Boulos Mansour, Tomas Vanecek, Liubov Kastnerova, Daniel Nosek, Dmitry V Kazakov, Michele Donati
Spitz tumors are melanocytic neoplasms characterized by specific, mutually exclusive driver molecular events, namely genomic rearrangements involving the threonine kinase BRAF and the tyrosine kinase receptors ALK, NTRK1, NTRK2, NTRK3, MET, RET, ROS1, and MAP3K8 or less commonly, mutations in HRAS or MAP2K1. We hereby report 5 Spitz tumors with a SQSTM1::NTRK2 fusion. All patients were woman with the ages at diagnosis ranging from 30 to 50 years. Locations included the lower extremity (n = 3), forearm, and back (one each)...
March 20, 2023: American Journal of Dermatopathology