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Immunology Letters | Page 2

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https://read.qxmd.com/read/31136754/increased-levels-of-adipose-tissue-resident-th17-cells-in-obesity-associated-with-mir-326
#21
Mariela Vega-Cárdenas, Edith E Uresti-Rivera, Juan D Cortés-García, Margarita Briones-Espinoza, Víctor M Ruíz-Rodríguez, Elizabeth Reynaga-Hernández, Alejandro Mendez-Mancilla, Diana P Portales-Pérez
miRNAs are important immune regulators in the control of the CD4 + T cells phenotype. miR-326 regulates the differentiation towards Th17 cells and the inhibition of miR-155 is associated with low levels of Treg cells. However, miRNAs expression and transcription factors associated with these lymphocyte subsets in obesity-induced adipose tissue inflammation is still unknown. The aim of this work was to identify Th17 cells in subcutaneous adipose tissue (SAT), proinflammatory cytokine production and their association with the miRNAs and transcription factors involved...
May 25, 2019: Immunology Letters
https://read.qxmd.com/read/31125591/the-polymorphism-rs4696480-in-the-tlr2-gene-is-associated-with-psoriasis-patients-in-the-turkish-population
#22
Seda Sabah-Özcan, Gülhan Gürel
BACKGROUND: Toll-like receptors (TLRs) have an important role in the host defense. Recent studies demonstrated that TLR polymorphisms might have a role in the pathogenesis of psoriasis vulgaris. The aim of this study was to indicate whether TLR2 rs11938228 and rs4696480 were associated with susceptibility to psoriasis in the Turkish population. METHODS: This case-control study included 140 psoriasis patients and 250 controls. Genotyping of 2 rs11938228 and rs4696480 SNPs of TLR2 were determined using LightSNiP Kit (Roche Diagnostic, GmBH, Mannheim, Germany)...
May 21, 2019: Immunology Letters
https://read.qxmd.com/read/31101375/retraction-notice-to-elevated-levels-of-follicular-t-helper-cells-and-their-association-with-therapeutic-effects-in-patients-with-chronic-lymphocytic-leukaemia-immunol-lett-197-2018-15-28
#23
Liannv Qiu, Yonglie Zhou, Yu Qinhua, Sujie Zheng, Zhenni Wang, Qiang Huang
No abstract text is available yet for this article.
May 14, 2019: Immunology Letters
https://read.qxmd.com/read/31095970/lack-of-association-between-serum-il-9-levels-and-beh%C3%A3-et-s-disease
#24
Masoud Nouri-Vaskeh, Aida Malek Mahdavi, Alireza Khabbazi, Golamreza Jadideslam
INTRODUCTION: Considering the role of interleukin (IL)-9 and IL-9-producing Th9 cells in pathogenesis of autoimmune diseases, this study aimed to evaluate serum IL-9 levels in patients with Behçet's disease (BD) compared to healthy subjects and to assess whether there is an association between serum IL-9 levels and disease characteristics in BD. METHODOLOGY: In this cross-sectional study, 32 BD patients according to the International Criteria for BD (ICBD) and 56 age-matched healthy controls were included...
May 13, 2019: Immunology Letters
https://read.qxmd.com/read/31091431/the-unicar-system-a-modular-car-t-cell-approach-to-improve-the-safety-of-car-t-cells
#25
REVIEW
Michael Bachmann
The idea to eliminate tumor cells via our own immune system is more than a hundred years old. However, a real break through came first with the development of check point inhibitors, bispecific antibodies (bsAbs) and T cells genetically modified to express Chimeric Antigen Receptors (CARs). Eventhough the clinical application of T cells equipped with CARs can lead to a complete remission, unfortunately, their application can also cause severe or even life threatening side effects as their activity can no more be adjusted once given to the patient...
May 12, 2019: Immunology Letters
https://read.qxmd.com/read/31077692/transforming-growth-factor-%C3%AE-tgf-%C3%AE-is-there-a-different-role-with-regard-to-distinct-phenotypes-of-endometriosis
#26
LETTER
Fabio Barra, Lorenzo Ferro Desideri, Simone Ferrero
No abstract text is available yet for this article.
May 8, 2019: Immunology Letters
https://read.qxmd.com/read/31075294/th-9-cells-in-beh%C3%A3-et-disease-possible-involvement-of-il-9-in-pulmonary-manifestations
#27
Wajih Kaabachi, Mnasria Khaouthar, Besma Hamdi, Ikbel Khalfallah, Jamel Ammar, Kamel Hamzaoui, Agnès Hamzaoui
Behçet disease (BD) is a multisystemic disease some of whose manifestations are characterized by pulmonary involvements. The purpose of the study was to evaluate the level of T-helper type 9 (Th9) cells and the cytokine interleukin (IL)-9 in peripheral blood and in bronchoalveolar lavage (BAL) of patients with Behçet's disease (BD) affected by pulmonary manifestations. Nevertheless, until recently there have been no studies on its role in BD. The Th9 (CD4+ IL-9+ T) cell, transcription factor PU.1 and IL-9 mRNA levels, as well as serum and BAL IL-9 concentration, were measured in BD patients and healthy controls...
May 7, 2019: Immunology Letters
https://read.qxmd.com/read/31059733/inhibition-of-hiv-1-envelope-dependent-membrane-fusion-by-serum-antilymphocyte-autoantibodies-is-associated-with-low-plasma-viral-load
#28
Mirna B Ruiz-Rivera, Guillermo Gómez-Icazbalceta, Marcela Vélez-Alavez, Mónica Viveros-Rogel, Santiago Pérez-Patrigeon, Edmundo Lamoyi, Luis Llorente, Carlos A Núñez-Álvarez, Leonor Huerta
The HIV-1 envelope protein (Env) mediates the membrane fusion process allowing virus entry to target cells and the efficiency to induce membrane fusion is an important determinant of HIV-1 pathogenicity. In addition to virus receptors, other adhesion/signaling molecules on infected and target cells and virus particles can enhance fusion. The presence of antilymphocyte autoantibodies (ALA) in HIV patients' serum suggests that they may contribute to the inhibition of Env-mediated membrane fusion. Here, sera from 38 HIV-1 infected treatment-naïve men and 30 healthy donors were analyzed for the presence of IgG and IgM able to bind to CD4-negative Jurkat cells...
May 3, 2019: Immunology Letters
https://read.qxmd.com/read/31026485/vaccine-platforms-for-the-prevention-of-lassa-fever
#29
REVIEW
Jyothi Purushotham, Teresa Lambe, Sarah C Gilbert
Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus (LASV), which is endemic throughout much of West Africa. The virus primarily circulates in the Mastomys natalensis reservoir and is transmitted to humans through contact with infectious rodents or their secretions; human-to-human transmission is documented as well. With the exception of Dengue fever, LASV has the highest human impact of any haemorrhagic fever virus. On-going outbreaks in Nigeria have resulted in unprecedented mortality...
April 23, 2019: Immunology Letters
https://read.qxmd.com/read/31059734/comparison-of-clinical-and-immunological-features-and-mortality-in-common-variable-immunodeficiency-and-agammaglobulinemia-patients
#30
Yasser Bagheri, Ahmad Vosughi, Gholamreza Azizi, Reza Yazdani, Fatemeh Kiaee, Nasim Hafezi, Shahriar Alimorad, Majid Khoshmirsafa, Farhad Seif, Gholamreza Hassanpour, Hassan Abolhassani, Asghar Aghamohammadi
Common Variable Immunodeficiency (CVID) and agammaglobulinemia are two of the main types of symptomatic primary antibody deficiencies. The pathogenic origins of these two diseases are different; agammaglobulinemia is a group of inherited disorders that usually are caused by mutations in the gene encoding Bruton Tyrosine Kinase (BTK) protein while CVID is a heterogeneous disorder mainly without monogenic cause. However, both diseases share a characteristic of frequent bacterial infections, a decline in serum immunoglobulin levels, and abnormality in antibody responses...
June 2019: Immunology Letters
https://read.qxmd.com/read/31029633/toll-like-receptor-signal-is-required-in-maintenance-of-immune-suppressive-capacity-of-regulatory-t-cells
#31
Miao Zhao, Hao-Tao Zeng, Gui Yang, Xiao-Rui Geng, Yuan-Yi Zhang, Fei Ma, Jiang-Qi Liu, Zhi-Qiang Liu, Mei-Zhen Zhao, Li-Hua Mo, Xiang-Qian Luo, Xiao-Wen Zhang, Da-Bo Liu, Ping-Chang Yang
Dysfunction of immune regulatory cells has been recognized in a variety of immune diseases; the underlying mechanism remains to be further investigated. This study aims to investigate the critical role of Toll-like receptor (TLR) signal in the maintenance of function of regulatory T cells (Tregs). In this study, Tregs were isolated from patients with allergic rhinitis (AR) and healthy control (HC) subjects. The role of TLR signal in the maintenance of Treg's function was tested with experiments of cell culture and an AR mouse model...
June 2019: Immunology Letters
https://read.qxmd.com/read/31004679/analysis-of-interleukin-17-and-interleukin-23-for-estimating-disease-activity-and-predicting-the-response-to-treatment-in-active-lupus-nephritis-patients
#32
Huang Dedong, Zhu Feiyan, Shi Jie, Lai Xiaowei, Wang Shaoyang
Renal biopsy is a "gold standard" for establishing the diagnosis and assessing prognosis and monitoring therapy in lupus nephritis (LN) patients, but it is an invasive and inconvenient procedure. Evidences showed that interleukin-17(IL-17) and interleukin-23(IL-23) may be as alternative biomarkers for diagnosing LN, monitoring LN activity and predicting the response to treatment of LN. To analyze the roles of IL-17 and IL-23 in evaluation activity of LN and predicting active LN response to immunosuppressive treatment, by comparison between IL-17, IL-23 and clinical data of LN...
June 2019: Immunology Letters
https://read.qxmd.com/read/30935876/the-molecular-and-clinical-evidence-of-vitamin-d-signaling-as-a-modulator-of-the-immune-system-role-in-beh%C3%A3-et-s-disease
#33
Sam Seydi Shirvani, Mohammad Nouri, Ebrahim Sakhinia, Zohreh Babaloo, Adel Mohammadzaeh, Shahriar Alipour, Golamreza Jadideslam, Alireza Khabbazi
Various tissues and cell types are the targets of vitamin D. However, the major targets of vitamin D in the immune system are monocytes/macrophages, dendritic cells (DCs), as well as B and T cells. Vitamin D plays an important role in the immune system modulation via regulating the expression of genes that generate pro-inflammatory mediators and inhibiting the proliferation of pro-inflammatory cells, both of which have been implicated in the pathophysiology of the inflammatory diseases. Recent studies have revealed the important relations between vitamin D and Behçet's disease (BD)...
June 2019: Immunology Letters
https://read.qxmd.com/read/30898660/exploration-of-some-new-secretory-proteins-to-be-employed-for-companion-diagnosis-of-mycobacterium-tuberculosis
#34
Dinesh K Tripathi, Kanchan Srivastava, Komal Lata Nagpal, Praveen K Shukla, Kishore K Srivastava
Tuberculosis (TB) is a highly infectious disease and its early and precise diagnosis is essential to reduce morbidity and mortality of patients. Since the routine diagnostic tests (like Monteux, AFB smear microscopy, chest X-Ray) do not give infallible results, additional tests are always recommended. Therefore to address the concerns about non-specificity of the present battery of diagnostic tests, we have attempted to analyze some unique secretory antigens which could be able to identify the stage specific infection of MTB...
May 2019: Immunology Letters
https://read.qxmd.com/read/31004681/in-vivo-deuterium-labelling-in-mice-supports-a-dynamic-model-for-memory-t-cell-maintenance-in-the-bone-marrow
#35
Mariona Baliu-Piqué, Sigrid A Otto, José A M Borghans, Kiki Tesselaar
The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62 L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes...
April 17, 2019: Immunology Letters
https://read.qxmd.com/read/31004680/inhibiting-phosphatase-ship-1-enhances-suboptimal-ige-mediated-activation-of-human-blood-basophils-but-inhibits-ige-mediated-activation-of-cultured-human-mast-cells
#36
Pernille Rasmussen, Edzard Spillner, Hans Jürgen Hoffmann
IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releasability of basophils. This study sought to clarify the regulatory role of SHIP-1 in degranulation of basophil granulocytes and mast cells by selective inhibition of the phosphatase function of SHIP-1with 3-α-aminocholestane (3-α-AC)...
April 17, 2019: Immunology Letters
https://read.qxmd.com/read/30998957/leishmania-infantum-leif-and-its-recombinant-polypeptides-induce-the-maturation-of-dendritic-cells-in-vitro-an-insight-for-dendritic-cells-based-vaccine
#37
Mourad Barhoumi, Olga S Koutsoni, Eleni Dotsika, Ikram Guizani
We previously showed that recombinant Leishmania infantum eukaryotic initiation factor (LieIF) was able to induce the secretion of cytokines IL-12, IL-10 and TNF-α by human monocytes. In this study, we explored in vitro the potential of LieIF to induce phenotypic maturation and functional differentiation of murine bone - marrow derived dendritic cells (BM-DCs). Moreover, in order to identify potential immunnomodulatory regions of LieIF, eight recombinant overlapping protein fragments covering the whole amino acid sequence ofprotein; were constructed and assessed in vitro for their ability to induce maturation of BM-DCs...
April 15, 2019: Immunology Letters
https://read.qxmd.com/read/30978362/allergy-to-mus-m-1-allergy-to-mus-m-1-a-review-of-structural-and-immunological-features
#38
REVIEW
Marlon Múnera, Andres Sanchez, Jorge Sánchez, Maria Nordmann, Mariana Perez, Dilia Aparicio
The prevalence of allergies to pets has been increasing over the past decades. Some of the most important animal-derived allergens are members of the lipocalin protein family, which are found in dander, saliva, and urine. These allergens disperse effectively and are widely present in indoor environments. Exposure to high levels of mouse urinary protein (Mus m 1, hereinafter called 'mouse allergen') has been previously linked to sensitization to mouse, and indicators of asthma severity or control in some studies...
April 9, 2019: Immunology Letters
https://read.qxmd.com/read/30959077/differential-effects-of-anaphylatoxin-c5a-on-antigen-presenting-cells-roles-for-c5ar1-and-c5ar2
#39
REVIEW
Anouk Zaal, S Marieke van Ham, Anja Ten Brinke
The anaphylatoxin C5a is well-known for its role as chemoattractant and contributes to immune cell recruitment into inflamed tissue and local inflammation. C5a has recently been implicated in modulation of antigen presenting cell function, such as macrophages and dendritic cells, which are pivotal for T cell activation and final T cell effector function. The published data on the effect of C5a on APC function and subsequent adaptive immune responses are in part conflicting, as both pro and anti-inflammatory effects have been described...
April 5, 2019: Immunology Letters
https://read.qxmd.com/read/30954509/mechanisms-of-polarized-cell-cell-communication-of-t-lymphocytes
#40
REVIEW
Torralba D, Martín-Cófreces Nb, Sanchez-Madrid F
Cell-cell communication comprises a variety of molecular mechanisms that immune cells use to respond appropriately to diverse pathogenic stimuli. T lymphocytes polarize in response to different stimuli, such as cytokines, adhesion to specific ligands and cognate antigens presented in the context of MHC. Polarization takes different shapes, from migratory front-back polarization to the formation of immune synapses (IS). The formation of IS between a T cell and an antigen-presenting cell involves early events of receptor-ligand interaction leading to the reorganization of the plasma membrane and the cytoskeleton to orchestrate vesicular and endosomal traffic and directed secretion of several types of mediators, including cytokines and nanovesicles...
April 4, 2019: Immunology Letters
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