Yu Dong, Chenyang Tao, Zhenyuan Li, Zhaowei Li, Liming Lu
BACKGROUND: Physical Exercise Therapy (PET) is increasingly applied in the treatment of Autism Spectrum Disorders (ASD), yet the empirical evidence supporting its efficacy remains ambiguous. This systematic review and meta-analysis aimed to investigate the effectiveness of PET for individuals with ASD, providing evidence-based support for clinical and scientific research. METHODS: We systematically searched four international databases (Medline via PubMed, Embase, Cochrane Libraries, and Web of Science) and three Chinese databases (CNKI, Wanfang, and VIP Libraries) up to July 31, 2023...
July 6, 2024: Psychiatry Research
https://read.qxmd.com/read/38968917/patient-derived-induced-pluripotent-stem-cells-tools-to-advance-the-understanding-and-drug-discovery-in-major-depressive-disorder
#5
REVIEW
Andreia Vaz, António Salgado, Patrícia Patrício, Luísa Pinto
Major Depressive Disorder (MDD) is a pleomorphic disease with substantial patterns of symptoms and severity with mensurable deficits in several associated domains. The broad spectrum of phenotypes observed in patients diagnosed with depressive disorders is the reflection of a very complex disease where clusters of biological and external factors (e.g., response/processing of life events, intrapsychic factors) converge and mediate pathogenesis, clinical presentation/phenotypes and trajectory. Patient-derived induced pluripotent stem cells (iPSCs) enable their differentiation into specialised cell types in the central nervous system to explore the pathophysiological substrates of MDD...
July 4, 2024: Psychiatry Research
https://read.qxmd.com/read/38968919/is-grammar-affected-in-schizophrenia
#6
LETTER
Martina Wiltschko
No abstract text is available yet for this article.
July 2, 2024: Psychiatry Research
https://read.qxmd.com/read/38996630/prevalence-and-clinical-correlates-of-dissociative-symptoms-in-people-with-complex-ptsd-is-complex-ptsd-a-dissociative-disorder
#7
JOURNAL ARTICLE
Hong Wang Fung, Guangzhe Frank Yuan, Caimeng Liu, Eleanor Sui Sum Lin, Stanley Kam Ki Lam, Janet Yuen-Ha Wong
The extent to which complex post-traumatic stress disorder (C-PTSD) can be conceptualized as a dissociative disorder remains an ongoing debate. This study investigated the prevalence and correlates of dissociative symptoms in people with C-PTSD. We analyzed baseline data from an international randomized controlled trial. A total of 165 intervention seekers who met the ICD-11 criteria for C-PTSD completed standardized self-report measures of trauma, C-PTSD symptoms, dissociative symptoms, depressive symptoms, and work and social impairments...
June 30, 2024: Psychiatry Research
https://read.qxmd.com/read/38968920/clinical-characteristics-associated-with-functioning-trajectories-following-admission-to-a-psychiatric-institution-a-prospective-cohort-study-of-individuals-with-psychosis
#8
JOURNAL ARTICLE
Beaudoin Mélissa, Giguère Sabrina, Giguère Charles-Edouard, Ziady Hind, Signature Consortium, Phraxayavong Kingsada, Potvin Stéphane, Dumais Alexandre
Psychotic disorders can be severely enabling, and functional recovery is often difficult to achieve. Admission to a psychiatric unit represents a key opportunity to implement strategies that will improve functional outcomes. In the current literature, there is a lack of consensus on which factors influence functional recovery. Therefore, the present longitudinal cohort study aimed to identify factors associated with functional trajectories following hospital admission for acute psychosis. A sample of 453 individuals with acute psychosis was extracted from the Signature Biobank database...
June 28, 2024: Psychiatry Research
https://read.qxmd.com/read/38964141/prevalence-of-sleep-disturbances-in-people-with-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#9
REVIEW
Wenping Mo, Xiaoji Liu, Miyae Yamakawa, Eriko Koujiya, Yasushi Takeya, Kazue Shigenobu, Hiroyoshi Adachi, Manabu Ikeda
This review was performed to determine sleep disturbance prevalence in individuals with mild cognitive impairment (MCI). The MEDLINE, Embase, Cochrane Library, CINAHL, PsycINFO, and Web of Science databases were systematically searched from inception to January 20, 2024. Fifty-two studies fulfilling the eligibility criteria were included. However, six of these studies were excluded from data synthesis due to poor methodological quality. The subjective sleep disturbance prevalence among all individuals with MCI was 35...
June 28, 2024: Psychiatry Research
https://read.qxmd.com/read/38954891/impact-of-vortioxetine-on-depressive-symptoms-moderated-by-symptoms-of-anxiety-in-persons-with-post-covid-19-condition-a-secondary-analysis
#10
JOURNAL ARTICLE
Gia Han Le, Angela T H Kwan, Ziji Guo, Kayla M Teopiz, Sabrina Wong, Shakila Meshkat, Giacomo d'Andrea, Roger Ho, Taeho Greg Rhee, Bing Cao, Sebastian Badulescu, Lee Phan, Joshua D Rosenblat, Rodrigo B Mansur, Mehala Subramaniapillai, Roger S McIntyre
OBJECTIVE: Recovery from a COVID-19 infection can lead to post-COVID-19 condition (PCC), which causes a multitude of debilitating symptoms that negatively affect an individual's health-related quality of life, including depressive and anxiety symptoms. We aim to examine the mediatory effects of anxiety on depressive symptoms in persons with PCC receiving vortioxetine. METHODS: We performed a post-hoc analysis of a randomized, double-blinded, placebo-controlled clinical trial investigating vortioxetine treatment on cognitive functioning in persons with PCC...
June 28, 2024: Psychiatry Research
https://read.qxmd.com/read/38981412/the-longitudinal-course-of-psychological-distress-and-resilience-in-patients-with-serious-mental-illnesses-during-the-first-two-years-of-the-covid-19-pandemic
#11
JOURNAL ARTICLE
Fabienne Post, Timo Schurr, Beatrice Frajo-Apor, Franziska Tutzer, Anna Schmit, Barbara Plattner, Andreas Conca, Martin Fronthaler, Christian Haring, Bernhard Holzner, Markus Huber, Josef Marksteiner, Carl Miller, Silvia Pardeller, Verena Perwanger, Roger Pycha, Martin Schmidt, Barbara Sperner-Unterweger, Alex Hofer
The positive effects of resilience on psychological distress has been found in previous studies in samples not including the seriously mentally ill. The present study aimed to investigate the course of psychological distress and resilience in the first two years of the Covid-19 pandemic in patients with severe mental illness (SMI) and major depressive disorder without psychotic features (MDD) compared to healthy control subjects. 141 patients with SMI or MDD who had been admitted to a psychiatric ward in Tyrol (Austria) or South Tyrol (Italy) in 2019 and 584 community controls participated in a longitudinal online survey...
June 27, 2024: Psychiatry Research
https://read.qxmd.com/read/38968918/associations-between-mental-health-symptoms-trauma-quality-of-life-and-coping-in-adults-living-in-ukraine-a-cross-sectional-study-a-year-after-the-2022-russian-invasion
#12
JOURNAL ARTICLE
Shanshan Wang, Emily Barrett, Madelyn Hsiao-Rei Hicks, Dmytro Martsenkovskyi, Irina Holovanova, Olga Marchak, Liudmyla Ishchenko, Ubydul Haque, Nancy Fiedler
We aimed to assess the mental health of adults living in Ukraine one year after onset of the Russo-Ukrainian war, along with quality of life and coping strategies. Quota sampling was used to collect online survey data from 2364 adults aged 18-79 years living in Ukraine from April 5, 2023 to May 15, 2023. Among adults living in Ukraine, 14.4 % had probable post-traumatic stress disorder (PTSD), another 8.9 % had complex PTSD (CPTSD), 44.2 % had probable depressive disorder, 23.1 % had anxiety disorder and 38...
June 26, 2024: Psychiatry Research
https://read.qxmd.com/read/38943787/evaluating-the-psychometric-structure-of-the-hamilton-rating-scale-for-depression-pre-and-post-treatment-in-antidepressant-randomised-trials-secondary-analysis-of-6843-individual-participants-from-20-trials
#13
JOURNAL ARTICLE
David Byrne, Frank Doyle, Susan Brannick, Robert M Carney, Pim Cuijpers, Alexandra L Dima, Kenneth Freedland, Suzanne Guerin, David Hevey, Bishember Kathuria, Emma Wallace, Fiona Boland
BACKGROUND: The 17-item Hamilton Rating Scale for Depression (HRSD-17) is the most popular depression measure in antidepressant clinical trials. Prior evidence indicates poor replicability and inconsistent factorial structure. This has not been studied in pooled randomised trial data, nor has a psychometrically optimal model been developed. AIMS: To examine the psychometric properties of the HRSD-17 for pre-treatment and post-treatment clinical trial data in a large pooled database of antidepressant randomised controlled trial participants, and to determine an optimal abbreviated version...
June 25, 2024: Psychiatry Research
https://read.qxmd.com/read/38943785/increasing-prevalence-of-self-harm-suicidal-behavior-and-suicidal-ideation-throughout-a-three-year-period-in-the-context-of-covid-19-pandemic-in-spain
#14
JOURNAL ARTICLE
Anna Giménez-Palomo, Giovanna Fico, Roger Borràs, Maria Sagué-Vilavella, Marta Gómez-Ramiro, Adriana Fortea, Lydia Fortea, Mireia Vázquez, Eduard Vieta
The COVID-19 pandemic had a great impact on mental health both in the general population and in individuals with preexisting mental disorders. Lockdown, social restrictions, changes in daily habits and limited access to health services led to changes in consultations in mental health services. This study aimed to determine changing trends in psychiatric admissions by the inclusion of adult patients admitted to the Emergency Department (ED) of Hospital Clínic of Barcelona between 2019 and 2021. Acute admissions, social issues and psychiatric diagnoses were compared between years, seasons and considering the interaction between both years and seasons...
June 25, 2024: Psychiatry Research
https://read.qxmd.com/read/38945102/utilization-of-psychiatry-services-in-the-emergency-department-following-a-terror-event-in-israel
#15
JOURNAL ARTICLE
Ligat Shalev, Aviv Avni, Oren Tene, Inbal Reuveni, Keren Avirame, Renana Eitan, Adam J Rose
In October 2023, Israel sustained a massive terror attack, with 1,300 people murdered, over 240 kidnapped, and millions exposed to the horrors. This study's aim is to examine the profile of patients arriving to the emergency department (ED) for psychiatric services during the month following the attack, compared to a similar period the year prior. In this cohort study, we compared patients arriving to the ED of a large general hospital in the center of Tel Aviv for psychiatric services during the month post-attack with the previous year using t-tests and chi-square exams...
June 23, 2024: Psychiatry Research
https://read.qxmd.com/read/38924900/effects-of-medical-cannabis-use-on-physical-and-psychiatric-symptoms-across-the-day-among-older-adults
#16
JOURNAL ARTICLE
Robert D Dvorak, Daniel Paulson, Michael E Dunn, Emily K Burr, Roselyn Peterson, Madison Maynard, Ardhys N De Leon, Samantha J Klaver, Angelina V Leary, Emma R Hayden, Quinn Allen, Ethan Toth
INTRODUCTION: Older adults are increasingly using medical cannabis (MC). It is unclear if therapeutic effects increase problematic use patterns. The current study addresses this issue by examining symptom trajectories across the day and using trajectories to predict problematic use. METHODS: One-hundred six older adults (age range 55-74) who endorsed medical conditions approved for treatment using MC were recruited online. Participants received six text messages/day to assess momentary symptoms for 15 days...
June 23, 2024: Psychiatry Research
https://read.qxmd.com/read/38936179/depression-disparities-among-sexual-minority-faculty-of-color-in-the-united-states
#17
JOURNAL ARTICLE
John P Salerno, Ruth E Zambrana
This study aimed to examine potential differences in depression symptoms between sexual minority (SM) and heterosexual faculty of color (FOC). A United States (U.S.) national survey of early and mid-career faculty experiences was undertaken. A total of N = 676 participants were screened, with a total usable sample size of N = 596 (n = 80 surveys were missing sexual orientation information). Participants were U.S. born and self-identified as African American/Black, Mexican, Puerto Rican, Native American/American Indian, or other Hispanic, and held a tenure-track assistant or associate professor position at a research university...
June 22, 2024: Psychiatry Research
https://read.qxmd.com/read/38924901/theory-of-mind-abilities-during-the-course-of-bipolar-disorder-a-longitudinal-study-using-mixed-models
#18
JOURNAL ARTICLE
Katharina Stix, Nina Dalkner, Susanne A Bengesser, Armin Birner, Frederike T Fellendorf, Alfred Häussl, Melanie Lenger, Alexander Maget, Annamaria Painold, Martina Platzer, Robert Queissner, Franziska Schmiedhofer, Elena Schönthaler, Andreas Schwerdtfeger, Tatjana Stross, Adelina Tmava-Berisha, Bernhard Weber, Human-F Unterrainer, Eva Z Reininghaus
Theory of mind (ToM) deficits, difficulties in recognizing the intentions, propensities, and beliefs of others have been shown in individuals with bipolar disorder in several studies; however, it is not yet elucidated how ToM abilities changes over the course of bipolar disorder and is related to illness symptoms. This is one of the first longitudinal studies to compare the ToM abilities of euthymic bipolar individuals and healthy controls over a four and a half years period. ToM abilities were measured using the Reading the Mind in the Eyes Test (RMET)...
June 22, 2024: Psychiatry Research
https://read.qxmd.com/read/38924899/genetic-testing-in-individuals-experiencing-psychosis-a-practical-guide-for-psychiatrists
#19
LETTER
Mark Ainsley Colijn
No abstract text is available yet for this article.
June 22, 2024: Psychiatry Research
https://read.qxmd.com/read/38959578/glycocalyx-shedding-patterns-identifies-antipsychotic-na%C3%A3-ve-patients-with-first-episode-psychosis
#20
JOURNAL ARTICLE
Helle G Andersen, Brian DellaValle, Hjalte Bøgehave, Phillip Bredahl Mogensen, Margaret K Hahn, Christoffer K Goth, Mikkel E Sørensen, Anne K Sigvard, Karen Tangmose, Kirsten B Bojesen, Mette Ø Nielsen, Simone Tonetto, Mathias L Jørgensen, Casper Hempel, Jørgen Rungby, Birte Y Glenthøj, Karen S Ambrosen, Bjørn H Ebdrup
Psychotic disorders have been linked to immune-system abnormalities, increased inflammatory markers, and subtle neuroinflammation. Studies further suggest a dysfunctional blood brain barrier (BBB). The endothelial Glycocalyx (GLX) functions as a protective layer in the BBB, and GLX shedding leads to BBB dysfunction. This study aimed to investigate whether a panel of 11 GLX molecules derived from peripheral blood could differentiate antipsychotic-naïve first-episode psychosis patients (n47) from healthy controls (HC, n49) and whether GLX shedding correlated with symptom severity...
June 21, 2024: Psychiatry Research
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