Immunology Letters | Page 2

Zhiyuan Chen, Yaling Liu, Li Yang, Peng Liu, Yu Zhang, Xiangyang Wang
This study aimed to research the effect of miR-149 on endoplasmic reticulum stress (ERS)-induced inflammation and apoptosis in non-alcoholic fatty liver disease (NAFLD). The mouse model with NAFLD was established by feeding with a high-fat diet, and the model establishment was subsequently confirmed by H&E staining and oil red O staining. MiR-149 agomir was injected into NAFLD mice to observe changes in liver tissues. After cell transfection, qRT-PCR and Western blot were performed to measure the expressions of lipid metabolism-related proteins (SCD-1, PPARα, and ABCA1), miR-149 and ATF6...
March 16, 2020: Immunology Letters
Jinpeng Bi, Fangshen Li, Mo Zhang, Huaiyu Wang, Jingcai Lu, Yong Zhang, Hong Ling, Jiaye Wang, Feng Gao, Wei Kong, Bin Yu, Xianghui Yu
Although many vaccines have been designed to induce effective mucosal immune responses against HIV-1, designing an effective HIV-1 vaccine remains a challenge. Bacterium-like particles (BLPs) are a new type of vector used to induce mucosal immune responses, and have already been used for some vaccines against respiratory tract viruses. In this study, we designed a mucosal vaccine against HIV-1 based on BLPs. The vaccine was used to immunize both mice and guinea pigs via intramuscular (i.m.) injection or intranasal (i...
March 12, 2020: Immunology Letters
Elena Niccolai, Federico Boem, Giacomo Emmi, Amedeo Amedei
Evidence establishes that chronic inflammation and autoimmunity are associated with cancer development and patients with a primary malignancy may develop autoimmune-like diseases. Despite immune dysregulation is a common feature of both cancer and autoimmune diseases, precise mechanisms underlying this susceptibility are not clarified and different hypotheses have been proposed, starting from genetic and environmental common features, to intrinsic properties of immune system. Moreover, as the development and use of immunomodulatory therapies for cancer and autoimmune diseases are increasing, the elucidation of this relationship must be investigated in order to offer the best and most secure therapeutic options...
March 4, 2020: Immunology Letters
Zeineb Zian, Mohcine Bennani Mechita, Khaoula Hamdouch, Mouna Maamar, Amina Barakat, Naima Ghailani Nourouti, Rajae El Aouad, Manuel M Valdivia, Naima Arji
BACKGROUND: Anti-centromere auto-antibodies (ACA) have been described as a marker in Systemic sclerosis (SSc) disease. CENP-B is the major centromere auto-antigen recognized by SSc patients with positive ACA. Our aim was to characterize the major epitope involved in the anti-CENP-B immune response of Moroccan SSc patients. PATIENTS AND METHOD: For identification of SSc biomarkers, 80 sera from patients with SSc and systemic lupus erythematosus (SLE) were screened by indirect immunofluorescence test (IIF) to assess the presence of ANA reactivity...
May 2020: Immunology Letters
Alireza Khabbazi, Haniyeh Rahbar Kafshboran, Maryam Nasiri Aghdam, Jafar Nouri Nojadeh, Hossein Daghagh, Yousef Daneshmandpour, Mina Kazemzadeh, Hamid Hamzeiy, Ebrahim Sakhinia
Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation (APLAID) is an autosomal dominant autoinflammatory disease characterized by episodic skin, musculoskeletal, ophthalmic and gastrointestinal tract symptoms. Here we report an 11-year-old girl with a history of repeated episodes of fever, myalgia, arthralgia, abdominal pain, and urticarial rash in the trunk and limbs. Chest and pelvic X-Ray, sacroiliac joints MRI, brain MRI and abdominal CT scan were normal. Anti-nuclear antibody, Rheumatoid factor, cryoglobulin, ANCA/PR3, p-ANCA/MPO, anti-smooth muscle antibody and anti-mitochondrial antibody were negative...
May 2020: Immunology Letters
Fateme Asadzadeh Manjili, Aliakbar Yousefi-Ahmadipour, Mohammad Kazemi Arababadi
Multiple sclerosis (MS) is a world-wide pro-inflammatory based disease, which is prevalent among young individuals. The etiology of the disease and its related complications are yet to be clarified. It has been hypothesized that environmental factors, including pathogen-associated molecular patterns (PAMPs) and the internal factors such as damage-associated molecular patterns (DAMPs), may be the most important inducers/stimulators of the disorder and its related complications. Previous investigations proved that pathogen recognition receptors (PRRs) are the main sensors for the PAMPs and DAMPs...
April 2020: Immunology Letters
Yunhe Liu, Songshan Ye, Xiaoxue Guo, Wentao Li, Ying Xia, Xiaohua Wen, Jianchun Yu, Yingjie Jia, Xu Liu, Yongtie Guo, Yan Zhao
BACKGROUND: CD3 and CD19 are the characteristic surface markers of mature T lymphocytes and B lymphocytes of human respectively. A special subset of immune cells that characteristically expressed the surface markers CD19+ of B lymphocytes and CD3+ of T lymphocytes simultaneously (CD19+CD3+ cells, hereinafter referred to as B-T cells) was found in the peripheral blood of human, yet it has not been reported in cancer research before. Our aims were to characterize the expression and possible value of B-T cells in cancer patients...
April 2020: Immunology Letters
Max Mimpen, Joost Smolders, Raymond Hupperts, Jan Damoiseaux
As the most common non-traumatic disabling disease among adolescents, multiple sclerosis (MS) is a devastating neurological inflammatory disease of the central nervous system. Research has not yet fully elucidated its pathogenesis, but it has shown MS to be a complex, multifactorial disease with many interplaying factors. One of these factors, natural killer (NK) cells, lymphocytes of the innate immune system, have recently gained attention due to the effects of daclizumab therapy, causing an expansion of the immunoregulatory subset of NK cells...
February 27, 2020: Immunology Letters
Susana Magadán
The adaptive immune response in jawed vertebrates relies on the huge diversity and specificity of the B cell and T cell antigen receptors, the immunoglobulins (IG) or antibodies and the T cell receptors (TR), respectively. The high level of diversity has represented a barrier to a comprehensive analysis of the adaptive immune response before the emergence of high-throughput sequencing (HTS) technologies. The size and complexity of HTS data requires the generation of novel computational and analytical approaches, which are transforming how the adaptive immune responses are deciphered to understand the clonal dynamics and properties of antigen-specific B and T cells in response to different kind of antigens...
February 27, 2020: Immunology Letters
Ke-Tao Jin, Shi-Bing Wang, Xiao-Jiang Ying, Huan-Rong Lan, Jie-Qing Lv, Li-Hua Zhang, Morteza Motallebnezhad, Xiao-Zhou Mou
Within the past decade, immune-checkpoint inhibitors (ICPIs), including anti-programmed cell death 1 (PD-1), anti-programmed cell death 1 ligand 1 (PD-L1), and anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies, are undoubtfully the most remarkable advances in cancer therapy. The immune responses are modulated by these ICPIs via blocking the inhibitory PD-1/PD-L1 path and result in immune activation in the suppressive microenvironment of the tumor. While ICPIs result in benefits for numerous patients with malignancy and lead to disease control and survival, toxicity and safety problems have emerged as well...
February 22, 2020: Immunology Letters
Silvia Cellone Trevelin, Ajay M Shah, Giovanna Lombardi
NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signalling and the discovery of Nox2 expression in different cell types, including macrophages, endothelial cells (ECs), dendritic cells (DCs), B and T lymphocytes, have changed this paradigm. For instance, Nox2 expressed in macrophages and neutrophils limits the transcription of cytokines and toll-like receptors (TLRs) induced by lipopolysaccharide (LPS), whereas Nox2 in DCs facilitates antigen cross-presentation to T cells...
February 21, 2020: Immunology Letters
Björn Corleis, Anca Dorhoi
Tuberculosis (TB) most frequently affects the lung, with Mycobacterium tuberculosis (Mtb), the etiologic agent of TB, promptly gaining access to lung-resident myeloid cells, notably alveolar macrophages. Historical observational case-contact surveys and recent epidemiological studies report on resistors. These, which are individuals are likely protected against infection by defense mechanisms occurring promptly after bacterial exposure. The early events proceeding within the Mtb-infected lung are critical for the outcome of the infection...
February 21, 2020: Immunology Letters
Pooja Raibagkar
No abstract text is available yet for this article.
February 21, 2020: Immunology Letters
Thalita Basso Scandolara, Carolina Panis
Myeloperoxidase is an enzyme present in neutrophils and has been demonstrated to be an important molecule for neutrophil extracellular traps (NETs) formation and function. Yet, it is also a source of autoantigens for anti-neutrophil or anti-myeloperoxidase antibodies (ANCAs), which are capable of activating these immune cells and provoke tissue damage in a sterile microenvironment. The presence of these antibodies in cancer has been related by case reports, but a few studies addressed the significance of this finding beyond autoimmunity context...
February 21, 2020: Immunology Letters
Tracy L Deem, James B Collins, Madison H DeVost, Chandler O Parker, Shelby C Saroka, Ryan J Zoldork, Fernando Gutierrez, Jenny M Russell, Chris S Lantz
Interleukin-3 (IL-3) is an important hematopoietic growth factor and immunregulatory cytokine. Although activated T helper cells represent a main source of IL-3, other cell types have been reported to express this cytokine. However, precise identification and quantification of the cells that produce IL-3 in vivo have not been performed. Therefore, we used a CRISPR/Cas approach to engineer mice containing a bicistronic mRNA linking a readily identifiable reporter, enhanced green fluorescent protein (ZsGreen1), to IL-3 expression...
February 18, 2020: Immunology Letters
Sahin Sultana, Biswadev Bishayi
S.aureus induced septic arthritis remains a serious medical concern due to its rapidly progressive disease profile. The multidrug resistant nature of S.aureus demands the development of new strategies for the treatment of S.aureus arthritis. Since monocyte/macrophage population has been recognized as an important axis in joint inflammation and destruction, selective depletion of peripheral blood monocytes might influence the outcome and progression of the disease. Therefore, in this study we have put forward the concept of monocyte depletion by using etoposide, a drug that selectively depletes the monocyte/macrophage population...
February 4, 2020: Immunology Letters
Zeyneb Hadjidj, Rabia Messali, Mourad Aribi
BACKGROUND: Red blood cells (RBCs) can have a modulatory effect on immune cells; so changes in their dynamism could considerably influence their physiology, and consequently the immune activities of neighboring cells, like natural killer (NK) cells. Herein, we studied the effect of both RBCs and lack of cell movement on the proliferation, survival and regulation of peripheral IL-2-stimulated NK cells from normal and malignant conditions. METHODS: Experiments were conducted on twelve cell culture groups, including NK cells from patients with solid malignant tumor or healthy controls, cultured alone or with autologous RBCs or nonautologous RBCs from healthy controls, under shaking or no shaking conditions...
February 3, 2020: Immunology Letters
Andres Sánchez, Jorge Sanchez
BACKGROUND: Human proteins such as interleukin-24 (IL24), thyroperoxidase (TPO) and thyroglobulin (Tg) are targets of IgE or IgG autoantibodies. Why these proteins are recognized by autoantibodies in some patients with chronic spontaneous urticaria (CSU) or hypothyroidism is unknown. OBJECTIVE: Through in silico analysis, identify antigen patches of TPO, Tg and IL24 and compare the sequences of these human proteins with some prevalent allergens. METHODS: The amino acids sequences of IL24, thyroperoxidase and thyroglobulin were compared between them and with 22 environmental allergens...
February 3, 2020: Immunology Letters
Saman Bahrambeigi, Morteza Molaparast, Farahnaz Sohrabi, Lachin Seifi, Alireza Faraji, Saba Fani, Vahid Shafiei-Irannejad
Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair immune responses against cancer cells. In the present study, we represent possible approaches for metabolic reprogramming of T cells in cancer immunotherapy to overcome tumor metabolic impositions on immune responses against cancer cells...
January 23, 2020: Immunology Letters
João A Oliveira-da-Silva, Amanda S Machado, Fernanda F Ramos, Grasiele S V Tavares, Daniela P Lage, Fernanda Ludolf, Bethina T Steiner, Thiago A R Reis, Thaís T O Santos, Lourena E Costa, Vívian T Martins, Nathália C Galvani, Ana T Chaves, Jamil S Oliveira, Miguel A Chávez-Fumagalli, Danielle F de Magalhães-Soares, Mariana C Duarte, Daniel Menezes-Souza, Julia A G Silveira, Ricardo L F Moreira, Ricardo A Machado-de-Ávila, Unaí Tupinambás, Denise U Gonçalves, Eduardo A F Coelho
Visceral leishmaniasis (VL) is a highly neglected disease that is present in several countries worldwide. Present-day treatments against this disease are unsuitable, mainly due to the toxicity and/or high cost of drugs. In addition, the development of vaccines is still insufficient. In this scenario, a prompt VL diagnosis was deemed necessary, although sensitivity and/or specificity values of the tests have been. In this context, new antigenic candidates should be identified to be employed in a more precise diagnosis of canine and human VL...
January 22, 2020: Immunology Letters
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