Noemie Plattard, Riciga Gnanasegaran, Aida Krekesheva, Pascal Carato, Antoine Dupuis, Virginie Migeot, Marion Albouy, Sami Haddad, Nicolas Venisse
BACKGROUND: Bisphenol A (BPA) is a ubiquitous contaminant that has endocrine-disrupting effects. Chlorinated derivatives of BPA are formed during chlorination of drinking water and have higher endocrine-disrupting activity. Dichlorobisphenol A (Cl2BPA) is the most abundant chlorinated BPA derivative found in several human biological matrices. Recent in vitro experiments have shown that Cl2BPA is metabolized in sulpho- and glucuro-conjugated compounds. To date, no assay has been developed to quantify the sulfo- and glucuro-conjugates of 3,3'-Cl2BPA (3,3'-Cl2BPA-S and 3,3'-Cl2BPA-G, respectively)...
January 16, 2023: Therapeutic Drug Monitoring