Shuai Guo, Shrikant Kolan, Gaoyang Li, Clara Louise Hammarström, Franco Grimolizzi, Linda Elin Birkhaug Stuhr, Bjørn Steen Skålhegg
Ablation of the immune-specific catalytic subunit Cβ2 of protein kinase A is associated with a proinflammatory phenotype and increased sensitivity to autoimmunity in mice. Here we show that tumour growth of the adenocarcinoma cell line EO771 in the breast and in the lung after injection into the mammary fat pad and tail vein, respectively, was significantly reduced in mice ablated for Cβ2 compared to wild-type mice. In both cases, the breast and lung tumours showed increased infiltration of immune cells in the mice lacking Cβ2 compared to wild-type mice...
June 20, 2024: Immunology Letters
Manuela Capone, Anna Vanni, Lorenzo Salvati, Giulia Lamacchia, Alessio Mazzoni, Laura Maggi, Lorenzo Cosmi, Francesco Liotta, Paola Romagnani, Luigi Cirillo, Elisa Buti, Vito Terlizzi, Chiara Azzari, Francesco Citera, Federica Barbati, Gian Maria Rossolini, Silvia Bresci, Beatrice Borchi, Annalisa Cavallo, Jessica Mencarini, Emanuela Francalanci, Seble Tekle Kiros, Alessandro Bartoloni, Francesco Annunziato
OBJECTIVE: Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2 protecting individuals, especially the immunocompromised, from COVID-19. Still, it remains largely unknown how solid organ transplant and different immunosuppressive medications affect development of vaccine-induced immunity. METHODS: In this work, we monitored humoral and cellular memory responses after mRNA SARS-CoV-2 two-doses and booster doses vaccination in cystic fibrosis lung transplanted patients (CFT) and compared them with both cystic fibrosis patients without lung transplant (CF) and with kidney transplant recipients (KT)...
June 19, 2024: Immunology Letters
Lisa U Teufel, Leo A B Joosten, Jéssica C Dos Santos
Leishmaniasis is a collective term for several tropical, neglected diseases caused by protozoans of the species Leishmania, 20 of which causing disease in humans ranging from localised self-healing lesions to chronic manifestations which affect the skin or inner organs. Although millions of infections are accounted for annually, treatment options are scarce and limited to medication associated with heavy side-effects and increasing antibiotic resistance. Case studies point towards immunotherapy as effective alternative treatment relying on immunomodulatory properties of e...
June 18, 2024: Immunology Letters
Ritis K Shyanti, Jazmyn Greggs, Shalie Malik, Manoj Mishra
The gut microbiota is a system of microorganisms in the human gastrointestinal (GI) system, consisting of trillions of microorganisms residing in epithelial surfaces of the body. Gut microbiota are exposed to various external and internal factors and form a unique gut-associated immunity maintained through a balancing act among diverse groups of microorganisms. The role of microbiota in dysbiosis of the gut in aiding prostate cancer development has created an urgency for extending research toward comprehension and preventative measures...
June 7, 2024: Immunology Letters
Wanpeng Cheng, Ziyi Huang, Yongzhe Hao, Hui Hua, Bo Zhang, Xiangyang Li, Fengqing Fu, Jing Yang, Kuiyang Zheng, Xueguang Zhang, Chunjian Qi
Anti-CD40 antibodies (Abs) have been shown to induce antitumor T-cell responses. We reported that the engineered agonistic anti-CD40 Ab (5C11, IgG4 isotype) recognized human CD40 antigen expressed on a human B lymphoblastoid cell line as well as on splenic cells isolated from humanized CD40 mice. Of note, a single high dosage of 5C11 was able to prohibit tumor growth in parallel with an increase in the population of infiltrated CD8+ T cells. Furthermore, the antitumor effects of 5C11 were enhanced in the presence of β-glucan along with an increase in the population of infiltrated CD8+ T cells...
May 27, 2024: Immunology Letters
Xue Yao, Sandro Matosevic
Wilms' tumor (WT1), a transcription factor highly expressed in various leukemias and solid tumors, is a highly specific intracellular tumor antigen, requiring presentation through complexation with HLA-restricted peptides.. WT1-derived epitopes are able to assemble with MHC-I and thereby be recognized by T cell receptors (TCR). Identification of new targetable epitopes derived from WT1 on solid tumors is a challenge, but meaningful for the development of therapeutics that could in this way target intracellular oncogenic proteins...
May 27, 2024: Immunology Letters
Adèle De Masson, Ingrid Lazaridou, Hélène Moins-Teisserenc, Caroline Ram-Wolff, Jérôme Giustiniani, Martine Bagot, Maxime Battistella, Armand Bensussan
Cutaneous T-cell lymphomas (CTCL) are a diverse group of malignant blood disorders characterized by initial skin infiltration, and sometimes, tumor spreading to lymph nodes, blood, and viscera. Mycosis fungoides is the most common form. Sézary syndrome is a distinctive form of CTCL marked by a significant presence of circulating tumor cells in peripheral blood. These diseases are characterized by the plasticity and heterogeneity of the tumor cells in the different tissue compartments, and a difficulty in identifying these tumor cells for diagnostic purposes and therapeutic monitoring...
May 25, 2024: Immunology Letters
Yue Hao, Wei Zhao, Lulu Chang, Xingfan Chen, Chonghui Liu, Yang Liu, Lixuan Hou, Yinchun Su, Hao Xu, Yu Guo, Qixu Sun, Lili Mu, Jinghua Wang, Hulun Li, Junwei Han, Qingfei Kong
No abstract text is available yet for this article.
May 24, 2024: Immunology Letters
Yi-Ting Chen, Yi-Mei Chang, Yu-Ling Chen, Yu-Hsuan Su, Chia-Chi Liao, Tien-Huang Chiang, Wen-Yu Chen, Yu-Chia Su
Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory intestinal disease that affects people around the world. The primary cause of IBD is an imbalance in the host immune response to intestinal flora. Several human genes, including IL10, STAT3, IRGM, ATG16L1, NOD2 and RUNX3, are associated with inappropriate immune responses in IBD. It has been reported that homozygous Runx3-knockout (ko) mice spontaneously develop colitis. However, the high mortality rate in these mice within the first two weeks makes it challenging to study the role of Runx3 in colitis...
May 22, 2024: Immunology Letters
Noah Rogozynski, Brian Dixon
For decades, the Th1/2 paradigm has been used to classify immune responses as either Th1 or Th2-biased. However, in recent years, a staggering amount of evidence has emerged to support rejection of the classical Th1/Th2 paradigm, such as the discoveries of new helper T cell subsets, helper T cell plasticity and protective mixed-Th1/Th2 responses. This opinion piece investigates the shortcomings of classical Th1/Th2 paradigm in the context of recent works, with the goal of facilitating the development of newer models to represent the diversity of Th cells...
May 22, 2024: Immunology Letters
Baisui Feng, Jin Liu, Jia Li, Shiyu Feng, Lingzhi Xu, Xiangyu Wang, Shuo Song, Yan Li, Aifa Tang, Yu Liu, Qing Shu, Pingchang Yang
Chronic inflammation is the pathological feature of inflammatory bowel diseases (IBD), but its etiology is unknown. Macrophages are one of the major immune cell fractions in the colon. The objectives of this study are to characterize the immune regulatory functions of macrophages in the colon of patients with ulcerative colitis (UC). UC patients (n = 30) were recruited into this study. Colon lavage fluid (CLF) was collected. Macrophages are isolated from the cellular components of CLF. The immune suppressive functions of macrophages were assessed using immunological approaches...
May 14, 2024: Immunology Letters
Lufei Yang, Yuanyuan Liang, Jincheng Pu, Li Cai, Ronglin Gao, Fang Han, Keni Chang, Shengnan Pan, Zhenzhen Wu, Youwei Zhang, Yanqing Wang, Jiamin Song, Huihong Wu, Jianping Tang, Xuan Wang
PURPOSE: To investigate the relationship between the lipid profiles of patients with primary Sjogren's syndrome (pSS) and other clinical characteristics, laboratory examination, disease activity, and inflammatory factors. In addition, the risk factors for hyperlipidemia-related complications of pSS and the effect of hydroxychloroquine (HCQ) usage on the lipid profile were incorporated into this study. METHODS: This is a single-center, retrospective study that included 367 patients who were diagnosed with pSS at Tongji Hospital, School of Medicine, Tongji University, China from January 2010 to March 2022...
May 3, 2024: Immunology Letters
Paula Basso Dias, Iara Messias-Reason, Kenzo Hokazono, Renato Nisihara
Diabetes mellitus (DM) is a chronic systemic disease characterized by a multifactorial nature, which may lead to several macro and microvascular complications. Diabetic retinopathy (DR) is one of the most severe microvascular complications of DM, which can result in permanent blindness. The mechanisms involved in the pathogenesis of DR are multiple and still poorly understood. Factors such as dysregulation of vascular regeneration, oxidative and hyperosmolar stress in addition to inflammatory processes have been associated with the pathogenesis of DR...
May 3, 2024: Immunology Letters
Ana Vizcaino Castro, Toos Daemen, Cesar Oyarce
Tumor-associated myeloid cells, including macrophages and myeloid-derived suppressor cells, can be highly prevalent in solid tumors and play a significant role in the development of the tumor. Therefore, myeloid cells are being considered potential targets for cancer immunotherapies. In this review, we focused on strategies aimed at targeting tumor-associated macrophages (TAMs). Most strategies were studied preclinically but we also included a limited number of clinical studies based on these strategies. We describe possible underlying mechanisms and discuss future challenges and prospects...
May 3, 2024: Immunology Letters
Yi Yang, Zexin Wen, Yanli Zhang, Pengfei Li, Junyao Zhao, Yujie Sun, Peng Wang, Wei Lin
BACKGROUND: Diabetic retinopathy (DR) stands as a prominent complication of diabetes. Berberine (BBR) has reported to be effective to ameliorate the retinal damage of DR. Studying the potential immunological mechanisms of BBR on the streptozotocin (STZ) induced DR mouse model will explain the therapeutic mechanisms of BBR and provide theoretical basis for the clinical application of this drug. METHODS: C57BL/6J mice were induced into a diabetic state using a 50 mg/(kg·d) dose of STZ over a 5-day period...
May 1, 2024: Immunology Letters
Qingyue Tong, Liyu Yao, Mengting Su, Yong-Guang Yang, Liguang Sun
Hematopoietic precursors (HPCs) entering into the thymus undergo a sequential process leading to the generation of a variety of T cell subsets. This developmental odyssey unfolds in distinct stages within the thymic cortex and medulla, shaping the landscape of T cell receptor (TCR) expression and guiding thymocytes through positive and negative selection. Initially, early thymic progenitors (ETPs) take residence in the thymic cortex, where thymocytes begin to express their TCR and undergo positive selection...
April 30, 2024: Immunology Letters
Ilaria Righi, Daria Trabattoni, Lorenzo Rosso, Valentina Vaira, Mario Clerici
Immune checkpoint (IC) molecules modulate immune responses upon antigen presentation; the interaction between different IC molecules will result in the stimulation or, rather, the thwarting of such responses. Tumor cells express increased amounts of inhibitory IC molecules in an attempt to evade immune responses; therapeutic agents have been developed that bind inhibitory IC molecules, restoring tumor-directed immune responses and changing the prognosis of a number of cancers. Stimulation of inhibitory IC molecules could be beneficial in preventing rejection in the setting of solid organ transplantation (SOT), and in vivo as well as in vivo results obtained in animal models show this to indeed to be the case...
April 25, 2024: Immunology Letters
Vallayyachari Kommoju, Christina Mary Mariaselvam, Sree Nethra Bulusu, Benita Nancy Reni, Chengappa Kavadichanda, Molly Mary Thabah, Vir Singh Negi
The synovial fluid (SF) microenvironment in rheumatoid arthritis (RA) may alter the stability and function of Tregs. In the present study, we assessed cytokine levels and percentage of Tregs, Tregs expressing CXCR3 (Th1-like Treg), CCR6 (Th17-like Treg) in RA peripheral blood (PB) and RA-SF using fluorescence cytometry. Effect of autologous SF on plasticity and function of RA-PB Tregs (pTregs; CD4+ CD25hi CD127Lo/- ) and induced vimentin-pulsed Tregs (iTregsVIM ) was assessed in vitro. Cytokines and percentage of Th1-like and Th17-like Tregs were higher in RA-PB than OA-PB; higher in RA-SF than osteoarthritis (OA)-SF...
April 24, 2024: Immunology Letters
Smita Kumari, Bharat Singh, Amit Kumar Kureel, Sheetal Saini, Satya Prakash, Aditi Chauhan, Prabin Kumar, Kulwant Singh, Ambak Kumar Rai
The function of CD5 protein in T cells is well documented, but regulation of its surface-level expression has yet to be fully understood. However, variation in its surface expression is associated with various immunopathological conditions and haematological malignancies. Briefly, expression of an alternate exon E1B of a human endogenous retroviruses (HERV) origin directly downregulates the conventional transcript variant (E1A), as its expression leads to the retention of the resultant protein at the intracellular level (cCD5)...
April 15, 2024: Immunology Letters
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