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Journals American Journal of Dermatopat...

American Journal of Dermatopathology

https://read.qxmd.com/read/38574087/a-novel-large-deletion-in-the-ever1-gene-in-a-family-with-epidermodysplasia-verruciformis-from-india
#1
JOURNAL ARTICLE
Adithya Christopher Godfred, Zachariah Thomas, Dincy Peter, Anjana Joseph, Lavanya Ravichandran, Anu Anna George, Susanne A Pulimood, Pranay Gaikwad, Ramesh Babu, Meera Thomas, Nihal Thomas, Aaron Chapla
Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis due to mutations in EVER1 and EVER2 genes. The genetic profile of Indian patients with EV has not been previously studied. This report describes the clinical presentation and molecular analysis of a family with EV. Using genomic DNA from two affected probands and healthy controls (two other siblings), conventional polymerase chain reaction (PCR) was conducted with novel primer sets designed to amplify the coding and splice-site regions in the genes EVER1 and EVER 2...
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574081/spiny-keratoderma-clinical-and-histopathological-findings-in-a-series-of-3-cases
#2
JOURNAL ARTICLE
Ailish Hanly, Noel Turner, Christine J Ko, Gauri Panse
Spiny keratoderma is a rare entity presenting with minute keratotic spines on the palms and soles. Spiny keratoderma can be inherited or acquired, and the acquired form may be associated with underlying malignancy or systemic disease. Clinically, the differential diagnosis includes other digitate keratoses on acral sites, most notably arsenical keratosis, filiform verruca, and punctate porokeratosis. Biopsy findings typically include a column of parakeratosis overlying a diminished granular cell layer. In this article, we present 3 cases of acquired spiny keratoderma in patients with various systemic diseases, but no underlying malignancy...
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574066/nail-telocytes-identification-potential-physiological-function-and-role-in-pathology-a-reappraisal-of-the-so-called-onychofibroblasts-onychodermis
#3
JOURNAL ARTICLE
Christophe Perrin
Some authors have suggested that the fibroblasts of the nail mesenchyme (onychofibroblasts) can be distinguished from skin fibroblasts by their high expression of CD10. My 2015 study documented the presence of a relatively sparse CD34+/CD10+ dendritic subpopulation in the dermis and hypodermis of the matrix. For some time now, my hypothesis has been that these interstitial dendritic mesenchymal cells of the matrix correspond to telocytes. Telocytes have been described as peculiar interstitial dendritic cells present in the mesenchymal tissue of numerous organs, including the skin, but their presence and characteristics in the nail unit have not been explored...
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574065/a-tale-of-two-tumors-a-collision-tumor-of-atypical-fibroxanthoma-and-basal-cell-carcinoma
#4
JOURNAL ARTICLE
Dilshad Dhaliwal, Shannon Sayyadioskoie, Hanna Siatecka, Christine Hunt, A Hafeez Diwan
A collision tumor is an infrequent phenomenon characterized by the presence of 2 histologically distinct tumor types (either benign or malignant) occurring within the same specific anatomical site. We describe a rare case of co-occurrence of basal cell carcinoma and atypical fibroxanthoma presenting as a single lesion on the scalp in a 76-year-old man. The lesion was clinically suspicious for basal cell carcinoma and biopsied. Histologic examination showed 2 distinct tumors, one with basaloid cells and the other one with pleomorphic spindle cells colliding and growing together...
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574061/a-case-of-cd4-t-cell-lymphoma-with-gamma-delta-phenotype-incidentally-manifesting-in-a-wound-debridement-sample
#5
JOURNAL ARTICLE
Paige E Adams, Vida Ehyayee, Aadil Ahmed
We report an 85-year-old male patient with a medical history significant for psoriasis who presented with a thigh wound that expanded slowly over the course of 9 months. The patient was previously treated with amputation of hand digits for osteomyelitis. Histologic examination of the tissue sample revealed a broad ulceration with large areas of necrosis extending into the subcutis. The edge of the specimen also revealed a nodular lymphoid infiltrate in the subcutaneous adipose tissue composed of atypical cells...
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574055/post-traumatic-bullous-pilomatrixoma-exploring-the-pathogenesis
#6
JOURNAL ARTICLE
Jesús I Martínez-Ortega, Grisell Ortega-Valerio, Arely G Ramirez-Cibrian
This report demonstrates the rare variant of bullous pilomatrixoma in a 10-year-old boy who presented with a rapidly growing, red-colored, bullous nodule on his neck after trauma. The exact etiology of this subtype of pilomatrixoma is unclear, but previous studies have suggested that mechanical trauma may trigger its development.
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574053/a-case-of-eruptive-xanthoma-with-the-lipidization-of-keratinocytes
#7
JOURNAL ARTICLE
Kai-Yi Zhou, Li-Wei Ran, Sheng Fang
No abstract text is available yet for this article.
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574049/lymphangitic-melanomatosis-case-report-of-intralymphatic-spread-of-melanoma-in-a-66-year-old-man
#8
JOURNAL ARTICLE
Shantanu Srivatsa, Collin-Jamal Smith, Omar P Sangüeza, Jayson Miedema, Frances A Collichio, Paul B Googe
Melanoma with lymphatic invasion has been associated with increased risk of metastasis, but the mechanisms and clinical implications are poorly understood. Although current reports have documented angiotropic spread of melanoma and suggest lymphatic spread of melanoma to increase the likelihood of metastasis, to our knowledge, lymphangitic metastatic melanoma resembling cutaneous carcinomatosis or presenting with facial hyperpigmentation has not been described. In this case report, we describe extensive cutaneous intralymphatic spread of melanoma, or lymphangitic melanomatosis, producing macular skin pigmentation in a 66-year-old man...
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574048/granulomatous-slack-skin-with-lung-and-esophagus-involvement-a-case-report-and-molecular-analysis
#9
JOURNAL ARTICLE
Filipa Galante Pereira, Gonçalo Esteves, Joaninha Costa Rosa, José Cabeçadas, Mariana Cravo, Maria Inês Matos Silva Barbosa Pereira, Alistair Robson
Granulomatous slack skin (GSS) is a rare subtype of mycosis fungoides, and few cases have been known to spread to the blood, lymph nodes, or viscera. We present a case with early dissemination to the lung. A 27-year-old woman, previously healthy, presented with scattered disseminated scaly patches, associated with vulvar and intergluteal firm swelling and groin-skin induration for 1 year. She also reported mild fatigue and breathlessness on moderate exertion. The patient underwent blood tests, skin biopsies, and computed tomography scan...
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38574041/cutaneous-syncytial-myoepithelioma-an-uncommon-and-distinct-variant-of-cutaneous-epithelioid-neoplasm
#10
JOURNAL ARTICLE
Nada Shaker, Robert Phelps, George Niedt, Omar P Sangueza, Julie Youngs, Scott Lauer, Dinesh Pradhan
BACKGROUND: Cutaneous syncytial myoepithelioma (CSM) is an uncommon and distinct variant of cutaneous myoepithelioma. We aim to present a case of CSM to enhance the recognition of this unique variant, encompassing its clinical characteristics, histopathological features, immunohistochemical staining, and therapeutic approaches. CASE PRESENTATION: A 10-year-old girl presented with a dome-shaped nodule located on the skin of her left medial distal arm. Microscopic examination of the skin biopsy revealed a well-defined dermal nodular lesion, surrounded by an epidermal collarette...
April 4, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38513131/cutaneous-collagenous-vasculopathy-a-short-case-series-and-literature-review
#11
JOURNAL ARTICLE
Anahita T Kodali, Meghana Agni, Arthur Marka, Denise Aaron, Jeffrey M Cloutier, Aravindhan Sriharan
Cutaneous collagenous vasculopathy (CCV) is a rare and idiopathic microangiopathy of superficial dermal blood vessels. There have been 75 cases described in the literature to date, not including the current report; however, given its clinical similarity to other primary telangiectasias, it is likely to be underreported and underdiagnosed. Here, we describe the clinical and histological features of 2 patients we newly diagnosed with CCV. Both generally fit the profile of prior cases and confirm previously described associations-they both are older White women, have rashes on their lower extremities, and have conditions and medications that are common among other reported cases...
March 19, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38513122/melanocytic-acral-nevus-with-intraepidermal-ascent-of-cells-five-cases
#12
JOURNAL ARTICLE
Angel Gabriel Boscolo Ruivo, Marcel Arakaki Asato, Luis Fernando Ferrari, Denise Rodrigues Poletto, Roberto Coelho Okida, Jose Candido Caldeira Xavier-Júnior
No abstract text is available yet for this article.
March 19, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38513120/melanocyte-density-in-the-diagnosis-of-melanoma-in-situ-in-sun-damaged-skin
#13
JOURNAL ARTICLE
Rieke Löper, Michael P Schön, Christina Mitteldorf
Histologic differentiation between melanoma in situ in chronically sun-damaged skin (CSDS) [lentigo maligna (LM)] and CSDS without malignancy is difficult because signs of melanocyte activation and proliferation are found in both. A potentially reliable and quantifiable criterion is melanocyte density (MD). Here, we evaluated whether and to what extent MD allows the distinction between LM and CSDS, which is particularly relevant for the evaluation of borderline cases and surgical margins.Articles assessing MD in LM and/or CSDS were evaluated in a systematic review...
March 19, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38513115/onychocytic-matricoma-a-clinical-dermoscopic-and-pathological-analysis-of-14-cases
#14
JOURNAL ARTICLE
Christophe Perrin, Michael Coutts, Feriel Boukari, Damien Ambrosetti
Onychocytic matricoma (OCM) is a benign neoplasm of the nail matrix. Only 18 cases of this tumor have been reported in the literature to date. We retrospectively analyzed the clinical features of 14 patients with OCM. The most common clinical feature was longitudinal xanthopachyonychia (n = 9), followed by longitudinal leukopachyonychia (=3) and longitudinal pachymelanonychia (n = 2). The most common clinical findings identified following dermoscopy and analysis at high magnification of classical photographs were free-edge thickening of the nail plate without pitting (n = 14), longitudinal ridging (n = 7), round white clods (n = 7), white dots (n = 7), and filiform hemorrhages (n = 7), followed by oval and linear white clods (n = 5), fuzzy lateral border (n = 5), and red-purple blood clods (n = 3)...
March 19, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38513130/chronic-radiation-dermatitis-secondary-to-narrow-band-ultraviolet-b-therapy-in-a-patient-with-primary-cutaneous-cd8-t-cell-lymphoma-with-cytotoxic-granules
#15
JOURNAL ARTICLE
Mia P Edelson, Jane J Gay, Robert W Thiel, Douglas J Grider
Conventional therapies for CD8+ cutaneous T-cell lymphoma include topical steroids, topical nitrogen mustard, topical bexarotene, ultraviolet B therapy, psoralen and ultraviolet A therapy, local radiotherapy, and interferon alfa; however, these treatments are often found to be ineffective. Presented is a case of CD8+ cutaneous T-cell lymphoma with near-complete response to narrow-band ultraviolet therapy because of chronic radiation dermatitis initially believed to be possible progression of a CD8+ cutaneous epidermotropic cytotoxic T-cell lymphoma...
March 12, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38513123/cocaine-induced-plasma-cell-orificial-dermatomucositis-a-more-accurate-descriptive-term-for-a-clearly-dermatological-entity
#16
JOURNAL ARTICLE
Angel Fernandez-Flores, José Manuel González Montero
Although the involvement of the nasal passages and nasal septum in cocaine users has been known for decades, a new presentation affecting the nostrils and upper lip with an inflamed appearance has recently been documented. The authors who identified this presentation termed it "cocaine-related plasma cell mucositis" due to the abundance of plasma cells in the infiltrate. In this article, we present a second case and emphasize the dermal involvement of the lip, leading us to consider the condition as a genuine dermatomucositis...
March 12, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38457743/a-case-of-early-morphea-mimicking-hypopigmented-mycosis-fungoides-in-a-pediatric-patient
#17
JOURNAL ARTICLE
Michelle D Colbert, Molly J Youssef, Julia S Lehman, Emma F Johnson
No abstract text is available yet for this article.
March 8, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38457692/cutaneous-hydrophilic-polymer-embolism-an-important-and-overlooked-clinical-entity
#18
JOURNAL ARTICLE
Kimberly Pei Rui Chan, Joyce Siong See Lee, Joel Hua Liang Lim
Hydrophilic polymer embolism from vascular medical devices is an underrecognized clinical entity that can cause deleterious end-organ ischemia and culminate in mortality. This is concerning as we are in the era where minimally invasive procedures are commonplace. Diagnosis is often made retrospectively after obtaining histopathological tissue samples showing endoluminal, cerebriform, amorphous, anucleate, basophilic, nonrefractile, nonpolarizable foreign body material. We detail 2 more cases of cutaneous hydrophilic polymer embolism to underscore its salient clinicopathological features and increase awareness of this important iatrogenic entity...
March 8, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38457690/metastatic-tonsil-squamous-cell-carcinoma-an-important-consideration-in-the-differential-diagnosis-of-malignant-basaloid-neoplasms-in-the-skin-case-report-and-review-of-the-literature
#19
JOURNAL ARTICLE
Bradley T Thigpen, Ronald B Johnston, Alessio Giubellino, Diana O Mogrovejo, Ashok R Jethwa, Willmar D Patino
Malignant basaloid neoplasms of the skin are frequent, and their accurate diagnosis holds paramount importance for treatment and prognosis. However, these neoplasms can present diagnostic challenges because of their extensive differential diagnosis, which encompasses cutaneous metastasis among many other possibilities. We present a case of a 74-year-old man with a history of p16-positive palatine tonsil squamous cell carcinoma (SCC) treated with surgery and adjuvant radiation with no prior evidence of recurrence who presented to the dermatologist with 2 chin papules...
March 8, 2024: American Journal of Dermatopathology
https://read.qxmd.com/read/38457688/perineural-inflammation-as-a-novel-feature-in-lichen-sclerosus-a-case-series-of-histologic-and-clinical-features
#20
JOURNAL ARTICLE
Joshua Del Papa, Aine Celestina Pucchio, Mark Schneider, Ami Wang
Lichen sclerosus (LS) is a frequently encountered inflammatory skin disorder characterized by whitened, atrophic patches that can cause pain and pruritus. The underlying cause of this condition remains unknown. Primarily affecting the genital area, this condition carries an increased risk of developing cutaneous cancers and frequently co-occurs with autoimmune disorders. Our retrospective study aimed to explore histologic features of LS, with a particular focus on a newly established finding and its potential implications...
March 8, 2024: American Journal of Dermatopathology
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