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Journal of Inorganic Biochemistry

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https://read.qxmd.com/read/31075719/effect-of-the-point-mutation-h54n-on-the-ferroxidase-process-of-rana-catesbeiana-h-ferritin
#1
Cecilia Pozzi, Flavio Di Pisa, Daniela Lalli, Camilla Rosa, Paola Turano, Stefano Mangani
Human H and Rana catesbeiana H' subunits in vertebrate ferritin protein cages catalyze the Fe(II) oxidation by molecular oxygen and promote the ferric oxide biomineral synthesis. By depositing iron biomineral, ferritins also prevent potentially toxic reactions products from Fe(II)-based Fenton chemistry. Recent work from our laboratory was aimed to describe the iron pathways within ferritin, from entrance into the cage to the ferroxidase site, and to understand the role played by amino-acid residues in iron trafficking and catalysis...
May 7, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31077890/design-synthesis-and-evaluation-of-phosphorescent-ir-iii-complexes-with-anticancer-activity
#2
Zhe Liu, JuanJuan Li, XingXing Ge, Shumiao Zhang, Zhishan Xu, Wenyuan Gao
A range of phosphorescent Ir(III) complexes containing four diverse P^P-chelating ligands of the type [Ir(ppy)2 (L)][PF6 ], (ppy = 2‑phenylpyridine) where L is 1,2‑bis(diphenylphosphino)benzene (L1), 1,2‑bis(diphenylphosphino)ethane (L2), 1,2‑bis(diphenylphosphino)propane(L3) and 1,8‑bis(diphenylphosphino)naphthalene (L4) were synthesized respectively. The iridium complexes possessed excellent antiproliferative properties, which was a substantial improvement over cisplatin, especially complex Ir1...
May 4, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31078872/antibacterial-activity-of-naphthyl-derived-bis-3-hydroxy-4-pyridinonate-copper-ii-complexes-against-multidrug-resistant-bacteria
#3
Andreia Leite, Lucinda J Bessa, Ana M G Silva, Paula Gameiro, Baltazar de Castro, Maria Rangel
In this work, we report the synthesis and characterization of three novel copper(II) complexes of naphthyl derived 3-hydroxy-4-pyridinone chelators. Their antibacterial activity against several Gram-positive and Gram-negative reference strains and multidrug-resistant clinical isolates was assessed through determination of the minimum inhibitory concentration (MIC). The complex Cu(naph1pp)2 shows the highest antibacterial activity, including against multidrug-resistant isolates, nonetheless, being more active against Gram-positive than Gram-negative bacteria...
May 2, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31071642/binding-propterties-of-two-ru-ii-polypyridyl-complexes-containing-dppz-units-and-fluorine-groups-with-poly-u-%C3%A2-poly-a-%C3%A2-poly-u-triplex
#4
Fangfang Wang, Shuai Ma, Yongdeng Feng, Xiaohua Liu, Lifeng Tan
In this work, two Ru(II)-dppz (dppz = dipyrido[3,2-a:2',3'-c]phenazine) complexes containing fluorine substituents, [Ru(bpy)2 (7-F-dppz)]2+ (Ru1, bpy = 2,2'-bipyridine, 7-F-dppz = 7-fluorodipyrido[3,2-a:2',3'-c]phenazine) and [Ru(phen)2 (7-F-dppz)]2+ (Ru2, phen = 1,10-phenanthroline), have been synthesized and characterized. Binding properties of Ru1 and Ru2 with the RNA poly(U)·poly(A) ∗ poly(U) triplex have been studied by spectroscopic methods and viscosity measurements. The obtained results indicate that the binding differences of the two complexes with the triplex may be attributed to the ancillary ligand effects, implying that the better planarity and greater hydrophobicity of ancillary ligands are advantageous to the π-π stacking interaction between Ru2 and the triplex, thus Ru2 stabilizes the triplex strongly than Ru1...
May 2, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31075720/inhibition-of-na-k-and-ca-2-atpase-activities-by-phosphotetradecavanadate
#5
Gil Fraqueza, Juan Fuentes, Lukáš Krivosudský, Saikat Dutta, Sib Sankar Mal, Alexander Roller, Gerald Giester, Annette Rompel, Manuel Aureliano
Polyoxometalates (POMs) are promising inorganic inhibitors for P-type ATPases. The experimental models used to study the effects of POMs on these ATPases are usually in vitro models using vesicles from several membrane sources. Very recently, some polyoxotungstates, such as the Dawson anion [P2 W18 O62 ]6- , were shown to be potent P-type ATPase inhibitors; being active in vitro as well as in ex-vivo. In the present study we broaden the spectrum of highly active inhibitors of Na+ /K+ -ATPase from basal membrane of epithelial skin to the bi-capped Keggin-type anion phosphotetradecavanadate Cs5...
April 29, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31055215/synthesis-of-a-novel-platinum-ii-complex-with-6-7-dichloro-5-8-quinolinedione-and-the-study-of-its-antitumor-mechanism-in-testicular-seminoma
#6
Zitaiyu Li, Jun Zhou, Yu Gan, Yinghao Yin, Wuchao Zhang, Jianfu Yang, Yuxin Tang, Yingbo Dai
A new platinum(II) complex, [Pt(ClClQ)(DMSO)Cl] (1), utilizing 6,7-dichloro-5,8-quinolinedione (ClClQ) as a ligand, has been synthesized and fully characterized. Single-crystal X-ray diffraction and other spectroscopic and analytical methods revealed that the coordination geometry of Pt(II) in complex 1 can also be described as a four-coordinated square planar geometry. The aim of the study was to explore the in vitro anticancer properties of complex 1. Our studies showed that complex 1 can regulate the viability of testicular seminoma cells in vitro, including cell proliferation and apoptosis...
April 27, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31055214/the-role-of-catalases-in-the-prevention-promotion-of-oxidative-stress
#7
Lidia Gebicka, Justyna Krych-Madej
Catalases, heme enzymes which catalyze decomposition of hydrogen peroxide to water and molecular oxygen, are important members of the antioxidant defense system of cells of almost all aerobic organisms. However, recent studies suggest that catalase may be involved in various other processes in the cell. The paper provides a review of reactions of catalases with their main substrate, hydrogen peroxide, and with oxidizing species such as hydroxyl radical, superoxide, nitric oxide, peroxynitrite, hypochlorous acid, and singlet oxygen...
April 26, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31054488/melatonin-protects-against-chromium-vi-induced-cardiac-injury-via-activating-the-ampk-nrf2-pathway
#8
Jiayi Li, Xiaoyan Zheng, Xiangyu Ma, Xinyue Xu, Yu Du, Qingjie Lv, Xuerui Li, Yuan Wu, Hongxing Sun, Lanjie Yu, Zhigang Zhang
Chromium (Cr) threatens health by causing oxidative stress. However, effective therapy for cardiac damage mediated by potassium dichromate (K2 Cr2 O7 ) still has not been defined. Melatonin (MT) possesses a number of biological activities. Our study was performed to explore the effect and mechanism of MT on Cr(VI)-induced cardiac damage by conducting both in vitro and in vivo studies. Twenty eight male Wistar rats were randomly assigned to four groups: control, MT (20 mg/kg subcutaneously), K2 Cr2 O7 (4 mg/kg intraperitoneally), and K2 Cr2 O7  + MT...
April 25, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31100543/bis-cations-with-two-2-3-diferrocenylcyclopropenium-fragments-stabilized-with-diamino-alkanes-synthesis-and-cytotoxic-activity
#9
Jesús García-Valdés, Jessica J Sánchez García, Alberto Sánchez-Castell, Ana G Alpizar-Mora, Marcos Flores-Álamo, Elena Martínez-Klimova, Teresa Ramírez Apan, Elena I Klimova
Bis-cations with two 2,3-diferrocenylcyclopropenium fragments 3a-d, and the cis-2-(1,2-diferrocenylvinyl)-2-imidazolinium tetrafluoroborates 4a, d or the cis-2-(1,2-diferrocenylvinyl)-3,4,5,6-tetrahydropyrimidin-2-ium tetrafluoroborates 4b, c were obtained by interactions of 2,3-diferrocenyl-1-ethoxycyclopropenium tetrafluoroborate 1 with bis-1,4-N,N-(2a, d) or bis-1,5-N,N-(2b, c) nucleophiles. The reactions of 3a-d with sodium azide proceed with high regioselectivity, forming tetraferrocenyl-substituted compounds: N,N'-bis-(4',6'-diferrocenyl-1',2',3'-triazin-5'-yl)-piperazine 5a, N,N'-bis-(4',6'-diferrocenyl-1',2',3'-triazin-5'-yl)-N,N'-dialkyl-1,3- or 1,2-alkanediamines 5b-d...
April 24, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31054487/azaindoles-suitable-ligands-of-cytotoxic-transition-metal-complexes
#10
Pavel Štarha, Zdeněk Trávníček
This minireview is devoted to the complexes of various transition metals, which contain azaindole ring coordinated to the metal centre, and whose cytotoxicity was studied. We decided to overview this interesting group of coordination compounds with the aim to highlight various structural types of complexes depending on the metal centre (i.e., Pt, Pd, Ru, Ir or Au) and type of the used co-ligand(s). The presented complexes are also reviewed in context of their toxicity, selectivity and processes connected with their mechanism of action...
April 24, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31075721/rapid-sequential-detection-of-hg-2-and-biothiols-by-a-probe-dna-mof-hybrid-sensory-system
#11
Nai-Han Huang, Rong-Tian Li, Cheng Fan, Ke-Yang Wu, Zhe Zhang, Jin-Xiang Chen
A one-dimensional (1D) metal-organic framework (MOF) of [Cu(Cdcbp)(H2 O)2 ·2H2 O]n (1, H3 CdcbpBr = 3-carboxyl-(3,5-dicarboxybenzyl)-pyridinium bromide) has been synthesized and characterized. MOF 1 features a cationic Cu2+ center, conjugated tricarboxylate ligand bearing positively charged pyridinium and uncoordinated carboxylate groups within its skeleton. These features enable MOF 1 to tightly adsorb thymine rich (T-rich) single-stranded DNA (ss-DNA) probe labeled with carboxyfluorescein (FAM) (denote as P-DNA) through π-stacking, electrostatic interactions and/or hydrogen bonding to give a hybrid complex (denote as P-DNA@1), and quenches its fluorescence via a photo-induced electron transfer (PET) process...
April 16, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31063931/the-pmob-subunit-of-particulate-methane-monooxygenase-pmmo-in-methylococcus-capsulatus-bath-the-cu-i-sponge-and-its-function
#12
Yu-Jhang Lu, Mu-Cheng Hung, Brian T-A Chang, Tsu-Lin Lee, Zhi-Han Lin, I-Kuen Tsai, Yao-Sheng Chen, Chin-Shuo Chang, Yi-Fang Tsai, Kelvin H-C Chen, Sunney I Chan, Steve S-F Yu
In this study, we describe efforts to clarify the role of the copper cofactors associated with subunit B (PmoB) of the particulate methane monooxygenase (pMMO) from Methylococcus capsulatus (Bath) (M. capsulatus). This subunit exhibits strong affinity toward CuI ions. To elucidate the high copper affinity of the subunit, the full-length PmoB, and the N-terminal truncated mutants PmoB33-414 and PmoB55-414 , each fused to the maltose-binding protein (MBP), are cloned and over-expressed into Escherichia coli (E...
April 15, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31005822/metal-dependent-interactions-of-metallothionein-3-%C3%AE-domain-with-amyloid-%C3%AE-peptide-and-related-physiological-implications
#13
Zhongxiu Jiang, Baochai Shen, Juan Xiang
Aberrant interactions of metal ions with amyloid-β peptide (Aβ) can potentiate Alzheimer's disease (AD) by participating in the aggregation process of Aβ and in the generation of reactive oxygen species (ROS). Metallothionein-3 (MT3), which is aberrantly expressed in AD brains, is believed to play an important role in the AD progression due to its ability of maintaining metal homeostasis and scavenging ROS. However, the related molecular mechanism is not clear. In this work, the metal-dependent interactions of MT3 β-domain (βMT3) with amyloid-β peptide (Aβ) were systematically studied...
April 13, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31005821/direct-electrochemical-reduction-of-carbon-dioxide-by-a-molybdenum-containing-formate-dehydrogenase
#14
Cristina M Cordas, Mariana Campaniço, Rita Baptista, Luísa B Maia, Isabel Moura, José J G Moura
Formate dehydrogenase enzymes catalyse the reversible two-electron oxidation of formate to carbon dioxide. The class of metal-dependent formate dehydrogenases comprises prokaryotic enzymes holding redox-active centres and a catalytic site, containing either molybdenum or tungsten ion, that mediates the formate/carbon dioxide interconversion. The carbon dioxide reduction is of a particular interest, since it may be a route for its atmospheric mitigation with the simultaneous production of added-value products, as formate-derived compounds...
April 13, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/30992146/corrigendum-to-nuclear-targeting-terpyridine-iron-ii-complexes-for-cellular-imaging-and-remarkable-photocytotoxicity-j-inorg-biochem-116-2012-77-87
#15
Uttara Basu, Imran Khan, Debasis Koley, Sounik Saha, Paturu Kondaiah, Akhil R Chakravarty
No abstract text is available yet for this article.
April 13, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31004991/synergistic-antibacterial-mechanism-of-bi-2-te-3-nanoparticles-combined-with-the-ineffective-%C3%AE-lactam-antibiotic-cefotaxime-against-methicillin-resistant-staphylococcus-aureus
#16
Xiangyu Liu, Lulu Ma, Fan Chen, Junzi Liu, Hao Yang, Zhong Lu
Methicillin-resistant Staphylococcus aureus (MRSA) infections have become a serious threat to public health because traditional antibiotics are less efficient. Here, we developed a simple and efficient combination of Bi2 Te3 nanoparticles (NPs) with β-lactam antibiotics cefotaxime (CTX), which presented significant synergistic antibacterial activity against MRSA. The minimal inhibitory concentration of CTX decreased from 256 to 32 μg/mL in the presence of 8 μg/mL Bi2 Te3 NPs. The results of cell membrane potential and cellular K+ content measurements demonstrated that the destruction of membrane functions is a factor in the synergistic mechanism...
April 12, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/30999221/inactivation-of-nikr-from-helicobacter-pylori-by-a-bismuth-drug
#17
Yu Guo, Chujun Guan, Heiyu Wan, Zhengrui Zhang, Hongyan Li, Hongzhe Sun, Wei Xia
The NikR protein is an essential DNA regulator of Helicobacter pylori, a human pathogen, which infects almost half of the world's population. Herein, we comprehensively characterized the interaction of a bismuth drug with Helicobacter pylori NikR. We show that Bi(III) can occupy the high-affinity Ni(II) site of NikR. The highly-conserved residue Cys107 at this site is critical for Bi(III) binding. Importantly, such a binding disassembles physiologically functional NikR tetramer into inactive dimer, leading to abrogation of the DNA-binding capability of NikR...
April 8, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/30999223/g-quadruplex-and-duplex-dna-binding-studies-of-novel-ruthenium-ii-complexes-containing-ascididemin-ligands
#18
Maierhaba Wumaier, Jing-Jing Shi, Tian-Ming Yao, Xiao-Chun Hu, Ru-Ru Gao, Shuo Shi
In this paper, three new Ruthenium(II) polypyridyl complexes containing ascididemin (ASC) as main ligand have been synthesized and characterized. Their interactions with different G-quadruplex (Htelo, c-myc and c-kit) (Htelo: human telomeric DNA, c-myc: cellular-myelocytomatosis viral oncogene, c-kit: oncogene c-kit promoter sequences) and duplex (ds26) DNA sequences were comparatively studied with the free ligand ASC by a series of spectroscopic techniques including UV-vis (ultraviolet-visible) spectroscopy, FID (fluorescent intercalator displacement) assay, and FRET (fluorescence resonance energy transfer) melting assay...
April 6, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/30999222/cobalt-ii-complexes-with-the-non-steroidal-anti-inflammatory-drug-diclofenac-and-nitrogen-donor-ligands
#19
Spyros Perontsis, Alexandra Dimitriou, Panagiota Fotiadou, Antonios G Hatzidimitriou, Athanasios N Papadopoulos, George Psomas
The interaction of the non-steroidal anti-inflammatory drug sodium diclofenac with CoCl2 in the absence or presence of the nitrogen-donor ligands 2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyridylamine, pyridine or imidazole resulted in the formation of six mononuclear Co(II) complexes. The complexes were characterized by diverse physicochemical and spectroscopic techniques and single-crystal X-ray crystallography revealing a monodentate or a bidentate chelating binding mode of the diclofenac ligands. The scavenging activity of the complexes was evaluated in vitro against the free radicals of 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and hydroxyl; the complexes present significant scavenging activity of ABTS and hydroxyl radicals...
April 5, 2019: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/31003065/heme-prevents-highly-amyloidogenic-human-calcitonin-hct-aggregation-a-potential-new-strategy-for-the-clinical-reuse-of-hct
#20
Huixian Ye, Jun Zhou, Hailing Li, Zhonghong Gao
Irreversible aggregation can extremely limit the bioavailability and therapeutic activity of peptide-based drugs. Thus, peptide fibrillation is an excellent challenge for biotechnological drug development. Human calcitonin (hCT) is such a peptide hormone known for its hypocalcaemic effect but has limited pharmaceutical potential due to a high tendency to aggregate. hCT is therefore not widely used preparation in clinical practice. Nonetheless, hCT seems to be still an ideal target for clinical therapy when fibrillation is effectively inhibited, because the alternatives of hCT can stimulate undesirable immune responses in patients and cause side effects...
April 1, 2019: Journal of Inorganic Biochemistry
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