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Hypertension

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https://read.qxmd.com/read/30782027/effect-of-morning-exercise-with-or-without-breaks-in-prolonged-sitting-on-blood-pressure-in-older-overweight-obese-adults
#1
Michael J Wheeler, David W Dunstan, Kathryn A Ellis, Ester Cerin, Sarah Phillips, Gavin Lambert, Louise H Naylor, Paddy C Dempsey, Bronwyn A Kingwell, Daniel J Green
Both exercise and breaks in prolonged sitting can reduce blood pressure (BP) in older overweight/obese adults. We investigated whether there is an additive hypotensive effect when exercise is combined with subsequent breaks in sitting. Sex differences and changes in plasma catecholamines as a potential candidate mechanism underlying BP responses were also examined. Sedentary older adults (n=67; 67±7 years; 31.2±4.1 kg/m2 ) completed 3 conditions in random order-sitting (SIT): uninterrupted sitting (8 hours, control); exercise+sitting (EX+SIT): sitting (1 hour), moderate-intensity walking (30 minutes), uninterrupted sitting (6...
February 20, 2019: Hypertension
https://read.qxmd.com/read/30776975/markers-or-makers
#2
EDITORIAL
Natalia R Barbaro, David G Harrison
No abstract text is available yet for this article.
February 19, 2019: Hypertension
https://read.qxmd.com/read/30776974/aging-arterial-stiffness-and-blood-pressure-association-in-chinese-adults
#3
Shouling Wu, Cheng Jin, Shanshan Li, Xiaoming Zheng, Xinyuan Zhang, Liufu Cui, Xiang Gao
Arterial stiffness and blood pressure (BP) both increase with aging synchronously. Whether elevated BP results from thickening of arterial wall or vice versa is controversial in previous studies. This study included 17 862 participants without history of myocardial infarction, stroke, atrial fibrillation or flutter, or cancer and with brachial-ankle pulse wave velocity (baPWV) and BP measurements during 2010 to 2016. Age was calculated from the self-reported birthdate to the first date of baPWV examination...
February 19, 2019: Hypertension
https://read.qxmd.com/read/30776973/hypertension-development-by-midlife-and-the-roles-of-premorbid-cognitive-function-sex-and-their-interaction
#4
Drew M Altschul, Christina Wraw, Geoff Der, Catharine R Gale, Ian J Deary
Higher early-life cognitive function is associated with better later-life health outcomes, including hypertension. Associations between higher prior cognitive function and less hypertension persist even when accounting for socioeconomic status, but socioeconomic status-hypertension gradients are more pronounced in women. We predicted that differences in hypertension development between sexes might be associated with cognitive function and its interaction with sex, such that higher early-life cognitive function would be associated with lower hypertension risk more in women than in men...
February 19, 2019: Hypertension
https://read.qxmd.com/read/30776972/apneic-sleep-insufficient-sleep-and-hypertension
#5
Meghna P Mansukhani, Naima Covassin, Virend K Somers
No abstract text is available yet for this article.
February 19, 2019: Hypertension
https://read.qxmd.com/read/30776971/inflammation-and-apparent-treatment-resistant-hypertension-in-patients-with-chronic-kidney-disease
#6
Jing Chen, Joshua D Bundy, L Lee Hamm, Chi-Yuan Hsu, James Lash, Edgar R Miller, George Thomas, Debbie L Cohen, Matthew R Weir, Dominic S Raj, Hsiang-Yu Chen, Dawei Xie, Panduranga Rao, Jackson T Wright, Mahboob Rahman, Jiang He
Apparent treatment-resistant hypertension (ATRH) is highly prevalent and associated with cardiovascular disease risk in patients with chronic kidney disease. We analyzed the association of inflammatory biomarkers with ATRH and its complications in patients with chronic kidney disease. ATRH was defined as blood pressure ≥140/90 mm Hg while taking ≥3 antihypertensive medications or blood pressure <140/90 mm Hg while taking ≥4 medications. Analyses included 1359 CRIC Study (Chronic Renal Insufficiency Cohort) participants with ATRH and 2008 hypertensive participants without...
February 19, 2019: Hypertension
https://read.qxmd.com/read/30739537/novel-role-of-t-cells-and-il-6-interleukin-6-in-angiotensin-ii-induced-microvascular-dysfunction
#7
Elena Y Senchenkova, Janice Russell, Alper Yildirim, D Neil Granger, Felicity N E Gavins
Hypertension is an established risk factor for subsequent cardiovascular diseases, with Ang II (angiotensin II) playing a major role in mediating thrombotic and inflammatory abnormalities. Although T cells and IL-6 (interleukin-6) play an important role in adaptive immune responses, little is known about their role(s) in the thromboinflammatory responses associated with Ang II. Here we show using intravital microscopy coupled with the light/dye injury model that Rag-1 deficient (Rag-1-/- ) and IL-6 deficient (IL-6-/- ) mice are afforded protection against Ang II-induced thrombosis...
February 11, 2019: Hypertension
https://read.qxmd.com/read/30739536/genetic-characteristics-of-aldosterone-producing-adenomas-in-blacks
#8
Kazutaka Nanba, Kei Omata, Celso E Gomez-Sanchez, Constantine A Stratakis, Andrew P Demidowich, Mari Suzuki, Lester D R Thompson, Debbie L Cohen, James M Luther, Lan Gellert, Anand Vaidya, Justine A Barletta, Tobias Else, Thomas J Giordano, Scott A Tomlins, William E Rainey
Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent studies, there appears to be racial differences in the prevalence of somatic KCNJ5 mutations, particularly between East Asians and Europeans. Despite the high cardiovascular disease mortality of blacks, there have been no studies focusing on somatic mutations in APAs in this population. In the present study, we investigated genetic characteristics of APAs in blacks using a CYP11B2 (aldosterone synthase) immunohistochemistry-guided next-generation sequencing approach...
February 11, 2019: Hypertension
https://read.qxmd.com/read/30739535/greater-blood-pressure-variability-is-associated-with-lower-cognitive-performance
#9
Tan Lai Zhou, Abraham A Kroon, Thomas T van Sloten, Martin P J van Boxtel, Frans R J Verhey, Miranda T Schram, Sebastian Köhler, Coen D A Stehouwer, Ronald M A Henry
An increasing number of individuals will face age-related cognitive difficulties because life expectancy has increased. It is, therefore, important to identify modifiable risk factors for cognitive impairment. Very short-term to mid-term blood pressure variability (BPV) may be such a factor because it may cause cerebral ischemia. To this end, we investigated whether greater systolic and diastolic BPV are cross-sectionally associated with memory function (n=1804), information processing speed (n=1793), and executive function (n=1780) in 40- to 75-year-old individuals from The Maastricht Study...
February 11, 2019: Hypertension
https://read.qxmd.com/read/30739534/impact-of-coming-demographic-changes-on-the-number-of-adults-in-need-of-care-for-hypertension-in-brazil-china-india-indonesia-mexico-and-south-africa
#10
Nikkil Sudharsanan, Pascal Geldsetzer
Over the coming decades, middle-income countries are expected to undergo substantial demographic changes. We estimated the consequences of these changes on the number of adults in need of hypertension care between 2015 and 2050 using nationally representative household-survey data collected in Brazil, China, India, Indonesia, Mexico, and South Africa (N=770 121). To reflect unmet need for healthcare, we defined hypertension as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg regardless of treatment status...
February 11, 2019: Hypertension
https://read.qxmd.com/read/30712426/urine-haptoglobin-and-haptoglobin-related-protein-predict-response-to-spironolactone-in-patients-with-resistant-hypertension
#11
Marta Martin-Lorenzo, Paula J Martinez, Montserrat Baldan-Martin, Juan A Lopez, Pablo Minguez, Aranzazu Santiago-Hernandez, Jesus Vazquez, Julian Segura, Gema Ruiz-Hurtado, Fernando Vivanco, Maria G Barderas, Luis M Ruilope, Gloria Alvarez-Llamas
Resistant hypertension prevalence is progressively increasing, and prolonged exposure to suboptimal blood pressure control results in higher cardiovascular risk and end-organ damage. Among various antihypertensive agents, spironolactone seems the most effective choice to treat resistant hypertension once triple therapy including a diuretic fails. However success in blood pressure control is not guaranteed, adverse effects are not negligible, and no clinical tools are available to predict patient's response...
February 4, 2019: Hypertension
https://read.qxmd.com/read/30712425/cardiovascular-system-in-preeclampsia-and-beyond
#12
Basky Thilaganathan, Erkan Kalafat
No abstract text is available yet for this article.
February 4, 2019: Hypertension
https://read.qxmd.com/read/30712424/dietary-nitrate-reduces-blood-pressure-in-rats-with-angiotensin-ii-induced-hypertension-via-mechanisms-that-involve-reduction-of-sympathetic-hyperactivity
#13
Drielle D Guimarães, Josiane C Cruz, Alynne Carvalho-Galvão, Zhengbing Zhuge, Stefanne M Marques, Lara M Naves, A Erik G Persson, Eddie Weitzberg, Jon O Lundberg, Camille M Balarini, Gustavo R Pedrino, Valdir A Braga, Mattias Carlström
Several experimental and clinical studies have shown that dietary nitrate supplementation can increase nitric oxide bioavailability. In the oral cavity, commensal bacteria reduce nitrate to nitrite, which is subsequently absorbed into the circulation where reduction to nitric oxide by enzymatic systems occur. Although it is well-known that boosting the nitrate-nitrite-nitric oxide pathway can improve cardiovascular, renal, and metabolic functions and that sympathoexcitation contributes to the development of the same disorders, the potential effects of dietary nitrate on sympathetic activity remain to be elucidated...
February 4, 2019: Hypertension
https://read.qxmd.com/read/30686087/caloric-restriction-exacerbates-angiotensin-ii-induced-abdominal-aortic-aneurysm-in-the-absence-of-p53
#14
Peng Gao, Hexuan Zhang, Qin Zhang, Xia Fang, Hao Wu, Miao Wang, Zongshi Lu, Xiao Wei, Gangyi Yang, Zhencheng Yan, Daoyan Liu, Zhiming Zhu
p53-dependent vascular smooth muscle cell senescence is a key pathological process of abdominal aortic aneurysm (AAA). Caloric restriction (CR) is a nonpharmacological intervention that prevents AAA formation. However, whether p53 is indispensable to the protective role of CR remains unknown. In this study, we investigated the necessity of p53 in the beneficial role of CR in AAA formation and the underlying mechanisms. We subjected p53+/+ and p53-/ - mice to 12 weeks of CR and then examined the incidence of Ang II (angiotensin II)-induced AAA formation...
January 28, 2019: Hypertension
https://read.qxmd.com/read/30686086/blood-pressure-and-cognitive-function-in-children-and-adolescents
#15
Marc B Lande, Juan C Kupferman
No abstract text is available yet for this article.
January 28, 2019: Hypertension
https://read.qxmd.com/read/30686085/circulating-long-noncoding-rna-lipcar-predicts-heart-failure-outcomes-in-patients-without-chronic-kidney-disease
#16
Laura Santer, Begoña López, Susana Ravassa, Christian Baer, Isabelle Riedel, Shambhabi Chatterjee, María U Moreno, Arantxa González, Ramón Querejeta, Florence Pinet, Thomas Thum, Javier Díez
The plasma levels of long noncoding RNA LIPCAR are elevated in heart failure (HF) patients with reduced ejection fraction and associated with left ventricular remodeling and poor outcomes. We studied whether the presence of chronic kidney disease (CKD), as defined by an estimated glomerular filtration rate value <60mL/(min·1.73m2) modified the associations of plasma LIPCAR with left ventricular remodeling and outcomes in HF patients. Two hundred and thirty-four patients (mean age 74 [9.14] years, 50% male) were enrolled and followed for 4...
January 28, 2019: Hypertension
https://read.qxmd.com/read/30686084/research-recommendations-from-the-national-institutes-of-health-workshop-on-predicting-preventing-and-treating-preeclampsia
#17
Christine Maric-Bilkan, Vikki M Abrahams, S Sonia Arteaga, Ghada Bourjeily, Kirk P Conrad, Janet M Catov, Maged M Costantine, Brian Cox, Vesna Garovic, Eric M George, Alison D Gernand, Arun Jeyabalan, S Ananth Karumanchi, Aaron D Laposky, Menachem Miodovnik, Megan Mitchell, Victoria L Pemberton, Uma M Reddy, Mark K Santillan, Eleni Tsigas, Kent L R Thornburg, Kenneth Ward, Leslie Myatt, James M Roberts
No abstract text is available yet for this article.
January 28, 2019: Hypertension
https://read.qxmd.com/read/30686083/medical-misinformation
#18
EDITORIAL
Joseph A Hill, Stefan Agewall, Adrian Baranchuk, George W Booz, Jeffrey S Borer, Paolo G Camici, Peng-Sheng Chen, Anna F Dominiczak, Çetin Erol, Cindy L Grines, Robert Gropler, Tomasz J Guzik, Markus K Heinemann, Ami E Iskandrian, Bradley P Knight, Barry London, Thomas F Lüscher, Marco Metra, Kiran Musunuru, Brahmajee K Nallamothu, Andrea Natale, Sanjeev Saksena, Michael H Picard, Sunil V Rao, Willem J Remme, Robert S Rosenson, Nancy K Sweitzer, Adam Timmis, Christiaan Vrints
No abstract text is available yet for this article.
January 28, 2019: Hypertension
https://read.qxmd.com/read/30661480/paying-the-toll-for-inflammation
#19
Cameron G McCarthy, Styliani Goulopoulou, R Clinton Webb
No abstract text is available yet for this article.
January 21, 2019: Hypertension
https://read.qxmd.com/read/30661479/pregnancy-increases-ca-2-sparks-spontaneous-transient-outward-currents-and-reduces-uterine-arterial-myogenic-tone
#20
Xiang-Qun Hu, Rui Song, Monica Romero, Chiranjib Dasgupta, Xiaohui Huang, Mark A Holguin, VaShon Williams, Daliao Xiao, Sean M Wilson, Lubo Zhang
Spontaneous transient outward currents (STOCs) at physiological membrane potentials of vascular smooth muscle cells fundamentally regulate vascular myogenic tone and blood flow in an organ. We hypothesize that heightened STOCs play a key role in uterine vascular adaptation to pregnancy. Uterine arteries were isolated from nonpregnant and near-term pregnant sheep. Ca2+ sparks were measured by confocal microscopy, and STOCs were determined by electrophysiological recording in smooth muscle cells. Percentage of Ca2+ spark firing myocytes increased dramatically at the resting condition in uterine arterial smooth muscle of pregnant animals, as compared with nonpregnant animals...
January 21, 2019: Hypertension
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