journal
https://read.qxmd.com/read/38772508/mental-health-trajectories-among-the-general-population-and-higher-risk-groups-following-the-covid-19-pandemic-in-switzerland-2021-2023
#1
JOURNAL ARTICLE
Stephanie Schrempft, Nick Pullen, Hélène Baysson, María-Eugenia Zaballa, Julien Lamour, Elsa Lorthe, Mayssam Nehme, Idris Guessous, Silvia Stringhini
BACKGROUND: Mental health deteriorated in the early stages of the COVID-19 pandemic, but improved relatively quickly as restrictions were eased, suggesting overall resilience. However, longer-term follow-up of mental health in the general population is scarce. METHODS: We examined mental health trajectories in 5624 adults (58 % women; aged 18-97 years) from the Specchio-COVID19 cohort, using the Generalised Anxiety Disorder scale-2 and the Patient Health Questionnaire-2, administered each month from February to June 2021, and in Spring 2022 and 2023...
May 19, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38772507/the-role-of-kcnq-channel-activators-in-management-of-major-depressive-disorder
#2
REVIEW
Shakila Meshkat, Angela T H Kwan, Gia Han Le, Sabrina Wong, Taeho Greg Rhee, Roger Ho, Kayla M Teopiz, Bing Cao, Roger S McIntyre
Depression, a complex disorder with significant treatment challenges, necessitates innovative therapeutic approaches to address its multifaceted nature and enhance treatment outcomes. The modulation of KCNQ potassium (K+) channels, pivotal regulators of neuronal excitability and neurotransmitter release, is a promising innovative therapeutic target in psychiatry. Widely expressed across various tissues, including the nervous and cardiovascular systems, KCNQ channels play a crucial role in modulating membrane potential and regulating neuronal activity...
May 19, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38772506/identifying-internet-addiction-profiles-among-adolescents-using-latent-profile-analysis-relations-to-aggression-depression-and-anxiety
#3
JOURNAL ARTICLE
Jinpeng Wang, Jingyan Chen, Peige Wang, Shenghao Zhang, Qi Li, Shan Lu, Jing Xiao
BACKGROUND: While many studies have established a positive correlation between adolescents' internet addiction and mental health problems, most of these studies have overlooked the internal heterogeneity of Internet addiction. This study aims to identify latent profiles among adolescents based on their Internet addiction and to examine the differences in aggression, depression, and anxiety across these profiles. METHODS: We conducted a survey involving 7422 adolescents and administered the Young's Internet Addiction Test, Aggression Behavior Questionnaire, Patient Health Questionnaire-9, and Generalized Anxiety Disorder Scale...
May 19, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38772505/the-associations-of-social-health-self-injurious-thoughts-and-behaviors-with-or-without-childhood-trauma-a-uk-biobank-study
#4
JOURNAL ARTICLE
Xuting Li, Yusheng Tian, Hui Chen, Xiaoping Wang, Yamin Li, Jiansong Zhou
BACKGROUND: Childhood trauma was known to increase risks of social isolation, loneliness and self-injurious thoughts and behaviors in adulthood. The aim of this study was to examine the protect and risk factors of social health, self-injurious thoughts and behaviors between adults with or without childhood trauma. METHOD: This was a cross-sectional study comprising of 145,043 participants enrolled in the UK Biobank. Childhood trauma was determined by the Childhood Trauma Screener...
May 19, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38772504/the-association-of-impulsivity-with-depression-and-anxiety-symptoms-a-transdiagnostic-network-analysis-and-replication
#5
JOURNAL ARTICLE
Zhihua Guo, Yi Cui, Rui Qiu, Lingbo Bu, Tianqi Yang, Yijun Li, Xia Zhu
BACKGROUND: Impulsivity increases the risk for depression and anxiety. However, the granular pathways among them remain unknown. A network approach that moves from disorder-level analysis to symptom-level analysis can provide further understanding of psychopathological mechanisms. In this study, we examined the network structure of impulsivity and separate and comorbid symptoms of depression and anxiety. METHODS: Regularized partial-correlation networks were estimated using cross-sectional data from 1047 Chinese participants aged 18-26 years (main dataset, mean age = 21...
May 19, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768827/total-testosterone-plays-a-crucial-role-in-the-pathway-from-hypothyroidism-to-broad-depression-in-women
#6
JOURNAL ARTICLE
Le Niu, Zhiwei Du, Zhihong Xie, Xuxu Liu, Qiang Wang, Yong Zhao, Hao Wang, Chenjun Hao, Dongbo Xue, Liyi Wang
BACKGROUND: Depression tends to develop in correlation with hypothyroidism, however it's unclear how testosterone traits contribute to this association. We examined the causal association between depression, testosterone traits, and hypothyroidism using Mendelian randomization (MR). METHOD: We conducted univariable and multivariable MR studies using summary-level statistics from genome-wide association studies (GWAS) of Hypothyroidism (n = 213,990), broad depression (n = 322,580), probable major depressive disorder (probable MDD) (n = 174,519), and International Classification of Diseases (ICD)-9 or ICD-10-coded MDD (n = 217,584) from European ancestry...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768826/associations-of-meeting-24-hour-movement-behavior-guidelines-with-social-and-emotional-function-in-youth-with-asd-adhd
#7
JOURNAL ARTICLE
Mengxian Zhao, Meijun Hou, Fabian Herold, Yanxia Chen, André O Werneck, Martin E Block, Arthur F Kramer, Alyx Taylor, Paolo M Cunha, Jean-Philippe Chaput, Ryan S Falck, Neville Owen, Liye Zou
BACKGROUND: The 24-hour movement behavior (24-HMB) guidelines recommend that children and adolescents should limit screen time (ST), get an adequate amount of sleep (SL), and engage in sufficient physical activity (PA) to ensure health and healthy development. Meeting 24-HMB guidelines is associated with positive mental health outcomes (e.g., social and emotional function) in the general population. However, it is unclear whether such findings extend to children and adolescents with comorbid Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD)...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768825/risk-prediction-models-of-depression-in-older-adults-with-chronic-diseases
#8
JOURNAL ARTICLE
Ying Zheng, Chu Zhang, Yuwen Liu
BACKGROUND: Detecting potential depression and identifying the critical predictors of depression among older adults with chronic diseases are essential for timely intervention and management of depression. Therefore, risk predictive models of depression in elderly people should to be further explored. METHODS: A total of 3959 respondents aged 60 years or older from the wave four survey of the China Health and Retired Longitudinal Study (CHARLS) were included in this study...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768824/exploring-the-l-shaped-relationship-between-atherogenic-index-of-plasma-and-depression-results-from-nhanes-2005-2018
#9
JOURNAL ARTICLE
Haokun Zhang, Genshan Zhang, Jie Fu
BACKGROUND: The Atherogenic Index of Plasma (AIP) is a novel metric linked to several diseases. However, there is inadequate evidence to investigate the relationship between AIP and depression. Therefore, we aim to elucidate the non-linear association between AIP and depression. METHODS: 12,453 participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2018 were included. The AIP was calculated as log10 (triglycerides/high-density lipoprotein cholesterol)...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768823/decreased-inter-hemispheric-cooperation-in-major-depressive-disorder-and-its-association-with-neurotransmitter-profiles
#10
JOURNAL ARTICLE
Hai Cao, Jinmei Sun, Qiang Hua, Tongqing Huang, Yuqing Wei, Yuqian Zhan, Xiaoqing Yao, Ting Zhang, Yinian Yang, Wenqiang Xu, Tongjian Bai, Yanghua Tian, Lei Zhang, Kai Wang, Gong-Jun Ji
BACKGROUND: Inter-hemispheric cooperation is a prominent feature of the human brain, and previous neuroimaging studies have revealed aberrant inter-hemispheric cooperation patterns in patients with major depressive disorder (MDD). Typically, inter-hemispheric cooperation is examined by calculating the functional connectivity (FC) between each voxel in one hemisphere and its anatomical (structurally homotopic) counterpart in the opposite hemisphere. However, bilateral hemispheres are actually asymmetric in anatomy...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768822/the-associations-between-dietary-flavonoids-intake-and-risk-of-depressive-symptom-in-diabetic-patients-data-from-nhanes-2007-2008-2009-2010-and-2017-2018
#11
JOURNAL ARTICLE
Qianqian Feng, Fang Liu, Jiaqi Nie, Yichi Yang, Xiaosong Li, Suqing Wang
BACKGROUND: The increasing incidence of depressive symptoms in diabetic patients contributes to the global burden of disease, but few epidemiological studies have evaluated the relationship between dietary flavonoids intake and depressive symptoms in diabetic patients in American adults. OBJECTIVE: This study intended to evaluate the associations of dietary flavonoids intake and depressive symptoms in diabetic patients in American adults. METHODS: We conducted a cross-sectional analysis of 1993 adults aged ≥20 years old who participated in the 2007-2008, 2009-2010, and 2017-2018 National Health and Nutrition Examination Surveys (NHANES)...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768821/crisis-response-in-texas-youth-impacted-by-hurricane-harvey-a-difference-in-differences-analysis
#12
JOURNAL ARTICLE
Trey Williamson, Margaret Sugg, Devyani Singh, Shannon Green, J D Runkle
BACKGROUND: Hurricane Harvey was the second costliest storm to impact the U.S. More research is needed to understand the mental health consequences of these extreme events in children and adolescents extending beyond the acute recovery period. METHODS: Daily anonymized Crisis Text Line (CTL) conversations were used to understand patterns in crisis responses for youth one year before and after Harvey's landfall. A quasi-experimental difference-in-differences analysis compared changes in texts for stress/anxiety, depression, thoughts of suicide, and self-harm following Harvey between exposed and unexposed youth in Texas...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768820/astrocyte-atrophy-induced-by-l-pgds-pgd2-src-signaling-dysfunction-in-the-central-amygdala-mediates-postpartum-depression
#13
JOURNAL ARTICLE
Zhihao Sheng, Qidong Liu, Yujie Song, Binglu Ye, Yujie Li, Yingcai Song, Jinqi Liu, Bing Zhang, Fei Guo, Zhendong Xu, Weijia Du, Siguang Li, Zhiqiang Liu
BACKGROUND: Postpartum depression (PPD) is a serious psychiatric disorder that has significantly adverse impacts on maternal health. Metabolic abnormalities in the brain are associated with numerous neurological disorders, yet the specific metabolic signaling pathways and brain regions involved in PPD remain unelucidated. METHODS: We performed behavioral test in the virgin and postpartum mice. We used mass spectrometry imaging (MSI) and targeted metabolomics analyses to investigate the metabolic alternation in the brain of GABAA R Delta-subunit-deficient (Gabrd-/- ) postpartum mice, a specific preclinical animal model of PPD...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768819/the-association-of-depressive-symptoms-with-adverse-clinical-outcomes-in-hypertension-data-from-sprint-randomized-trail
#14
JOURNAL ARTICLE
Junfeng Zhou, Zhao Zeng, Liudang He, Cuirong Guo, Ning Ding, Yingjie Su, Jiao Qin
OBJECTIVE: This study intends to explore the effect of depressive symptoms on adverse clinical outcomes in middle-aged and elderly hypertensive patients. METHODS: This post hoc analysis was conducted using data from the Systolic Blood Pressure Intervention Trial (SPRINT), and we used cox proportional risk regression to examine the relationship between depressive symptoms and adverse clinical outcomes (primary outcome, all-cause mortality, cardiovascular disease(CVD) mortality, heart failure(HF), myocardial infarction(MI), non-myocardial infarction acute coronary syndrome(non-MI ACS))...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38768818/association-of-social-health-with-all-cause-mortality-and-cause-specific-mortality-a-population-based-cohort-study
#15
JOURNAL ARTICLE
Tingshan Duan, Zhi Cao, Xianhong Huang, Xiaohe Wang, Tao Sun, Chenjie Xu
BACKGROUND: Previous studies only focused on the individual social factors, without considering the overall social health patterns. The present study was aimed to develop an integrated social health score (SHS) and investigate its associations with all-cause, cardiovascular disease (CVD), cancer mortality. METHODS: A total of 330,716 participants (mean age 56.3 years; 52.4 % female) from UK Biobank was included between 2006 and 2010, and thereafter followed up to 2021...
May 18, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38762035/effect-of-pharmacogenomic-testing-on-the-clinical-treatment-of-patients-with-depressive-disorder-a-randomized-clinical-trial
#16
JOURNAL ARTICLE
Lei Xu, Liyin Li, Qiutang Wang, Bing Pan, Leilei Zheng, Zheng Lin
BACKGROUND: Pharmacotherapy is one of the primary treatment modalities for depression. However, there is considerable variability in the individual response to antidepressant medications. Personalized medicine guided by pharmacogenomic testing may hold promise in addressing this issue. METHODS: In this study, 665 depressive patients were randomly enrolled into two groups: the pharmacogenomic testing group (n = 333) and the control group (n = 332)...
May 16, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38759504/the-role-of-temperament-and-character-in-the-anxiety-depression-spectrum-among-korean-adults
#17
REVIEW
Hyun Sook Oh, C Robert Cloninger
BACKGROUND: Temperament and character are useful in risk assessment and therapy of individuals in the anxiety-depression spectrum but understudied in South Korea. OBJECTIVE: The study aimed to identify the temperament and character features associated with anxiety and/or depression in individuals with clinical disorders and in the general population. METHODS: A representative sample of 1384 Korean adults over 18 years old (58 % female) were assessed with the Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Temperament and Character Inventory (TCI)...
May 16, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38754598/efficacy-of-life-goals-collaborative-care-for-bipolar-disorder-a-systematic-review
#18
REVIEW
Christopher J Miller, Hannah M Bailey, Erica A Abel, Claire M Burgess, Samantha L Connolly, Aleda Franz, Eric Smith, Mark S Bauer
BACKGROUND: Bipolar disorder remains a disabling mental health condition despite the availability of effective treatments. Collaborative chronic care models (CCMs) represent an evidence-based way to structure care for conditions like bipolar disorder. Life Goals Collaborative Care (LGCC) was designed specifically for bipolar disorder, featuring psychoeducation alongside collaborative components (e.g. nurse care management or expert psychiatric consultation). Despite the use of Life Goals across health systems, a systematic review summarizing its effectiveness has never been conducted...
May 14, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38754597/an-integrated-machine-learning-framework-for-developing-and-validating-a-diagnostic-model-of-major-depressive-disorder-based-on-interstitial-cystitis-related-genes
#19
JOURNAL ARTICLE
Bohong Chen, Xinyue Sun, Haoxiang Huang, Cong Feng, Dapeng Wu, Wei Chen
BACKGROUND: Major depressive disorder (MDD) and interstitial cystitis (IC) are two highly debilitating conditions that often coexist with reciprocal effect, significantly exacerbating patients' suffering. However, the molecular underpinnings linking these disorders remain poorly understood. METHODS: Transcriptomic data from GEO datasets including those of MDD and IC patients was systematically analyzed to develop and validate our model. Following removal of batch effect, differentially expressed genes (DEGs) between respective disease and control groups were identified...
May 14, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38754596/unravelling-robust-brain-behavior-links-of-depressive-complaints-through-granular-network-models-for-understanding-heterogeneity
#20
JOURNAL ARTICLE
René Freichel, Agatha Lenartowicz, Linda Douw, Johann D Kruschwitz, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Nathalie Holz, Christian Baeuchl, Michael N Smolka, Nilakshi Vaidya, Robert Whelan, Vincent Frouin, Gunter Schumann, Henrik Walter, Tessa F Blanken
BACKGROUND: Depressive symptoms are highly prevalent, present in heterogeneous symptom patterns, and share diverse neurobiological underpinnings. Understanding the links between psychopathological symptoms and biological factors is critical in elucidating its etiology and persistence. We aimed to evaluate the utility of using symptom-brain networks to parse the heterogeneity of depressive complaints in a large adolescent sample. METHODS: We used data from the third wave of the IMAGEN study, a multi-center panel cohort study involving 1317 adolescents (52...
May 14, 2024: Journal of Affective Disorders
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