journal
Journals Journal of Biomechanical Engin...

Journal of Biomechanical Engineering

https://read.qxmd.com/read/38421364/numerical-and-analytical-simulation-of-the-growth-of-amyloid-%C3%AE-plaques
#21
JOURNAL ARTICLE
Andrey Kuznetsov
Numerical and analytical solutions were employed to calculate the radius of an amyloid-β (Aβ) plaque over time. To the author's knowledge, this study presents the first model simulating the growth of Aβ plaques. Findings indicate that the plaque can attain a diameter of 50 μm after 20 years of growth, provided the Aβ monomer degradation machinery is malfunctioning. A mathematical model incorporates nucleation and autocatalytic growth processes using the Finke-Watzky model. The resulting system of ordinary differential equations was solved numerically, and for the simplified case of infinitely long Aβ monomer half-life, an analytical solution was found...
February 29, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38421346/biomechanical-considerations-of-refreshable-braille-and-tactile-graphics-towards-equitable-access-a-review
#22
JOURNAL ARTICLE
Anne Zakrajsek, Samuel Foulkes, Nicole Nagel, Fred Neurohr, Eric Nauman
This review highlights the biomechanical foundations of braille and tactile graphic discrimination within the context of design innovations in information access for the blind and low vision community. Braille discrimination is a complex and poorly understood process that necessitates the coordination of motor control, mechanotransduction, and cognitive linguistic processing. Despite substantial technological advances and multiple design attempts over the last fifty years, a low-cost, high-fidelity refreshable braille and tactile graphics display has yet to be delivered...
February 29, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38421345/primary-mouse-aortic-smooth-muscle-cells-exhibit-region-and-sex-dependent-biological-responses-in-vitro
#23
JOURNAL ARTICLE
Niyousha Karbasion, Yujun Xu, J Caleb Snider, Matthew R Bersi
Despite advancements in elucidating biological mechanisms of cardiovascular remodeling, cardiovascular disease (CVD) remains the leading cause of death worldwide. When stratified by sex, clear differences in CVD prevalence and mortality between males and females emerge. Regional differences in phenotype and biological response of cardiovascular cells are important for localizing the initiation and progression of CVD. Thus, to better understand region and sex differences in CVD presentation we have focused on characterizing in vitro behaviors of primary vascular smooth muscle cells (VSMCs) from the thoracic and abdominal aorta of male and female mice...
February 29, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38421341/remodeling-of-murine-branch-pulmonary-arteries-under-chronic-hypoxia-and-short-term-normoxic-recovery
#24
JOURNAL ARTICLE
Abhay Ramachandra, Bo Jiang, Isabella Jennings, Edward P Manning, Jay Humphrey
Chronic hypoxia plays a central role in diverse pulmonary pathologies, but its effects on longitudinal changes in the biomechanical behavior of proximal pulmonary arteries remain poorly understood. Similarly, effects of normoxic recovery have not been well studied. Here we report hypoxia-induced changes in composition, vasoactivity, and passive biaxial mechanics in the main branch pulmonary artery of C57BL/6J mice exposed to 10% FiO2 for 1, 2, or 3 weeks. We observed significant changes in extracellular matrix, and consequently wall mechanics, as early as 1 week of hypoxia...
February 29, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38421339/in-silico-investigation-of-biomechanical-response-of-a-human-brain-subjected-to-primary-blast
#25
JOURNAL ARTICLE
Sunil Sutar, Shailesh Ganpule
The brain response to the explosion-induced primary blast waves is actively sought. Over the past decade, reasonable progress has been made in the fundamental understanding of bTBI using head surrogates and animal models. Yet, the current understanding of how blast waves interact with human is in nascent stages, primarily due to the lack of data in human. The biomechanical response in human is critically required to faithfully establish the connection to the aforementioned bTBI models. In this work, the biomechanical cascade of the brain under a primary blast has been elucidated using a detailed, full-body human model...
February 29, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38395449/integrating-cardiovascular-engineering-and-biofluid-mechanics-in-high-school-stem-education-an-experiential-approach
#26
JOURNAL ARTICLE
Magen Radke, Fatiesa Sulejmani, Brennan Vogl, Hoda Hatoum
STEM education workshops and programs play a key role in promoting early exposure to scientific applications and questions, early engagement that leads to growing not only interest in science but also passion and skill development including hands-on learning and critical thinking. Integrating physiology and engineering together is necessary especially to promote health technology awareness and introduce the young generation to areas where innovation is needed and where there is no separation between health-related matters and engineering methods and applications...
February 23, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38376458/an-experiential-learning-opportunity-in-norway-computation-for-bioengineering-and-mechanical-engineering-students
#27
JOURNAL ARTICLE
Julia Clarin, Ana I Vargas, Turner Jennings, Samuel D Salinas, Reza Amini, Yustianto Tjiptowidjojo, Benjamin Yelle, Mojgan Y Jacobsen, Trine Eide, Cecilie Udberg-Helle, Torjer A Olsen, Jonathan Crossen, Victorien Prot, Bj Rn Skallerud, Rouzbeh Amini
The global learning initiative at Northeastern University is focused on fostering intercultural communication skills. The Dialogue of Civilization (DOC) program serves as a mechanism to achieve such a goal by offering faculty-led international experiences. In this manuscript, we have presented a detailed account of a DOC program that took place in Norway. The primary objective of the program was to teach mechanical engineering and bioengineering students computational skills while stimulating critical thinking about the cultural and social aspects of technology and engineering in Norway...
February 20, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38376449/the-biores-21-survey-insights-into-remote-and-online-education-in-biomechanics-and-mechanobiology
#28
JOURNAL ARTICLE
Debanjan Mukherjee, Victor Lai, Zhongping Huang, Anita Singh
The Covid-19 pandemic necessitated mainstream adoption of online and remote learning approaches which were highly advantageous yet challenging in many ways. The online modality, while teaching biomedical engineering-related topics in the areas of biomechanics, mechanobiology, and biomedical sciences, further added to the complexity faced by the faculty and students. Both the benefits and the challenges have not been explored systematically by juxtaposing experiences and reflections of both the faculty and students...
February 20, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38376443/computational-pulsatile-flow-and-efficiency-analysis-of-biocompatible-microfluidic-artificial-lungs-for-different-fiber-configurations
#29
JOURNAL ARTICLE
Ahmet Yusuf Asiltürk, Kunt Atalik
Average-sized microfluidic artificial lungs consisting of rows and columns of fiber bundles with different column to row aspect ratios (AR) are numerically analyzed for flow characteristics, maximum gas transfer performance, minimum pressure drop, and proper wall shear stress (WSS) values in terms of biocompatibility. The flow is fully laminar and assumed to be incompressible and Newtonian. The transport analysis is performed using a combined convection-diffusion-reaction model, and the numerical simulations are carried out with the finite element method...
February 20, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38345603/sensitivity-of-phonation-onset-pressure-to-vocal-fold-stiffness-distribution
#30
JOURNAL ARTICLE
Jonathan Deng, Sean Peterson
Phonation onset is characterized by the unstable growth of vocal fold vibrations that ultimately results in self-sustained oscillation and the production of modal voice. Motivated by histological studies, much research has focused on the role of the layered structure of the vocal folds in influencing phonation onset, wherein the outer 'cover' layer is relatively soft and the inner 'body' layer is relatively stiff. Recent research, however, suggests that the body-cover (BC) structure over-simplifies actual stiffness distributions by neglecting important spatial variations, such as inferior-superior (IS) and anterior-posterior gradients and smooth transitions in stiffness from one histological layer to another...
February 12, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38345601/catalyzing-clinically-driven-undergraduate-design-projects-at-the-nexus-of-engineering-medicine-and-business
#31
JOURNAL ARTICLE
Byron D Erath, Kevin Fite, Laurel Kuxhaus
Design projects, particularly those related to assistive technology, offer unparalleled educational opportunities for undergraduate students to synthesize engineering knowledge with a clinically-driven need to produce a product that can improve quality of life. Such projects are most effective when engineering, clinical, and business perspectives are considered throughout. However, the logistics of successfully implementing such interdisciplinary projects can be challenging. This paper presents outcomes from 12 undergraduate design team projects in assistive technology performed over 5 years...
February 12, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38345599/vascular-remodeling-during-late-gestation-pregnancy-an-in-vitro-assessment-of-the-murine-ascending-thoracic-aorta
#32
JOURNAL ARTICLE
Ana I Vargas, Samar A Tarraf, Turner Jennings, Chiara Bellini, Rouzbeh Amini
Maternal mortality due to cardiovascular disease is a rising concern in the U.S. Pregnancy triggers changes in the circulatory system, potentially influencing the structure of the central vasculature. Evidence suggests a link between a woman's pregnancy history and future cardiovascular health, but our understanding remains limited. To fill this gap, we examined the passive mechanics of the murine ascending thoracic aorta during late gestation. By performing biaxial mechanical testing on the ascending aorta, we were able to characterize the mechanical properties of both control and late-gestation tissues...
February 12, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38329432/atherosclerotic-calcifications-have-a-local-effect-on-the-peel-behavior-of-human-aortic-media
#33
JOURNAL ARTICLE
Carly Donahue, Ruturaj Badal, Thomas Younger, Weihua Guan, Elena G Tolkacheva, Victor H Barocas
Aortic dissections, characterized by the propagation of a tear through the layers of the vessel wall, are critical, life-threatening events. Aortic calcifications are a common comorbidity in both acute and chronic dissections, yet their impact on dissection mechanics remains unclear. Using micro-CT imaging, peel testing, and finite element modeling, this study examines the interplay between atherosclerotic calcifications and dissection mechanics. Samples cut from cadaveric human thoracic aortas were micro-CT imaged and subsequently peel-tested to map peel tension curves to the location of aortic calcifications...
February 8, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38329431/role-of-microtubule-network-in-the-passive-anisotropic-viscoelasticity-of-healthy-right-ventricle
#34
JOURNAL ARTICLE
Kristen LeBar, Wenqiang Liu, Adam Chicco, Zhijie Wang
Cardiomyocytes are viscoelastic and key determinants of right ventricle (RV) mechanics. Intracellularly, microtubules are found to impact the viscoelasticity of isolated cardiomyocytes or trabeculae; whether they contribute to the tissue-level viscoelasticity is unknown. Our goal was to reveal the role of the microtubule network in the passive anisotropic viscoelasticity of the healthy RV. Equibiaxial stress relaxation tests were conducted in healthy RV free wall (RVFW) under early (6%) and end (15%) diastolic strain levels, and at sub- and physiological stretch rates...
February 8, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38323715/building-a-partnership-between-a-university-and-local-high-school-to-foster-and-grow-interest-in-biomedical-sciences-and-engineering
#35
JOURNAL ARTICLE
Ryan M Castile, Jamie Jobe, Leanne E Iannucci, Rebecca F Reals, Shawn N Pavey, Jon Fitzgerald, Spencer P Lake
To help foster interest in science, technology, engineering, and math (STEM) it is important to develop opportunities which excite and teach young minds about STEM-related fields. Over the past several years our university-based research group has sought to help grow excitement around the biomechanics and biomedical engineering fields. The purposes of this technical brief are to (1) discuss the development of a partnership built between a St. Louis area high school and biomechanics research lab and (2) provide practical guidance for other researchers looking to implement a long-term outreach program...
February 7, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38323667/exogenous-collagen-crosslinking-is-highly-detrimental-to-articular-cartilage-lubrication
#36
JOURNAL ARTICLE
Meghan E Kupratis, Uriel Gonzalez, Atia Rahman, David L Burris, Elise Corbin, Christopher Price
Healthy articular cartilage is a remarkable bearing material optimized for near-frictionless joint articulation. Because its limited self-repair capacity renders it susceptible to osteoarthritis, approaches to reinforce or rebuild degenerative cartilage are of significant interest. While exogenous collagen crosslinking (CXL) treatments improve cartilage's mechanical properties and resist its susceptibility to enzymatic degradation, their effects on cartilage lubrication remain less clear. Here, we examined how the collagen crosslinking agents genipin (GP) and glutaraldehyde (GTA) impact cartilage lubrication using the convergent stationary contact area (cSCA) configuration...
February 7, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38323620/a-comparative-study-of-machine-learning-and-algorithmic-approaches-to-automatically-identify-the-yield-point-in-normal-and-aneurysmal-human-aortic-tissues
#37
JOURNAL ARTICLE
Timothy Chung, Joseph Kim, Pete Gueldner, David A Vorp, Madhavan L Raghavan
The stress-strain curve of biological soft tissues helps characterize their mechanical behavior. The yield point on this curve is when a specimen breaches its elastic range due to irreversible microstructural damage. The yield point is easily found using the offset yield method in traditional engineering materials. However, correctly identifying the yield point in soft tissues can be subjective due to its nonlinear material behavior. The typical method for yield point identification is visual inspection, which is investigator-dependent and does not lend itself to automation of the analysis pipeline...
February 7, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38319186/an-integrated-experimental-computational-study-of-vocal-fold-vibration-in-type-i-thyroplasty
#38
JOURNAL ARTICLE
Amit Avhad, Azure Wilson, Lea Sayce, Zheng Li, James Doyle, Bernard Rousseau, Haoxiang Luo
Subject-specific computational modeling of vocal fold vibration was integrated with an ex vivo animal experiment of type 1 thyroplasty to study the effect of the implant on the vocal fold vibration. In the experiment, a rabbit larynx was used to simulate type 1 thyroplasty, where one side of the vocal fold was medialized with a trans-muscular suture while the other side was medialized with a silastic implant. Vocal fold vibration was then achieved by flowing air through the larynx and was filmed with a high-speed camera...
February 6, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38319176/simmact-a-software-demonstrator-to-improve-maximum-actuation-joint-torques-simulation-for-ergonomics-assessment
#39
JOURNAL ARTICLE
Jonathan Savin, Nasser Rezzoug
The maximum actuation joint torques that operators can perform at the workplace are essential parameters for biomechanical risk assessment. However, workstation designers generally only have at their disposal the imprecise and sparse estimates of these quantities provided with digital manikin (DHM) software. For instance, such tools consider only static postures and ignore important specificities of the human musculoskeletal system such as inter-joints couplings. To alleviate the weaknesses of existing approaches implemented in digital human modelling tools relying on torque databases, this paper describes a methodology based on a class of polytopes called zonotopes and musculoskeletal simulation to assess maximum actuation torques...
February 6, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38308104/special-issue-on-current-trends-in-impact-and-injury-biomechanics
#40
JOURNAL ARTICLE
Matthew B Panzer, Francisco Jose Lopez-Valdes, Barclay Morrison
No abstract text is available yet for this article.
February 3, 2024: Journal of Biomechanical Engineering
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