Jacqueline Matz, Mireia Perera Gonzalez, Peter Niedbalski, Hannah Kim, Ye Chen, Paola Sebastiani, Michael Gollner, Chiara Bellini, Jessica Oakes
Wildland firefighters (WLFFs) experience lung function decline due to occupational exposure to fire smoke. To pinpoint the biological underpinnings of abnormal respiratory function following 3-7 years of WLFF service, we exposed mice to Douglas Fir Smoke (DFS) over 8 weeks. Following exposure, we assessed changes in lung structure through Magnetic Resonance Imaging (MRI) and histological analysis, which was supported by immunohistochemistry staining. With MRI, we assessed the signal decay time, T2*, from ultrashort echo time images and utilized this metric as a measure of airspace enlargement...
April 6, 2024: Journal of Biomechanical Engineering