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American Journal of Dermatopathology

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https://read.qxmd.com/read/30730394/spontaneous-hair-repigmentation-in-an-80-year-old-man-a-case-of-melanoma-associated-hair-repigmentation-and-review-of-the-literature
#1
Cynthia Chan, Cynthia M Magro, Anh Khoa Pham, Robert E LeBlanc, Shaofeng Yan, Dorothea T Barton, Nicole C Pace, M Shane Chapman, Shabnam Momtahen
Spontaneous hair repigmentation of physiologically white or gray hair is a rare occurrence that may be associated with melanoma in elderly individuals. We present the first case of this phenomenon in a man. A gray-haired, 80-year-old man presented to dermatology clinic with a 3-cm lock of black hair on his vertex scalp that developed over 1 year. Punch biopsies showed an increase in junctional dendritic melanocytes with rare pagetoid cells and extension along the follicular outer root sheath epithelium and interfollicular epidermis, associated with prominent dendritic melanocytic hyperplasia and pigment-containing melanocytes within the hair bulbs...
January 29, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30730393/retiform-purpura-after-percutaneous-angioplasty-challenge
#2
Cristina López-Sánchez, Caterina Fumagalli, Ana Mozos, Víctor Flores-Climente, Eduardo Rozas-Muñoz
No abstract text is available yet for this article.
January 29, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30730392/skin-colored-nodule-on-the-cutaneous-lip-challenge
#3
Ashley E Brown, Gabriel Isaza-Gonzalez, Jason B Lee, Sylvia Hsu
No abstract text is available yet for this article.
January 29, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30730391/collision-of-subungual-neurofibroma-and-onychomatricoma-s100-positivity-as-a-clue
#4
Mar Llamas-Velasco, Pablo Espinosa, Enrique Ovejero-Merino, Yosmar Carolina Pérez-González
We present a 41-year-old man with a hemionychodystrophy of the first toe, appearing as a longitudinal thickening of the nail plate, overcurved and with holes in its thickened free margin, thus leading to the clinical diagnosis of onychomatricoma. Complete excision showed typical nail plate of onychomatricoma and, underlying it, curvy disorganized neural-looking fascicles without atypia and with diffuse positivity for S100, interpreted as subungual neurofibroma (NF). Subungual NF is a very rare tumor, with only 12 previous cases reported...
January 29, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30730390/a-unique-and-rare-case-of-extramammary-paget-disease-with-concomitant-herpes-simplex
#5
Valencia Long, Liang W T Michelle, Lee S S Joyce
We describe a rare and unique case of extramammary Paget disease in the genitals with concomitant histological features of herpes virus infection. This is a very rare and interesting association that has only been reported in 1 article in the literature so far.
January 29, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30702455/intraoral-cutaneous-hamartomas-clinicopathologic-and-immunohistochemical-characteristics-of-3-cases
#6
Peter E Wilkinson, Rajaram Gopalakrishnan, Prokopios P Argyris
Intraoral cutaneous hamartomas (ICHs) are uncommon mucosal lesions characterized microscopically by a combination of cutaneous structures, including various stages of follicular and sebaceous elements. Due to their rarity, the clinicopathologic and immunohistochemical attributes of ICHs have not been thoroughly delineated. Three cases of ICH were identified from our records, and formalin-fixed paraffin-embedded sections were immunohistochemically stained with antibodies against androgen receptor, estrogen receptor, and progesterone receptor, p63, factor XIIIα, and CD34...
January 22, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30702454/superficial-cd34-positive-fibroblastic-tumor-a-case-report-and-review-of-the-literature
#7
Teng-Li Lin, Chi-Shun Yang, Chao-Kuei Juan, Yu-Ching Weng, Yi-Ju Chen
No abstract text is available yet for this article.
January 22, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30702453/a-reactive-peripheral-gamma-delta-t-cell-lymphoid-proliferation-after-a-tick-bite
#8
Seth M Martin, Richard Flowers, Arturo P Saavedra, Alejandro A Gru
Peripheral gamma-delta T-cell proliferations are encountered in reaction to certain infections and in primary malignancies. Identifying sources of benign reactions is key in avoiding unnecessary workup and surveillance of these aggressive malignancies. Borrelia infections have been implicated in a number of lymphoproliferative disorders, but rarely, if ever, in this setting. While gamma-delta T-cells are known to play a prominent role in the immune response to Borrelia infection, B-cell differentiation is encountered in the majority of Borrelia-associated proliferations...
January 22, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30663996/multiple-papules-on-an-elderly-man-challenge
#9
Aubrey Allen, Richard S Lewis, John A Papalas, Omar P Sangueza
No abstract text is available yet for this article.
January 14, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30640763/a-perianal-mass-associated-with-eosinophilic-granulomatosis-with-polyangiitis-challenge
#10
Siobhan McCarthy, Lisa Murphy, Morgan McCourt, David Curran, Michelle Murphy, James Fitzgibbon
No abstract text is available yet for this article.
January 11, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30640762/lack-of-deletion-of-1p36-in-8-cases-of-primary-adenoid-cystic-carcinoma-of-the-skin
#11
Liubov Kyrpychova, Petr Šteiner, Michal Michal, Dmitry V Kazakov
No abstract text is available yet for this article.
January 11, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30640761/hailey-hailey-like-pattern-of-acantholysis-on-the-scalp-should-raise-the-possibility-of-incipient-pemphigus-vulgaris
#12
Silvija P Gottesman, Syed M Abedi, Jason R Rosen, Geoffrey J Gottlieb
Hailey-Hailey disease (familial benign chronic pemphigus) is a genodermatosis with a typical clinical presentation of macerated plaques involving intertriginous areas of the body and affects multiple family members. Epidermal acanthosis, incipient, and completed acantholysis of many of the spinous keratinocytes of the epidermis and foci of dyskeratosis are well-recognized histologic findings. We have observed solitary lesions on the "scalp" of patients having a Hailey-Hailey-like pattern, and not the suprabasilar clefting of pemphigus represents the first manifestation of pemphigus vulgaris, which was confirmed with direct immunofluorescence in all our patients...
January 11, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30640760/reflectance-confocal-microscopy-features-of-plaque-psoriasis-overlap-with-horizontal-histopathological-sections-a-case-series
#13
Anna Elisa Verzì, Francesco Lacarrubba, Rosario Caltabiano, Giuseppe Broggi, Maria Letizia Musumeci, Giuseppe Micali
Reflectance confocal microscopy (RCM) displays horizontal, en face tissue sections of the epidermis and upper dermis, and interpretation of its features is classically based on the comparison with vertical conventional histopathological sections that, as known, do not reflect the same plane of observation. In 10 patients affected by psoriasis, we correlated RCM images with horizontal histopathological sections from skin biopsies, observing in all cases marked overlaps between the 2 techniques. Although vertical section examination remains the gold standard for the diagnosis of psoriasis, this novel comparative approach may contribute to a more precise definition of RCM findings and could represent the drive for further research as well as an innovative tool for educational purposes...
January 11, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30640759/a-large-crusted-nodule-on-the-upper-ear-challenge
#14
Ali Rashidbaigi, Hannah Kopelman, Bonnie A Lee
No abstract text is available yet for this article.
January 11, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30640758/rare-presentation-of-a-rare-cutaneous-neoplasm-nonacral-sclerosing-perineuroma
#15
Alexis J Lukach, Kevin M Donnelly, Carrie A Cusack
Sclerosing perineuromas are rare, benign peripheral nerve sheath tumors classically reported on the fingers and palms of young men. We present the case of a 12-year-old boy with a slow-growing nodule on his right knee. Excision was performed, and pathology was consistent with a sclerosing perineuroma. This case highlights an atypical presentation of a rare lesion and provides useful knowledge of the clinical scenarios in which sclerosing perineuromas should be included in a differential diagnosis.
January 11, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30640757/histological-features-of-flagellate-erythema
#16
Daniel Ching, Benjamin A Wood, Shevya Tiwari, Jonathan Chan, Nathan T Harvey
Flagellate erythema is a distinctive eruption characterized by "whip-like" linear or curvilinear streaks and plaques, occurring mainly on the trunk. It has classically been described in 2 disparate clinical settings: chemotherapy with bleomycin and ingestion of mushrooms (most commonly Shiitake mushrooms). Most of the literature comprises single case reports, often with minimal histological description of rather nonspecific features. We describe in detail the histological features of 3 cases of flagellate erythema (2 related to bleomycin therapy and one related to ingestion of mushrooms) and review the findings described in the literature to define the spectrum of histological changes encountered in this eruption...
January 11, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30640756/high-risk-human-papillomavirus-e6-e7-mrna-is-rarely-detected-in-nonanogenital-cutaneous-squamous-cell-carcinoma-an-rna-in-situ-hybridization-based-tissue-microarray-study
#17
Masakazu Fujimoto, Ibu Matsuzaki, Yuichi Takahashi, Yoshifumi Iwahashi, Kenji Warigaya, Fumiyoshi Kojima, Masatoshi Jinnin, Shin-Ichi Murata
High-risk human papillomavirus (HR-HPV) is known to play an oncogenic role in squamous cell carcinoma (SCC) at certain anatomical sites, namely the uterine cervix, oropharynx, and anogenital skin. However, the association between HR-HPV and nonanogenital cutaneous SCC (CSCC) remains controversial. In this study, we addressed this controversy by performing HR-HPV E6/E7 mRNA in situ hybridization (ISH) on 243 CSCC samples. A cocktail of E6/E7 mRNA ISH probes, recognizing 18 HR-HPV genotypes, was applied to a tissue microarray of paraffin-embedded sections of 154 invasive and 89 in situ CSCC specimens...
January 11, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30648991/the-life-and-work-of-felix-pinkus-a-reminder-on-the-occasion-of-his-150th-birthday
#18
Wolfgang Weyers
No abstract text is available yet for this article.
January 10, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30624245/primary-orbital-synovial-sarcoma-mimicking-a-periocular-cyst
#19
Francesca Portelli, Giulia Pieretti, Nicola Santoro, Greta Gorelli, Vincenzo De Giorgi, Daniela Massi, Angelo Paolo Dei Tos, Cinzia Mazzini
Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma occurring predominantly in older children and young adults. Only approximately 7% occur in the head and neck region, with SS representing less than 0.1% of all head and neck cancers. Orbital location is exceedingly rare with only 8 cases reported so far in the literature. It is noted for its propensity for late local recurrences and metastases. Histologically, SS is monophasic, biphasic, or poorly differentiated and harbors a specific chromosomal translocation t(X;18)(p11...
January 3, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30624244/primary-cutaneous-anaplastic-lymphoma-kinase-positive-large-b-cell-lymphoma
#20
Werner Kempf, Rocco Torricelli, Andreas Zettl, Anne-Katrin Zimmermann, Arbeneshe Berisha, Michele Ghielmini
Large B-cell lymphomas include several subtypes. Recently, anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma has been delineated as a distinct entity involving mostly lymph nodes and rarely affecting extranodal sites. We describe the first case of a primary cutaneous ALK-positive large B-cell lymphoma in a 48-year-old man with a solitary nodule on the back, and describe the histologic and phenotypic features. Accurate staging confirmed the absence of other lesions, and so surgical excision and postoperative local radiation therapy were initiated and resulted in complete remission...
January 3, 2019: American Journal of Dermatopathology
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