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Journals American Journal of Dermatopat...

American Journal of Dermatopathology

https://read.qxmd.com/read/36939143/radiotherapy-associated-cutaneous-mastocytosis-in-a-patient-with-breast-carcinoma-case-report-and-review-of-the-literature
#1
JOURNAL ARTICLE
Michael Murphy, Rodolfo Valentini, Emily Shaughnessy
Mast cell skin disease is rarely described after external beam radiation therapy in patients with breast carcinoma, with only 7 previous reports in the literature. Skin changes typically occur within (but are not limited to) the radiation field. We present a 64-year-old woman with postradiotherapy cutaneous mastocytosis on the left breast and adjacent chest wall. The clinical and laboratory findings in all reported patients, including the current case, are reviewed. No clear mechanism has been presented to explain disease pathogenesis; although, mast cell accumulation secondary to local mediators produced in response to radiation damage and/or koebnerization phenomenon have been proposed...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939136/random-skin-biopsy-for-diagnosis-of-intravascular-large-b-cell-lymphoma-a-case-report-and-literature-review
#2
JOURNAL ARTICLE
Yuanjie Lv, Lingen Xu, Xiaoping Liu, Yaling Wang
BACKGROUND: Intravascular large B-cell lymphoma (IVLBCL) is a rare, aggressive B-cell lymphoma. The heterogeneity of its clinical symptoms makes it hard to be diagnosed. The diagnosis is followed by pathological examination of affected tissues and organs including skin, central nervous system, and bone marrow. Random skin biopsy (RSB) with high sensitivity and less invasiveness becomes a common method for diagnosis in suspected patients without skin lesions. CASE REPORT: We reported the case of a 67-year-old man who complained of fever, dizziness, unsteady gait, numbness in both lower extremities, and incontinence...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939135/apocrine-papillary-hidrocystoma-with-mucinous-metaplasia-goblet-cell-type-a-case-report-and-review-of-the-literature
#3
JOURNAL ARTICLE
Jonathan Epperson, Wilma Bergfeld
Mucinous metaplasia (goblet cell type) is exceptionally rare in the skin. This is the second case of apocrine papillary hidrocystoma with mucinous metaplasia (goblet cell type) and a review of the literature exploring the significance and frequency of mucinous metaplasia with goblet cells in nongenital skin. The patient is an elderly man who presented with a blue-pigmented nodule on the scalp that was clinically suggestive of an atypical nevus. Histologically, the lesion was composed of a simple cyst of cuboidal cells with decapitation secretion and mucinous metaplasia with goblet cells...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939134/agminated-halo-nevus-a-novel-presentation
#4
JOURNAL ARTICLE
Hussein M M Hassab-El-Naby, Mahmoud A Rageh
Halo nevus is a benign type of melanocytic nevi commonly found in children and manifests as a central pigmented part surrounded by a well-defined hypopigmented area. Halo nevi are commonly located on the trunk. The central nevus may show partial or complete regression, whereas the associated halo may persist or enlarge. The term 'agminated nevus' refers to a cluster of melanocytic nevi restricted to an area of the body and commonly reported with acquired melanocytic nevi, blue nevi, and Spitz nevi. To the best of our knowledge, agminated halo nevus has not been previously described...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939133/a-rare-case-of-hydrophilic-polymer-embolization-after-transcatheter-aortic-valve-replacement
#5
JOURNAL ARTICLE
Alanna Shefler, Scott C Blaszak, Christopher R Shea, Angad A Chadha
Endovascular procedures that use a hydrophilic polymer-coated device carry a risk of embolization and ischemic complications when used intravascularly. Because these coatings are increasingly used worldwide, it is important to identify potential adverse effects early. Cutaneous complications of hydrophilic polymer emboli are rare and not commonly described in the literature. Therefore, we report a case of hydrophilic polymer embolization with cutaneous findings in a patient who underwent a recent transcatheter aortic valve replacement...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939132/type-2-dermal-dendrocytes-are-telocytes-and-so-should-they-be-called
#6
JOURNAL ARTICLE
Angel Fernandez-Flores, David S Cassarino
No abstract text is available yet for this article.
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939130/lymphomatoid-papulosis-type-e-affecting-the-palate-a-detailed-case-report-and-review-of-literature
#7
JOURNAL ARTICLE
Heitor Albergoni Silveira, Paula Verona Ragusa Silva, Bruna Gonçalves Pimentel, Gustavo Milhomens Nogueira, Fernando Chahud, Mariângela Ottoboni Brunaldi, Jorge Esquiche León
Lymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30+ lymphoproliferative disorders, characterized by chronic, recurrent, self-healing papules, small nodules, or ulcers. The clinicopathological features of LyP can mimic overt lymphomas. To date, about 27 intraoral LyP cases have been reported. Of them, only 2 cases were diagnosed as angioinvasive LyP (type E). Herein, we report a 24-year-old Brazilian man who presented a large ulcerated lesion on the hard palate with rapid evolution...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939129/gain-of-ccnd1-may-occur-too-infrequently-in-cutaneous-melanoma-and-too-late-in-melanomagenesis-to-be-diagnostically-useful-genomic-analysis-of-88-cases
#8
JOURNAL ARTICLE
Jason R McFadden, Advaita S Chaudhari, Mirjana Stevanovic, Gregory J Tsongalis, Edward G Hughes, Aravindhan Sriharan
Genomic analysis is an important tool in the diagnosis of histologically ambiguous melanocytic neoplasms. Melanomas, in contrast to nevi, are characterized by the presence of multiple copy number alterations. One such alteration is gain of the proto-oncogene CCND1 at 11q13. In melanoma, gain of CCND1 has been reported in approximately one-fifth of cases. Exact frequencies of CCND1 gain vary by melanoma subtype, ranging from 15.8% for lentigo maligna to 25.1% for acral melanoma. We present a cohort of 72 cutaneous melanomas from 2017-2022 in which only 6 (8...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939128/skin-barrier-function-and-its-relationship-with-il-17-il-33-and-filaggrin-in-malar-melasma
#9
JOURNAL ARTICLE
Juan Pablo Castanedo-Cázares, Juan Diego Cortés-García, Gabriela Pérez-Coronado, Diana Hernández-Blanco, Bertha Torres-Alvarez
BACKGROUND: The pathogenesis of melasma remains unclear. Interleukin (IL)-17, a proinflammatory mediator, disturbs barrier function. Filaggrin (FLG) is a protein involved in epidermal barrier homeostasis and may be affected by IL-17 and IL-33. OBJECTIVE: To evaluate epidermal barrier function in malar melasma and its association with the expression of FLG, IL-17, and IL-33. METHODS: Twenty patients with malar melasma were included in this study...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939127/no-more-cavernous-hemangioma-please
#10
JOURNAL ARTICLE
Angel Fernandez-Flores, David S Cassarino, Isabel Colmenero
No abstract text is available yet for this article.
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939126/vesicular-lymphomatoid-papulosis-with-dusp22-irf4-rearrangement-on-chromosome-6p25-3-a-case-report
#11
JOURNAL ARTICLE
Po-Yang Pan, Jia-Bin Liao, Shu-Min Hsieh, Hui-Wen Tseng
Lymphomatoid papulosis (LyP) with DUSP22-IRF4 rearrangement on chromosome 6p25.3 is a newly identified subtype of LyP. It is characterized by an older age of onset, localized skin lesions, with good prognosis, and it resembles a hybrid of LyP types B and C in histopathology. A limited number of cases have been reported so far. In this article, we reported a case of a 72-year-old man with recurrent episodes of widespread multiple discrete papular or vesicular eruptions on a region of the head, trunk, and 4 extremities for about 3 years...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939122/herpesvirus-infection-masquerading-as-a-neoplasm-in-an-hiv-positive-patient-a-potential-diagnostic-pitfall
#12
JOURNAL ARTICLE
Kaitlyn Levett, Julie Youngs, Claire Hoppenot, Ramya P Masand
Herpesvirus infection classically presents as a clustered, vesicular rash over mild erythema. However, unusual presentations may mimic tumors and be a potential pitfall. We describe the case of a 55-year-old HIV positive woman with this unusual manifestation of a common disease which was initially diagnosed as a benign neoplasm. Review of pathology revealed histologic features characteristic of this form of herpesvirus eruption. Awareness of this rare clinical and microscopic presentation is important to guide appropriate use of immunostains, prevent misdiagnosis, and promptly institute of antiviral therapy...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36939120/spitz-tumor-with-sqstm1-ntrk2-fusion-a-clinicopathological-study-of-5-cases
#13
JOURNAL ARTICLE
Boulos Mansour, Tomas Vanecek, Liubov Kastnerova, Daniel Nosek, Dmitry V Kazakov, Michele Donati
Spitz tumors are melanocytic neoplasms characterized by specific, mutually exclusive driver molecular events, namely genomic rearrangements involving the threonine kinase BRAF and the tyrosine kinase receptors ALK, NTRK1, NTRK2, NTRK3, MET, RET, ROS1, and MAP3K8 or less commonly, mutations in HRAS or MAP2K1. We hereby report 5 Spitz tumors with a SQSTM1::NTRK2 fusion. All patients were woman with the ages at diagnosis ranging from 30 to 50 years. Locations included the lower extremity (n = 3), forearm, and back (one each)...
March 20, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36825932/lichen-planopilaris-pemphigoides-a-novel-bullous-dermatosis-due-to-programmed-cell-death-protein-1-inhibitor-therapy
#14
JOURNAL ARTICLE
Shuo S Liu, Tara Howard, Yasmin H Fattah, Amy Adams, Andrew J Hanly, Laszlo J Karai
Lichen planus pemphigoides (LPPemph), apart from bullous pemphigoid, is a rare bullous dermatosis that can be induced by programmed cell death protein-1 (PD-1)/PD ligand 1 (PD-L1) inhibitors. The primary location of PD-1/PD-L1 inhibitor-induced LPPemph has previously only been reported at the nonfollicular dermal-epidermal junction. We present a case of nivolumab-induced LPPemph with an intense perifollicular lichenoid reaction, prominent multifocal perifollicular clefting, which in addition, was also accompanied by linear IgG and C3 immunofluorescence deposits along the dermal-epidermal junction as well as demonstrating a perifollicular pattern...
February 22, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36898007/tert-promoter-mutational-analysis-as-an-ancillary-diagnostic-tool-for-diagnostically-challenging-melanocytic-neoplasms
#15
JOURNAL ARTICLE
Anastasiya Boutko, Sepideh Asadbeigi, Andrew Roth, Nathaniel Lampley, Shantel Olivares, David Dittmann, David Dittmann, Lawrence Jennings, Pedram Gerami
Telomerase reverse transcriptase promoter mutations (TPMs) have been shown to be common in melanoma and uncommon in benign nevi. To assess the use of TPMs as an ancillary diagnostic tool, we report the concordance of the TPM status with the final diagnosis in clinical cases with distinct differential diagnostic scenarios: dysplastic nevus versus melanoma, atypical Spitz nevus versus melanoma, atypical deep penetrating nevus (DPN) versus melanoma, and atypical blue nevus versus malignant blue nevus. In a control cohort, we found a positive TPM in 51/70 (73%) of the total melanomas with the highest frequency in vertical growth phase melanoma cases...
February 17, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36806052/pseudolymphoma-to-lymphoma-a-case-of-chronic-reactive-lymphoid-hyperplasia-transforming-to-primary-cutaneous-marginal-zone-lymphoma
#16
JOURNAL ARTICLE
Neha Singh, Kiley K Fagan, Riya T Patel, Douglas J Grider
Primary cutaneous marginal zone lymphoma (PCMZL) is a low-grade malignant B-cell lymphoma that originates from the skin. It often presents as erythematous solitary or multiple papules, nodules, and/or plaques. It is one of the 3 main subtypes of primary cutaneous B-cell lymphomas. PCMZLs are believed to develop from chronic antigenic stimulation such as from tick-borne bacteria, vaccines, tattoo pigment, or other foreign body. In addition, cutaneous lymphoid hyperplasia, a documented precursor to malignant PCMZL, often presents in response to areas of chronic inflammation...
February 17, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36805540/perifollicular-microscarring-in-alopecia-areata-and-pattern-hair-loss
#17
JOURNAL ARTICLE
John Plante, Manuel Valdebran, Jessica Forcucci, John Bosland, Amira Elbendary, Richa Jaiswal, Dirk Elston
No abstract text is available yet for this article.
February 17, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36805355/disseminated-protothecosis-due-to-prototheca-zopfii-and-literature-review
#18
JOURNAL ARTICLE
Feifan Chen, Mario Saab-Chalhoub, Joy Tao, Amanda T Harrington, Fritzie S Albarillo, Andrew S Crone, Nina M Clark, Jodi J Speiser
Prototheca species are achlorophyllic algae that are a rare cause of infection in humans. It most commonly causes localized cutaneous disease and rarely disseminated infection. Immunocompromised patients have the highest risk of disseminated protothecosis, with a higher mortality rate than localized cutaneous infections. At the species level, infections caused by Prototheca zopfii are reported less frequently than those caused by Prototheca wickerhamii. The diagnosis can be made using histopathology, culture, and molecular testing...
February 17, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36801831/langerhans-cell-histiocytosis-evolving-into-juvenile-xanthogranuloma-two-linked-entities
#19
JOURNAL ARTICLE
Nada Shaker, Omar P Sangueza
BACKGROUND: Langerhans cell histiocytosis (LCH) represents a myeloid clonal proliferation that involves the skin and other organs. Occasionally, cases of LCH evolve into juvenile xanthogranuloma (JXG). CASE PRESENTATION: A 7-month-old boy presented with an itchy, flaky rash resembling seborrheic dermatitis affecting the scalp and eyebrows. The lesions started at 2 months old. On physical examination, there were reddish/brown lesions on the trunk, denuded areas on the groin and neck, and a large lesion behind his bottom teeth...
February 17, 2023: American Journal of Dermatopathology
https://read.qxmd.com/read/36791334/radiation-induced-localized-bullous-pemphigoid
#20
JOURNAL ARTICLE
Neelesh Jain, Diane Whitaker-Worth, Michael J Murphy
No abstract text is available yet for this article.
February 8, 2023: American Journal of Dermatopathology
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