Jean Golding
No abstract text is available yet for this article.
February 15, 2024: Neurotoxicology
Mengdie Wang, Namin Feng, Jia Qin, Shengqiang Wang, Jiabao Chen, Shaojie Qian, Yulin Liu, Foquan Luo
Recent evidence showed that general anesthesia produces long-term neurotoxicity and cognitive dysfunction. However, it remains unclear whether maternal non-obstetric surgery under ketamine anesthesia during second trimester causes cognitive impairment in offspring. The present study assigned pregnant rats into three groups: 1) normal control group receiving no anesthesia and no surgery, 2) ketamine group receiving ketamine anesthesia for 2h on the 14th day of gestation but no surgery, and 3) surgery group receiving abdominal surgery under ketamine anesthesia on the 14th day of gestation...
February 10, 2024: Neurotoxicology
Sanchez-Yepez Jonathan, Acevedo-Huergo Triana, Mendoza-Trejo Maria Soledad, Corona Rebeca, Hernandez-Plata Isela, Viñuela-Berni Veronica, Giordano Magda, M Rodríguez Veronica
Several studies have shown that chronic exposure to the herbicide atrazine (ATR) causes alterations in locomotor activity and markers of the dopaminergic systems of male rats. However, few studies have evaluated the sex-dependent effects of atrazine exposure. The aim of the present study was to evaluate whether chronic ATR exposure causes alterations in behavioral performance and dopaminergic systems of female rats. At weaning, two groups of rats were exposed to 1 or 10 mg ATR/kg body weight daily thorough the food, while the control group received food without ATR for 14 months...
February 8, 2024: Neurotoxicology
Bingxin Zhao, Sheng Zhang, Nashwa Amin, Jie Pan, Fei Wu, Guanghong Shen, Mingming Tan, Zongjie Shi, Yu Geng
Acute ischemic stroke followed by microglia activation, and the regulation of neuroinflammatory responses after ischemic injury involves microglia polarization. microglia polarization is involved in the regulation of neuroinflammatory responses and ischemic stroke-related brain damage. Thymoquinone (TQ) is an anti-inflammatory agent following ischemic stroke onset. However, the significance of TQ in microglia polarization following acute ischemic stroke is still unclear. We predicted that TQ might have neuroprotective properties by modulating microglia polarization...
February 5, 2024: Neurotoxicology
Cheryl Tyszkiewicz, Seo-Kyoung Hwang, Jamie K DaSilva, Ramesh C Kovi, Kelly A Fader, Madhu P Sirivelu, June Liu, Chris Somps, Jon Cook, Chang-Ning Liu, Helen Wang
Adeno-associated virus (AAV)-based vectors are commonly used for delivering transgenes in gene therapy studies, but they are also known to cause dorsal root ganglia (DRG) and peripheral nerve toxicities in animals. However, the functional implications of these pathologic findings and their time course remain unclear. At 2, 4, 6, and 8 weeks following a single dose of an AAV9 vector carrying human frataxin transgene in rats, non-standard functional assessments, including von Frey filament, electrophysiology, and Rotarod tests, were conducted longitudinally to measure allodynia, nerve conduction velocity, and coordination, respectively...
February 3, 2024: Neurotoxicology
Jiuyang Ding, Jun Wu, Xiaotao Hou, Li Yang, Yingdong Gao, Juan Zheng, Nannan Jia, Zheng He, Hui Zhang, Chengfei Wang, Xiaolan Qi, Jiang Huang, Xianglin Pei, Jiawen Wang
Methamphetamine (METH) - induced cognitive impairments may be related to synaptic degeneration at mossy fiber terminals, critical for spatial memory formation in hippocampal circuits. We have previously found METH-induced neurodegeneration in the striatum by increasing the α-synuclein (α-SYN) level. However, whether and how the METH-induced mossy fiber degeneration is also blamed for the abnormal accumulation of α-SYN remains to be elucidated. Chronic METH exposure decreased mossy fiber density but upregulatedα-SYN and phosphorylated TAU (TAU-pSer396) in hippocampal CA3, associated with glial cell overactivation, axonal neuropathies, and memory impairment...
February 2, 2024: Neurotoxicology
Nicholas V C Ralston, Laura J Raymond, Christy L Gilman, Reni Soon, Lucia A Seale, Marla J Berry
Selenium (Se) is required for synthesis of selenocysteine (Sec), an amino acid expressed in the active sites of Se-dependent enzymes (selenoenzymes), including forms with essential functions in fetal development, brain activities, thyroid hormone metabolism, calcium regulation, and to prevent or reverse oxidative damage. Homeostatic mechanisms normally ensure the brain is preferentially supplied with Se to maintain selenoenzymes, but high methylmercury (CH3 Hg) exposures irreversibly inhibit their activities and impair Sec synthesis...
January 23, 2024: Neurotoxicology
Guilherme Luz Emerick, Valfran da Silva Lima, Bruna Francisquete Costa, Vitoria Hioko da Silva Nakamura, Dayana Veruska Lentz, Juliandra Spagnol Bonache, Marion Ehrich
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are useful markers to assess the effects of exposure to anticholinesterase insecticides (Anti-AChE). In addition, lymphocyte neuropathy target esterase (LNTE) has been used as biomarker of neuropathic organophosphate compounds (OPs). Thus, this study evaluates the main types of circulating biomarkers related to the cholinergic system and to the neuropathy induced by OPs in standardized human samples. To achieve this objective, total protein of human plasma, erythrocytes and lymphocytes were first standardized, and then AChE, BChE and LNTE activities in human blood were evaluated in the presence of inhibitors...
January 13, 2024: Neurotoxicology
Julia L Cromberg, Thomas Schettgen, Klaus Willmes, Jessica Lang, Thomas Kraus, Bruno Fimm
Occupational exposure to polychlorinated biphenyls (PCBs) continues to affect the health of exposed individuals until today. This study aims to expand previous findings by examining the development of neuropsychological functions of occupationally exposed participants over time. Especially verbal fluency and sensorimotor processing, found to be impaired in a previous study, were thus of particular interest. A total of 116 participants, who were part of the HELPcB cohort, underwent a neuropsychological test battery covering a multitude of cognitive functions...
January 10, 2024: Neurotoxicology
Jingyu Wang, Li Zou, Peiyun Jiang, Mengmeng Yao, Qu Xu, Qin Hong, Jiansheng Zhu, Xia Chi
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social deficits and repetitive/stereotyped behaviors. Prenatal exposure to valproic acid (VPA) has been reported to induce ASD-like symptoms in human and rodents. However, the etiology and pathogenesis of ASD have not been well elucidated. This study aimed to explore the mechanisms underlying VPA-induced ASD-like behaviors using zebrafish model and investigated whether vitamin A could prevent VPA-induced neurotoxicity. Here, zebrafish embryos were exposed to 0, 25 and 50μM VPA from 4 to 96hours post fertilization (hpf) and the neurotoxicity was assessed...
January 6, 2024: Neurotoxicology
Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
No abstract text is available yet for this article.
December 23, 2023: Neurotoxicology
Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
No abstract text is available yet for this article.
December 21, 2023: Neurotoxicology
G Hageman, P van Broekhuizen, J Nihom
Chronic low-level exposure to toxic compounds in airplane cabin air may result in Aerotoxic Syndrome (AS). Aetiologic agents are organophosphates and numerous volatile organic hydrocarbons originating from leaks of engine oil and hydraulic fluids. Despite a documented history spanning decades, the role of carbon monoxide remains controversial. What evidence exists that carbon monoxide (CO), present in the cocktail of toxic compounds in bleed air, contributes to the AS? We selected 22 publications encompassing 888 flights with 18 different aircraft types...
December 21, 2023: Neurotoxicology
Maria Wesolowska, Alison J Yeates, Emeir M McSorley, Gene E Watson, Edwin van Wijngaarden, Nathalie Bodin, Rodney Govinden, Juddy Jean-Baptiste, Stephanie Desnousse, Conrad F Shamlaye, Gary J Myers, J J Strain, Maria S Mulhern
Some health agencies have issued precautionary principle fish advisories to pregnant women based on the presence of methylmercury (MeHg) in fish that could possibly be harmful to the developing fetus. Fish, however, is a rich source of selenium (Se) and other nutrients essential for normal brain development. Selenium is also thought to have a key role in alleviating MeHg toxicity. We estimated the dietary Se and MeHg intakes and dietary Se:Hg molar ratios from the fish consumed in a high fish-eating pregnant cohort where no adverse associations of fish consumption and outcomes has been reported...
December 20, 2023: Neurotoxicology
Monica Weng, Natalia V Dolgova, Linda I Vogt, Muhammad Qureshi, Dimosthenis Sokaras, Thomas Kroll, Hisashi Saitō, John L O'Donoghue, Gene E Watson, Gary J Myers, Tomoko Sekikawa, Ingrid J Pickering, Graham N George
The insidious and deadly nature of mercury's organometallic compounds is informed by two large scale poisonings due to industrial mercury pollution that occurred decades ago in Minamata and Niigata, Japan. The present study examined chemical speciation for both mercury and selenium in a historic umbilical cord sample from a child born to a mother who lived near the Agano River in Niigata. The mother had experienced mercury exposure leading to more than 50 ppm mercury measured in her hair and was symptomatic 9 years prior to the birth...
January 2024: Neurotoxicology
Xuexin Lin, Liling Li, Jia Luo, Dan Chen, Jingqian Tan, Peng Li
Cobalt is widely used in the medical industry, mainly including cobalt alloy joint implants and cobalt-chromium porcelain crowns. However, unexplained ototoxicity and neurotoxicity often occur in the clinical use of cobalt agents at present, which limits the development of the cobalt industry. In this study, based on the clinical problem of cobalt ototoxicity, we first conducted an extensive search and collation of related theories, and on this basis, prepared an HEI-OC1 cell model and basilar membrane organotypic cultures after cobalt treatment...
January 2024: Neurotoxicology
Janine Cubello, Elena Marvin, Katherine Conrad, Alyssa K Merrill, Jithin V George, Kevin Welle, Brian P Jackson, David Chalupa, Günter Oberdörster, Marissa Sobolewski, Deborah A Cory-Slechta
Exposures to ambient ultrafine particle (UFP) air pollution (AP) during the early postnatal period in mice (equivalent to human third trimester brain development) produce male-biased changes in brain structure, including ventriculomegaly, reduced brain myelination, alterations in neurotransmitters and glial activation, as well as impulsive-like behavioral characteristics, all of which are also features characteristic of male-biased neurodevelopmental disorders (NDDs). The purpose of this study was to ascertain the extent to which inhaled Cu, a common contaminant of AP that is also dysregulated across multiple NDDs, might contribute to these phenotypes...
January 2024: Neurotoxicology
Andrew S Clark, Javier Huayta, Katherine S Morton, Joel N Meyer, Adriana San-Miguel
Caenorhabditis elegans (C. elegans) is an excellent model system to study neurodegenerative diseases, such as Parkinson's disease, as it enables analysis of both neuron morphology and function in live animals. Multiple structural changes in neurons, such as cephalic dendrite morphological abnormalities, have been considered hallmarks of neurodegeneration in this model, but their relevance to changes in neuron function are not entirely clear. We sought to test whether hallmark morphological changes associated with chemically induced dopaminergic neuron degeneration, such as dendrite blebbing, breakage, and loss, are indicative of neuronal malfunction and result in changes in behavior...
January 2024: Neurotoxicology
Xiang Liu, Jiaxu Yu, Xiaona Tan, Qi Zhang, Junfang Niu, Zhiyong Hou, Qiujun Wang
Perioperative neurocognitive disorders are a common surgical and postanesthesia complication. Necroptosis contributes to the emergence of various neurological disorders. We conjecture that cognitive impairment is associated with necroptosis of hippocampal neurons, which is mediated by NMDA receptors leading to cytoplasmic calcium imbalance. C57BL/6 J male mice ( 18 months) were randomly divided into the C ( control group), S ( sevoflurane group), S+M ( sevoflurane plus the NMDA receptor antagonist memantine group) and S+N ( sevoflurane plus necrostatin-1) group...
January 2024: Neurotoxicology
John Staton Laws, Scott D Smid
BACKGROUND: Cannabis sativa L. (C. sativa) can efficiently synthesize of over 200 terpenes, including monoterpenes, sesquiterpenes and triterpenes that may contribute to the known biological activities of phytocannabinoids of relevance for the burgeoning access to medicinal cannabis formulations globally; however, to date have been uncharacterized. We assessed twelve predominant terpenes in C. sativa for neuroprotective and anti-aggregative properties in semi-differentiated PC12 neuronal cell line that is robust and validated as a cell model responsive to amyloid β (Aβ1-42 ) protein exposure and oxidative stress...
January 2024: Neurotoxicology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.