Journals Journal of Clinical Gastroente...

Journal of Clinical Gastroenterology
Ayush Anand, Prakasini Satapathy, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Sarvesh Rustagi, Nathnael Abera Woldehana
No abstract text is available yet for this article.
June 21, 2024: Journal of Clinical Gastroenterology
Subin Heo, Jimi Huh, Jai Keun Kim, Ki Myung Lee
PURPOSE: To determine the clinical and imaging factors associated with surgical treatment in patients with delayed perforation after endoscopic resection of upper gastrointestinal tumors. METHODS: We retrospectively included patients with delayed perforation after endoscopic tumor resection for gastric or duodenal tumors between January 2007 and December 2021 in a tertiary hospital. We compared the clinical, endoscopic, and CT findings of the surgical and conservative treatment groups...
June 20, 2024: Journal of Clinical Gastroenterology
Ziqing Yu, Xuemin Yan, Xiaoyin Bai, Gechong Ruan, Wei Han, Huijun Shu, Hong Yang
GOAL: We aim to explore the relationship between the newly introduced CVH indicator "Life's Essential 8 (LE8)" and cirrhosis. BACKGROUND: The global burden of cirrhosis is increasing, with a rising number of deaths, leading to significant societal and economic challenges. Cardiovascular health (CVH) has been found to have potential associations with liver diseases. MATERIALS AND METHODS: All participants aged 20 and older from National Health and Nutrition Examination Survey 2005 to 2018 were included...
June 20, 2024: Journal of Clinical Gastroenterology
Manjeet Kumar Goyal, Kanwarpal Kaur Dhaliwal, Sangeeta Agrawal
Syphilitic hepatitis is a very rare presentation of syphilis infection, characterized by inflammation of the liver due to the invasion of hepatic tissue by the bacterium Treponema pallidum. This review article provides an in-depth analysis of the existing body of information pertaining to syphilitic hepatitis. The article primarily concentrates on key aspects such as the epidemiology, clinical manifestations, diagnostic methods, and therapeutic approaches associated with this condition. Despite its rarity, awareness of syphilitic hepatitis is vital for accurate diagnosis and appropriate intervention...
June 20, 2024: Journal of Clinical Gastroenterology
Raj H Patel, Charmy Parikh, Mahendra Pratap Singh, Rakesh Kumar Sharma, Shilpa Gaidhane, Ayush Anand
No abstract text is available yet for this article.
June 19, 2024: Journal of Clinical Gastroenterology
Jing Xu, Qiu Qu, Yu Yang, Jie Yang, Ting Fang, Jiajia Yin, Qiquan Mo, Zihan Wu, Linran Zeng, Huiping He, Jinxiao Fu, Hongjian Zhou, Wei Huang, Hong Ju Yang
OBJECTIVE: The diagnosis of RGERD in patients typically involves 24-hour esophageal pH monitoring, but due to its invasiveness and low patient compliance, new screening methods are needed. In this study, a lactulose breath test (LBT) was conducted to detect the growth of small intestine bacteria (SIBO) and explore the potential relationship between LBT and RGERD to identify a new treatment method for RGERD. METHODS: A total of 178 patients with gastroesophageal reflux were enrolled from June 2020 to December 2022 in the Gastroenterology Department, Building 3, the First Affiliated Hospital of Kunming Medical University; these patients included 96 patients with nonrefractory GERD (NRGERD) and 82 patients with RGERD...
June 13, 2024: Journal of Clinical Gastroenterology
Hongyi Dong, Ying Luo, Diangang Liu, Xing Du, Haijun Du
OBJECTIVES: As a GABAB receptor agonist, baclofen has demonstrated efficacy in alleviating symptoms of refractory gastroesophageal reflux disease (r-GERD). This meta-analysis aims to evaluate the safety and effectiveness of baclofen as an add-on therapy for this condition. METHOD: We conducted a comprehensive search of the PubMed, Embase, and Web of Science databases for studies published up until October 2023. Subsequently, we performed a meta-analysis encompassing all eligible trials...
June 13, 2024: Journal of Clinical Gastroenterology
Marcello Maida, Alessandro Vitello, Angelo Zullo, Daryl Ramai, Antonio Facciorusso, Roberto Vassallo
OBJECTIVE: Bowel cleansing is a key element for a quality colonoscopy. Despite recent advances, not all predictors of successful cleansing are fully known. This post hoc analysis of an RCT aims to explore gender differences in bowel cleansing quality. METHODS: The "OVER" trial was a multicenter phase-4 RCT including 478 patients randomized 1:1 to receive split-dose 1L polyethylene glycol plus ascorbate (PEG+ASC) or 4L-PEG. In this post hoc analysis, multivariable logistic regression models were designed to assess predictors of cleansing success (CS) and adenoma detection rate (ADR) by gender...
June 7, 2024: Journal of Clinical Gastroenterology
Amol N Patil, Muhammad Aaqib Shamim, Akash Roy, Naveen C Hegde, Pankaj Khatri, Shivam Sharma, Sahaj Rathi, Arka De, Ajay Duseja, Sunil Taneja
Acute-on-chronic liver failure (ACLF) is a global health problem. Little scientific evidence exists on its prevalence in autoimmune hepatitis. Treatment response and mortality outcomes have also been reported differently. The study was conducted to estimate the overall prevalence of ACLF among patients with autoimmune hepatitis (AIH) and determine the associated treatment response and mortality. We scrutinized wide literature in Scopus, PubMed, Embase, Web of Science, and Cochrane, and assessed published articles completely, studies performed and reported from around the globe, until December 07, 2023, according to the PROSPERO registered protocol (CRD42023412176)...
June 5, 2024: Journal of Clinical Gastroenterology
Ritu R Singh, Harishankar Gopakumar, Sonu Dhillon
GOALS AND BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis. We aim to explore the clinical outcomes of NASH cirrhosis compared with other etiologies of cirrhosis. METHODS: We utilized an EHR-based database (TriNetX) to study the outcomes of NASH cirrhosis. Patients diagnosed with NAFLD or NASH and cirrhosis between January 2016 and December 2019 were identified utilizing appropriate ICD-10-CM codes. The primary outcome was 3-year overall survival...
May 29, 2024: Journal of Clinical Gastroenterology
Harris Ahmad, Benjamin Click, Heather L Morris, Julie M Crawford, Jiyoon Choi, Millie D Long
BACKGROUND: There is limited evidence that histologic remission improves outcomes in Crohn's disease (CD). We aimed to characterize a cohort of patients with CD in endoscopic remission and explore factors associated with subsequent loss of remission (LOR). METHODS: In total, 4474 patients were enrolled in TARGET-IBD, a longitudinal, observational cohort study. Patients with a normal steroid-free colonoscopy (index) were defined as "in endoscopic remission" and were followed for LOR, defined as presence of inflammation, erosion, ulceration, or stricturing on a subsequent colonoscopy or commencement of steroids...
May 22, 2024: Journal of Clinical Gastroenterology
Benjamin D Gold, Bridgett Goodwin, Kimberly Davis, Carolyn Sweeney, Ryan Ziemiecki, Jeanne Jiang, Tao Fan, Mena Boules, Szu-Ta Chen, David A Katzka
GOALS: We assessed satisfaction with and adherence to off-label corticosteroids in patients with eosinophilic esophagitis (EoE) in the United States. BACKGROUND: EoE is a chronic inflammatory disease for which there are currently no US Food and Drug Administration-approved swallowed topical corticosteroids. STUDY: This noninterventional, cross-sectional, web-based survey included caregivers of adolescents (aged 11 to 17 y) and adults (aged 18 years or older) with a self-reported [or caregiver-reported (adolescents)] physician diagnosis of EoE who were receiving corticosteroids...
May 15, 2024: Journal of Clinical Gastroenterology
Daniel Yan Zheng Lim, Yu Bin Tan, Jonathan Tian En Koh, Joshua Yi Min Tung, Gerald Gui Ren Sng, Damien Meng Yew Tan, Chee-Kiat Tan
No abstract text is available yet for this article.
May 7, 2024: Journal of Clinical Gastroenterology
Muhammad Aziz, Hossein Haghbin, Manesh K Gangwani, Rawish Fatima, Amir H Sohail, Hassam Ali, Zakaria A Alyousif, Dushyant S Dahiya, Wade Lee-Smith, Azizullah Beran, Faisal Kamal, Ali Nawras
INTRODUCTION: Multiple pharmacological interventions have been studied for managing eosinophilic esophagitis (EoE). We performed a comprehensive systematic review and network meta-analysis of all available randomized controlled trials (RCT) to assess the efficacy and safety of these interventions in EoE in adults and children. METHODS: We performed a comprehensive review of Embase, PubMed, MEDLINE OVID, Cochrane CENTRAL, and Web of Science through May 10, 2023. We performed frequentist approach network meta-analysis using random effects model...
May 6, 2024: Journal of Clinical Gastroenterology
Saqr Alsakarneh, Fouad Jaber, Willie Mohammed, Mohammad Almeqdadi, Abdallah Al-Ani, Yassine Kilani, Saeed Abughazaleh, Laith Momani, Muhammad Shah Miran, Hassan Ghoz, John Helzberg, Wendell Clarkston, Mohamed Othman
Limited objective data exist on the comparison of post-endoscopic retrograde cholangiopancreatography (ERCP) complications in patients with cirrhosis based on the severity of the disease. We evaluated the effectiveness of the Child-Turcotte-Pugh (CTP) score system in anticipating the risk of post-ERCP complications in patients with cirrhosis. The PubMed, Scopus, Embase, and Cochrane databases were searched from inception through September 2022 to identify studies comparing post-ERCP complications in patients with cirrhosis based on CTP score...
May 1, 2024: Journal of Clinical Gastroenterology
Russell D Dolan, Thomas R McCarty, Ahmad Najdat Bazarbashi, Christopher C Thompson
BACKGROUND: Gastric per-oral endoscopic myotomy (G-POEM) is an innovative treatment that has become increasingly utilized for patients with refractory gastroparesis. The aim of this systematic review and meta-analysis was to evaluate the safety and effectiveness of G-POEM for the treatment of gastroparesis. METHODS: Individualized search strategies were developed through February 2021 in accordance with the PRISMA and MOOSE guidelines. This meta-analysis was performed by calculating pooled proportions and mean difference preprocedure and postprocedure with rates estimated using random effects models...
April 30, 2024: Journal of Clinical Gastroenterology
Wenfeng Shi, Weiguo Xu, Ningning Fan, Yong Li, Xiaoqiong Chen, Yujie Zhao, Xiao Bai, Yang Yang
BACKGROUND: The relationship between body composition and the risk of overt hepatic encephalopathy (OHE) following transjugular intrahepatic portosystemic shunt (TIPS) needs to be investigated. METHODS: Overall, 571 patients from 5 medical centers were included. To assess body compositions, we evaluated skeletal muscle indices, adipose tissue indices, sarcopenia, and myosteatosis at the third lumbar vertebral level. Univariate and Multivariate logistic regression analyses were performed to identify independent risk factors for post-TIPS OHE...
April 30, 2024: Journal of Clinical Gastroenterology
Spyridon Zouridis, Daniel Sofia, Osama Alshakhatreh, Madeline Cleary, Omar Daghstani, Paul J Feustel, Maheep Sangha, Seth Richter
GOALS: The goal of this study is to investigate fecal occult blood test's (FOBT) usage in cases of suspected gastrointestinal bleeding and how it may affect hospitalization length and inpatient endoscopy procedures. BACKGROUND: FOBT is an approved modality used in colorectal cancer screening but is often used inappropriately for the investigation of suspected gastrointestinal bleeding (GIB) in the hospital setting. The efficiency of FOBT when used for this purpose is questionable...
April 29, 2024: Journal of Clinical Gastroenterology
Zhen Yang, Jin Yan, Hai-Sheng Qian, Zi-Hang Zhong, Ruo-Yun Yang, Ke-Dong Li, Han Chen, Yu-Han Zhao, Xin Gao, Zi-Hao Kong, Guo-Xin Zhang, Yun Wang
BACKGROUND: There is a lack of sufficient evidence on whether mixed-type differentiated predominant early gastric cancer (MD-EGC) can be treated endoscopically by referring to the criteria for differentiated-type early gastric cancer (EGC). This study aims to evaluate the efficacy of endoscopic submucosal dissection (ESD) in MD-EGC. METHODS: Patients with differentiated-type EGC treated with ESD first from January 2015 to June 2021 were reviewed, including MD-EGC and pure differentiated-type EGC (PD-EGC)...
April 24, 2024: Journal of Clinical Gastroenterology
Manu V Venkat, Ling Chen, Jason D Wright, Benjamin Lebwohl
OBJECTIVE: To characterize the frequency and predictors of follow-up endoscopic biopsy in patients with celiac disease. BACKGROUND: The utility of routine follow-up biopsy in patients after a diagnosis of celiac disease is uncertain, especially in patients whose symptoms resolve on the gluten-free diet. PATIENTS AND METHODS: Using the Merative MarketScan U.S. commercial insurance and Medicare databases, we identified 30,737 patients with biopsy-diagnosed celiac disease...
April 23, 2024: Journal of Clinical Gastroenterology
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