journal
https://read.qxmd.com/read/38490275/strong-cross-immune-responses-against-sarbecoviruses-but-not-merbecoviruses-in-sars-cov-2-ba-5-bf-7-infected-individuals-with-or-without-inactivated-covid-19-vaccination
#1
LETTER
Lujia Sun, Qiuhong Man, Hui Zhang, Shuai Xia, Lu Lu, Xinling Wang, Lize Xiong, Shibo Jiang
No abstract text is available yet for this article.
March 13, 2024: Journal of Infection
https://read.qxmd.com/read/38479495/covid-19-mortality-amongst-the-immunosuppresed
#2
LETTER
Víctor Moreno-Torres, María Martínez-Urbistondo, Jorge Calderón-Parra, Carmen de Mendoza, Vicente Soriano
No abstract text is available yet for this article.
March 11, 2024: Journal of Infection
https://read.qxmd.com/read/38462077/within-episode-repeat-antibiotic-prescriptions-in-patients-with-respiratory-tract-infections-a-population-based-cohort-study
#3
JOURNAL ARTICLE
A Lalmohamed, R P Venekamp, A Bolhuis, P C Souverein, J van de Wijgert, M Gulliford, A D Hay
BACKGROUND: Antimicrobial stewardship interventions mainly focus on initial antibiotic prescriptions, with few considering within-episode repeat prescriptions. We aimed to describe the magnitude, type and determinants of within-episode repeat antibiotic prescriptions in patients presenting to primary care with respiratory tract infections (RTIs). METHODS: We conducted a population-based cohort study among 530 sampled English general practices within the Clinical Practice Research Datalink (CPRD)...
March 8, 2024: Journal of Infection
https://read.qxmd.com/read/38462076/emergence-of-astrakhan-rickettsial-fever-in-china
#4
LETTER
Zhong-Qiu Teng, Li Yang, Na Zhao, Xin-Ting Li, Lu-Peng Dai, Xue Zhang, Tong-Tong Shao, Ling Han, Rong-Jiong Zheng, Bo-Hai Wen, Biao Kan, Jian-Guo Xu, Xiao-Bo Lu, Tian Qin
No abstract text is available yet for this article.
March 8, 2024: Journal of Infection
https://read.qxmd.com/read/38452934/clinical-features-based-machine-learning-models-to-separate-sexually-transmitted-infections-from-other-skin-diagnoses
#5
JOURNAL ARTICLE
Nyi N Soe, Phyu M Latt, Zhen Yu, David Lee, Cham-Mill Kim, Daniel Tran, Jason J Ong, Zongyuan Ge, Christopher K Fairley, Lei Zhang
INTRODUCTION: Many sexual health services are overwhelmed and cannot cater for all the individuals who present with sexually transmitted infections (STIs). Digital health software that separates STIs from non-STIs could improve the efficiency of clinical services. We developed and evaluated a machine learning model that predicts whether patients have an STI based on their clinical features. METHODS: We manually extracted 25 demographic features and clinical features from 1,315 clinical records in the electronic health record system at Melbourne Sexual Health Centre...
March 5, 2024: Journal of Infection
https://read.qxmd.com/read/38432583/mycophenolate-mofetil-hampers-antibody-responses-to-a-broad-range-of-vaccinations-in-kidney-transplant-recipients-results-from-a-randomized-controlled-study
#6
JOURNAL ARTICLE
Z Al Fatly, M G H Betjes, W A Dik, R A M Fouchier, M E J Reinders, A E de Weerd
OBJECTIVES: To study the effect of mycophenolate mofetil (MMF) on various vaccination responses in kidney transplant recipients. METHODS: In a randomized controlled trial (EudraCT nr.: 2014-001372-66), low immunologically risk kidney transplant recipients were randomized to TAC/MMF or TAC-monotherapy (TACmono), six months post-transplantation. One year after transplantation, in a pre-specified sub-study, recipients were vaccinated against pneumococcus, tetanus and influenza...
March 2, 2024: Journal of Infection
https://read.qxmd.com/read/38432584/current-state-of-covid-19-in-children-4-years-on
#7
REVIEW
Annabel A Powell, Alexander C Dowell, Paul Moss, Shamez N Ladhani
Children have been disproportionately affected by the COVID-19 pandemic. Despite evidence of a very low risk of severe disease, children were subjected to extensive lockdown, restriction and mitigation measures, including school closures, to control the rapid spread of SARS-CoV-2 in most parts of the world. In this review we summarise the UK experience of COVID-19 in children four years into the largest and longest pandemic of this century. We address the risks of SARS-CoV-2 infection, immunity, transmission, severity and outcomes in children...
March 1, 2024: Journal of Infection
https://read.qxmd.com/read/38431156/azd1222-effectiveness-against-severe-covid-19-in-individuals-with-comorbidity-or-frailty-the-raven-cohort-study
#8
JOURNAL ARTICLE
Wilhelmine Meeraus, Mark Joy, Mario Ouwens, Kathryn S Taylor, Sudhir Venkatesan, John Dennis, Trung N Tran, Ashkan Dashtban, Xuejuan Fan, Robert Williams, Tamsin Morris, Lucy Carty, Debasish Kar, Uy Hoang, Michael Feher, Anna Forbes, Gavin Jamie, William Hinton, Kornelia Sanecka, Rachel Byford, Sneha N Anand, F D Richard Hobbs, David Clifton, Andrew J Pollard, Sylvia Taylor, Simon de Lusignan
OBJECTIVES: Despite being prioritized during initial COVID-19 vaccine rollout, vulnerable individuals at high risk of severe COVID-19 (hospitalization, intensive care unit admission, or death) remain underrepresented in vaccine effectiveness (VE) studies. The RAVEN cohort study (NCT05047822) assessed AZD1222 (ChAdOx1 nCov-19) two-dose primary series VE in vulnerable populations. METHODS: Using the Oxford-Royal College of General Practitioners Clinical Informatics Digital Hub, linked to secondary care, death registration, and COVID-19 datasets in England, COVID-19 outcomes in 2021 were compared in vaccinated and unvaccinated individuals matched on age, sex, region, and multimorbidity...
February 29, 2024: Journal of Infection
https://read.qxmd.com/read/38431155/ivermectin-for-covid-19-in-adults-in-the-community-principle-an-open-randomised-controlled-adaptive-platform-trial-of-short-and-longer-term-outcomes
#9
JOURNAL ARTICLE
Gail Hayward, Ly-Mee Yu, Paul Little, Oghenekome Gbinigie, Milensu Shanyinde, Victoria Harris, Jienchi Dorward, Benjamin R Saville, Nicholas Berry, Philip H Evans, Nicholas Pb Thomas, Mahendra G Patel, Duncan Richards, Oliver Van Hecke, Michelle A Detry, Christina Saunders, Mark Fitzgerald, Jared Robinson, Charlotte Latimer-Bell, Julie Allen, Emma Ogburn, Jenna Grabey, Simon de Lusignan, Fd Richard Hobbs, Christopher C Butler
BACKGROUND: The evidence for whether ivermectin impacts recovery, hospital admissions, and longer-term outcomes in COVID-19 is contested. The WHO recommends its use only in the context of clinical trials. METHODS: In this multicentre, open-label, multi-arm, adaptive platform randomised controlled trial, we included participants aged ≥18 years in the community, with a positive SARS-CoV-2 test, and symptoms lasting ≤14 days. Participants were randomised to usual care, usual care plus ivermectin tablets (target 300-400 μg/kg per dose, once daily for 3 days), or usual care plus other interventions...
February 29, 2024: Journal of Infection
https://read.qxmd.com/read/38431154/intra-host-genetic-diversity-of-sars-cov-2-omicron-variants-in-children
#10
LETTER
Pengcheng Liu, Jiehao Cai, He Tian, Jingjing Li, Lijuan Lu, Menghua Xu, Xunhua Zhu, Huaqing Zhong, Ran Jia, Xiaomin Fu, Xiangshi Wang, Yanling Ge, Yanfeng Zhu, Mei Zeng, Jin Xu
No abstract text is available yet for this article.
February 29, 2024: Journal of Infection
https://read.qxmd.com/read/38431153/lymphopenia-is-associated-with-broad-host-response-aberrations-in-community-acquired-pneumonia
#11
JOURNAL ARTICLE
Susanne E Doeleman, Tom D Y Reijnders, Sebastiaan C M Joosten, Alex R Schuurman, Tjitske S R van Engelen, Jan Verhoeff, Valentine Léopold, Xanthe Brands, Bastiaan W Haak, Jan M Prins, Maadrika M N P Kanglie, Inge A H van den Berk, Daniël R Faber, Renée A Douma, Jaap Stoker, Anno Saris, Juan J Garcia Vallejo, W Joost Wiersinga, Tom van der Poll
OBJECTIVES: Lymphopenia at hospital admission occurs in over one-third of patients with community-acquired pneumonia (CAP), yet its clinical relevance and pathophysiological implications remain underexplored. We evaluated outcomes and immune features of patients with lymphopenic CAP (L-CAP), a previously described immunophenotype characterized by admission lymphocyte count <0.724×109 cells/L. METHODS: Observational study in 149 patients admitted to a general ward for CAP...
February 29, 2024: Journal of Infection
https://read.qxmd.com/read/38395070/identification-of-a-newly-emerging-second-generation-hiv-1-circulating-recombinant-form-crf145_0755-among-men-who-have-sex-with-men-in-china
#12
LETTER
Min Chen, Yanling Ma, Huichao Chen, Jie Dai, Lijuan Dong, Manhong Jia
No abstract text is available yet for this article.
February 21, 2024: Journal of Infection
https://read.qxmd.com/read/38382858/is-paracetamol-a-missing-piece-of-the-severe-acute-hepatitis-of-unknown-aetiology-jigsaw
#13
LETTER
Pietro Vajro, Claudia Mandato, Björn Fischler
No abstract text is available yet for this article.
February 19, 2024: Journal of Infection
https://read.qxmd.com/read/38373574/bacteriophage-therapy-and-current-delivery-strategies-for-orthopedic-infections-a-scoping-review
#14
REVIEW
Jason Young, Sang W Lee, Mohammad J Shariyate, Alexandria Cronin, John J Wixted, Ara Nazarian, Christopher F Rowley, Edward K Rodriguez
OBJECTIVES: Interest in phages as adjunctive therapy to treat difficult infections has grown in the last decade. However, phage dosing and delivery for orthopedic infections have not been systematically summarized. METHODS: Following PRISMA-ScR guidelines, we conducted a SCOPING review through September 1st, 2023, of MEDLINE, Embase, Web of Science Core Collection, and Cochrane Central. RESULTS: In total, 77 studies were included, of which 19 (24...
February 17, 2024: Journal of Infection
https://read.qxmd.com/read/38367706/people-living-with-hiv-who-have-poor-immune-status-are-a-key-population-for-sars-cov-2-prevention
#15
LETTER
Jie Zhou, Liuyan Lan, Sufang Ai, Jianyan Lin, Ningmei Liu, Yulan Xie, Ping Cui, Hao Liang, Li Ye, Jiegang Huang, Zhiman Xie
No abstract text is available yet for this article.
February 15, 2024: Journal of Infection
https://read.qxmd.com/read/38367705/tixagevimab-cilgavimab-azd7442-for-the-treatment-of-patients-hospitalized-with-covid-19-discovery-a-phase-3-randomized-double-blind-placebo-controlled-trial
#16
LETTER
Maya Hites, Clément R Massonnaud, Simon Jamard, François Goehringer, François Danion, Jean Reignier, Nathalie de Castro, Denis Garot, Eva Larranaga Lapique, Karine Lacombe, Violaine Tolsma, Emmanuel Faure, Denis Malvy, Thérèse Staub, Johan Courjon, France Cazenave-Roblot, Anne Ma Dyrhol Riise, Paul Leturnier, Guillaume Martin-Blondel, Claire Roger, Karolina Akinosoglou, Vincent Le Moing, Lionel Piroth, Pierre Sellier, Xavier Lescure, Marius Trøseid, Philippe Clevenbergh, Olav Dalgard, Sébastien Gallien, Marie Gousseff, Paul Loubet, Fanny Vardon-Bounes, Clotilde Visée, Leila Belkhir, Élisabeth Botelho-Nevers, André Cabié, Anastasia Kotanidou, Fanny Lanternier, Elisabeth Rouveix-Nordon, Susana Silva, Guillaume Thiery, Pascal Poignard, Guislaine Carcelain, Alpha Diallo, Noémie Mercier, Vida Terzic, Maude Bouscambert-Duchamp, Alexandre Gaymard, Mary-Anne Trabaud, Grégory Destras, Laurence Josset, Drifa Belhadi, Nicolas Billard, Jérémie Guedj, Thi-Hong-Lien Han, Sandrine Couffin-Cadiergues, Aline Dechanet, Christelle Delmas, Hélène Esperou, Claire Fougerou-Leurent, Soizic Le Mestre, Anabelle Métois, Marion Noret, Isabelle Bally, Sebastián Dergan-Dylon, Sarah Tubiana, Ouifiya Kalif, Nathalie Bergaud, Benjamin Leveau, Joe Eustace, Richard Greil, Edit Hajdu, Monika Halanova, Jose-Artur Paiva, Anna Piekarska, Jesus Rodriguez Baño, Kristian Tonby, Milan Trojánek, Sotirios Tsiodras, Serhat Unal, Charles Burdet, Dominique Costagliola, Yazdan Yazdanpanah, Nathan Peiffer-Smadja, France Mentré, Florence Ader
No abstract text is available yet for this article.
February 15, 2024: Journal of Infection
https://read.qxmd.com/read/38367704/molecular-insights-into-the-adaptive-evolution-of-sars-cov-2-spike-protein
#17
REVIEW
Zhuocheng Yao, Lin Zhang, Yuange Duan, Xiaolu Tang, Jian Lu
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially damaged the global economy and human health. The spike (S) protein of coronaviruses plays a pivotal role in viral entry by binding to host cell receptors. Additionally, it acts as the primary target for neutralizing antibodies in those infected and is the central focus for currently utilized or researched vaccines. During the virus's adaptation to the human host, the S protein of SARS-CoV-2 has undergone significant evolution...
February 15, 2024: Journal of Infection
https://read.qxmd.com/read/38360357/antibiotics-to-eradicate-streptococcus-pyogenes-pharyngeal-carriage-in-asymptomatic-children-and-adults-a-systematic-review
#18
REVIEW
Te-Yu Hung, Linny K Phuong, Anneke Grobler, Steven Y C Tong, Pippin Freeth, Asika Pelenda, Katherine B Gibney, Andrew C Steer
UNLABELLED: Streptococcus pyogenes (S. pyogenes) is a Gram-positive bacteria which causes a spectrum of diseases ranging from asymptomatic infection to life-threatening sepsis. Studies report up to 2000 times greater risk of invasive S. pyogenes disease in close contacts of index cases within 30-days of symptom onset. Despite this, there is variability in the management of asymptomatic carriage of S. pyogenes and those at risk of secondary cases of invasive S. pyogenes infection. OBJECTIVE: Our systematic review assessed the efficacy of different antibiotic regimens used for eradication of S...
February 13, 2024: Journal of Infection
https://read.qxmd.com/read/38360356/altered-igg4-antibody-response-to-repeated-mrna-versus-recombinant-protein-sars-cov-2-vaccines
#19
LETTER
Raj Kalkeri, Mingzhu Zhu, Shane Cloney-Clark, Joyce S Plested, Anand Parekh, Drew Gorinson, Rongman Cai, Soham Mahato, Pradhipa Ramanathan, L Carissa Aurelia, Kevin John Selva, Anthony M Marchese, Louis Fries, Amy W Chung, Lisa M Dunkle
No abstract text is available yet for this article.
February 13, 2024: Journal of Infection
https://read.qxmd.com/read/38342382/the-clinical-outcome-of-covid-19-is-strongly-associated-with-microbiome-dynamics-in-the-upper-respiratory-tract
#20
JOURNAL ARTICLE
Linlin Xie, Gengyan Luo, Zhongzhou Yang, Wei-Chen Wu, Jintao Chen, Yuting Ren, Zhikun Zeng, Guangming Ye, Yunbao Pan, Wen-Jing Zhao, Yao-Qing Chen, Wei Hou, Yanni Sun, Deying Guo, Zifeng Yang, Jun Li, Edward C Holmes, Yirong Li, Liangjun Chen, Mang Shi
OBJECTIVES: The respiratory tract is the portal of entry for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although a variety of respiratory pathogens other than SARS-CoV-2 have been associated with severe cases of COVID-19 disease, the dynamics of the upper respiratory microbiota during disease the course of disease, and how they impact disease manifestation, remain uncertain. METHODS: We collected 349 longitudinal upper respiratory samples from a cohort of 65 COVID-19 patients (cohort 1), 28 samples from 28 recovered COVID-19 patients (cohort 2), and 59 samples from 59 healthy controls (cohort 3)...
February 9, 2024: Journal of Infection
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