Riya Garg, Ralph B D'Agostino, Nathaniel O'Connell, Glenn J Lesser, Fadi N Salloum, Anika L Hines, Giselle C Meléndez, Jennifer H Jordan, Bonnie Ky, Lynne I Wagner, Arnethea L Sutton, Wendy Bottinor, Kristine Olson, Amy C Ladd, W Gregory Hundley
BACKGROUND: Hypertension is a risk factor for experiencing left ventricular ejection fraction (LVEF) declines during receipt of potentially cardiotoxic breast cancer (BC) treatment. We sought to determine whether the hypertension stage is associated with LVEF decline during BC treatment. METHODS: Across 24 centers, cardiac magnetic resonance measures of LVEF and brachial arterial blood pressure (BP) measurements were performed in women with stages I to III BC before and 3 months after initiating potentially cardiotoxic chemotherapy...
April 18, 2024: Hypertension
Natalia M Mathieu, Eden E Tan, John J Reho, Daniel T Brozoski, Patricia C Muskus, Ko-Ting Lu, Kelsey K Wackman, Justin L Grobe, Pablo Nakagawa, Curt D Sigmund
BACKGROUND: ANG (angiotensin II) elicits dipsogenic and pressor responses via activation of the canonical Gαq (G-protein component of the AT1 R [angiotensin type 1 receptor])-mediated AT1 R in the subfornical organ. Recently, we demonstrated that ARRB2 (β-arrestin 2) global knockout mice exhibit a higher preference for salt and exacerbated pressor response to deoxycorticosterone acetate salt. However, whether ARRB2 within selective neuroanatomical nuclei alters physiological responses to ANG is unknown...
April 17, 2024: Hypertension
Sergey N Arkhipov, Tang-Dong S Liao, D'Anna L Potter, Kevin R Bobbitt, Veniamin Ivanov, Pablo A Ortiz, Tengis S Pavlov
BACKGROUND: Every year, thousands of patients with hypertension reduce salt consumption in the efforts to control their blood pressure. However, hypertension has a self-sustaining character in a significant part of the population. We hypothesized that chronic hypertension leads to irreversible renal damage that remains after removing the trigger, causing an elevation of the initial blood pressure. METHODS: Dahl salt-sensitive rat model was used for chronic, continuous observation of blood pressure...
April 15, 2024: Hypertension
Konstantinos G Kyriakoulis, Anastasios Kollias, Ariadni Menti, Panagiotis Chardouvelis, George S Stergiou
BACKGROUND: Atrial fibrillation (AF) is often asymptomatic and undiagnosed. As AF and hypertension often coexist, opportunistic AF detection during routine automated blood pressure (BP) measurement appears to be an attractive screening method. METHODS: A systematic literature search was conducted to identify studies assessing the diagnostic test accuracy of office, home, or 24-hour ambulatory BP measuring devices with AF detection algorithms versus reference electrocardiography...
April 11, 2024: Hypertension
Mateusz Dziedzic, Ewelina Józefczuk, Tomasz J Guzik, Mateusz Siedlinski
BACKGROUND: Higher levels of plasma glycine are linked to a reduced risk, while increased levels of total branched-chain amino acids (tBCAAs) are associated with a higher risk of essential hypertension (HTN) and coronary heart disease (CHD). As these metabolic components are interconnected, analyzing the tBCAAs/glycine ratio may help to understand their interplay in the pathogenesis of cardiovascular disease. METHODS: The Cox regression approach was combined with the development of novel genetic tools for assessments of associations between plasma metabolomic data (glycine, tBCAAs, and tBCAAs/glycine ratio) from the UK Biobank and the development of hypertension and CHD...
April 8, 2024: Hypertension
Hamdi A Jama, Matthew Snelson, Aletta E Schutte, Jane Muir, Francine Z Marques
According to several international, regional, and national guidelines on hypertension, lifestyle interventions are the first-line treatment to lower blood pressure (BP). Although diet is one of the major lifestyle modifications described in hypertension guidelines, dietary fiber is not specified. Suboptimal intake of foods high in fiber, such as in Westernized diets, is a major contributing factor to mortality and morbidity of noncommunicable diseases due to higher BP and cardiovascular disease. In this review, we address this deficiency by examining and advocating for the incorporation of dietary fiber as a key lifestyle modification to manage elevated BP...
April 8, 2024: Hypertension
Lucas Lauder, Justyna Siwy, Emmanouil Mavrogeorgis, Felix Keller, Michael Kunz, Angelika Wachter, Insa Emrich, Michael Böhm, Harald Mischak, Felix Mahfoud
BACKGROUND: Catheter-based renal denervation (RDN) reduces blood pressure in hypertension. Urinary peptides are associated with cardiovascular and renal disease and provide prognostic information. We aimed to investigate the effect of RDN on urinary peptide-based biomarker panels associated with chronic kidney and heart disease and to identify urinary peptides affected by RDN. METHODS: This single-arm, single-center study included patients undergoing catheter-based RDN...
April 4, 2024: Hypertension
Kathryn Foti, Josef Coresh, Paul K Whelton, Kunihiro Matsushita, Shakia T Hardy, Kristi Reynolds, C Barrett Bowling, Keenan A Walker, Anna Kucharska-Newton, B Gwen Windham, Michael Griswold, Joseph E Schwartz, Paul Muntner
BACKGROUND: It is unknown whether maintaining normal blood pressure (BP) from middle to older age is associated with improved health outcomes. METHODS: We estimated the proportion of Atherosclerosis Risk in Communities study participants who maintained normal BP from 1987 to 1989 (visit 1) through 1996 to 1998 and 2011 to 2013 (over 4 and 5 visits, respectively). Normal BP was defined as systolic BP <120 mm Hg and diastolic BP <80 mm Hg, without antihypertensive medication...
April 3, 2024: Hypertension
Mona Elgazzaz, Catalin Filipeanu, Eric Lazartigues
ACE2 (angiotensin-converting enzyme 2), a multifunctional transmembrane protein, is well recognized as an important member of the (RAS) renin-angiotensin system with important roles in the regulation of cardiovascular function by opposing the harmful effects of Ang-II (angiotensin II) and AT1R (Ang-II type 1 receptor) activation. More recently, ACE2 was found to be the entry point for the SARS-CoV-2 virus into cells, causing COVID-19. This finding has led to an exponential rise in the number of publications focused on ACE2, albeit these studies often have opposite objectives to the preservation of ACE2 in cardiovascular regulation...
April 3, 2024: Hypertension
Michael C Honigberg, Katherine E Economy, Maria A Pabón, Xiaowen Wang, Claire Castro, Jenifer M Brown, Sanjay Divakaran, Brittany N Weber, Leanne Barrett, Anna Perillo, Anina Y Sun, Tajmara Antoine, Faranak Farrohi, Brenda Docktor, Emily S Lau, Doreen DeFaria Yeh, Pradeep Natarajan, Amy A Sarma, Robert M Weisbrod, Naomi M Hamburg, Jennifer E Ho, Jason D Roh, Malissa J Wood, Nandita S Scott, Marcelo F Di Carli
BACKGROUND: Preeclampsia is a pregnancy-specific hypertensive disorder associated with an imbalance in circulating proangiogenic and antiangiogenic proteins. Preclinical evidence implicates microvascular dysfunction as a potential mediator of preeclampsia-associated cardiovascular risk. METHODS: Women with singleton pregnancies complicated by severe antepartum-onset preeclampsia and a comparator group with normotensive deliveries underwent cardiac positron emission tomography within 4 weeks of delivery...
April 2, 2024: Hypertension
Kimmie B Christensen, Şeyda Ünsal, Morten F Ebbesen, Line Hemstra, Anders Schlosser, Kristoffer Rosenstand, Pernille B L Hansen, Boye L Jensen, Maria Bloksgaard, Ulf Simonsen, Grith L Sorensen
BACKGROUND: Abnormalities of resistance arteries may play essential roles in the pathophysiology of aging and hypertension. Deficiency of the vascular extracellular matrix protein MFAP4 (microfibrillar-associated protein 4) has previously been observed as protective against aberrant arterial remodeling. We hypothesized that MFAP4-deficiency would reduce age- and hypertension-dependent arterial changes in extracellular matrix composition and stiffening. METHODS: Mesenteric arteries were isolated from old (20-23 months) littermate Mfap4 +/+ and Mfap4 -/- mice, and 2-photon excitation microscopy imaging was used to quantify elastin and collagen volumes and dimensions in the vascular wall...
April 2, 2024: Hypertension
James E Sharman, Petr Otahal, Michael Stowasser, Tony Stanton, Christopher M Reid, Mark Nolan, Philip Roberts-Thomson, Kazuaki Negishi, Robert Greenough, Simon Stewart, Thomas H Marwick, Walter P Abhayaratna
BACKGROUND: Cuff blood pressure (BP) is recommended for guiding hypertension management. However, central BP has been proposed as a superior clinical measurement. This study aimed to determine whether controlling hypertension as measured by central BP was beneficial in reducing left ventricular mass index beyond control of standard cuff hypertension. METHODS: This multicenter, open-label, blinded-end point trial was conducted in individuals treated for uncomplicated hypertension with controlled cuff BP (<140/90 mm Hg) but elevated central BP (≥0...
April 2, 2024: Hypertension
Murray D Esler, John W Osborn, Markus P Schlaich
The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the 20th century, through to the 1960s. Here, the sympathetic nervous system was identified as a target for the treatment of hypertension, and an extensive range of antiadrenergic therapies were developed. Then, after a period of lapsed interest, in a second era from 1985 on, the development of precise measures of human sympathetic nerve firing and transmitter release allowed demonstration of the importance of neural mechanisms in the initiation and maintenance of the arterial blood pressure elevation in hypertension...
April 1, 2024: Hypertension
Mitsuhiro Nishimoto, Karen Griffin, Brandi M Wynne, Toshiro Fujita
Salt-sensitive hypertension (SS-HT) is characterized by blood pressure elevation in response to high dietary salt intake and is considered to increase the risk of cardiovascular and renal morbidity. Although the mechanisms responsible for SS-HT are complex, the kidneys are known to play a central role in the development of SS-HT and the salt sensitivity of blood pressure (SSBP). Moreover, several factors influence renal function and SSBP, including the renin-angiotensin-aldosterone system, sympathetic nervous system, obesity, and aging...
March 28, 2024: Hypertension
Beau R Forester, Ronghao Zhang, Brett Schuhler, Autumn Brostek, Agustin Gonzalez-Vicente, Jeffrey L Garvin
BACKGROUND: A fructose high-salt (FHS) diet increases systolic blood pressure and Ang II (angiotensin II)-stimulated proximal tubule (PT) superoxide (O2 - ) production. These increases are prevented by scavenging O2 - or an Ang II type 1 receptor antagonist. SGLT4 (sodium glucose-linked cotransporters 4) and SGLT5 are implicated in PT fructose reabsorption, but their roles in fructose-induced hypertension are unclear. We hypothesized that PT fructose reabsorption by SGLT5 initiates a genetic program enhancing Ang II-stimulated oxidative stress in males and females, thereby causing fructose-induced salt-sensitive hypertension...
March 28, 2024: Hypertension
Kailash N Pandey
The pioneering work of Dr Lewis K. Dahl established a relationship between kidney, salt, and high blood pressure (BP), which led to the major genetic-based experimental model of hypertension. BP, a heritable quantitative trait affected by numerous biological and environmental stimuli, is a major cause of morbidity and mortality worldwide and is considered to be a primary modifiable factor in renal, cardiovascular, and cerebrovascular diseases. Genome-wide association studies have identified monogenic and polygenic variants affecting BP in humans...
March 28, 2024: Hypertension
Kamal Rahmouni
The interplay of various body systems, encompassing those that govern cardiovascular and metabolic functions, has evolved alongside the development of multicellular organisms. This evolutionary process is essential for the coordination and maintenance of homeostasis and overall health by facilitating the adaptation of the organism to internal and external cues. Disruption of these complex interactions contributes to the development and progression of pathologies that involve multiple organs. Obesity-associated cardiovascular risks, such as hypertension, highlight the significant influence that metabolic processes exert on the cardiovascular system...
March 27, 2024: Hypertension
Zhongzheng Niu, Rima Habre, Tingyu Yang, Xinci Chen, Mario Vigil, Karina Barragan, Fred Lurmann, Nathan R Pavlovic, Brendan H Grubbs, Claudia M Toledo-Corral, Jill Johnston, Genevieve F Dunton, Deborah Lerner, Nathana Lurvey, Laila Al-Marayati, Sandrah P Eckel, Carrie V Breton, Theresa M Bastain, Shohreh F Farzan
BACKGROUND: Air pollution has been associated with gestational hypertension (GH) and preeclampsia, but susceptible windows of exposure and potential vulnerability by comorbidities, such as prenatal depression, remain unclear. METHODS: We ascertained GH and preeclampsia cases in a prospective pregnancy cohort in Los Angeles, CA. Daily levels of ambient particles (with a diameter of ≤10 μm [PM10 ] or ≤2.5 μm [PM2.5 ]), nitrogen dioxide, and ozone were averaged for each week from 12 weeks preconception to 20 gestational weeks...
March 27, 2024: Hypertension
Giovanni Pintus, Teresa Maria Seccia, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Jiří Widimský, Mitsuhide Naruse, Tomaz Kocjan, Aurelio Negro, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Peter J Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Chin-Chen Chang, Vin-Cent Wu, Zuzana Krátká, Michele Battistel, Domenico Bagordo, Brasilina Caroccia, Giulio Ceolotto, Giacomo Rossitto, Gian Paolo Rossi
BACKGROUND: Current guidelines and consensus documents recommend withdrawal of mineralocorticoid receptor antagonists (MRAs) before primary aldosteronism (PA) subtyping by adrenal vein sampling (AVS), but this practice can cause severe hypokalemia and uncontrolled high blood pressure. Our aim was to investigate if unilateral PA can be identified by AVS during MRA treatment. METHODS: We compared the rate of unilateral PA identification between patients with and without MRA treatment in large data sets of patients submitted to AVS while off renin-angiotensin system blockers and β-blockers...
March 25, 2024: Hypertension
Francisco J Rios, Carolina de Ciuceis, Georgios Georgiopoulos, Antonios Lazaridis, Ryszard Nosalski, George Pavlidis, Simon Tual-Chalot, Claudia Agabiti-Rosei, Livia L Camargo, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Mariarosaria Lopreiato, Georgios Mavraganis, Alessandro Mengozzi, Augusto C Montezano, Konstantinos Stavropoulos, Pawel J Winklewski, Jacek Wolf, Sarah Costantino, Michael Doumas, Eugenia Gkaliagkousi, Guido Grassi, Tomasz J Guzik, Ignatios Ikonomidis, Krzysztof Narkiewicz, Francesco Paneni, Damiano Rizzoni, Kimon Stamatelopoulos, Konstantinos Stellos, Stefano Taddei, Rhian M Touyz, Agostino Virdis
Inflammatory responses in small vessels play an important role in the development of cardiovascular diseases, including hypertension, stroke, and small vessel disease. This involves various complex molecular processes including oxidative stress, inflammasome activation, immune-mediated responses, and protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, including DNA methylation, histone modifications, and microRNAs influence vascular inflammation and injury...
March 21, 2024: Hypertension
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