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Journal of Clinical Gastroenterology

Hyeki Cho, Young Chang, Jeong-Hoon Lee, Young Youn Cho, Joon Yeul Nam, Yun Bin Lee, Dong Ho Lee, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jeong Min Lee, Jung-Hwan Yoon
BACKGROUND AND GOALS: Although nonalcoholic fatty liver disease (NAFLD) is a risk factor of hepatocellular carcinoma (HCC), it is unclear whether NAFLD additionally increases the risk of HCC among chronic hepatitis B (CHB) patients. This study evaluated the association between NAFLD and the risk of HCC in patients whose hepatitis B virus (HBV) was well controlled. STUDY: This study included consecutive CHB patients whose serum HBV DNA levels were continuously suppressed <2000 IU/mL with antiviral treatment...
April 26, 2019: Journal of Clinical Gastroenterology
Stergios A Polyzos, Jannis Kountouras
No abstract text is available yet for this article.
April 26, 2019: Journal of Clinical Gastroenterology
Fernando J Castro, Baker Al-Khairi, Harjinder Singh, Mosaab Mohameden, Kanwarpreet Tandon, Rocio Lopez
GOALS: We compare bowel cleanliness in patients taking same-day versus split-dose 4-L polyethylene glycol laxative for afternoon colonoscopy. Secondary objectives included patient satisfaction, adverse effects and patient tolerability. BACKGROUND: Afternoon colonoscopies have been associated with inadequate bowel preparation and lower adenoma detection rates. Same-day (morning) or split-dosing of the laxative have improved preparation quality but differences between these options are unclear...
April 23, 2019: Journal of Clinical Gastroenterology
Alain Braillon
No abstract text is available yet for this article.
April 23, 2019: Journal of Clinical Gastroenterology
Shyam Menon, Peter Nightingale, Nigel Trudgill
BACKGROUND: Chronic gastroesophageal reflux predisposes to the development of esophageal adenocarcinoma (EAC). Asthma and medication to treat it are associated with gastroesophageal reflux and EAC. We studied subjects with chronic obstructive pulmonary disease (COPD) to examine the relationship between COPD and medication used to treat it, and the risk of reflux esophagitis, Barrett esophagus, and EAC. METHODS: A case-control study from the UK General Practice Research Database was conducted...
April 17, 2019: Journal of Clinical Gastroenterology
Gyanranjan Rout, Shalimar, Deepak Gunjan, Soumya J Mahapatra, Saurabh Kedia, Pramod K Garg, Baibaswata Nayak
GOALS: The aim of this study was to assess the use of thromboelastography (TEG)-directed blood product transfusion in cirrhotic patients with acute variceal bleeding compared with conventional transfusion for correction of coagulopathy. BACKGROUND: Coagulopathy is common in patients with cirrhosis. Recommendations for correction of conventional parameters of coagulation-platelets and the international normalized ratio before endoscopy in patients with acute variceal bleeding-need more validation...
April 17, 2019: Journal of Clinical Gastroenterology
Artin Galoosian, Mona Rezapour, Benny Liu, Taft Bhuket, Robert J Wong
GOAL: The goal of this study was to evaluate disparities in hospital outcomes among inflammatory bowel disease (IBD) related hospitalizations in the United States with a focus on ethnicity-specific disparities. BACKGROUND: IBD-related hospitalizations contribute to significant morbidity and health care economic burden. METHODS: IBD-related hospitalizations (identified with ICD-9) among US adults were evaluated using 2007 to 2013 Nationwide Inpatient Sample...
April 17, 2019: Journal of Clinical Gastroenterology
Cong Dai, Min Jiang, Ming-Jun Sun, Qin Cao
OBJECTIVE: Persistent disease activity is associated with a poor prognosis in inflammatory bowel disease (IBD) patients. Therefore, monitoring of IBD activity can avoid the poor prognosis. Serum biomarkers reflect a summation of systemic host responses rather than being specific for intestinal inflammation. And endoscopic monitoring is invasive, costly, and time consuming. The objective of our study was to perform a meta-analysis evaluating the diagnostic accuracy of fecal lactoferrin (FL) in assessing IBD activity...
April 15, 2019: Journal of Clinical Gastroenterology
Hólmfridur Helgadóttir, Sigrún H Lund, Sveinbjörn Gizurarson, David C Metz, Einar S Björnsson
GOALS: The goal of this study was to elucidate the most important predictors for elevation of gastrin in patients on long-term PPI therapy through analysis of data from 2 published studies in Icelandic patients with erosive GERD. BACKGROUND: Gastrin elevation is a known but variable consequence of proton pump inhibitor (PPI) therapy. Concerns have been raised about the clinical importance of chronic PPI induced gastrin elevation. STUDY: This cross-sectional analysis included patients with endoscopically verified erosive esophagitis receiving long-term PPI therapy...
April 15, 2019: Journal of Clinical Gastroenterology
Jennifer Nayor, Aiden Feng, Taha Qazi, Shelley Hurwitz, John R Saltzman
GOALS: To evaluate the effect of an automated time-released colonoscopy reminder program on preparation quality and the rates of canceled procedures. BACKGROUND: Patients missing colonoscopy appointments or arriving with inadequate bowel preparations result in delays in care and increase in health care costs. STUDY: We initiated a quality improvement program which included switching to a split-dose preparation and delivering preparation instructions and appointment reminders via text messages and emails sent with an automated time-released HIPAA-compliant software platform...
April 15, 2019: Journal of Clinical Gastroenterology
Sushil K Garg, Shashank Sarvepalli, Dupinder Singh, Itegbemie Obaitan, Thoetchai Peeraphatdit, Loretta Jophlin, Sumeet K Asrani, Vijay H Shah, Michael D Leise
BACKGROUND: Alcohol abuse and liver disease are associated with high rates of 30-day hospital readmission, but factors linking alcoholic hepatitis (AH) to readmission are not well understood. We aimed to determine the incidence rate of 30-day readmission for patients with AH and to evaluate potential predictors of readmission. METHODS: We used the Nationwide Readmissions Database to determine the 30-day readmission rate for recurrent AH between 2010 and 2014 and examined trends in readmissions during the study period...
April 3, 2019: Journal of Clinical Gastroenterology
Audrey H Calderwood, Kathy Cazares, Sharon O'Connor
GOALS AND BACKGROUND: Surveillance colonoscopy is the most common indication for colonoscopy in older adults, yet factors involved in patient decision-making are poorly defined. We sought to understand general perspectives of older adults toward surveillance colonoscopy. STUDY: We conducted 2 in-person, 90-minute semistructured focus groups at a rural, tertiary care, academic facility with a total of 20 English-speaking participants with a history of colon polyps...
April 3, 2019: Journal of Clinical Gastroenterology
Juan Lasa, Astrid Rausch, Ignacio Zubiaurre
No abstract text is available yet for this article.
April 3, 2019: Journal of Clinical Gastroenterology
Yuanjian Huang, Xiang Cheng, Ping Sun, Tong Li, Zifang Song, Qichang Zheng
BACKGROUND: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Sorafenib is considered a supplementary treatment to surgical or locoregional therapies for improving outcomes. We evaluated the efficacy of sorafenib as a supplementary therapy for HCC. METHODS: We conducted a meta-analysis including 11 randomized controlled trials. Patients with HCC and studies in which sorafenib was administered alone and compared with placebo or those in which sorafenib was administered in combination with another treatment and compared with that treatment alone were included...
April 1, 2019: Journal of Clinical Gastroenterology
Shali Tan, Yan Peng, Xiaowei Tang
No abstract text is available yet for this article.
April 1, 2019: Journal of Clinical Gastroenterology
Arvind Rengarajan, C Prakash Gyawali
BACKGROUND: High-resolution manometry (HRM) allows characterization of esophagogastric junction (EGJ) morphology and identification of hiatus hernia using novel software tools. AIM: The main purpose of this study was to determine the impact of HRM-based EGJ and lower esophageal sphincter (LES) metrics in predicting abnormal reflux burden. METHODS: Total, upright, and supine acid exposure times (AETs) were extracted from ambulatory reflux monitoring performed off therapy in 482 patients (54...
April 1, 2019: Journal of Clinical Gastroenterology
Joseph C Anderson, Zvi A Alpern
No abstract text is available yet for this article.
March 26, 2019: Journal of Clinical Gastroenterology
Kexin Zheng, Eric M Yoshida, Frank Tacke, Yingying Li, Xiaozhong Guo, Xingshun Qi
BACKGROUND AND AIMS: Liver cirrhosis can lead to abnormal coagulation, rendering patients at risk for bleeding but also thrombotic complications. We conducted a systematic review and meta-analysis to explore the epidemiology of stroke in liver cirrhosis and the potential association between them. MATERIALS AND METHODS: Studies were searched through the PubMed, EMBASE, and Cochrane Library databases. Incidence and prevalence of unspecific stroke, hemorrhagic stroke, intracranial hemorrhage, subarachnoid hemorrhage, and ischemic stroke were pooled by using a random-effect model...
March 13, 2019: Journal of Clinical Gastroenterology
Jessica R Allegretti, Zain Kassam, Monika Fischer, Colleen Kelly, Walter W Chan
BACKGROUND: Fecal microbiota transplantation (FMT) is a promising therapy for recurrent Clostridioides difficile infection (CDI). Many patients report altered bowel habits including constipation, bloating, gas and loose stool post-FMT despite resolution of CDI, and the etiology remains unclear. METHODS: This was a prospective cohort study of adult patients with recurrent CDI who underwent FMT (1) via colonoscopy with patient-selected donor stool, (2) via colonoscopy from a universal stool bank donor, or (3) via capsules from a universal stool bank...
March 13, 2019: Journal of Clinical Gastroenterology
Yuan Li, Ciren Yangjin, Yanyan Shi, Yue Wen, Zhu Jin, Rongli Cui, Hejun Zhang, Shigang Ding
GOALS: The main aim of this study was to investigate the significance of a pale area via flexible spectral imaging color enhancement (FICE) in the diagnosis of esophageal dysplasia and cancer. BACKGROUND: The early diagnosis of esophageal squamous cancer is challenging, and the indication of Lugol's chromoendoscopy has not yet been well established. STUDY: The esophageal mucosa of patients at our endoscopic center were sequentially evaluated with white-light endoscopy and FICE during insertion of the endoscope, followed by staining with Lugol's solution during withdrawal...
February 27, 2019: Journal of Clinical Gastroenterology
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