journal
https://read.qxmd.com/read/38557153/sympathetic-pathophysiology-in-hypertension-origins-the-path-to-renal-denervation
#41
REVIEW
Murray D Esler, John W Osborn, Markus P Schlaich
The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the 20th century, through to the 1960s. Here, the sympathetic nervous system was identified as a target for the treatment of hypertension, and an extensive range of antiadrenergic therapies were developed. Then, after a period of lapsed interest, in a second era from 1985 on, the development of precise measures of human sympathetic nerve firing and transmitter release allowed demonstration of the importance of neural mechanisms in the initiation and maintenance of the arterial blood pressure elevation in hypertension...
April 1, 2024: Hypertension
https://read.qxmd.com/read/38545804/salt-sensitive-hypertension-and-the-kidney
#42
REVIEW
Mitsuhiro Nishimoto, Karen Griffin, Brandi M Wynne, Toshiro Fujita
Salt-sensitive hypertension (SS-HT) is characterized by blood pressure elevation in response to high dietary salt intake and is considered to increase the risk of cardiovascular and renal morbidity. Although the mechanisms responsible for SS-HT are complex, the kidneys are known to play a central role in the development of SS-HT and the salt sensitivity of blood pressure (SSBP). Moreover, several factors influence renal function and SSBP, including the renin-angiotensin-aldosterone system, sympathetic nervous system, obesity, and aging...
March 28, 2024: Hypertension
https://read.qxmd.com/read/38545789/knocking-out-sodium-glucose-linked-transporter-5-prevents-fructose-induced-renal-oxidative-stress-and-salt-sensitive-hypertension
#43
JOURNAL ARTICLE
Beau R Forester, Ronghao Zhang, Brett Schuhler, Autumn Brostek, Agustin Gonzalez-Vicente, Jeffrey L Garvin
BACKGROUND: A fructose high-salt (FHS) diet increases systolic blood pressure and Ang II (angiotensin II)-stimulated proximal tubule (PT) superoxide (O2 - ) production. These increases are prevented by scavenging O2 - or an Ang II type 1 receptor antagonist. SGLT4 (sodium glucose-linked cotransporters 4) and SGLT5 are implicated in PT fructose reabsorption, but their roles in fructose-induced hypertension are unclear. We hypothesized that PT fructose reabsorption by SGLT5 initiates a genetic program enhancing Ang II-stimulated oxidative stress in males and females, thereby causing fructose-induced salt-sensitive hypertension...
March 28, 2024: Hypertension
https://read.qxmd.com/read/38545780/genetic-and-epigenetic-mechanisms-regulating-blood-pressure-and-kidney-dysfunction
#44
REVIEW
Kailash N Pandey
The pioneering work of Dr Lewis K. Dahl established a relationship between kidney, salt, and high blood pressure (BP), which led to the major genetic-based experimental model of hypertension. BP, a heritable quantitative trait affected by numerous biological and environmental stimuli, is a major cause of morbidity and mortality worldwide and is considered to be a primary modifiable factor in renal, cardiovascular, and cerebrovascular diseases. Genome-wide association studies have identified monogenic and polygenic variants affecting BP in humans...
March 28, 2024: Hypertension
https://read.qxmd.com/read/38533662/neural-circuits-underlying-reciprocal-cardiometabolic-crosstalk-2023-arthur-c-corcoran-memorial-lecture
#45
REVIEW
Kamal Rahmouni
The interplay of various body systems, encompassing those that govern cardiovascular and metabolic functions, has evolved alongside the development of multicellular organisms. This evolutionary process is essential for the coordination and maintenance of homeostasis and overall health by facilitating the adaptation of the organism to internal and external cues. Disruption of these complex interactions contributes to the development and progression of pathologies that involve multiple organs. Obesity-associated cardiovascular risks, such as hypertension, highlight the significant influence that metabolic processes exert on the cardiovascular system...
March 27, 2024: Hypertension
https://read.qxmd.com/read/38533642/increased-risk-of-gestational-hypertension-by-periconceptional-exposure-to-ambient-air-pollution-and-effect-modification-by-prenatal-depression
#46
JOURNAL ARTICLE
Zhongzheng Niu, Rima Habre, Tingyu Yang, Xinci Chen, Mario Vigil, Karina Barragan, Fred Lurmann, Nathan R Pavlovic, Brendan H Grubbs, Claudia M Toledo-Corral, Jill Johnston, Genevieve F Dunton, Deborah Lerner, Nathana Lurvey, Laila Al-Marayati, Sandrah P Eckel, Carrie V Breton, Theresa M Bastain, Shohreh F Farzan
BACKGROUND: Air pollution has been associated with gestational hypertension (GH) and preeclampsia, but susceptible windows of exposure and potential vulnerability by comorbidities, such as prenatal depression, remain unclear. METHODS: We ascertained GH and preeclampsia cases in a prospective pregnancy cohort in Los Angeles, CA. Daily levels of ambient particles (with a diameter of ≤10 μm [PM10 ] or ≤2.5 μm [PM2.5 ]), nitrogen dioxide, and ozone were averaged for each week from 12 weeks preconception to 20 gestational weeks...
March 27, 2024: Hypertension
https://read.qxmd.com/read/38525605/subtype-identification-of-surgically-curable-primary-aldosteronism-during-treatment-with-mineralocorticoid-receptor-blockade
#47
JOURNAL ARTICLE
Giovanni Pintus, Teresa Maria Seccia, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Jiří Widimský, Mitsuhide Naruse, Tomaz Kocjan, Aurelio Negro, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Peter J Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Chin-Chen Chang, Vin-Cent Wu, Zuzana Krátká, Michele Battistel, Domenico Bagordo, Brasilina Caroccia, Giulio Ceolotto, Giacomo Rossitto, Gian Paolo Rossi
BACKGROUND: Current guidelines and consensus documents recommend withdrawal of mineralocorticoid receptor antagonists (MRAs) before primary aldosteronism (PA) subtyping by adrenal vein sampling (AVS), but this practice can cause severe hypokalemia and uncontrolled high blood pressure. Our aim was to investigate if unilateral PA can be identified by AVS during MRA treatment. METHODS: We compared the rate of unilateral PA identification between patients with and without MRA treatment in large data sets of patients submitted to AVS while off renin-angiotensin system blockers and β-blockers...
March 25, 2024: Hypertension
https://read.qxmd.com/read/38511317/mechanisms-of-vascular-inflammation-and-potential-therapeutic-targets-a-position-paper-from-the-esh-working-group-on-small-arteries
#48
REVIEW
Francisco J Rios, Carolina de Ciuceis, Georgios Georgiopoulos, Antonios Lazaridis, Ryszard Nosalski, George Pavlidis, Simon Tual-Chalot, Claudia Agabiti-Rosei, Livia L Camargo, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Mariarosaria Lopreiato, Georgios Mavraganis, Alessandro Mengozzi, Augusto C Montezano, Konstantinos Stavropoulos, Pawel J Winklewski, Jacek Wolf, Sarah Costantino, Michael Doumas, Eugenia Gkaliagkousi, Guido Grassi, Tomasz J Guzik, Ignatios Ikonomidis, Krzysztof Narkiewicz, Francesco Paneni, Damiano Rizzoni, Kimon Stamatelopoulos, Konstantinos Stellos, Stefano Taddei, Rhian M Touyz, Agostino Virdis
Inflammatory responses in small vessels play an important role in the development of cardiovascular diseases, including hypertension, stroke, and small vessel disease. This involves various complex molecular processes including oxidative stress, inflammasome activation, immune-mediated responses, and protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, including DNA methylation, histone modifications, and microRNAs influence vascular inflammation and injury...
March 21, 2024: Hypertension
https://read.qxmd.com/read/38506074/treatment-of-sleep-apnea-and-reduction-in-blood-pressure-the-role-of-heart-rate-response-and-hypoxic-burden
#49
JOURNAL ARTICLE
Ludovico Messineo, Scott Sands, Christopher Schmickl, Gonzalo Labarca, Wen-Hsin Hu, Neda Esmaeili, Daniel Vena, Laura Gell, Nicole Calianese, Atul Malhotra, Daniel J Gottlieb, Andrew Wellman, Susan Redline, Ali Azarbarzin
BACKGROUND: Obstructive sleep apnea is associated with increased blood pressure (BP). Obstructive sleep apnea treatment reduces BP with substantial variability, not explained by the apnea-hypopnea index, partly due to inadequate characterization of obstructive sleep apnea's physiological consequences, such as oxygen desaturation, cardiac autonomic response, and suboptimal treatment efficacy. We sought to examine whether a high baseline heart rate response (ΔHR), a marker of high cardiovascular risk in obstructive sleep apnea, predicts a larger reduction in posttreatment systolic BP (SBP)...
March 20, 2024: Hypertension
https://read.qxmd.com/read/38506059/long-term-blood-pressure-reductions-following-catheter-based-renal-denervation-a-systematic-review-and-meta-analysis
#50
JOURNAL ARTICLE
Gianni Sesa-Ashton, Janis M Nolde, Ida Muente, Revathy Carnagarin, Vaughan G Macefield, Tye Dawood, Elisabeth A Lambert, Gavin W Lambert, Antony Walton, Murray D Esler, Markus P Schlaich
BACKGROUND: Renal denervation is a recognized adjunct therapy for hypertension with clinically significant blood pressure (BP)-lowering effects. Long-term follow-up data are critical to ascertain durability of the effect and safety. Aside from the 36-month follow-up data available from randomized control trials, recent cohort analyses extended follow-up out to 10 years. We sought to analyze study-level data and quantify the ambulatory BP reduction of renal denervation across contemporary randomized sham-controlled trials and available long-term follow-up data up to 10 years from observational studies...
March 20, 2024: Hypertension
https://read.qxmd.com/read/38506051/prognostic-relevance-of-short-term-blood-pressure-variability-the-spanish-abpm-registry
#51
JOURNAL ARTICLE
Alejandro de la Sierra, Bryan Williams, Michael Bursztyn, Gianfranco Parati, George Stergiou, Ernest Vinyoles, Julián Segura, Manuel Gorostidi, Luis M Ruilope
BACKGROUND: The prognostic relevance of short-term blood pressure (BP) variability in hypertension is not clearly established. We aimed to evaluate the association of short-term BP variability, with all-cause and cardiovascular mortality in a large cohort of patients with hypertension. METHODS: We selected 59 124 patients from the Spanish Ambulatory Blood Pressure Monitoring Registry from 2004 to 2014 (median follow-up: 9.7 years). Systolic and diastolic BP SD and coefficient of variation from daytime and nighttime, weighted SD, weighted coefficient of variation, average real variability (mean of differences between consecutive readings), and BP variability ratio (ratio between systolic and diastolic 24-hour SD) were calculated through baseline 24-hour ambulatory BP monitoring...
March 20, 2024: Hypertension
https://read.qxmd.com/read/38501250/coarctation-duration-and-severity-predict-risk-of-hypertension-precursors-in-a-preclinical-model-and-hypertensive-status-among-patients
#52
JOURNAL ARTICLE
Arash Ghorbannia, Hilda Jurkiewicz, Lith Nasif, Abdillahi Ahmed, Jennifer Co-Vu, Mehdi Maadooliat, Ronald K Woods, John F LaDisa
BACKGROUND: Coarctation of the aorta (CoA) often leads to hypertension) posttreatment. Evidence is lacking for the current >20 mm Hg peak-to-peak blood pressure (BP) gradient (BPGpp) guideline, which can cause aortic thickening, stiffening, and dysfunction. This study sought to find the BPGpp severity and duration that avoid persistent dysfunction in a preclinical model and test if predictors translate to hypertension status in patients with CoA. METHODS: Rabbits (n=75; 5-12/group) were exposed to mild, intermediate, or severe CoA (≤12, 13-19, ≥20 mm Hg BPGpp) for ≈1, 3, or 22 weeks using dissolvable and permanent sutures with thickening, stiffening, contraction, and endothelial function evaluated via multivariate regression...
March 19, 2024: Hypertension
https://read.qxmd.com/read/38501243/association-between-gestational-diabetes-mellitus-and-hypertension-a-systematic-review-and-meta-analysis-of-cohort-studies-with-a-quantitative-bias-analysis-of-uncontrolled-confounding
#53
JOURNAL ARTICLE
Xinyue Liu, Roch Nianogo, Carla Janzen, Zhe Fei, Marissa Seamans, Renee Wen, Xiang Li, Liwei Chen
BACKGROUND: Whether individuals with gestational diabetes (GDM) had an increased risk of hypertension remains unclear. We conducted a systematic literature review and meta-analysis to examine the association between GDM and hypertension and performed a quantitative bias analysis to quantify the impact of uncontrolled confounding due to antenatal psychological stress. METHODS: We searched databases (PUBMED, EMBASE, and Web of Science) through 2022/11. Eligible studies were cohort studies that reported the association of GDM with hypertension...
March 19, 2024: Hypertension
https://read.qxmd.com/read/38865474/to-screen-or-not-to-screen-for-atrial-fibrillation-in-patients-with-hypertension-that-is-not-the-question
#54
EDITORIAL
Elsayed Z Soliman, Lin Yee Chen
No abstract text is available yet for this article.
July 2024: Hypertension
https://read.qxmd.com/read/38865473/in-memoriam-stephen-c-textor
#55
JOURNAL ARTICLE
Lilach O Lerman
No abstract text is available yet for this article.
July 2024: Hypertension
https://read.qxmd.com/read/38752357/prediabetes-increases-the-risk-of-frailty-in-prefrail-older-adults-with-hypertension-beneficial-effects-of-metformin
#56
JOURNAL ARTICLE
Gaetano Santulli, Valeria Visco, Fahimeh Varzideh, Germano Guerra, Urna Kansakar, Maurizio Gasperi, Anna Marro, Scott Wilson, Mario Nicola Vittorio Ferrante, Antonella Pansini, Armando Pirone, Francesco Di Lorenzo, Domenico Tartaglia, Guido Iaccarino, Gaetano Macina, Esther Densu Agyapong, Imma Forzano, Stanislovas S Jankauskas, Klara Komici, Michele Ciccarelli, Pasquale Mone
BACKGROUND: Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals. METHODS: We screened elders with prefrail hypertension from March 2021 to January 2023. We assessed the correlation linking cognitive dysfunction (Montreal Cognitive Assessment score), insulin resistance (triglyceride-to-glucose index), and physical impairment (5-meter gait speed)...
July 2024: Hypertension
https://read.qxmd.com/read/38748768/regarding-immune-mechanisms-driving-hypertension-in-regards
#57
REVIEW
Ernesto L Schiffrin
No abstract text is available yet for this article.
June 2024: Hypertension
https://read.qxmd.com/read/38748767/gestational-diabetes-mellitus-and-postpartum-hypertension-evidence-for-a-tight-linkage-toward-women-s-cardiovascular-health
#58
REVIEW
Yun Shen, Gang Hu
No abstract text is available yet for this article.
June 2024: Hypertension
https://read.qxmd.com/read/38748766/a-worrying-and-puzzling-case-of-hypertension-presenting-to-the-emergency-department
#59
JOURNAL ARTICLE
Teresa M Seccia, Giacomo Rossitto, Gian Paolo Rossi
No abstract text is available yet for this article.
June 2024: Hypertension
https://read.qxmd.com/read/38748765/short-lived-active-prorenin-precursor-of-so-called-native-prorenin
#60
REVIEW
Maarten A D H Schalekamp, Jaap Deinum, A H Jan Danser
The enzymatic activity of the aspartic protease, renin, is critical for its function in blood pressure regulation and sodium homeostasis. Incubation of so-called native prorenin at low pH leads to its activation. After binding to transition-state mimicking renin inhibitors at neutral pH, prorenin attains the active conformation, as indicated by immunosorbent assay using monoclonal antibodies specific for epitopes of the prosegment or the renin body. A comparison of immunosorbent assay with enzyme-kinetic assay revealed the intermediary steps of prorenin auto-activation/inactivation...
June 2024: Hypertension
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