journal
https://read.qxmd.com/read/38599549/distinct-patterns-of-vital-sign-and-inflammatory-marker-responses-in-adults-with-suspected-bloodstream-infection
#1
JOURNAL ARTICLE
Qingze Gu, Jia Wei, Chang Ho Yoon, Kevin Yuan, Nicola Jones, Andrew Brent, Martin Llewelyn, Tim Ea Peto, Koen B Pouwels, David W Eyre, A Sarah Walker
OBJECTIVES: To identify patterns in inflammatory marker and vital sign responses in adult with suspected bloodstream infection (BSI) and define expected trends in normal recovery. METHODS: We included patients ≥16y from Oxford University Hospitals with a blood culture taken between 01-January-2016 to 28-June-2021. We used linear and latent class mixed models to estimate trajectories in C-reactive protein (CRP), white blood count, heart rate, respiratory rate and temperature and identify CRP response subgroups...
April 8, 2024: Journal of Infection
https://read.qxmd.com/read/38588960/genomic-evolution-of-human-respiratory-syncytial-virus-during-a-decade-2013-2023-bridging-the-path-to-monoclonal-antibody-surveillance
#2
JOURNAL ARTICLE
Maria Piñana, Alejandra González-Sánchez, Cristina Andrés, Jorgina Vila, Anna Creus-Costa, Ignasi Prats-Méndez, Maria Arnedo-Muñoz, Narcís Saubi, Juliana Esperalba, Ariadna Rando, Patricia Nadal-Baron, Josep Quer, Juan José González-López, Pere Soler-Palacín, Jaime Martínez-Urtaza, Nieves Larrosa, Tomàs Pumarola, Andrés Antón
OBJECTIVES: This study investigated the prevalence, genetic diversity, and evolution of human respiratory syncytial virus (HRSV) in Barcelona from 2013 to 2023. METHODS: Respiratory specimens from patients with RTI suspicion at Hospital Universitari Vall d'Hebron were collected from October/2013 to May/2023 for laboratory-confirmation of respiratory viruses. Next-generation sequencing was performed in randomly-selected samples with Illumina technology. Phylogenetic analyses of whole genome sequences were performed with BEAST v1...
April 6, 2024: Journal of Infection
https://read.qxmd.com/read/38588959/viruses-associated-with-measles-like-illnesses-in-uganda
#3
JOURNAL ARTICLE
Prossy Namuwulya, Shirin Ashraf, Marc Niebel, Alfred Ssekagiri, Phionah Tushabe, Proscovia Kakooza, Lily Tong, Henry Bukenya, Hanna Jerome, Chris Davis, Molly Birungi, Irene Turyahabwe, Arnold Mugaga, James Peter Eliku, Aine Francis, Lucy Nakabazzi, Fred Nsubuga, Edson Katushabe, Annet Kisakye, Immaculate Ampeire, Ann Nanteza, Pontiano Kaleebu, Barnabas Bakamutumaho, Peninah Nsamba, Anne Kazibwe, Ana da Silva Filipe, Robert Tweyongyere, Josephine Bwogi, Emma C Thomson
OBJECTIVES: In this study, we investigated the causes of measles-like illnesses (MLI) in the Uganda national surveillance programme in order to inform diagnostic assay selection and vaccination strategies. METHODS: We used metagenomic next-generation sequencing (M-NGS) on the Illumina platform to identify viruses associated with MLI (defined as fever and rash in the presence of either cough, coryza or conjunctivitis) in patient samples that had tested IgM negative for measles between 2010 and 2019...
April 6, 2024: Journal of Infection
https://read.qxmd.com/read/38583722/change-in-age-profile-of-respiratory-syncytial-virus-disease-over-the-course-of-annual-epidemics-a-multi-national-study
#4
JOURNAL ARTICLE
Saverio Caini, Jean-Sebastien Casalegno, Ana Paula Rodrigues, Vernon Lee, Cheryl Cohen, Q Sue Huang, Alfredo Bruno Caicedo, Anne Teirlinck, Raquel Guiomar, Li Wei Ang, Jocelyn Moyes, Tim Wood, Doménica de Mora, Mathieu Bangert, Rolf Kramer, Lisa Staadegaard, Susanne Heemskerk, Jojanneke van Summeren, Adam Meijer, John Paget
OBJECTIVES: We aimed to study whether the percentwise age distribution of RSV cases changes over time during annual epidemics. METHODS: We used surveillance data (2008-2019) from the Netherlands, Lyon (France), Portugal, Singapore, Ecuador, South Africa, and New Zealand. In each country, every season was divided into "epidemic quarters", i.e. periods corresponding to each quartile of RSV cases. Multinomial logistic regression models were fitted to evaluate whether the likelihood of RSV cases being aged <1 or ≥5 years (vs...
April 5, 2024: Journal of Infection
https://read.qxmd.com/read/38582127/transcriptomic-crosstalk-between-viral-and-host-factors-drives-aberrant-homeostasis-of-t-cell-proliferation-and-cell-death-in-hiv-infected-immunological-non-responders
#5
JOURNAL ARTICLE
Shengquan Tang, Yanqiu Lu, Feng Sun, Yuanyuan Qin, Vijay Harypursat, Renni Deng, Gong Zhang, Yaokai Chen, Tong Wang
BACKGROUND: Immunological non-responders (INRs) among people living with HIV have inherently higher mortality and morbidity rates. The underlying immunological mechanisms whereby failure of immune reconstitution occurs in INRs require elucidation. METHOD: HIV DNA and HIV cell-associated RNA (CA-HIV RNA) quantifications were conducted via RT-qPCR. Transcriptome sequencing (RNA-seq), bioinformatics, and biological verifications were performed to discern the crosstalk between host and viral factors...
April 4, 2024: Journal of Infection
https://read.qxmd.com/read/38574776/parasitological-and-clinical-effects-of-malaria-chemoprevention-with-sulfadoxine-pyrimethamine-in-pregnant-women-from-southern-mozambique
#6
JOURNAL ARTICLE
Glória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cístero, Henriques Mbeve, Anna Escoda, Gizela Bambo, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Kevin K A Tetteh, Chris Drakeley, Benoit Gamain, Chetan Chitnis, Virander Chauhan, Llorenç Quintó, Eusébio Macete, Alfredo Mayor
OBJECTIVE: The effectiveness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is threatened by increasing SP resistance in Africa. We assessed the level of SP-resistance markers, and the clinical and parasitological effectiveness of IPTp-SP in southern Mozambique. METHODS: P. falciparum infection, antimalarial antibodies and dhfr/dhps SP-resistance mutants were detected by quantitative polymerase chain reaction (qPCR), suspension array technology and targeted deep sequencing, respectively, among 4016 HIV negative women in Maputo province (2016-2019)...
April 2, 2024: Journal of Infection
https://read.qxmd.com/read/38574775/-risk-of-death-in-klebsiella-pneumoniae-bloodstream-infections-is-associated-with-specific-phylogenetic-lineages
#7
JOURNAL ARTICLE
Aasmund Fostervold, Niclas Raffelsberger, Marit A K Hetland, Ragna Bakksjø, Eva Bernhoff, Ørjan Samuelsen, Arnfinn Sundsfjord, Jan E Afset, Christopher F Berntsen, Roar Bævre-Jensen, Marit H Ebbesen, Karianne W Gammelsrud, Anja D Guleng, Nina Handal, Aleksandra Jakovljev, Simreen K Johal, Åshild Marvik, Ane Natvik, Rolf-Arne Sandnes, Ståle Tofteland, Jørgen V Bjørnholt, Iren H Löhr
BACKGROUND: Klebsiella pneumoniae species complex (KpSC) bloodstream infections (BSIs) are associated with considerable morbidity and mortality, particularly in elderly and multimorbid patients. Multidrug resistant (MDR) strains have been associated with poorer outcome. However, the clinical impact of KpSC phylogenetic lineages on BSI outcome is unclear. METHODS: In an 18-month nationwide Norwegian prospective study of KpSC BSI episodes in adults, we used whole genome sequencing to describe the molecular epidemiology of KpSC, and multivariable Cox regression analysis including clinical data to determine adjusted hazard ratios (aHR) for death associated with specific genomic lineages...
April 2, 2024: Journal of Infection
https://read.qxmd.com/read/38574774/an-early-and-trustable-indicator-suggestive-of-non-tuberculosis-mycobacteria-isolation-in-a-high-tuberculosis-burden-setting
#8
JOURNAL ARTICLE
Qian Liang, Xiaoyi Jiang, Junnan Jia, Liping Zhao, Yunxu Li, Fen Wang, Lingling Dong, Yi Xue, Guanglu Jiang, Hairong Huang
BACKGROUND: Distinguishing between non-tuberculous mycobacterial (NTM) lung infections and pulmonary tuberculosis becomes challenging due to their similar clinical manifestations and radiological images. Consequently, instances of delayed diagnosis or misdiagnosis are highly frequent. A feasible and reliable indicator of the existence of NTM in the early stages of the disease would help to solve this dilemma. METHODS: In this study, we evaluated the potential of smear-positive and Xpert assay (Cepheid, USA) negative outcomes as an early indicator of possible NTM infection in a high TB burden setting retrospectively and prospectively...
April 2, 2024: Journal of Infection
https://read.qxmd.com/read/38570164/role-of-sars-cov-2-mutations-in-the-evolution-of-the-covid-19-pandemic
#9
JOURNAL ARTICLE
Philippe Colson, Hervé Chaudet, Jérémy Delerce, Pierre Pontarotti, Anthony Levasseur, Jacques Fantini, Bernard La Scola, Christian Devaux, Didier Raoult
OBJECTIVES: The SARS-CoV-2 pandemic and large-scale genomic surveillance provided an exceptional opportunity to analyze mutations that appeared over three years in viral genomes. Here we studied mutations and their epidemic consequences for SARS-CoV-2 genomes from our center. METHODS: We analyzed 61,397 SARS-CoV-2 genomes we sequenced from respiratory samples for genomic surveillance. Mutations frequencies were calculated using Nextclade, Microsoft Excel, and an in-house Python script...
April 1, 2024: Journal of Infection
https://read.qxmd.com/read/38561066/relapsing-epidemic-typhus-brill-zinsser-disease-in-china
#10
LETTER
Miao Lu, Shizhe Chen, Huafeng Li, Wen Wang, Kun Li
No abstract text is available yet for this article.
March 30, 2024: Journal of Infection
https://read.qxmd.com/read/38555035/utility-of-an-in-house-real-time-pcr-in-whole-blood-samples-as-a-minimally-invasive-method-for-early-and-accurate-diagnosis-of-invasive-mould-infections
#11
JOURNAL ARTICLE
Mragnayani Pandey, Immaculata Xess, Janya Sachdev, Neha Sharad, Sonakshi Gupta, Gagandeep Singh, Renu Kumari Yadav, Bhaskar Rana, Stephen Raj, M Nizam Ahmad, Neha Nityadarshini, Upendra Baitha, Manish Soneja, Shalimar, Bindu Prakash, Kapil Sikka, Purva Mathur, Viveka P Jyotsna, Rakesh Kumar, Naveet Wig, Sudesh Gourav, Ashutosh Biswas, Alok Thakar
INTRODUCTION: Invasive mould infections (IMIs) are a leading cause of death in patients with compromised immune systems. Proven invasive mould infection requires detection of a fungus by histopathological analysis of a biopsied specimen, sterile culture, or fungal DNA amplification by PCR in tissue. However, the clinical performance of a PCR assay on blood samples taken from patients suspected of invasive mould disease has not been fully evaluated, particularly for the differential diagnosis of invasive aspergillosis (IA) and invasive Mucormycosis (IM)...
March 28, 2024: Journal of Infection
https://read.qxmd.com/read/38552719/paediatric-meningitis-in-the-conjugate-vaccine-era-and-a-novel-clinical-decision-model-to-predict-bacterial-aetiology
#12
JOURNAL ARTICLE
Martin Ng, Defres S, Willis L, Beckley R, Hardwick H, Coxon A, Kadambari S, Yu L-M, Liu X, Galal U, Conlin K, Griffiths Mj, Kneen R, Nadel S, Heath Pt, Kelly Df, Solomon T, Sadarangani M, Pollard Aj
OBJECTIVES: The aims of this study were to assess aetiology and clinical characteristics in childhood meningitis, and develop clinical decision rules to distinguish bacterial meningitis from other similar clinical syndromes. METHODS: Children aged <16 years hospitalised with suspected meningitis/encephalitis were included, and prospectively recruited at 31 UK hospitals. Meningitis was defined as identification of bacteria/viruses from cerebrospinal fluid (CSF) and/or a raised CSF white blood cell count...
March 27, 2024: Journal of Infection
https://read.qxmd.com/read/38548243/evaluation-of-metagenomic-and-pathogen-targeted-next-generation-sequencing-for-diagnosis-of-meningitis-and-encephalitis-in-adults-a-multicenter-prospective-observational-cohort-study-in-china
#13
JOURNAL ARTICLE
Weibi Chen, Gang Liu, Lili Cui, Fei Tian, Jiatang Zhang, Jiahua Zhao, Ying Lv, Jianxin Du, Xinyu Huan, Yingfeng Wu, Yan Zhang
BACKGROUND: Next-generation sequencing (NGS) might aid in identification of causal pathogens. However, the optimal approaches applied to cerebrospinal fluid (CSF) for detection are unclear, and studies evaluating application of different NGS workflows for diagnosis of intracranial infections are limited. METHODS: In this multicenter, prospective observational cohort study, we described the diagnostic efficacy of pathogen-targeted NGS (ptNGS) and metagenomic NGS (mNGS) compared to that of composite microbiologic assays, for infectious meningitis/encephalitis (M/E)...
March 26, 2024: Journal of Infection
https://read.qxmd.com/read/38531430/understanding-immune-dysregulation-in-post-acute-sequelae-of-covid-19-pasc-the-hunt-for-effective-treatments
#14
LETTER
Norman B Gaylis, Otto O Yang
No abstract text is available yet for this article.
March 24, 2024: Journal of Infection
https://read.qxmd.com/read/38527653/novel-antivirals-for-severe-enterovirus-infection-in-immunocompromised-hosts-a-case-series
#15
LETTER
Andrea Meinhardt, Liam Reilly, Marios Kaliakatsos, Khaled Abdel-Aziz, Sondus Alsharidah, Istvan Bodi, Claire Booth, Kritika Chetty, Jennifer Evans, Laura Ferreras-Antolín, Susannah Froude, Clare M Galtrey, Suba Guruprasad, Robert D Hadden, Jane Hassell, Heikki Hyöty, Alexandra Y Kreins, Jutta E Laiho, David M Lowe, Michael P Lunn, Kshitij Mankad, Siske Struik, Elizabeth Whittaker, Austen Worth, Patrick Yong, Liqun Zhang, Judith Breuer, Seilesh Kadambari
No abstract text is available yet for this article.
March 23, 2024: Journal of Infection
https://read.qxmd.com/read/38513739/re-emergence-of-diphtheria-after-covid-19-pandemic-in-pakistan-time-to-consider-booster-vaccination-strategies
#16
LETTER
Muhammad Salman, Muhammad Suleman Rana, Muhammad Usman, Muhammad Tahir, Kashif Muqarrab, Muhammad Babar Alam, Massab Umair, Muhammad Anas, Nadeem Ullah, Ayesha Farooq, Zurva Ashraf
No abstract text is available yet for this article.
March 19, 2024: Journal of Infection
https://read.qxmd.com/read/38513738/resurgence-and-atypical-patterns-of-pertussis-in-china
#17
LETTER
Guo Mengyang, Hu Yahong, Meng Qinghong, Shi Wei, Yao Kaihu
No abstract text is available yet for this article.
March 19, 2024: Journal of Infection
https://read.qxmd.com/read/38490275/strong-cross-immune-responses-against-sarbecoviruses-but-not-merbecoviruses-in-sars-cov-2-ba-5-bf-7-infected-individuals-with-or-without-inactivated-covid-19-vaccination
#18
LETTER
Lujia Sun, Qiuhong Man, Hui Zhang, Shuai Xia, Lu Lu, Xinling Wang, Lize Xiong, Shibo Jiang
No abstract text is available yet for this article.
March 13, 2024: Journal of Infection
https://read.qxmd.com/read/38479495/covid-19-mortality-amongst-the-immunosuppresed
#19
LETTER
Víctor Moreno-Torres, María Martínez-Urbistondo, Jorge Calderón-Parra, Carmen de Mendoza, Vicente Soriano
No abstract text is available yet for this article.
March 11, 2024: Journal of Infection
https://read.qxmd.com/read/38462077/within-episode-repeat-antibiotic-prescriptions-in-patients-with-respiratory-tract-infections-a-population-based-cohort-study
#20
JOURNAL ARTICLE
A Lalmohamed, R P Venekamp, A Bolhuis, P C Souverein, J van de Wijgert, M Gulliford, A D Hay
BACKGROUND: Antimicrobial stewardship interventions mainly focus on initial antibiotic prescriptions, with few considering within-episode repeat prescriptions. We aimed to describe the magnitude, type and determinants of within-episode repeat antibiotic prescriptions in patients presenting to primary care with respiratory tract infections (RTIs). METHODS: We conducted a population-based cohort study among 530 sampled English general practices within the Clinical Practice Research Datalink (CPRD)...
March 8, 2024: Journal of Infection
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