journal
MENU ▼
Read by QxMD icon Read
search

Journal of Veterinary Pharmacology and Therapeutics

journal
https://read.qxmd.com/read/31410874/changes-in-the-oxidative-stress-factors-and-inflammatory-proteins-following-the-treatment-of-bph-induced-dogs-with-an-anti-proliferative-agent-called-tadalafil
#1
Nooshin Dearakhshandeh, Asghar Mogheiseh, Saeed Nazifi, Mohammad Saeed Ahrari Khafi, Mohammad Abbaszadeh Hasiri, Kamran Golchin-Rad
BACKGROUND: Finding a medical treatment which can combat cell proliferation and relax smooth muscles in canine benign prostatic hyperplasia (BPH) appears to be imperative. AIMS: This study aimed to evaluate the oxidative stress and inflammatory proteins following the treatment of dogs induced for BPH with an anti-proliferative agent called tadalafil. MATERIALS AND METHODS: Twenty-five adult intact male dogs were randomly designated into five groups (n = 5): Control group was not induced for BPH and not treated with tadalafil; dogs induced for BPH by testosterone enanthate and estradiol benzoate and treated with tadalafil (5 mg/day P...
August 13, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31393637/pharmacokinetics-of-injectable-marbofloxacin-after-intravenous-and-intramuscular-administration-in-red-eared-sliders-trachemys-scripta-elegans
#2
Olimpia R Lai, Pedro Marín, Pietro Laricchiuta, Donatella Gelli, Elisa Escudero, Giuseppe Crescenzo
Fluoroquinolone antibacterial drugs are currently used in reptilian medicine because of their broad spectrum of activity including the most frequent pathogens of these species. The disposition kinetics of marbofloxacin (MBX) at a single dose of 2 mg/kg were determined in healthy red-eared sliders after intravenous (IV) and intramuscular (IM) administration. The influence of renal portal system on the bioavailability of the drug was investigated by using forelimb and hindlimb as IM injection sites. Apparent volume of distribution at steady-state (Vss ) and systemic clearance (Cl) of marbofloxacin after IV administration were estimated to be 48...
August 8, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31373697/pharmacokinetics-of-sodium-baicalin-following-intravenous-and-intramuscular-administration-to-piglets
#3
Yu Liu, Wenhua Zhao, Jianfeng Xu, Xiaolin Yu, Chun Ye, Shulin Fu, Yinsheng Qiu
The purpose of this study was to determine the pharmacokinetics of baicalin after intravenous and intramuscular administration of sodium baicalin at 50 mg/kg to piglets. Plasma baicalin levels were determined by high-performance liquid chromatography. The plasma concentration-time data of baicalin for both administration routes were best described by two-compartmental open model. The area under the plasma concentration-time curve and the elimination half-lives were 77.47 ± 6.14 µg/ml × h and 1.73 ± 0...
August 2, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31369157/nonlinear-mixed-effects-pharmacokinetic-modeling-of-the-novel-cox-2-selective-inhibitor-vitacoxib-in-dogs
#4
Jianzhong Wang, Benjamin K Schneider, Pan Sun, Xiaohui Gong, Jicheng Qiu, Jing Li, Yeon-Jung Seo, Jonathan P Mochel, Xingyuan Cao
The objective of this study was to develop a nonlinear mixed-effects model of vitacoxib disposition kinetics in dogs after intravenous (I.V.), oral (P.O.), and subcutaneous (S.C.) dosing. Data were pooled from four consecutive pharmacokinetic studies in which vitacoxib was administered in various dosing regimens to 14 healthy beagle dogs. Plasma concentration versus time data were fitted simultaneously using the stochastic approximation expectation maximization (SAEM) algorithm for nonlinear mixed-effects as implemented in Monolix version 2018R2...
August 1, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31353535/pharmacokinetics-and-pharmacodynamics-of-intravenous-and-transdermal-flunixin-meglumine-in-alpacas
#5
Emily J Reppert, Michael D Kleinhenz, Shawnee R Montgomery, Jared Heiman, Amanda Sura, Heather N Bornheim, Geraldine Magnin, Pritam K Sidhu, Yuntao Zhang, Hyun Joo, Johann F Coetzee
The aim of this study was to determine the pharmacokinetics and prostaglandin E2 (PGE2 ) synthesis inhibiting effects of intravenous (IV) and transdermal (TD) flunixin meglumine in eight, adult, female, Huacaya alpacas. A dose of 2.2 mg/kg administered IV and 3.3 mg/kg administered TD using a cross-over design. Plasma flunixin concentrations were measured by LC-MS/MS. Prostaglandin E2 concentrations were determined using a commercially available ELISA. Pharmacokinetic (PK) analysis was performed using noncompartmental methods...
July 29, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31353505/pharmacokinetics-of-ceftriaxone-in-freshwater-crocodiles-crocodylus-siamensis-after-intramuscular-administration-at-two-dosages
#6
Saranya Poapolathep, Mario Giorgi, Narongsak Chaiyabutr, Narumol Klangkaew, Napasorn Phaochoosak, Tara Wongwaipairote, Amnart Poapolathep
One of the major obstacles to the successful treatment of infectious disease in freshwater crocodile species is incorrect dosing of antibiotics. There are few reports on pharmacokinetics and dosage regimens of antimicrobial drugs in crocodiles. The purpose of the present study was to clarify the pharmacokinetic characteristics of ceftriaxone (CEF) in Siamese freshwater crocodiles (Crocodylus siamensis). Freshwater crocodiles, Crocodylus siamensis, in breeding farms were treated with a single intramuscular administration of CEF at two dosages, 12...
July 29, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31328799/in-vitro-and-in-vivo-effects-of-chlorpyrifos-and-cypermethrin-on-blood-cholinesterases-in-sheep
#7
Karen E Larsen, Adrián L Lifschitz, Carlos E Lanusse, Guillermo L Virkel
The combination of the organophosphate (OP) chlorpyrifos (CPF) and the pyrethroid cypermethrin (CPM) is commonly marketed as pour-on formulations for the control of sheep lice, ked, and blowflies. CPF irreversibly inhibits acetylcholinesterases (AChE), while pyrethroids are not AChE inhibitors. However, combinations of pyrethroids with OPs showed a highly synergistic effect on AChE inhibition. Thus, the aim of the current work was to evaluate in vitro and in vivo the inhibitory potency of both pesticides, alone and in combination with AChE and butyrylcholinesterase (BChE) activities in sheep blood...
July 22, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31325172/pharmacokinetics-and-tissue-residues-of-enrofloxacin-in-the-largemouth-bass-micropterus-salmoides-after-oral-administration
#8
Qi Shan, Jingxin Wang, Guangming Zheng, Xinping Zhu, Yuanhao Yang, Lisha Ma, Cheng Zhao, Lichun Li, Yi Yin
The study was carried out to evaluate the pharmacokinetic disposition of enrofloxacin (ENF) with a single dose of 20 mg/kg after oral administration in largemouth bass (Micropterus salmoides) at 28°C. The concentrations of ENF and of its metabolite ciprofloxacin (CIP) in plasma, liver, and muscle plus skin in natural proportions were determined using HPLC. The concentration-time data for ENF in plasma were best described by a two-compartment open model. After oral administration, the maximum ENF concentration (Cmax ) of 10...
July 20, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31325161/glucose-and-insulin-response-after-intravenous-and-subcutaneous-somatostatin-administration-in-healthy-horses
#9
Daniela Luethy, Amy L Johnson, Darko Stefanovski, Raymond C Boston, James Anthony Orsini
Equine metabolic syndrome (EMS) is prevalent in the equine population, and somatostatin analogs might be useful for diagnosis and/or treatment of EMS in horses. The purpose of this study was to evaluate the glucose and insulin responses to subcutaneous and intravenous administration of somatostatin. Six healthy research horses were included in this prospective study. An initial pilot study was performed to assess several different doses (10-22 µg/kg [4.5-10 µg/lb]) in two horses, then a final dosage of 22 µg/kg (10 µg/lb) was administered to six horses IV and SQ in a two-period randomized cross-over study performed over a 3-month study period...
July 20, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31318080/pharmacokinetics-of-dexmedetomidine-during-administration-of-vatinoxan-in-male-neutered-cats-anesthetized-with-isoflurane
#10
Bruno H Pypendop, Hanna Ahokoivu, Juhana Honkavaara
Dexmedetomidine is an alpha-2 adrenoceptor agonist, and vatinoxan is an alpha-2 antagonist believed to poorly cross the blood-brain barrier in cats. Dexmedetomidine-vatinoxan combinations are of interest in anesthetized cats because the anesthetic sparing effect of dexmedetomidine may be preserved while vatinoxan attenuates the adverse cardiovascular effects of dexmedetomidine. The aim of this study was to characterize the pharmacokinetics of dexmedetomidine in cats during administration of isoflurane and vatinoxan...
July 18, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31271466/pharmacokinetics-of-enrofloxacin-and-its-metabolite-ciprofloxacin-in-freshwater-crocodiles-crocodylus-siamensis-after-intravenous-and-intramuscular-administration
#11
Saranya Poapolathep, Mario Giorgi, Narongsak Chaiyabutr, Chanat Chokejaroenrat, Narumol Klangkaew, Napasorn Phaochoosak, Tara Wongwaipairote, Amnart Poapolathep
To the best of the authors' knowledge, pharmacokinetic information to establish suitable therapeutic plans for freshwater crocodiles is limited. Therefore, the purpose of this study was to clarify the pharmacokinetic characteristics of enrofloxacin (ENR) in freshwater crocodiles, Crocodylus siamensis, following single intravenous and intramuscular administration at a dosage of 5 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 168 hr. The plasma concentrations of ENR and its metabolite ciprofloxacin (CIP) were measured by liquid chromatography tandem-mass spectrometry...
July 4, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31271454/the-lower-limit-of-quantification-in-pharmacokinetic-analyses
#12
Andrew Woodward, Ted Whittem
No abstract text is available yet for this article.
July 4, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31222770/pharmacokinetics-of-altrenogest-in-gilts
#13
Hongzhi Xiao, Pan Sun, Feifei Sun, Jicheng Qiu, Jie Wang, Jianzhong Wang, Yalong Lin, Xiaohui Gong, Lu Zhang, Suxia Zhang, Xingyuan Cao
Altrenogest, a synthetic progestogen, is characterized by its estrus synchronization in mares, ewes, sows, and gilts. To investigate the pharmacokinetic profile and evaluate its accumulation in gilts, 18 oral doses of 20 mg altrenogest/gilt/day were given to eight healthy gilts at an interval of 24 hr. Plasma samples were collected, and altrenogest was determined by ultra-high-performance liquid chromatography with mass spectrometry. WinNonlin 6.4 software was used to calculate the pharmacokinetic parameters through noncompartmental model analysis...
June 20, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31222751/plasma-and-synovial-fluid-pharmacokinetics-of-a-single-intravenous-dose-of-meropenem-in-adult-horses
#14
Vernon C Langston, Robin L Fontenot, Julie A Byers, Caroline M Andrews, Cathleen A Mochal-King
The objective of this study was to determine the pharmacokinetics of meropenem in horses after intravenous (IV) administration. A single IV dose of meropenem was administered to six adult horses at 10 mg/kg. Plasma and synovial fluid samples were collected for 6 hr following administration. Meropenem concentrations were determined by bioassay. Plasma and synovial fluid data were analyzed by compartmental and noncompartmental pharmacokinetic methods. Mean ± SD values for elimination half-life, volume of distribution at steady-state, and clearance after IV administration for plasma samples were 0...
June 20, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31206734/evaluation-of-sedative-analgesic-physiological-and-laboratory-effects-of-two-doses-off-medetomidine-and-xylazine-in-dromedary-calves
#15
Amir Saeed Samimi, Ehsanollah Sakhaee, Fattah Iranmanesh
The present study aims to comparatively evaluate the effects of different doses of intravenous xylazine and medetomidine on sedation and antinociception scores, and physiological and laboratory parameters in dromedary calves. Thirty clinically healthy male dromedary calves 15 ± 2 weeks old and weighing 95 ± 5.5 kg were studied. Two groups received xylazine at low (0.2 mg/kg) and high (0.4 mg/kg) doses. Two groups received medetomidine at low (10 µg/kg) and high (20 µg/kg) doses. One group received normal saline...
June 17, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31206720/pharmacokinetics-of-levosulpiride-after-single-dose-administration-in-goats-capra-hircus-by-different-routes-of-administration
#16
Beata Łebkowska-Wieruszewska, Giovanni Barsotti, Francesco Camillo, Alessandra Rota, Duccio Panzani, Amnart Poapolathep, Andrzej Lisowski, Mario Giorgi
Levosulpiride (LSP) is the l-enantiomer of sulpiride, and LSP recently replacing sulpiride in several EU countries. Several studies about LSP in humans are present in the literature, but neither pharmacodynamic nor pharmacokinetic data of LSP is present for veterinary species. The aim of this study was to assess the pharmacokinetic profile of LSP after intravenous (IV), intramuscular (IM), and oral (PO) administration in goats. Animals (n = 6) were treated with 50 mg LSP by IV, IM, and PO routes according to a randomized cross-over design (3 × 3 Latin-square)...
June 17, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31206719/pharmacokinetics-and-pharmacodynamics-of-intramammary-cefquinome-in-lactating-goats-with-and-without-experimentally-induced-staphylococcus-aureus-mastitis
#17
Shymaa A El Badawy, Aziza M M Amer, Gehan M Kamel, Kamal M Eldeib, Peter D Constable
Values for pharmacokinetic variables are usually obtained in healthy animals, whereas drugs are frequently administered to diseased animals. This study investigated cefquinome pharmacokinetics in healthy goats and goats with experimentally induced mastitis. Five adult lactating goats received 75 mg of cefquinome intramammary infusion using a commercially available product into one udder half in healthy goats and goats with clinical mastitis that was induced by intracisternal infusion of 100 cfu of Staphylococcus aureus ATCC 29213 suspended in 5 ml of sterile culture broth...
June 17, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31197852/pharmacokinetics-of-florfenicol-in-blunt-snout-bream-megalobrama-amblycephala-at-two-water-temperatures-with-single-dose-oral-administration
#18
Yuqing Huang, Xiaoxuan Chen, Huan Wang, Hui Zhao, Yaner Luo, Zhixin Wu
The pharmacokinetics and residue elimination of florfenicol (FFC) and its metabolite florfenicol amine (FFA) were studied in healthy blunt-snout bream (Megalobrama amblycephala, 50 ± 10 g). The study was conducted with a single-dose (25 mg/kg) oral administration at a water temperature of 18 or 28°C, while in the residue elimination study, fish were administered at 25 mg/kg daily for three consecutive days by oral gavage to determine the withdrawal period (WDT) at 28°C. The FFC and FFA levels in plasma and tissues (liver, kidneys and muscle) were analysed using high-performance liquid chromatography (HPLC)...
June 14, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31197850/pharmacokinetics-and-bioavailability-of-cefquinome-and-ceftriaxone-in-premature-calves
#19
Orhan Corum, Ramazan Yildiz, Merve Ider, Feray Altan, Mahmut Ok, Kamil Uney
The aim of this study was to evaluate the pharmacokinetics and bioavailability of cefquinome (CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) administrations in premature calves. Using a parallel design, 24 premature calves were randomly divided into the two antibiotic groups. Each of the six animals in the first group received CFQ (2 mg/kg) through IV or IM administration. The second group received CTX (20 mg/kg) via the same administration route. Plasma concentrations of the drugs were analyzed by high-performance liquid chromatography and noncompartmental methods...
June 14, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/31197847/clinical-pharmacokinetics-of-a-dexmedetomidine-methadone-combination-in-dogs-undergoing-routine-anaesthesia-after-buccal-or-intramuscular-administration
#20
Federica Di Cesare, Daniela Gioeni, Giuliano Ravasio, Alberto Pellegrini, Lorena Lucatello, Vittoria Bisutti, Roberto Villa, Petra Cagnardi
This study aimed to define the pharmacokinetic profiles of dexmedetomidine and methadone administered simultaneously in dogs by either an oral transmucosal route or intramuscular route and to determine the bioavailability of the oral transmucosal administration relative to the intramuscular one of both drugs, so as the applicability of this administration route in dogs. Twelve client-owned dogs, scheduled for diagnostic procedures, were treated with a combination of dexmedetomidine hydrochloride (10 μg/kg) and methadone hydrochloride (0...
June 14, 2019: Journal of Veterinary Pharmacology and Therapeutics
journal
journal
27811
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"