journal
https://read.qxmd.com/read/38984536/new-predictive-equation-for-the-estimation-of-plasma-concentrations-of-formed-colistin-in-patients-treated-with-colistimethate-sodium-for-multidrug-resistant-gram-negative-bacterial-infections
#1
JOURNAL ARTICLE
Sonia Luque, Luisa Sorlí, Jian Li, Xènia Fernández-Sala, Nuria Berenguer, Elena Colominas-González, Adela Benítez-Cano, María Milagro Montero, Isaac Subirana, Nuria Prim, Ramón García-Paricio, Juan Pablo Horcajada, Santiago Grau
BACKGROUND: The clinical use of colistin methanesulphonate (CMS) is limited by potential nephrotoxicity. The selection of an efficient and safe CMS dose for individual patients is complicated by the narrow therapeutic window and high interpatient pharmacokinetic variability. In this study, a simple predictive equation for estimating the plasma concentration of formed colistin in patients with multidrug and extremely drug-resistant gram-negative bacterial infections was developed. METHODS: The equation was derived from the largest clinical cohort of patients undergoing therapeutic drug monitoring (TDM) of colistin for over 8 years in a tertiary Spanish hospital...
July 9, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38967524/switching-vancomycin-monitoring-from-trough-concentration-to-area-under-the-curve-estimation-by-bayesian-forecasting-a-short-communication-on-a-cost-benefit-study-in-resource-limited-settings
#2
JOURNAL ARTICLE
João Paulo Telles, Diogenes Coelho, Karen Cristina Migotto, Mariana Suelotto Diegues, Erica Rocha Leao, Rodrigo Reghini, Natalia Martinez Martos, Pedro Caruso, Ivan Leonardo França E Silva
BACKGROUND: This study was conducted to evaluate the cost-benefit indicators of a vancomycin monitoring protocol based on area under the curve estimation using commercial Bayesian software. METHODS: This quasi-experimental study included patients who were aged >18 years with a vancomycin prescription for >24 hours. Patients who were terminally ill or those with acute kidney injury (AKI) ≤24 hours were excluded. During the preintervention period, doses were adjusted based on the trough concentration target of 15-20 mg/L, whereas the postintervention period target was 400-500 mg × h/L for the area under the curve...
July 5, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38967521/association-among-vitamin-d-supplementation-serum-25-oh-d-concentrations-and-mortality-risk-a-prospective-cohort-study-using-nhanes-2007-2018-data
#3
JOURNAL ARTICLE
Hong Liu, Yu Bai
BACKGROUND: To determine the associations among self-reported vitamin D (VD) supplementation, measured serum 25-hydroxyvitamin D (25[OH]D) concentrations, and all-cause and cause-specific mortality risks. METHODS: Self-reported VD supplementation, serum 25(OH)D concentration, and all-cause and cause-specific mortality data from the National Health and Nutrition Examination Survey 2007-2018 were examined for 10,793 adults ≥20 years from the United States. VD dosage was categorized as <800 or ≥800 IU/d...
July 5, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38953704/quantification-of-the-plasma-concentration-of-vadadustat-by-high-performance-liquid-chromatography-with-ultraviolet-detection-and-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#4
JOURNAL ARTICLE
Satoshi Yokoyama, Junichi Nakagawa, Michiko Shimada, Kayo Ueno, Masahiro Ishiyama, Norio Nakamura, Hirofumi Tomita, Takenori Niioka
BACKGROUND: An inexpensive, simple, and accurate plasma concentration measurement system is needed to actively conduct pharmacokinetic and pharmacodynamic analyses of vadadustat, hypoxia-inducible factor-prolyl hydroxylase inhibitor, in clinical settings. In this study, the authors aimed to develop a method for measuring vadadustat in human plasma that could be applied for therapeutic drug monitoring using high-performance liquid chromatography with ultraviolet detection (HPLC-UV) in a clinical setting...
July 2, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38953703/from-bed-to-bench-pre-analytical-stability-of-29-anti-infective-agents-in-plasma-and-whole-blood-to-improve-accuracy-of-therapeutic-drug-monitoring
#5
JOURNAL ARTICLE
Sophie Magreault, Dorine Pierredon, Judith Akinotcho-Relouzat, Frédéric Méchaï, Brigitte Lamy, Françoise Jaureguy, Vincent Jullien
BACKGROUND: Therapeutic drug monitoring requires a validated assay and appropriate conditions for sample shipment and storage based on the stability of the compound to be analyzed. This study evaluated the stability of 29 antimicrobial compounds in whole blood (WB) and plasma samples under various storage conditions. METHODS: The pre-analytical stability of 22 antibiotics (amoxicillin, aztreonam, cefazolin, cefepime, cefotaxime, cefoxitin, ceftazidime, ceftobiprole, ceftolozane, ceftriaxone, ciprofloxacin, clindamycin, cloxacillin, daptomycin, levofloxacin, linezolid, meropenem, metronidazole, moxifloxacin, piperacillin, sulfamethoxazole, and trimethoprim), 2 beta-lactamase inhibitors (avibactam, tazobactam), and 5 antituberculosis drugs (ethambutol, isoniazid, pyrazinamide, rifabutin, and rifampicin) was assessed by WB for up to 24 hours at room temperature (RT) and 72 hours at +4°C...
July 2, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38950127/continuous-vs-intermittent-administration-of-meropenem-in-critically-ill-patients
#6
JOURNAL ARTICLE
Manon Launay, Sophie Perinel-Ragey, Guillaume Thiery
No abstract text is available yet for this article.
June 28, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38950124/optimizing-cefiderocol-dosing-through-population-pharmacokinetic-pharmacodynamic-simulation-an-assessment-of-drug-cost-reductions
#7
JOURNAL ARTICLE
Kazutaka Oda, Hirofumi Jono, Hideyuki Saito
BACKGROUND: Cefiderocol is a siderophore cephalosporin antibiotic with bactericidal activity against carbapenem-resistant Enterobacterales. However, an efficient dosing strategy is yet to be developed. This study aimed to evaluate efficient lower-dose regimens and estimate potential drug cost reductions. METHODS: This simulation study used a virtual population of 10,000 resampled individuals based on a reported population pharmacokinetic model. The target index for maximal bactericidal activity was the time for the unbound cefiderocol concentration to be above the minimum inhibitory concentration (TAM_unbound) of 100%, which was determined using a minimum inhibitory concentration distribution or specific value...
June 26, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38950121/personalized-amoxicillin-therapy-in-a-critically-ill-patient-undergoing-renal-replacement-therapy-a-grand-round
#8
JOURNAL ARTICLE
Philippine Garrigue, Margot Reber, Sophie Perinel-Ragey, Manon Launay
BACKGROUND: The case study discusses a complex scenario involving the use of amoxicillin in a critically ill patient undergoing intermittent renal replacement therapy.Severe infections are complicated by septic shock and organ failure, requiring urgent and effective antibiotic treatment. METHODS: The patient's comorbidities, including obesity and acute kidney injury, required careful consideration of the amoxicillin dosing strategies. RESULTS: Therapeutic drug monitoring is critical for dose adjustment during treatment...
June 26, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38935410/dried-blood-spot-method-development-and-clinical-validation-for-the-analysis-of-elexacaftor-elexacaftor-m23-tezacaftor-tezacaftor-m1-ivacaftor-ivacaftor-carboxylate-and-hydroxymethyl-ivacaftor-using-lc-ms-ms
#9
JOURNAL ARTICLE
Steffie E M Vonk, Marloes van der Meer-Vos, Renate Kos, Anne H Neerincx, Suzanne W J Terheggen-Lagro, Josje Altenburg, Anke H Maitland-van der Zee, Ron A A Mathôt, E Marleen Kemper
BACKGROUND: The highly effective Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulator, elexacaftor-tezacaftor-ivacaftor, is now widely being used by people with cystic fibrosis. However, few independent studies have detailed the pharmacokinetics (PK) of CFTR modulators. Blood collection by venipuncture is the gold standard for PK measurements, but it is invasive. The aim of this study was to develop and clinically validate a quantification method for elexacaftor, tezacaftor, ivacaftor, and their main metabolites in dried blood spots (DBSs) using liquid chromatography with tandem mass spectrometry...
June 25, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38917376/development-and-validation-of-a-high-performance-liquid-chromatography-coupled-with-ultraviolet-detection-method-for-quantification-of-bictegravir-in-human-plasma
#10
JOURNAL ARTICLE
Ran Xiao, Qiang Fu, Ling Chen, Taisheng Li, Xiaoli Du
BACKGROUND: To establish a method for determining the bictegravir (BIC) concentration in human plasma using high-performance liquid chromatography coupled with ultraviolet detection. METHODS: The analysis was performed on a CLC-octadecylsilane column (150 × 6.0 mm, 5 μm) using a mixture of phosphate buffer and acetonitrile (62:38, v/v) as the mobile phase at the flow rate of 1.4 mL/min. The column temperature was maintained at 40°C. Using triamcinolone acetonide as the internal standard, 100 μL of plasma sample was extracted by methyl tert-butyl ether, followed by evaporating under nitrogen stream, redissolving with 100 μL mobile phase, and injection of 20-40 μL of supernatant into the chromatographic system...
June 21, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38917389/development-and-validation-of-a-high-performance-liquid-chromatography-with-ultraviolet-detection-method-to-facilitate-therapeutic-monitoring-of-teicoplanin-using-dried-blood-spots
#11
JOURNAL ARTICLE
Ola Ramadan, Patrick Opitz, Georg Hempel
BACKGROUND: In neonatal and pediatric intensive care units, Gram-positive infections are a significant cause of morbidity and mortality. The increase in infections caused by methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococci have led to the increased use of glycopeptides, which treat invasive infections caused by Gram-positive organisms, particularly those resistant to beta-lactam antibiotics. Teicoplanin has bacteriostatic activity against Gram-positive bacteria, but its pharmacokinetics in children is highly variable, with most children failing to reach target levels at the recommended dose...
June 18, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38885146/simulation-based-optimization-of-sampling-schedules-for-model-informed-precision-dosing-of-once-daily-and-4-times-daily-busulfan-in-pediatric-patients
#12
JOURNAL ARTICLE
Khalil Ben Hassine, Youssef Daali, Yvonne Gloor, Tiago Nava, Yves Théorêt, Maja Krajinovic, Henrique Bittencourt, Chakradhara Rao Satyanarayana Uppugunduri, Marc Ansari
BACKGROUND: Therapeutic drug monitoring (TDM) is crucial in optimizing the outcomes of hematopoietic stem cell transplantation by guiding busulfan (Bu) dosing. Limited sampling strategies show promise for efficiently adjusting drug doses. However, comprehensive assessments and optimization of sampling schedules for Bu TDM in pediatric patients are limited. We aimed to establish optimal sampling designs for model-informed precision dosing (MIPD) of once-daily (q24h) and 4-times-daily (q6h) Bu administration in pediatric patients...
June 14, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38864581/quantification-of-efavirenz-hydroxymetabolites-in-human-plasma-using-lc-hrms-ms
#13
JOURNAL ARTICLE
Madeleine Pettersson Bergstrand, Sandra Soeria-Atmadja, Victoria Barclay, Jelena Tolic, Lars Navér, Lars L Gustafsson, Anton Pohanka
BACKGROUND: Efavirenz (EFV) is a drug used to treat HIV. Low plasma concentrations of EFV result in suboptimal viral suppression, whereas high concentrations can cause adverse neuropsychiatric side reactions. Some studies have identified a correlation between the plasma concentrations of EFV metabolites and neurotoxicity. To our knowledge, no studies have investigated the metabolism of EFV in young children and its effect on treatment outcomes. Therefore, the aim of this study was to develop and validate a method for quantifying EFV and its metabolites in human plasma derived from children...
June 11, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38858812/correlation-between-tacrolimus-levels-in-blood-samples-obtained-from-central-catheter-and-peripheral-venipuncture-in-lung-transplant-patients-ven-cat-study
#14
JOURNAL ARTICLE
Verónica Diego-Fernández, María Del Mar García-Saiz, Ana Llorente-Cantalapiedra, José Antonio Arquero-González, María Victoria Bermúdez-García, María Montserrat Catalán-Ramírez, Patricia Cornejo-Callejo, María Nuria de Pedro-Simón, María Jesús Díez-Pérez, Paula Gandarillas-Ruiz, Francisco Hernández-González, Patricia Herranz-Arenillas, María Jesús Laso-Boada, Gema Medina-Gonzalo, Adrián Rodríguez-López, Miriam Ruiz-Antolín, Marta Álamo-Ibañez, María de Los Ángeles Cos-Cossio, Lucía Lavín-Alconero, Víctor M Mora-Cuesta
BACKGROUND: Following lung transplantation (LT), receiving immunosuppressive therapy is crucial. Tacrolimus is considered a drug with a narrow therapeutic range and its use requires constant monitoring. This study aimed to evaluate the correlation between tacrolimus levels obtained from central venous catheter and direct venipuncture in adult patients undergoing LT. METHODS: This prospective study included LT patients hospitalized in conventional ward carrying a central catheter through which no intravenous tacrolimus was administered...
June 11, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38858809/a-retrospective-study-evaluating-neonatal-vancomycin-loading-doses-to-achieve-a-therapeutic-target
#15
JOURNAL ARTICLE
Aaqilah Fataar, Veshni Pillay-Fuentes Lorente, Eric H Decloedt, Andrew van Eck, Kessendri Reddy, Angela Dramowski, Adrie Bekker
BACKGROUND: Vancomycin is a glycopeptide antibiotic that has been used to treat hospital-acquired gram-positive infections for more than 5 decades. However, the literature is divided regarding the therapeutic advantages of vancomycin loading doses in neonates. OBJECTIVES: This study aimed to investigate the effect of vancomycin loading doses on therapeutic target attainment in neonates with sepsis. METHODS: A retrospective cohort study was conducted to compare the vancomycin target attainment (area under the curve 0-24 hours/minimum inhibitory concentration ≥400) in neonates before and after the 2019 change in vancomycin prescription guidelines at a neonatal unit in Cape Town, South Africa...
June 11, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38845090/medication-adherence-monitoring-using-alternative-sample-matrices-bridging-the-gap-between-analytical-validation-and-clinical-interpretation
#16
JOURNAL ARTICLE
Tanja R Zijp, Zamrotul Izzah, Daan J Touw, Job F M van Boven
No abstract text is available yet for this article.
June 7, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38857472/optimization-of-vancomycin-initial-dosing-regimen-in-neonates-using-an-externally-evaluated-population-pharmacokinetic-model
#17
JOURNAL ARTICLE
Mathieu Blouin, Marie-Élaine Métras, Mehdi El Hassani, Aysenur Yaliniz, Amélie Marsot
BACKGROUND: Vancomycin therapeutic monitoring guidelines were revised in March 2020, and a population pharmacokinetics-guided Bayesian approach to estimate the 24-hour area under the concentration-time curve to the minimum inhibitory concentration ratio has since been recommended instead of trough concentrations. To comply with these latest guidelines, we evaluated published population pharmacokinetic models of vancomycin using an external dataset of neonatal patients and selected the most predictive model to develop a new initial dosing regimen...
June 6, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38842546/making-clozapine-therapeutic-drug-monitoring-essential-for-optimal-patient-care-letter-to-the-editor
#18
JOURNAL ARTICLE
Jonathan G Leung, Katie N Bye, Megan R Leloux, Matej Markota, Nicholas D Allen
No abstract text is available yet for this article.
June 6, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38840334/catching-the-culprit-benzylpenicillin-neurotoxicity-confirmed-by-therapeutic-drug-monitoring-in-a-critically-ill-patient-with-continuous-venovenous-hemofiltration
#19
JOURNAL ARTICLE
Thomas G van Gelder, Valentijn A Schweitzer, Esther V Uijtendaal, Maaike A Sikma
We present the case of a 65-year-old patient who was treated with high-dose benzylpenicillin for severe invasive pneumococcal pneumonia, complicated by acute renal failure managed with continuous venovenous hemofiltration. After cessation of continuous venovenous hemofiltration, the patient experienced multiple tonic-clonic seizures. Therapeutic drug monitoring revealed high total serum concentrations of benzylpenicillin, identifying it as the likely cause of the neurotoxicity. This case study presents the first documented total serum benzylpenicillin concentration associated with neurotoxicity...
June 6, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38840327/efficacy-and-safety-of-programmed-death-1-programmed-death-ligand-1-plus-cytotoxic-t-lymphocyte-associated-antigen-4-inhibitors-for-advanced-or-metastatic-non-small-cell-lung-cancer-a-meta-analysis-based-on-randomized-controlled-trials
#20
JOURNAL ARTICLE
Wei Ren, Yingying Fang, Yujing He, Yifeng Ren, Minfang Wang, Anyi Xu, Jiale Ruan, Qinghua Tao
BACKGROUND: This meta-analysis aims to investigate the efficacy and safety of programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) combined with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitors for patients with advanced or metastatic non-small cell lung cancer (NSCLC). METHODS: Authors conducted a comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, Scopus, and Medline for randomized controlled trials comparing the prognosis and safety of PD-1/PD-L1 plus CTLA-4 inhibitors with other therapies for advanced or metastatic NSCLC...
June 6, 2024: Therapeutic Drug Monitoring
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