Jane Read, Andrew Reid, Claire Thomson, Marshall Plit, Ross Mejia, Darryl A Knight, Muriel Lize, Karim El Kasmi, Christopher Grainge, Heiko Stahl, Michael Schuliga
Patients with pulmonary fibrosis (PF) often experience exacerbations of their disease, characterised by a rapid, severe deterioration in lung function that is associated with high mortality. Whilst the pathobiology of such exacerbations is poorly understood, virus infection is a trigger. This study investigated virus-induced injury responses of alveolar and bronchial epithelial cells (AECs and BECs respectively) from patients with PF and age-matched controls (Ctrls). Air liquid interface (ALI) cultures of AECs, comprising type I and II pneumocytes or BECs were inoculated with influenza A virus (H1N1) at 0...
April 5, 2024: Clinical Science (1979-)