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Immunology Letters

Alessio Mazzoni, Mario Milco D'Elios, David Royo Mayaregua, Michele Spinicci, Marianne Strohmeyer, Francesco Cosmi, Lorenzo Cosmi
No abstract text is available yet for this article.
August 7, 2019: Immunology Letters
Chen En, Chen ChunJing, Chen FuChao, Yu Ping, Lin Lin
The disease progression and morbidity of tuberculosis (TB) infections are determined by virulence of the micro-organism, host genetic factors and environmental factors. The highly polymorphic MHC class I chain-related gene (MIC) could serve as a potential host genetic candidate. To investigate the association of MIC polymorphism with TB infection, 124 patients and 191 ethnically matched controls from Hunan province, Southern China, were genotyped for the MIC polymorphism using polymerase chain reaction-sequence specific priming and sequencing-based typing...
August 7, 2019: Immunology Letters
Yuwei Li, Yuwei Wang, Pixin Ran, Pingchang Yang, Zhigang Liu
Dermatophagoides farinae is a common indoor allergen source that produces more than 30 allergens, which induces diverse allergic diseases such as allergic rhinitis, allergic asthma and atopic dermatitis. Der f 32 is an inorganic pyrophosphatase and an important allergen from Dermatophagoides farinae. In the present study, Der f 32 was cloned, expressed and purified in order to better understand its structure and immunogenicity. Immunoblotting analysis and ELISA showed 5 of 5 positive reactions to recombinant Der f 32 using serum from house dust mite (HDM)-allergic patients...
August 2, 2019: Immunology Letters
Na Li, Xiude Fan, Xiaoyun Wang, Huan Deng, Kun Zhang, Xiaoge Zhang, Qunying Han, Yi Lv, Zhengwen Liu
T cell exhaustion is involved in the pathogenesis of chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). B lymphocyte-induced maturation protein 1 (BLIMP-1), encoded by the PRDM1 gene, plays a crucial role in T cell exhaustion. This study investigated Prdm1 rs1010273 and rs2185379 polymorphisms in 403 patients with chronic HBV infection [171 chronic hepatitis, 119 liver cirrhosis and 113 HCC], 70 spontaneous HBV infection resolvers and 196 healthy controls. The results showed that the rs1010273 and rs2185379 polymorphisms had no significant differences between patients with chronic HBV infection and healthy controls or between patients with different clinical diseases...
July 31, 2019: Immunology Letters
Zhiqing Zhang, Xiang Wei, Yanling Lin, Fang Huang, Jia Shao, Jialong Qi, Tingting Deng, Zizhen Li, Shuangquan Gao, Shaoyong Li, Hai Yu, Qinjian Zhao, Shaowei Li, Ying Gu, Ningshao Xia
The production of broadly neutralizing antibodies (bNAbs) is a major goal in the development of an HIV-1 vaccine. The membrane-proximal external region (MPER) of gp41, which plays a critical role in the virus membrane fusion process, is highly conserved and targeted by bNAbs 2F5, 4E10, and 10E8. As such, MPER could be a promising epitope for vaccine design. In this study, diphtheria toxin domain A (CRM197, amino acids 1-191) was used as a scaffold to display the 2F5 and 4E10 epitopes of MPER, named CRM197-A-2F5 and CRM197-A-4E10...
July 26, 2019: Immunology Letters
Juanjuan Xiong, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Present study clarified role of melatonin nuclear receptor RORα in monochromatic light-induced T-lymphocyte proliferation in chicks. Green light elevated plasma melatonin level and organ index, T-lymphocyte proliferation and IL-2 production in thymus, but decreased RORα, p-P65 and p-IκB expressions relative to red light. By contrast, pinealectomy decreased the melatonin content and reversed the stimulatory effect of green light, and resulted in that these thymus parameters were not significantly different among the light-treated groups...
July 18, 2019: Immunology Letters
Bin Zhao, Jun Lian, Danyang Wang, Quanxiao Li, Shuangshuang Feng, Jinyao Li, Ailian Zhang
Adjuvants can improve the efficacy of influenza vaccines and are still a hot spot in the study and development of influenza vaccines. In this report, the effects of aqueous extracts of Cistanche deserticola (AECD) as a polysaccharide adjuvant on seasonal influenza vaccines (IVV) were explored. The experimental data of anti-IVV IgG1 and IgG as well as hemagglutinin inhibition (HI) titers in young adult mice indicated that IVV intramuscularly co-injected with AECD was significantly more immunogenic than alum-adjuvanted or non-adjuvanted IVV...
July 8, 2019: Immunology Letters
Ayaz Shahid, Mausumi Bharadwaj
Cancer Stem Cells (CSCs) are the subpopulation of cells present in the tumors with capabilities of self-renewal, differentiation, and tumorigenicity when transplanted into an animal host. Therefore, the research work on the CSC has provided a promising approach for the improvement of cancer therapies in the future. The CSCs have a close connection with the cytokines related with the T helper 17 (Th17) cell and other factors present in the tumor microenvironment, and these play a pivotal role in tumor progression and metastasis...
July 3, 2019: Immunology Letters
XianTing Jiao, Lei Wang, ZhenZhen Wei, Bin Liu, XiaoYan Liu, XiaoDan Yu
The effects of maternal vitamin D status on offspring's Th1/Th2 cell function and the related mechanisms have not been reported. In this study, we established the rat model of vitamin D deficiency during pregnancy. 48 female Sprague-Dawley rats (8 weeks old) were randomly assigned to three groups (n = 16/group): control group (fed with standard AIN-93 G diet until parturition), vitamin D deficiency group (VDD group, fed with vitamin D deficient diet until parturition) and vitamin D supplementation group (VDS group, fed with vitamin D deficient diet prior to mating and with standard AIN-93 G diet during pregnancy)...
June 28, 2019: Immunology Letters
Saman Bahrambeigi, Davoud Sanajou, Vahid Shafiei-Irannejad
Despite the major progresses in comprehending the mechanisms of tumor immunosurveillance and the role of innate and adaptive immune systems in recent years, there are still a number of obstacles hindering successful and effective immunotherapy of cancer. Such obstacles have been mainly attributed to the ability of tumors in creating a tolerant microenvironment and exploiting a plethora of immunosuppressive factors that counter effective immune responses against tumor cells. Here we represent a new insight into probable links between immune system disability with metabolism and chronic psychological stress which is beyond the other strategies recruited by tumors to thwart tumor immunosurveillance...
June 28, 2019: Immunology Letters
Dace Pjanova, Laima Mandrika, Ramona Petrovska, Kristine Vaivode, Simona Donina
Double-stranded RNA (dsRNA), regardless of the origin and nucleotide sequence, exhibits multiple biological activities, including the establishment of an antiviral state and modulation of the immune response. Both involve the stimulation of innate immunity primarily via the release of pro-inflammatory cytokines, which in turn shapes the adaptive immune response. In this study, we compared the immune response triggered by two different dsRNAs: 1) a well-known synthetic dsRNA-poly (I:C); and 2) bacteriophage-derived dsRNA (bf-dsRNA) that is a replicative form of ssRNA bacteriophage f2...
June 26, 2019: Immunology Letters
Sina Alizadeh, Shiva Irani, Azam Bolhassani, Seyed Mehdi Sadat
No abstract text is available yet for this article.
June 26, 2019: Immunology Letters
Maryam Tabasinezhad, Yeganeh Talebkhan, Wolfgang Wenzel, Hamzeh Rahimi, Eskandar Omidinia, Fereidoun Mahboudi
Current advances in antibody engineering driving the strongest growth area in biotherapeutic agents development. Affinity improvement that is mainly important for biological activity and clinical efficacy of therapeutic antibodies, has still remained a challenging task. In the human body, during a course of immune response affinity maturation increase antibody activity by several rounds of somatic hypermutation and clonal selection in the germinal center. The final outputs are antibodies representing higher affinity and specificity against a particular antigen...
June 24, 2019: Immunology Letters
Chao Hou, Dong Wang, Xiang Li, Yufeng He, Chuansheng Wei, Rong Jiang, Jun Liu, Lijie Feng, Yuxian Shen
Splenic immune cells, especially macrophages, play a key role in multiple pathological processes. With a proved anti-inflammatory and immunoregulatory function of mesencephalicastrocyte-derived neurotrophic factor (MANF) in inflammatory disorders, how MANF affects splenic immune cells in physiological and pathophysiological situations is still unknown. In this study, we constructed mono-macrophage-specific MANF knockout (Mø MANF-/- ) mice and found the increased splenic M1 macrophages, but no significant change of splenic morphology and size compared with wild type (WT) mice...
June 18, 2019: Immunology Letters
Emilie Pollenus, Bert Malengier-Devlies, Leen Vandermosten, Thao-Thy Pham, Tania Mitera, Hendrik Possemiers, Louis Boon, Ghislain Opdenakker, Patrick Matthys, Philippe E Van den Steen
Neutrophil-depleting antibodies, such as anti-GR1 (RB6-8C5) and anti-Ly6G (1A8), are commonly used to study the in vivo function of neutrophils in murine disease models. Anti-Ly6G antibodies became the standard, because in contrast to anti-GR1, these do not bind Ly6C. The efficiency of the depletion needs to be carefully analysed as flow cytometry plots may be misinterpreted. For example, the staining intensity of GR1 on neutrophils (CD11b+ GR1hi ) drops upon anti-Ly6G administration. We show that this drop is due to competition between anti-GR1 and anti-Ly6G antibodies...
June 18, 2019: Immunology Letters
Sousan Kolahi, Alireza Khabbazi, Nastaran Kazemi, Aida Malek Mahdavi
INTRODUCTION: This study aimed to compare serum vitamin D levels in Spondyloarthritis (SpA) patients and control group and to evaluate the associations between vitamin D and disease activity in SpA patients. METHODOLOGY: In this study, 86 SpA patients according to the International Criteria and 117 age and sex-matched healthy controls were included. In patients, clinical examination was performed and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were recorded...
June 18, 2019: Immunology Letters
Balázs L Barátki, Krisztina Huber, Gabriella Sármay, János Matkó, Dorottya Kövesdi
IL-10 is a suppressive cytokine that has been implicated in the pathophysiology of autoimmune disorders and can be produced by different cell types such as regulatory B-cells. Our previous work showed that under inflammatory condition MZ B-cells differentiated into IL-10 producing cells and contributed to the downregulation of collagen-induced arthritis, while follicular B-cells failed to do so. Based on these observations, we aimed to investigate how inflammatory signals mediated through the BCR, TLR9 and IFN-γ receptors trigger IL-10 production in MZ B-cells but leave FO B-cells unresponsive...
June 16, 2019: Immunology Letters
Jian Zhang, Wenpei Liu, Ting Xie, Liyan Huang, Yabin Hu, Bo Wen, Ping Tang, Fengfan Guo, Kun Jin, Ping Zhang, Ling Niu, Ziyan Liu, Xiaowang Qu
Lymphocyte activation gene-3 (LAG-3), an inhibitory molecule, which has been shown co-expressed with multiple inhibitory receptors on CD8+ T and natural killer (NK) cells and negatively regulates T and NK cell responses during hepatitis C virus (HCV) infection. However, whether LAG-3 is involved in the regulation of the antibody response remains unclear. This study aims to investigate the relationship of LAG-3 with neutralizing antibody (nAb) response during HCV infection. A total of 66 HCV-infected individuals and 36 sex- and age-matched healthy controls from a population of intravenous drug users were recruited...
June 16, 2019: Immunology Letters
Takahito Nei, Shinya Urano, Natsuki Motoi, Atsushi Hashimoto, Nobutaka Kitamura, Takahiro Tanaka, Kazuhide Nakagaki, Jun Takizawa, Chinatsu Kaneko, Ryushi Tazawa, Koh Nakata
The IgG-type neutralizing GM-CSF autoantibody (GMAb) is known to be the causative agent for autoimmune pulmonary alveolar proteinosis (APAP). Previous studies report that serum levels of IgG-GMAb are approximately 50-fold higher in APAP patients than in healthy subjects (HS). Serum levels of IgM-GMAb are also higher in APAP patients than in HS, but this has been assumed to be an etiological bystander. However, the mechanism for the excessive production of IgG-GMAb in APAP remains unclear. To investigate this, we detected putative GMAb-producing B cells (PGMPB) by inoculated B cells from the peripheral blood of APAP patients, HS, and umbilical cord blood mononuclear cells (UCBMNs) with Epstein-Barr virus...
June 10, 2019: Immunology Letters
Eleonora Ponterio, Sabrina Mariotti, Claudio Tabolacci, Franco Maria Ruggeri, Roberto Nisini
Norovirus (NoV) is now recognized as a major cause of gastroenteritis outbreaks, worldwide. Norovirus replication mechanisms are still poorly understood, mainly because a reliable cell culture system is still lacking. The present study aims at understanding some aspects of the immune response against norovirus, and particularly the capacity of virus like particles (VLPs) from an Italian strain, belonging to the GII.4 genotype predominating worldwide, to interact with target cells via Toll Like Receptors (TLRs)...
May 30, 2019: Immunology Letters
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