Jing Guo, Chenhui Wang, Qun Xiang, Zeqing Feng, Lei Fei, Guoning Guo, Yongjun Shang, Yunfei An, Zhihua Ruan, Yongwen Chen, Xiaoyong Huang
Our previous work has demonstrated that the tetraspan MS4A6D interacts with MHC-II to be a complex that promotes macrophage activation (Mol Immunol. 2023; 160: 121-132), however, the exact role of MS4A6D in controlling macrophage-derived inflammation is still poorly understood. Here, we showed that Ms4a6d-deficient (Ms4a6d-/- ) mice manifested a lower level of footpad swelling induced by subcutaneous injection of 100 μL of 1% Carrageenan (CGN, w/v) plus CaCl2 (50 mM), a phenomenon that is similar to Nlrp3-/- , Casp-1-/- , and Ilr1-/- mice...
March 16, 2024: Molecular Immunology