Soraya Játiva, Selene Torrico, Priscila Calle, Esteban Poch, Angeles Muñoz, Miriam García, Ana Belén Larque, Maria Teresa Torres Salido, Georgina Hotter
Macrophages must remove apoptotic cells to shield tissues from the deleterious components of dying cells. The development of chronic inflammation and autoimmune symptoms in systemic lupus is influenced by a deficiency in phagocytosis of apoptotic cells but the underlying mechanism is still unknown. Modifications in monocyte/macrophage phenotype brought on by an increase in their inflammatory phenotype would cause them to decrease the expression of CPT1a, which would reduce their ability to phagocytose, aggravating kidney damage in lupus nephritis...
February 6, 2024: Immunology Letters
Ilenia Cammarata, Valeria Pinna, Ilenia Pacella, Ivano Rotella, Annarosa Soresina, Raffaele Badolato, Alessandro Plebani, Claudio Pignata, Emilia Cirillo, Anna Maria Zicari, Francesco Violi, Roberto Carnevale, Lorenzo Loffredo, Silvia Piconese
The X-linked chronic granulomatous disease (X-CGD), a rare genetic disease characterised by recurrent infections, is caused by mutations of NOX2. Significant proportions of X-CGD patients display signs of immune dysregulation. Regulatory T cells (Tregs) are CD4+ T lymphocytes that expand in active inflammation and prevent autoimmune disorders. Here we asked whether X-CGD is associated to Treg dysfunctions in adult patients. To this aim, the frequency of Tregs was analysed through intracellular flow cytometry in a cohort of adult X-CGD patients, carriers and controls...
February 1, 2024: Immunology Letters
Andrea Pasta, Francesco Calabrese, Shirin Djahandideh Sheijani, Manuele Furnari, Edoardo G Giannini, Federica Grillo, Elisa Marabotto, Luca Mastracci, Giuseppe Murdaca, Simone Negrini, Edoardo Vincenzo Savarino, Vincenzo Savarino, Patrizia Zentilin
INTRODUCTION: Systemic sclerosis (SSc) affects the connective tissue and leads to an abnormal fibrotic process in the skin and internal organs. Epidermal Growth Factor Receptor (EGFR) is able to induce cell proliferation and differentiation, and its expression is increased in SSc patients with pulmonary artery hypertension and in skin biopsies in patients with scleroderma. To date, no data on esophageal expression of EGFR are available in SSc patients. We aimed to evaluate whether the pro-fibrogenic pathways of SSc may affect EGFR expression in the esophagus...
February 2024: Immunology Letters
Kamel Hamzaoui, Sabrine Louhaichi, Mariem Salhi, Fayçal Haj Sassi, Ahmed Laathar, Agnes Hamzaoui
The etiological complexity of Behçet disease (BD), an immune-mediated rare form of vasculitis characterized by multi-organ involvement, is still elusive due to an incomplete understanding of the synergy between genetic susceptibility, environmental triggers, and an abnormal immune response. The diagnosis of BD relies on clinical symptoms. Lung inflammatory disorders are severe conditions of patients with BD, here we focus on the expression of biomarkers in BD patients with pulmonary manifestations. Aiming to identify additional discriminating biomarker patterns, we measured and compared protein and gene expression of IL-38 and a broad panel of selected genes in bronchoalveolar cells of patients suffering from BD with and without pulmonary involvement compared to controls...
January 31, 2024: Immunology Letters
Huijing Wang, Lan Lan, Jiahui Wang, Jianghua Chen, Liang Xiao, Fei Han
OBJECTIVES: Idiopathic membranous nephropathy (MN) is an autoimmune disease characterized by specific antibodies. However, the underlying mechanisms by which lymphocytes promote the development of MN remain poorly understood. This study aims to determine the changes of B-cell subsets and their clinical significance in MN patients. METHODS: We included a cohort of 21 idiopathic MN patients with new onset or a relapse, 19 healthy controls (HCs) and 10 patients with minimal change disease (MCD)...
January 24, 2024: Immunology Letters
Hamid Ahmadi, Mohammad Sadegh Soltani-Zangbar, Mehdi Yousefi, Behzad Baradaran, Saro Bromand, Leili Aghebati-Maleki, Julia Szekeres-Bartho
Recurrent pregnancy loss (RPL) is a multifactorial disorder, associated with immunologic abnormalities. During pregnancy, the maternal immune system uses different tolerance mechanisms to deal with a semi-allogenic fetus. The expression of immune checkpoints and their related miRNAs in immune cells can ensure pregnancy at the feto-maternal interface by modulating immune responses. This study aims to evaluate the expression of the immune checkpoint molecules PD-1 and Tim-3 on circulating T cells by flow cytometry, that of mir-138 and mir-155 in PBMCs by Real-time PCR, and the concentrations of TGF-β and IP-10 in the sera of women suffering from RPL as well as of gestational age-matched healthy pregnant women by ELISA...
January 22, 2024: Immunology Letters
Ufuk Oguz Idiz, Basak Aru, Cemal Kaya, Kivanc Derya Peker, Cihad Tatar, Mert Guler, Abdurrahman Tunay, Gulderen Yanikkaya Demirel, Ali Osman Gurol
PURPOSE: This study aimed to assess the significance of immunophenotyping and serum cytokines in predicting the clinical progression of acute biliary pancreatitis (ABP). MATERIALS AND METHODS: Cytokine levels, T-helper, cytotoxic T, natural killer (NK) cells, monocytes, HLA-DR, and PD-1, as well as PDL-1 immune checkpoints, were measured in ABP patients at the time of diagnosis and compared with results from healthy volunteers. The study also compared leukocyte counts, hematocrit, immunophenotyping results, cytokine statuses, and PD-1, PDL-1 expression between healthy volunteers and ABP subgroups categorized by pancreatitis severity...
January 8, 2024: Immunology Letters
Karl J Harber, Thuc-Anh Nguyen, Bauke V Schomakers, Daan A F Heister, Helga E de Vries, Michel van Weeghel, Jan Van den Bossche, Menno P J de Winther
Immunometabolism has been unveiled in the last decade to play a major role in controlling macrophage metabolism and inflammation. There has been a constant effort to understand the immunomodulating properties of regulated metabolites during inflammation with the aim of controlling and re-wiring aberrant macrophages in inflammatory diseases. M-CSF and GM-CSF-differentiated macrophages play a key role in mounting successful innate immune responses. When a resolution phase is not achieved however, GM-CSF macrophages contribute substantially more towards an adverse inflammatory milieu than M-CSF macrophages, consequently driving disease progression...
December 22, 2023: Immunology Letters
Masamichi Itoga, Yoshiko Ishioka, Tomonori Makiguchi, Hisashi Tanaka, Kageaki Taima, Norihiro Saito, Hirofumi Tomita, Sadatomo Tasaka
BACKGROUND AND AIM: G protein-coupled estrogen receptor (GPER) is an estrogen receptor located on the plasma membrane. We previously reported that the administration of G-1, a GPER-specific agonist, suppressed development of acute ovalbumin (OVA)-induced asthma in a mouse model. Herein, we evaluate the involvement of GPER in a mouse model of chronic OVA asthma. METHODS: G-1 or saline was administered subcutaneously to BALB/c mice with chronic OVA asthma, and pathological and immunological evaluation was performed...
December 22, 2023: Immunology Letters
Muwei Jiang, Renske Karsenberg, Frans Bianchi, Geert van den Bogaart
The membrane protein CD36 is a lipid transporter, scavenger receptor, and receptor for the antiangiogenic protein thrombospondin 1 (TSP1). CD36 is expressed by cancer cells and by many associated cells including various cancer-infiltrating immune cell types. Thereby, CD36 plays critical roles in cancer, and it has been reported to affect cancer growth, metastasis, angiogenesis, and drug resistance. However, these roles are partly contradictory, as CD36 has been both reported to promote and inhibit cancer progression...
December 18, 2023: Immunology Letters
Riccardo Asero
There is growing evidence suggesting that in a subset of patients with severe chronic urticaria (CSU) mast cells are activated via mechanisms that bypass the high affinity IgE receptor. This might explain why some patients do not respond at all to anti-IgE therapy (omalizumab). The present article reviews the pathogenic mechanisms able to lead to histamine release from mast cells described so far in patients with CSU. These include the activation of the coagulation cascade, the activation of the complement system, the activation of the MRGPRX2 receptor, and the platelet activating factor vicious circle...
November 30, 2023: Immunology Letters
Jinmei Xue, Limin Suo, Yunfang An, Xinxin Wang, Shuang Zhang, Huazhen Liu, Yongjin Wu, Xizhuo Sun, Changqing Zhao, Pingchang Yang
Type 1 regulatory T cells (Tr1 cells) play an important role in the maintenance of the immune homeostasis in the body. The induction of Tr1 cell is to be further investigated. The interaction of phosphatidylserine (PS) with TIM3 has immune regulation functions. The objective of this study is to elucidate the role of PS-TIM3 signals in inducing Tr1 cells. In this study, mice were treated using PS or specific immunotherapy by nasal instillation. A murine model of allergic rhinitis was developed using ovalbumin as a specific antigen...
November 24, 2023: Immunology Letters
Xiao-Yong Zhan, Hui Chen, Huimin Kong, Tongfei Meng, Jieyu Ye, Yong Liu, Margaret H L Ng, Liang Li, Yuming Zhang, Jinqi Huang, Qiang Peng, Chun Chen, Yulong He, Mo Yang
Significant decreases in platelet counts and ITP relapses have been documented in ITP patients receiving COVID-19 mRNA vaccines; however, the effect of the inactivated COVID-19 vaccine on ITP patients remains unclear. The present study aimed to investigate the impact of inactivated COVID-19 vaccines on ITP patients, with a focus on platelet dropping events, bleeding events/scores, and the requirement of a new round of treatment. A total of 118 ITP patients, with 97 chronic ITP and 21 persistent ITP, who received inactivated COVID-19 immunization were investigated retrospectively...
November 24, 2023: Immunology Letters
Thais Garcias Moreira, Ana Maria Caetano Faria
No abstract text is available yet for this article.
November 16, 2023: Immunology Letters
Yongjie Cai, Ruiqing Yu, Zhanqi Zhang, Di Li, Baicheng Yi, Zhihui Feng, Qiong Xu
As one of the most prevalent modifications on RNA, N6-methyladenosine (m6 A) has been recently found implicated in various pathological processes. Emerging studies have demonstrated the role of m6 A and its writer Mettl3 in fine-tuning the immune response, which now becomes a research hotspot owing to its potential therapeutic value. However, the results are inconsistent and even contradictory, suggesting that there might be multiple Mettl3 target genes involved in different pathways. To delve deeper into the function of Mettl3 in the cellular inflammatory response, we first conducted bioinformatics analysis using RNA-seq in Mettl3 ablation macrophages, and found that Mettl3 might attenuate LPS-induced proinflammatory pathways and reactive oxygen species (ROS) generation process...
November 10, 2023: Immunology Letters
Shujie Zhang, Guoqing Huang, Mingcai Li, Yushan Mao, Yan Li
BACKGROUND: Interleukin (IL)-41 is a recently discovered secreted protein that is expressed in a variety of tissues, and it is associated with several immune and metabolic diseases. However, IL-41 has not been studied in hyperuricemia (HUA). METHODS: Forty-four HUA patients and 44 healthy controls (HCs) were included in this study, and we collected theirgeneral and biochemical parameters, including white blood cell, neutrophil, lymphocyte, and platelet counts, mean platelet volume, platelet distribution width, serum creatinine, blood urea nitrogen, fasting blood glucose, total triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, total protein, albumin, alkaline phosphatase, gamma-glutamyltransferase, and hemoglobin concentration...
November 7, 2023: Immunology Letters
Xiaohui Xia, Zhao Yang, Jiangwei Zhang, Xiongjie Fu, Bin Han, Qijiang Xiong, Anyong Yu
BACKGROUND: Intracerebral hemorrhage (ICH) is a serious medical problem, and promising strategy is limited. Macrophage initiated brain inflammatory injury following ICH, but the molecular mechanism had not been well identified. E3 ligase Nedd4L is implicated in the pathogenesis of the inflammatory immune response. METHODS: In the present study, we detected the levels of Nedd4L in macrophages following ICH. Furthermore, Macrophage M1 polarization, pro-inflammatory cytokine production, BBB disruption, brain water content and neurological function were examined in ICH mice...
November 6, 2023: Immunology Letters
Annemiek van Spriel, Rudi W Hendriks
No abstract text is available yet for this article.
November 2, 2023: Immunology Letters
Ding Li, Lin Wang, Zhihong Zhao, Changsen Bai, Xichuan Li
In innate immunity, macrophages play critical roles in defending against pathogens via the lysosomal degradation function of autophagy. Two distinct autophagy pathways have been identified in decades: canonical autophagy (referred to as autophagy) and LC3-associated phagocytosis (LAP). Since several conflicting findings about the anti-Candida capability of autophagy (or LAP) have been reported, they serve as the foe or friend for Candida survival is still unclearly. The current study showed that the fungicidal process of THP-1-derived macrophages (THP-1-MФ) against Candida albicans is divided into three stages as follows, the early stage (the first 12 h, increasing in the killing capability), the mid-stage (12-24 h, no change in killing capability), and the late stage (24-48 h, decreasing of the killing capability)...
November 2023: Immunology Letters
Jingjing Zhang, Yali Zhu, Shuxian Chen, Zujin Xu, Bin Zhang, Anpeng Liu, Qianwen He, Jia Zhan
BACKGROUND: It has been reported that cannabinoid receptors 2 (CB2 receptors) play an important role in the pathophysiological process of sepsis, which may also be associated with the regulation of pyroptosis, an inflammatory programmed cell death. The present study aimed to investigate the protective effect of CB2 receptors on myocardial damage in a model of septic mice by inhibiting pyroptosis. METHODS: The C57BL/6 mice underwent cecal ligation and puncture (CLP) to induce sepsis...
October 31, 2023: Immunology Letters
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