Deeksha Mohan, Heather L Sherman, Ankita Mitra, Rebecca Lawlor, Sudarvili Shanthalingam, Jacob Ullom, Elena L Pobezinskaya, Guodong Zhang, Barbara A Osborne, Leonid A Pobezinsky, Gregory N Tew, Lisa M Minter
Following activation, CD4 T cells undergo metabolic and transcriptional changes as they respond to external cues and differentiate into T helper (Th) cells. T cells exhibit plasticity between Th phenotypes in highly inflammatory environments, such as colitis, in which high levels of IL-6 promote plasticity between regulatory T (Treg) cells and Th17 cells. Protein Kinase C theta (PKCθ) is a T cell-specific serine/threonine kinase that promotes Th17 differentiation while negatively regulating Treg differentiation...
April 3, 2023: Molecular Immunology