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Immunology Letters

Liannv Qiu, Yonglie Zhou, Yu Qinhua, Sujie Zheng, Zhenni Wang, Qiang Huang
No abstract text is available yet for this article.
May 14, 2019: Immunology Letters
Masoud Nouri-Vaskeh, Aida Malek Mahdavi, Alireza Khabbazi, Golamreza Jadideslam
INTRODUCTION: Considering the role of interleukin (IL)-9 and IL-9-producing Th9 cells in pathogenesis of autoimmune diseases, this study aimed to evaluate serum IL-9 levels in patients with Behçet's disease (BD) compared to healthy subjects and to assess whether there is an association between serum IL-9 levels and disease characteristics in BD. METHODOLOGY: In this cross-sectional study, 32 BD patients according to the International Criteria for BD (ICBD) and 56 age-matched healthy controls were included...
May 13, 2019: Immunology Letters
Michael Bachmann
The idea to eliminate tumor cells via our own immune system is more than a hundred years old. However, a real break through came first with the development of check point inhibitors, bispecific antibodies (bsAbs) and T cells genetically modified to express Chimeric Antigen Receptors (CARs). Eventhough the clinical application of T cells equipped with CARs can lead to a complete remission, unfortunately, their application can also cause severe or even life threatening side effects as their activity can no more be adjusted once given to the patient...
May 12, 2019: Immunology Letters
Fabio Barra, Lorenzo Ferro Desideri, Simone Ferrero
No abstract text is available yet for this article.
May 8, 2019: Immunology Letters
Wajih Kaabachi, Mnasria Khaouthar, Besma Hamdi, Ikbel Khalfallah, Jamel Ammar, Kamel Hamzaoui, Agnès Hamzaoui
Behçet disease (BD) is a multisystemic disease some of whose manifestations are characterized by pulmonary involvements. The purpose of the study was to evaluate the level of T-helper type 9 (Th9) cells and the cytokine interleukin (IL)-9 in peripheral blood and in bronchoalveolar lavage (BAL) of patients with Behçet's disease (BD) affected by pulmonary manifestations. Nevertheless, until recently there have been no studies on its role in BD. The Th9 (CD4+ IL-9+ T) cell, transcription factor PU.1 and IL-9 mRNA levels, as well as serum and BAL IL-9 concentration, were measured in BD patients and healthy controls...
May 7, 2019: Immunology Letters
Yasser Bagheri, Ahmad Vosughi, Gholamreza Azizi, Reza Yazdani, Fatemeh Kiaee, Nasim Hafezi, Shahriar Alimorad, Majid Khoshmirsafa, Farhad Seif, Gholamreza Hassanpour, Hassan Abolhassani, Asghar Aghamohammadi
Common Variable Immunodeficiency (CVID) and agammaglobulinemia are two of the main types of symptomatic primary antibody deficiencies. The pathogenic origins of these two diseases are different; agammaglobulinemia is a group of inherited disorders that usually are caused by mutations in the gene encoding Bruton Tyrosine Kinase (BTK) protein while CVID is a heterogeneous disorder mainly without monogenic cause. However, both diseases share a characteristic of frequent bacterial infections, a decline in serum immunoglobulin levels, and abnormality in antibody responses...
May 3, 2019: Immunology Letters
Mirna B Ruiz-Rivera, Guillermo Gómez-Icazbalceta, Marcela Vélez-Alavez, Mónica Viveros-Rogel, Santiago Pérez-Patrigeon, Edmundo Lamoyi, Luis Llorente, Carlos A Núñez-Álvarez, Leonor Huerta
The HIV-1 envelope protein (Env) mediates the membrane fusion process allowing virus entry to target cells and the efficiency to induce membrane fusion is an important determinant of HIV-1 pathogenicity. In addition to virus receptors, other adhesion/signaling molecules on infected and target cells and virus particles can enhance fusion. The presence of antilymphocyte autoantibodies (ALA) in HIV patients' serum suggests that they may contribute to the inhibition of Env-mediated membrane fusion. Here, sera from 38 HIV-1 infected treatment-naïve men and 30 healthy donors were analyzed for the presence of IgG and IgM able to bind to CD4-negative Jurkat cells...
May 3, 2019: Immunology Letters
Jyothi Purushotham, Teresa Lambe, Sarah C Gilbert
Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus (LASV), which is endemic throughout much of West Africa. The virus primarily circulates in the Mastomys natalensis reservoir and is transmitted to humans through contact with infectious rodents or their secretions; human-to-human transmission is documented as well. With the exception of Dengue fever, LASV has the highest human impact of any haemorrhagic fever virus. On-going outbreaks in Nigeria have resulted in unprecedented mortality...
April 23, 2019: Immunology Letters
Mariona Baliu-Piqué, Sigrid A Otto, José A M Borghans, Kiki Tesselaar
The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62 L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes...
April 17, 2019: Immunology Letters
Pernille Rasmussen, Edzard Spillner, Hans Jürgen Hoffmann
IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releasability of basophils. This study sought to clarify the regulatory role of SHIP-1 in degranulation of basophil granulocytes and mast cells by selective inhibition of the phosphatase function of SHIP-1with 3-α-aminocholestane (3-α-AC)...
April 17, 2019: Immunology Letters
Mourad Barhoumi, Olga S Koutsoni, Eleni Dotsika, Ikram Guizani
We previously showed that recombinant Leishmania infantum eukaryotic initiation factor (LieIF) was able to induce the secretion of cytokines IL-12, IL-10 and TNF-α by human monocytes. In this study, we explored in vitro the potential of LieIF to induce phenotypic maturation and functional differentiation of murine bone - marrow derived dendritic cells (BM-DCs). Moreover, in order to identify potential immunnomodulatory regions of LieIF, eight recombinant overlapping protein fragments covering the whole amino acid sequence ofprotein; were constructed and assessed in vitro for their ability to induce maturation of BM-DCs...
April 15, 2019: Immunology Letters
Marlon Múnera, Andres Sanchez, Jorge Sánchez, Maria Nordmann, Mariana Perez, Dilia Aparicio
The prevalence of allergies to pets has been increasing over the past decades. Some of the most important animal-derived allergens are members of the lipocalin protein family, which are found in dander, saliva, and urine. These allergens disperse effectively and are widely present in indoor environments. Exposure to high levels of mouse urinary protein (Mus m 1, hereinafter called 'mouse allergen') has been previously linked to sensitization to mouse, and indicators of asthma severity or control in some studies...
April 9, 2019: Immunology Letters
Anouk Zaal, S Marieke van Ham, Anja Ten Brinke
The anaphylatoxin C5a is well-known for its role as chemoattractant and contributes to immune cell recruitment into inflamed tissue and local inflammation. C5a has recently been implicated in modulation of antigen presenting cell function, such as macrophages and dendritic cells, which are pivotal for T cell activation and final T cell effector function. The published data on the effect of C5a on APC function and subsequent adaptive immune responses are in part conflicting, as both pro and anti-inflammatory effects have been described...
April 5, 2019: Immunology Letters
Torralba D, Martín-Cófreces Nb, Sanchez-Madrid F
Cell-cell communication comprises a variety of molecular mechanisms that immune cells use to respond appropriately to diverse pathogenic stimuli. T lymphocytes polarize in response to different stimuli, such as cytokines, adhesion to specific ligands and cognate antigens presented in the context of MHC. Polarization takes different shapes, from migratory front-back polarization to the formation of immune synapses (IS). The formation of IS between a T cell and an antigen-presenting cell involves early events of receptor-ligand interaction leading to the reorganization of the plasma membrane and the cytoskeleton to orchestrate vesicular and endosomal traffic and directed secretion of several types of mediators, including cytokines and nanovesicles...
April 4, 2019: Immunology Letters
Jun Wang, Hui Jiang, Yang Qiu, Yicun Wang, Guojing Sun, Jianning Zhao
Delayed union and nonunion occur in a minor subject of bone fractures, presenting ongoing challenges to treatment. RANKL, which promotes the differentiation of bone-resorbing osteoclasts, is thought to negatively impact bone healing. In this study, we recruited patients with isolated closed tibial fracture, who were later categorized into normal healing and delayed healing groups based on their healing progression. The regulatory T cell (Treg) compartment was then investigated in each patient. Based on CD45RA and CD62 L expression, we distinguished circulating Treg cells into CD45RA+ CD62L+ naive (N), CD45RA- CD62L+ central memory (CM), and CD45RA- CD62L- effector memory (EM) subsets...
April 1, 2019: Immunology Letters
Sam Seydi Shirvani, Mohammad Nouri, Ebrahim Sakhinia, Zohreh Babaloo, Adel Mohammadzaeh, Shahriar Alipour, Golamreza Jadideslam, Alireza Khabbazi
Various tissues and cell types are the targets of vitamin D. However, the major targets of vitamin D in the immune system are monocytes/macrophages, dendritic cells (DCs), as well as B and T cells. Vitamin D plays an important role in the immune system modulation via regulating the expression of genes that generate pro-inflammatory mediators and inhibiting the proliferation of pro-inflammatory cells, both of which have been implicated in the pathophysiology of the inflammatory diseases. Recent studies have revealed the important relations between vitamin D and Behçet's disease (BD)...
March 29, 2019: Immunology Letters
Wei Lin, Tingting Liu, Beibei Wang, Hongsheng Bi
Dendritic cells (DCs) act as a bridge between innate and adoptive immunity. They are widely distributed in various tissues and organs. Resident ocular DCs are found in the peripheral margins and juxtapapillary areas of the retina, usually in an immature state. During inflammation, DCs are activated and participate in the development of uveitis, an ocular inflammatory disease. Herein, the characteristics and status of DCs in uveitis, the possible factors affecting the status of DCs, and the clinical methods for detecting the DCs in patients are described...
March 26, 2019: Immunology Letters
Sahin Sultana, Rajen Dey, Biswadev Bishayi
uPA/tPA-mediated activation of plasminogen/plasmin pathway during S.aureus arthritis facilitates the invasion of phagocytes in the affected joint, induces production of cytokines and triggers inflammatory pathways. PAI-1, an effective inhibitor of both uPA and tPA, attenuates plasmin activity. Hence, the objective of our study was to evaluate the effect of exogenously administered PAI-1 on uPA/tPA-mediated activation of plasminogen/plasmin and its impact on the progression of arthritis. The mice were infected with live S...
March 25, 2019: Immunology Letters
Atri Ghods, Abbas Ghaderi, Mahmoud Shariat, Abdol-Rasoul Talei, Fereshteh Mehdipour
Tumor necrosis factor-α (TNF-α) is a key cytokine in inflammation and a driving force for leukocyte migration and recruitment. However, it may exert contrasting effects on the immune responses depend on its differential binding to its receptors (TNFR1 or TNFR2). The expression of TNF receptors by lymphocytes in the tumor draining lymph nodes (TDLNs) has not been thoroughly investigated. Herein, the expression of TNFRs on lymphocytes in the breast TDLNs was assessed. 40 axillary LN samples were obtained from breast cancer patients...
March 22, 2019: Immunology Letters
Jingyao Lian, Jianling Liu, Ying Yue, Feng Li, Xinfeng Chen, Zhen Zhang, Yu Ping, Guohui Qin, Lifeng Li, Kai Zhang, SaiSai Liu, Lei Zhang, Shenglong Qiao, Na Liu, Yujia Zheng, Jian Wu, Qiang Zeng, Yi Zhang
T cell immunity is dependent on T cell receptor (TCR) recognition of large numbers of antigenic peptides presented in the context of major histocompatibility complex (MHC) class I and II molecules. To explore whether the TCR β-chain repertoire changes with different ages and genders in healthy Chinese individuals, we analyzed the TCR β-chain repertoire in 154 healthy Chinese individuals by High-throughput sequencing (HTS) with age (age range: 6-70) and each age group contains about 20 individuals (male and female)...
March 21, 2019: Immunology Letters
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