journal
https://read.qxmd.com/read/38224782/human-blood-markers-of-cholinergic-neurotoxicity-and-neuropathy-a-useful-guide-for-laboratory-applications
#21
JOURNAL ARTICLE
Guilherme Luz Emerick, Valfran da Silva Lima, Bruna Francisquete Costa, Vitoria Hioko da Silva Nakamura, Dayana Veruska Lentz, Juliandra Spagnol Bonache, Marion Ehrich
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are useful markers to assess the effects of exposure to anticholinesterase insecticides (Anti-AChE). In addition, lymphocyte neuropathy target esterase (LNTE) has been used as biomarker of neuropathic organophosphate compounds (OPs). Thus, this study evaluates the main types of circulating biomarkers related to the cholinergic system and to the neuropathy induced by OPs in standardized human samples. To achieve this objective, total protein of human plasma, erythrocytes and lymphocytes were first standardized, and then AChE, BChE and LNTE activities in human blood were evaluated in the presence of inhibitors...
January 13, 2024: Neurotoxicology
https://read.qxmd.com/read/38215798/occupational-exposure-to-polychlorinated-biphenyls-development-of-neuropsychological-functions-over-time
#22
JOURNAL ARTICLE
Julia L Cromberg, Thomas Schettgen, Klaus Willmes, Jessica Lang, Thomas Kraus, Bruno Fimm
Occupational exposure to polychlorinated biphenyls (PCBs) continues to affect the health of exposed individuals until today. This study aims to expand previous findings by examining the development of neuropsychological functions of occupationally exposed participants over time. Especially verbal fluency and sensorimotor processing, found to be impaired in a previous study, were thus of particular interest. A total of 116 participants, who were part of the HELPcB cohort, underwent a neuropsychological test battery covering a multitude of cognitive functions...
January 10, 2024: Neurotoxicology
https://read.qxmd.com/read/38191030/vitamin-a-ameliorates-valproic-acid-induced-autism-like-symptoms-in-developing-zebrafish-larvae-by-attenuating-oxidative-stress-and-apoptosis
#23
JOURNAL ARTICLE
Jingyu Wang, Li Zou, Peiyun Jiang, Mengmeng Yao, Qu Xu, Qin Hong, Jiansheng Zhu, Xia Chi
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social deficits and repetitive/stereotyped behaviors. Prenatal exposure to valproic acid (VPA) has been reported to induce ASD-like symptoms in human and rodents. However, the etiology and pathogenesis of ASD have not been well elucidated. This study aimed to explore the mechanisms underlying VPA-induced ASD-like behaviors using zebrafish model and investigated whether vitamin A could prevent VPA-induced neurotoxicity. Here, zebrafish embryos were exposed to 0, 25 and 50μM VPA from 4 to 96hours post fertilization (hpf) and the neurotoxicity was assessed...
January 6, 2024: Neurotoxicology
https://read.qxmd.com/read/38128735/synchrotron-speciation-of-umbilical-cord-mercury-and-selenium-after-environmental-exposure-in-niigata
#24
JOURNAL ARTICLE
Monica Weng, Natalia V Dolgova, Linda I Vogt, Muhammad Qureshi, Dimosthenis Sokaras, Thomas Kroll, Hisashi Saitō, John L O'Donoghue, Gene E Watson, Gary J Myers, Tomoko Sekikawa, Ingrid J Pickering, Graham N George
The insidious and deadly nature of mercury's organometallic compounds is informed by two large scale poisonings due to industrial mercury pollution that occurred decades ago in Minamata and Niigata, Japan. The present study examined chemical speciation for both mercury and selenium in a historic umbilical cord sample from a child born to a mother who lived near the Agano River in Niigata. The mother had experienced mercury exposure leading to more than 50 ppm mercury measured in her hair and was symptomatic 9 years prior to the birth...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38101458/cobalt-induced-apoptosis-of-cochlear-organotypic-cultures-and-hei-oc1-cells-is-mediated-by-dicer
#25
JOURNAL ARTICLE
Xuexin Lin, Liling Li, Jia Luo, Dan Chen, Jingqian Tan, Peng Li
Cobalt is widely used in the medical industry, mainly including cobalt alloy joint implants and cobalt-chromium porcelain crowns. However, unexplained ototoxicity and neurotoxicity often occur in the clinical use of cobalt agents at present, which limits the development of the cobalt industry. In this study, based on the clinical problem of cobalt ototoxicity, we first conducted an extensive search and collation of related theories, and on this basis, prepared an HEI-OC1 cell model and basilar membrane organotypic cultures after cobalt treatment...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38081392/the-contributions-of-neonatal-inhalation-of-copper-to-air-pollution-induced-neurodevelopmental-outcomes-in-mice
#26
JOURNAL ARTICLE
Janine Cubello, Elena Marvin, Katherine Conrad, Alyssa K Merrill, Jithin V George, Kevin Welle, Brian P Jackson, David Chalupa, Günter Oberdörster, Marissa Sobolewski, Deborah A Cory-Slechta
Exposures to ambient ultrafine particle (UFP) air pollution (AP) during the early postnatal period in mice (equivalent to human third trimester brain development) produce male-biased changes in brain structure, including ventriculomegaly, reduced brain myelination, alterations in neurotransmitters and glial activation, as well as impulsive-like behavioral characteristics, all of which are also features characteristic of male-biased neurodevelopmental disorders (NDDs). The purpose of this study was to ascertain the extent to which inhaled Cu, a common contaminant of AP that is also dysregulated across multiple NDDs, might contribute to these phenotypes...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38070655/morphological-hallmarks-of-dopaminergic-neurodegeneration-are-associated-with-altered-neuron-function-in-caenorhabditis-elegans
#27
JOURNAL ARTICLE
Andrew S Clark, Javier Huayta, Katherine S Morton, Joel N Meyer, Adriana San-Miguel
Caenorhabditis elegans (C. elegans) is an excellent model system to study neurodegenerative diseases, such as Parkinson's disease, as it enables analysis of both neuron morphology and function in live animals. Multiple structural changes in neurons, such as cephalic dendrite morphological abnormalities, have been considered hallmarks of neurodegeneration in this model, but their relevance to changes in neuron function are not entirely clear. We sought to test whether hallmark morphological changes associated with chemically induced dopaminergic neuron degeneration, such as dendrite blebbing, breakage, and loss, are indicative of neuronal malfunction and result in changes in behavior...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38070654/necroptosis-involved-in-sevoflurane-induced-cognitive-dysfunction-in-aged-mice-by-activating-nmda-receptors-increasing-intracellular-calcium
#28
JOURNAL ARTICLE
Xiang Liu, Jiaxu Yu, Xiaona Tan, Qi Zhang, Junfang Niu, Zhiyong Hou, Qiujun Wang
Perioperative neurocognitive disorders are a common surgical and postanesthesia complication. Necroptosis contributes to the emergence of various neurological disorders. We conjecture that cognitive impairment is associated with necroptosis of hippocampal neurons, which is mediated by NMDA receptors leading to cytoplasmic calcium imbalance. C57BL/6 J male mice ( 18 months) were randomly divided into the C ( control group), S ( sevoflurane group), S+M ( sevoflurane plus the NMDA receptor antagonist memantine group) and S+N ( sevoflurane plus necrostatin-1) group...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38070653/characterizing-cannabis-prevalent-terpenes-for-neuroprotection-reveal-a-role-for-%C3%AE-and-%C3%AE-pinenes-in-mitigating-amyloid-%C3%AE-evoked-neurotoxicity-and-aggregation-in-vitro
#29
JOURNAL ARTICLE
John Staton Laws, Scott D Smid
BACKGROUND: Cannabis sativa L. (C. sativa) can efficiently synthesize of over 200 terpenes, including monoterpenes, sesquiterpenes and triterpenes that may contribute to the known biological activities of phytocannabinoids of relevance for the burgeoning access to medicinal cannabis formulations globally; however, to date have been uncharacterized. We assessed twelve predominant terpenes in C. sativa for neuroprotective and anti-aggregative properties in semi-differentiated PC12 neuronal cell line that is robust and validated as a cell model responsive to amyloid β (Aβ1-42 ) protein exposure and oxidative stress...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38065418/preferential-potentiation-of-ampa-mediated-currents-in-brainstem-hypoglossal-motoneurons-by-subchronic-exposure-of-mice-expressing-the-human-superoxide-dismutase-1-g93a-gene-mutation-to-neurotoxicant-methylmercury-in-vivo
#30
JOURNAL ARTICLE
Yukun Yuan, Jordan M Bailey, Gretchen M Rivera-Lopez, William D Atchison
The exact causes of Amyotrophic lateral sclerosis (ALS), a progressive and fatal neurological disorder due to loss of upper and/or lower motoneurons, remain elusive. Gene-environment interactions are believed to be an important factor in the development of ALS. We previously showed that in vivo exposure of mice overexpressing the human superoxide dismutase 1 (hSOD1) gene mutation (hSOD1G93A; G93A), a mouse model for ALS, to environmental neurotoxicant methylmercury (MeHg) accelerated the onset of ALS-like phenotype...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38065417/predicted-versus-observed-activity-of-pcb-mixtures-toward-the-ryanodine-receptor
#31
JOURNAL ARTICLE
Justin A Griffin, Xueshu Li, Hans-Joachim Lehmler, Erika B Holland
Non-dioxin-like polychlorinated biphenyls (NDL PCBs) alter the activity of the ryanodine receptor (RyR), and this activity is linked to developmental neurotoxicity. Most work to date has focused on the activity of single congeners rather than relevant mixtures. The current study assessed the RyR activity of single congeners or binary, tertiary, and complex PCB mixtures. Observed mixture activity was then compared to the expected activity calculated using the concentration addition (CA) model or a RyR-specific neurotoxic equivalency scheme (rNEQ)...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38056506/mohamed-bahie-abou-donia-pioneer-in-organophosphorus-induced-neurotoxicity
#32
JOURNAL ARTICLE
Theodore A Slotkin
No abstract text is available yet for this article.
January 2024: Neurotoxicology
https://read.qxmd.com/read/38043637/preventive-and-therapeutic-effects-of-azithromycin-on-acrylamide-induced-neurotoxicity-in-rats
#33
JOURNAL ARTICLE
Homa Fazeli Kakhki, Mahboobeh Ghasemzadeh Rahbardar, Bibi Marjan Razavi, Mahmoud Reza Heidari, Hossein Hosseinzadeh
BACKGROUND: Acrylamide (ACR) can induce neurotoxicity through different pathways, including oxidative stress and apoptosis. Azithromycin is well-known for its antioxidant and anti-apoptotic properties. OBJECTIVE: To evaluate the potential neuroprotective effect of azithromycin in an in vivo model of ACR-induced neurotoxicity, by investigating its impact on oxidative stress and apoptosis pathways. METHODS: Male rats were divided into eleven groups at random (n = 6)...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38040126/%C3%AE-pyrrolidinononanophenone-derivatives-induce-differentiated-sh-sy5y-neuroblastoma-cell-apoptosis-via-reduction-of-antioxidant-capacity-involvement-of-no-depletion-and-inactivation-of-nrf2-ho1-signaling-pathway
#34
JOURNAL ARTICLE
Yuji Sakai, Daisuke Egawa, Junta Hattori, Yoshifumi Morikawa, Koichi Suenami, Tomohiro Takayama, Atsushi Nagai, Tomomi Michiue, Akira Ikari, Toshiyuki Matsunaga
α-Pyrrolidinononanophenone (α-PNP) derivatives are known to be one of the hazardous new psychoactive substances due to the most extended hydrocarbon chains of any pyrrolidinophenones on the illicit drug market. Our previous report showed that 4'-iodo-α-PNP (I-α-PNP) is the most potent cytotoxic compound among α-PNP derivatives and induces apoptosis due to mitochondrial dysfunction and suppression of nitric oxide (NO) production in differentiated human neuronal SH-SY5Y cells. In this study, to clarify the detailed action mechanisms by I-α-PNP, we investigated the mechanism of reactive oxygen species (ROS) -dependent apoptosis by I-α-PNP in differentiated SH-SY5Y with a focus on the antioxidant activities...
January 2024: Neurotoxicology
https://read.qxmd.com/read/38143152/corrigendum-to-in-utero-exposure-to-dexamethasone-causes-a-persistent-and-age-dependent-exacerbation-of-the-neurotoxic-effects-and-glia-activation-induced-by-mdma-in-dopaminergic-brain-regions-of-c57bl-6j-mice-neurotoxicology-83-2021-%C3%A2-1-13
#35
Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
No abstract text is available yet for this article.
December 23, 2023: Neurotoxicology
https://read.qxmd.com/read/38135581/corrigendum-to-in-utero-exposure-to-dexamethasone-causes-a-persistent-and-age-dependent-exacerbation-of-the-neurotoxic-effects-and-glia-activation-induced-by-mdma-in-dopaminergic-brain-regions-of-c57bl-6j-mice-neurotoxicology-83-2021-%C3%A2-1-13
#36
Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
No abstract text is available yet for this article.
December 21, 2023: Neurotoxicology
https://read.qxmd.com/read/38135191/the-role-of-carbon-monoxide-in-aerotoxic-syndrome
#37
REVIEW
G Hageman, P van Broekhuizen, J Nihom
Chronic low-level exposure to toxic compounds in airplane cabin air may result in Aerotoxic Syndrome (AS). Aetiologic agents are organophosphates and numerous volatile organic hydrocarbons originating from leaks of engine oil and hydraulic fluids. Despite a documented history spanning decades, the role of carbon monoxide remains controversial. What evidence exists that carbon monoxide (CO), present in the cocktail of toxic compounds in bleed air, contributes to the AS? We selected 22 publications encompassing 888 flights with 18 different aircraft types...
December 21, 2023: Neurotoxicology
https://read.qxmd.com/read/38135192/dietary-selenium-and-mercury-intakes-from-fish-consumption-during-pregnancy-seychelles-child-development-study-nutrition-cohort-2
#38
JOURNAL ARTICLE
Maria Wesolowska, Alison J Yeates, Emeir M McSorley, Gene E Watson, Edwin van Wijngaarden, Nathalie Bodin, Rodney Govinden, Juddy Jean-Baptiste, Stephanie Desnousse, Conrad F Shamlaye, Gary J Myers, J J Strain, Maria S Mulhern
Some health agencies have issued precautionary principle fish advisories to pregnant women based on the presence of methylmercury (MeHg) in fish that could possibly be harmful to the developing fetus. Fish, however, is a rich source of selenium (Se) and other nutrients essential for normal brain development. Selenium is also thought to have a key role in alleviating MeHg toxicity. We estimated the dietary Se and MeHg intakes and dietary Se:Hg molar ratios from the fish consumed in a high fish-eating pregnant cohort where no adverse associations of fish consumption and outcomes has been reported...
December 20, 2023: Neurotoxicology
https://read.qxmd.com/read/38006911/long-term-lps-systemic-administration-leads-to-memory-impairment-and-disturbance-in-astrocytic-homeostasis
#39
JOURNAL ARTICLE
Gabriel Henrique Schirmbeck, Marina Seady, Fernanda Telles Fróes, Jéssica Taday, Carollina Da Ré, Jéssica Maria Souza, Carlos Alberto Gonçalves, Marina Concli Leite
Dementia is the most prevalent neurodegenerative disorder, characterized by progressive loss of memory and cognitive function. Inflammation is a major aspect in the progression of brain disorders, and inflammatory events have been associated with accelerated deterioration of cognitive function. In the present work, we investigated the impact of low-grade repeated inflammation stimuli induced by lipopolysaccharide (LPS) in hippocampal function and spatial memory. Adult male Wistar rats received a weekly injection of LPS (500 ug/kg) for sixteen weeks, eliciting systemic inflammation...
December 2023: Neurotoxicology
https://read.qxmd.com/read/37981056/evaluating-the-toxic-mechanism-of-1-2-diacetylbenzene-in-neural-cells-tissues-the-favorable-impact-of-silibinin
#40
JOURNAL ARTICLE
Li-Yu Fay, Jun-Yi Chien, Ching-Feng Weng, Huai-Sheng Kuo, Dann-Ying Liou, Wei-Hao Weng, Chi-Hung Lin, Ya-Tzu Chen, Wen-Hung Huang, Wen-Cheng Huang, May-Jywan Tsai, Henrich Cheng
1,2-diacetylbenzene (1,2-DAB) is a neurotoxic component of aromatic solvents commonly used in industrial applications that induces neuropathological changes in animals. This study unraveled the toxic impact of 1,2-DAB in nerve tissues, explant cultures, and neuron-glial cultures, and explored whether herbal products can mitigate its toxicity. The effects of DAB on axonal transport were studied in retinal explant cultures grown in a micro-patterned dish. The mitochondrial movement in the axons was captured using time-lapse video recordings...
December 2023: Neurotoxicology
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