Katherine A Walker, Simone T Rhodes, Deborah A Liberman, Andrea C Gore, Margaret R Bell
Polychlorinated biphenyls are ubiquitous environmental contaminants linked with peripheral immune and neural dysfunction. Neuroimmune signaling is critical to brain development and later health; however, effects of PCBs on neuroimmune processes are largely undescribed. This study extends our previous work in neonatal or adolescent rats by investigating longer-term effects of perinatal PCB exposure on later neuroimmune responses to an inflammatory challenge in adulthood. Male and female Sprague-Dawley rats were exposed to a low-dose, environmentally relevant, mixture of PCBs (Aroclors 1242, 1248, and 1254, 1:1:1, 20μg / kg dam BW per gestational day) or oil control during gestation and via lactation...
July 20, 2024: Neurotoxicology
Fen Li, Lin Zhang, Xingxu Zhang, Qimeng Fang, Yingshun Xu, Hui Wang
Lead (Pb) is harmful to almost all organs, particularly the developmental neural system, and previous studies revealed oxidative stress played an important role in Pb neurotoxicity. Rutin, a type of flavonoid glycoside found in various plants and fruits, is widely used as a dietary supplement due to its antioxidant and anti-inflammatory properties, but whether rutin could protect against Pb neurotoxicity is unclear. In this study, we found rutin treatment significantly alleviated Pb-induced cell death, oxidative stress, and inflammation, resulting in cell survival...
July 18, 2024: Neurotoxicology
Ziyi Yang, Jie Zhang, Mingbo Wang, Xin Wang, Huahua Liu, Feng Zhang, Hong Fan
PURPOSE: Considering that endocrine disruptors have certain effects on fetal growth, we conducted a systematic review of epidemiological literature to elucidate the correlation between exposure to endocrine-disrupting chemicals during pregnancy and the neurodevelopment of offspring. METHOD: We systematically explored PubMed, Web of Science, and CINAHL databases from inception to April 4, 2023. References from pertinent studies were reviewed, and data regarding the link between maternal prenatal EDC exposure and offspring neurological development were compiled...
July 14, 2024: Neurotoxicology
Pignatelli Angela, Mascia Benedusi, Mario Barbieri, Alessandra Pecorelli, Giuseppe Valacchi
Ozone (O3 ) forms in the Earth's atmosphere, both naturally and by reactions of man-made air pollutants. Deleterious effects of O3 have been found in the respiratory system. Here, we examine whether O3 alters olfactory behavior and cellular properties in the olfactory system. For this purpose, mice were exposed to O3 at a concentration found in highly polluted city air [0.8 ppm], and the behavior elicited by social and non-social odors in habituation/dishabituation tests was assessed. In addition, the electrical responses of dopaminergic olfactory bulb (OB) neurons were also evaluated...
July 12, 2024: Neurotoxicology
Guodong Zhang, Chuang Sun, Gang Zhou, Qihang Zhang
Isoflurane is one of the most commonly used anaesthetic agents in surgery procedures. During the past decades, isoflurane has been found to cause impairment in neurological capabilities in new-borns and elderly patients. Luteolin is a flavonoid that has been documented to possess a neuroprotective effect. Here we investigated the putative neuroprotective effects of luteolin on isoflurane-induced neurotoxicity in mouse hippocampal neuronal HT22 cells and explored the potential mechanisms. We demonstrated that luteolin improved mitochondrial dysfunction and reduced oxidative stress and apoptosis in isoflurane-treated HT22 cells, and thus inhibiting the isoflurane-induced neuronal injury...
July 12, 2024: Neurotoxicology
D A Cory-Slechta, E Marvin, K Welle, C Goeke, D Chalupa, G Oberdörster, M Sobolewski
Air pollution (AP) exposures have been associated with numerous neurodevelopmental and psychiatric disorders, including autism spectrum disorder, attention deficit hyperactivity disorder and schizophrenia, all male-biased disorders with onsets from early life to late adolescence/early adulthood. While prior experimental studies have focused on effects of AP exposures during early brain development, brain development actually extends well into early adulthood. The current study in mice sought to extend the understanding of developmental brain vulnerability during adolescence, a later but significant period of brain development and maturation to the ultrafine particulate (UFPs) component of AP, considered its most reactive component...
July 11, 2024: Neurotoxicology
Gianna Nossa, Humberto Monsivais, Chang Geun Lee, Grace Francis, Ellen M Wells, Jae Hong Park, Ulrike Dydak
Inhalation of welding fumes can cause metal accumulation in the brain, leading to Parkinsonian-like symptoms. Metal accumulation and altered neurochemical profiles have been observed using magnetic resonance imaging (MRI) in highly exposed welders, being associated with decreased motor function and cognition. While MRI is impractical to use as a health risk assessment tool in occupational settings, toenail metal levels are easier to assess and have been demonstrated to reflect an exposure window of7-12 months in the past...
July 11, 2024: Neurotoxicology
B Boamah, C Morse, S Siciliano, N Hogan, M Hecker, M Hanson, P Campbell, R Peters, A N Al-Dissi, T D Olver, L Weber
Exposure to industrial contaminants has been implicated in neurobehavioral toxicity in humans. To explore this potential risk, we investigated the neurotoxic effects of oral exposure to a complex groundwater mixture containing petroleum hydrocarbons, pesticides, heavy metals, and unknown parent and breakdown products using male and female Sprague Dawley rats. Rats were randomly divided into six groups and orally exposed daily via drinking water to: (i) tap water, (ii) 10% v/v low impact groundwater, and (iii) 0...
July 9, 2024: Neurotoxicology
Douglas Lisboa Ramalho, Jadyellen Rondon Silva, Michelle Fernanda Brugnera, Sidnei Moura, Anderson de Oliveira Souza
The Advanced Oxidative Processes have demonstrated potential for application in the degradation of organic pollutants, such as Paraquat (PQ) from water and wastewater, due to their low price, high efficiency, and non-toxic properties. In this study, we investigated whether the photodegradation of PQ with TiO2 nanotubes reduced its toxicity in Drosophila melanogaster. However, dietary ingestion of degradation products PQ for larvae resulted in a low axial ratio (pupal volume). In the adults, products of photodegradation of PQ exposure markedly diminished climbing ability in a time-dependent manner after 10 days of feeding...
July 7, 2024: Neurotoxicology
Cina M Mack, Alethea Tsui-Bowen, Alicia R Smith, Karl F Jensen, Prasada Rao S Kodavanti, Virginia C Moser, William R Mundy, Timothy J Shafer, David W Herr
The US EPA's Toxicity Forecaster (ToxCast) is a suite of high-throughput in vitro assays to screen environmental toxicants and predict potential toxicity of uncharacterized chemicals. This work examines the relevance of ToxCast assay intended gene targets to putative molecular initiating events (MIEs) of neurotoxicants. This effort is needed as there is growing interest in the regulatory and scientific communities about developing new approach methodologies (NAMs) to screen large numbers of chemicals for neurotoxicity and developmental neurotoxicity...
July 6, 2024: Neurotoxicology
Jiayu Wu, Qiaoying Zhang, Mingyue Ma, Yan Dong, Pengfeng Sun, Ming Gao, Peng Liu, Xiaoping Wu
BACKGROUND: Chronic overexposure to manganese (Mn) may result in neurotoxicity, which is characterized by motor and cognitive dysfunctions. This study aimed to utilize multivariate source-based morphometry (SBM) to explore the biomarkers for distinguishing Mn-exposed welders from healthy controls (HCs). METHODS: High-quality 3D T1-weighted MRI scans were obtained from 45 Mn-exposed full-time welders and 33 age-matched HCs in this study. After extracting gray matter structural covariation networks by SBM, multiple classic interaction linear models were applied to investigate distinct patterns in welders compared to HCs, and Z-transformed loading coefficients were compared between the two groups...
July 3, 2024: Neurotoxicology
Ismail Gbadamosi, Emmanuel Olusola Yawson, Justice Akesinro, Opeyemi Adeleke, Olorunfemi Tokunbo, Olawande Bamisi, Rukayat Ibrahim-Abdulkareem, Paul Awoniran, Rukayat Gbadamosi, Ezra Lambe, Aminat Atoyebi, Adedamola Aminat Bayo-Olugbami, Taiwo Adekemi Abayomi, Tolulope Timothy Arogundade
BACKGROUND: Monosodium glutamate (MSG) is a commonly used flavor enhancer that has raised concerns due to its potential adverse effects on various organs. This study explored the neuroprotective potential of Vitamin D, a beneficial micronutrient, in mitigating MSG-induced neurotoxicity. MATERIALS & METHODS: Adult male Wistar rats were categorized into five groups: control (2ml/kg PBS orally for 30 days), MSG (40mg/kg orally for 30 days), VIT-D (oral cholecalciferol; 500 IU/kg for 30 days), MSG+VIT-D (MSG for 30 days followed by VIT-D for another 30 days), and VIT-D/MSG (concurrent VIT-D and MSG for 30 days)...
July 2, 2024: Neurotoxicology
Fatema Currim, Reeya Tanwar, Josephine M Brown-Leung, Neha Paranjape, Jennifer Liu, Laurie H Sanders, Jonathan A Doorn, Jason R Cannon
Parkinson's disease (PD) is a debilitating neurodegenerative disease affecting millions of individuals worldwide. Hallmark features of PD pathology are the formation of Lewy bodies in neuromelanin-containing dopaminergic (DAergic) neurons of the substantia nigra pars compacta (SNpc), and the subsequent irreversible death of these neurons. Although genetic risk factors have been identified, around 90 % of PD cases are sporadic and likely caused by environmental exposures and gene-environment interaction...
July 2, 2024: Neurotoxicology
Amanda S Latham, Savannah M Rocha, Casey P McDermott, Philip Reigan, Richard A Slayden, Ronald B Tjalkens
Parkinson's disease (PD) is the most common neurodegenerative movement disorder worldwide. Current treatments for PD largely center around dopamine replacement therapies and fail to prevent the progression of pathology, underscoring the need for neuroprotective interventions. Approaches that target neuroinflammation, which occurs prior to dopaminergic neuron (DAn) loss in the substantia nigra (SN), represent a promising therapeutic strategy. The glucocorticoid receptor (GR) has been implicated in the neuropathology of PD and modulates numerous neuroinflammatory signaling pathways in the brain...
July 1, 2024: Neurotoxicology
Marta Bassi, Sabrine Bilel, Micaela Tirri, Giorgia Corli, Fabiana Di Rosa, Adolfo Gregori, Alaaldin M Alkilany, Ousama Rachid, Elisa Roda, Fabrizio De Luca, Pietro Papa, Eleonora Buscaglia, Giorgio Zauli, Carlo Alessandro Locatelli, Matteo Marti
The 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a synthetic cathinone closely related to 3,4-methylenedioxypyrovalerone (MDPV), one of the most common synthetic cathinones present in the "bath salts". MDPHP has recently gained attention due to increasing seizures and involvement in human intoxications which occurred in Europe and Italy in the last years, but currently there is a lack of information about its pharmaco-toxicological effects. With the aim at filling this gap, the present study is endeavoured to (i) evaluate the effects of acute administration of MDPHP (0...
June 30, 2024: Neurotoxicology
Hikari Tachibana, Moeka Nomura, Takeshi Funakoshi, Kana Unuma, Toshihiko Aki, Koichi Uemura
There is a propensity for synthetic cannabinoid abuse to spread worldwide. CP-55,940, a synthetic cannabinoid having the ability to activate both CB1 and CB2 receptors, has been shown to induce cell death in neurons as well as other cells. Here we investigate molecular events underling the adverse effects of CP-55,940 on neuronal cells. Exposure of mouse neuroblastoma Neuro2a cells to 10-50µM CP-55,940 results in concentration-dependent cell death that is not accompanied by an induction of apoptosis. CP-55,940 also stimulates autophagy, but the stimulation is not followed by an increase in autophagic degradation...
June 26, 2024: Neurotoxicology
Yuanyuan Gao, Rihui Li, Qianheng Ma, Joseph M Baker, Stephen Rauch, Robert B Gunier, Ana M Mora, Katherine Kogut, Asa Bradman, Brenda Eskenazi, Allan L Reiss, Sharon K Sagiv
BACKGROUND: Early life exposure to organophosphate (OP) pesticides is linked with adverse neurodevelopment and brain function in children. However, we have limited knowledge of how these exposures affect functional connectivity, a measure of interaction between brain regions. To address this gap, we examined the association between early life OP pesticide exposure and functional connectivity in adolescents. METHODS: We administered functional near-infrared spectroscopy (fNIRS) to 291 young adults with measured prenatal or childhood dialkylphosphates (DAPs) in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a longitudinal study of women recruited during pregnancy and their offspring...
June 20, 2024: Neurotoxicology
Qin Tian, Jie Zhou, Zhenzhen Xu, Bin Wang, Jiashun Liao, Ke Duan, Xiaoting Li, Enping Huang, Wei-Bing Xie
Methamphetamine (METH) is a widely abused amphetamine-type psychoactive drug that causes serious health problems. Previous studies have demonstrated that METH can induce neuron autophagy and apoptosis in vivo and in vitro. However, the molecular mechanisms underlying METH-induced neuron autophagy and apoptosis remain poorly understood. Stromal interacting molecule 1 (STIM1) was hypothesized to be involved in METH-induced neuron autophagy and apoptosis. Therefore, the expression of STIM1 protein was measured and the effect of blocking STIM1 expression with siRNA was investigated in cultured neuronal cells, and the hippocampus and striatum of mice exposed to METH...
June 18, 2024: Neurotoxicology
Rebecca J Wilson, Youjun P Suh, Ilknur Dursun, Felipe da Costa Souza, Ana Cristina Grodzki, Julia Y Cui, Hans-Joachim Lehmler, Pamela J Lein
Developmental exposures to PCBs are implicated in the etiology of neurodevelopmental disorders (NDDs). This observation is concerning given the continued presence of PCBs in the human environment and the increasing incidence of NDDs. Previous studies reported that developmental exposure to legacy commercial PCB mixtures (Aroclors) or single PCB congeners found in Aroclors caused NDD-relevant behavioral phenotypes in animal models. However, the PCB congener profile in contemporary human samples is dissimilar to that of the legacy Aroclors, raising the question of whether human-relevant PCB mixtures similarly interfere with normal brain development...
June 15, 2024: Neurotoxicology
Avril Gagnon-Chauvin, Mathieu Fornasier-Bélanger, Sandra W Jacobson, Joseph L Jacobson, Yohann Courtemanche, Pierre Ayotte, Richard E Bélanger, Gina Muckle, Dave Saint-Amour
This study aimed to assess associations between prenatal and postnatal exposure to lead (Pb), mercury (Hg) and polychlorinated biphenyls (PCBs) and gray matter volume of key regions of the brain reward circuit, namely the caudate nucleus, putamen, nucleus accumbens (nAcc), the amygdala, the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC). Structural magnetic resonance imaging (MRI) was conducted in 77 Inuit adolescents (mean age = 18.39) from Nunavik, Canada, who also completed the Brief Sensation Seeking Scale (BSSS-4) and Sensation Seeking - 2 (SS-2), two self-report questionnaires evaluating the tendency toward sensation seeking, which is a proxy of reward-related behaviors...
June 14, 2024: Neurotoxicology
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