Janine Cubello, Elena Marvin, Katherine Conrad, Alyssa K Merrill, Jithin V George, Kevin Welle, Brian P Jackson, David Chalupa, Günter Oberdörster, Marissa Sobolewski, Deborah A Cory-Slechta
Exposures to ambient ultrafine particle (UFP) air pollution (AP) during the early postnatal period in mice (equivalent to human third trimester brain development) produce male-biased changes in brain structure, including ventriculomegaly, reduced brain myelination, alterations in neurotransmitters and glial activation, as well as impulsive-like behavioral characteristics, all of which are also features characteristic of male-biased neurodevelopmental disorders (NDDs). The purpose of this study was to ascertain the extent to which inhaled Cu, a common contaminant of AP that is also dysregulated across multiple NDDs, might contribute to these phenotypes...
January 2024: Neurotoxicology