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Nutrition and Cancer

Mamta Shekhawat, Devashree Jahagirdar, Sunny Yadav, Nilesh Kumar Sharma
Insights in RNA biology have opened up a plethora of opportunities to explore the small regulatory RNAs from various natural and artificial sources. These small RNAs have been suggested to play a role too in tumor progression by either as oncogenic or tumor suppressor small RNAs. In this study, authors have attempted to evaluate the therapeutic potential of small RNAs fractionated from corn (Zea mays) upon growth and survival of HeLa. Here, authors have employed standard cellular-based approaches including microscopy, spectroscopy, and flow cytometry-based staining assays...
February 20, 2019: Nutrition and Cancer
Sparkle Springfield, Angela Odoms-Young, Lisa M Tussing-Humphreys, Sally Freels, Melinda R Stolley
PURPOSE: Little is known about the dietary behaviors of African-American breast cancer survivors (AABCS). We sought to describe dietary intake and quality in AABCS and examine associations with demographic, social, lifestyle, and body composition factors to potentially inform the development of effective dietary interventions. METHODS: Baseline data from a prospective weight loss trial of 210 AABCS were assessed. A food frequency questionnaire was used to evaluate dietary intake and diet quality via the Healthy Eating Index 2010 (HEI-2010) and Alternative Healthy Eating Index 2010 (AHEI-2010)...
February 18, 2019: Nutrition and Cancer
Yunok Oh, Kil-Bo Shim, Chang-Bum Ahn, Sam Sun Kim, Jae-Young Je
Recent evidence provides that seafood has a lot of health benefits due to its unique bioactive compounds. Sea squirt is widely cultured and consumed as a foodstuff in Korea; however, seldom reports with reference to bioactivities are available until now. In this study, edible part of sea squirt was hydrolyzed by pepsin and its hydrolysates was evaluated for anticancer effect on human colon cancer HT-29 cells. Sea squirt hydrolysates (SSQ) reduced HT-29 cell viability. Treatment with SSQ resulted in the increase in reactive oxygen species (ROS) generation followed by disruption of mitochondrial membrane potential (MMP)...
February 9, 2019: Nutrition and Cancer
Bartholomew P McKay, Annabel L Larder, Vincent Lam
Despite improvements in safety of hepatic resection post-operative complications occur in up to a half of patients. A systematic review was undertaken to compare the effect of pre-operative and peri-operative nutritional supplementation on post-operative outcomes in patients undergoing hepatic resection for malignancy. Included studies were identified through a search of PubMed (1966 to November 2016), Embase (1947 to November 2016) and the Cochrane Library (1993 to November 2016). Eleven studies involving a total of 725 patients were included in this systematic review...
February 9, 2019: Nutrition and Cancer
Sérgio Ricardo de Brito Bello, Katya Naliwaiko, Mariana Scudeller Vicentini, Francini Xavier Rossetti, Luiz Claudio Fernandes, Iara José de Messias-Reason
Capsaicin (trans-8-methyl-n-vanillyl-6-nonenamide) is the main pungent component found in hot peppers. AIM: In this study, we investigated the effect of capsaicin treatment on tumor growth and the metabolic indicators of cachexia in Walker 256 tumor-bearing rats. METHODS: Male Wistar rats were inoculated subcutaneously in the right flank with 1 ml of a sterile suspension of 3 × 107 Walker tumor cells. The treated groups received capsaicin intraperitoneal 5 mg/kg body weight for 13 days...
February 9, 2019: Nutrition and Cancer
Jeyan Arthur Moses, Sayantani Dutta, C Anandharamakrishnan
At present, cancer is one of the major diseases in the world affecting numerous lives. There have been various approaches to combat the disease, particularly involving chemical interventions (chemotherapy). However, owing to serious side effects of chemotherapy, employment of natural supplements in cancer therapy has been long desired. Nutraceuticals are currently being studied as a medicament, to act as both preventive and curative measure. Nutraceuticals provide both nutrition and therapeutic benefits; besides, they are natural and biocompatible, and therefore pose no side effects...
February 9, 2019: Nutrition and Cancer
Chunhua Song, Jingjing Cao, Feng Zhang, Chang Wang, Zengqing Guo, Yuan Lin, Yingying Shi, Wen Hu, Yi Ba, Hongxia Xu, Wei Li, Hanping Shi
Malnutrition is a problem affecting tumor patients greatly. This study aims to investigate whether demographic characteristics are related to the malnutrition of cancer patients. Twenty-three thousand nine hundred and four (23,904) patients with 16 common malignant tumors were enrolled in the study. Patient Generated Subjective Global Assessment (PG-SGA) was used as a screening tool to assess the nutritional risk of patients and analysis of variance was used to compare PG-SGA scores of patients. Correlations between PG-SGA scores and demographic characteristics were evaluated by correlation analysis...
February 9, 2019: Nutrition and Cancer
Julia Freckelton, Daniel Croagh, Darcy Quinn Holt, Adrian Fox, Rachel Wong, Margaret Lee, Gregory Thomas Moore
Combination gemcitabine and nab-paclitaxel (Gem-Nab-P) is a common regimen used to treat metastatic pancreatic ductal adenocarcinoma (PDAC). Toxicity from this regimen is associated with significant morbidity. Currently, Gem-Nab-P is dosed using estimated body surface area, derived from height and weight. This study investigates whether skeletal muscle assessment could be a useful tool in the dosing of Gem-Nab-P in metastatic PDAC. This study included 52 patients who had received first-line treatment with Gem-Nab-P for PDAC...
February 9, 2019: Nutrition and Cancer
Julia E Inglis, Po-Ju Lin, Sarah L Kerns, Ian R Kleckner, Amber S Kleckner, Daniel A Castillo, Karen M Mustian, Luke J Peppone
Cancer-related fatigue (CRF) is a debilitating syndrome that persists for many cancer survivors for years after treatment. Symptoms include early and persistent fatigue, functional decline, depression, and cognitive difficulties. Inflammation, assessed using pro-inflammatory biomarkers, is increased in cancer survivors with fatigue and treatments for fatigue are often aimed at reducing inflammation. Additionally, cancer and its treatment lead to nutritional complications, changes in body composition, and nutritional deficiencies that potentially weaken the cancer survivor and impact CRF...
January 26, 2019: Nutrition and Cancer
Tomofumi Miura, Yoshihisa Matsumoto, Takashi Kawaguchi, Yuto Masuda, Ayumi Okizaki, Hiroko Koga, Keita Tagami, Yuki Sumazaki Watanabe, Yuko Uehara, Takuhiro Yamaguchi, Tatsuya Morita
OBJECTIVES: Phase angle (PA) is a poor prognostic factor in patients with advanced cancer. This study aimed to identify possible correlations between PA and symptoms, quality of life, fluid retention, and laboratory data in cancer patients in palliative care settings. METHODS: Individuals who visited the outpatient clinic or were admitted to the palliative care unit were eligible. Patients with a performance status of 4 and/or those unable to complete questionnaires were excluded...
January 26, 2019: Nutrition and Cancer
Sheyda Ranjbar, Seyed Afshin Seyednejad, Haniye Azimi, Hossein Rezaeizadeh, Roja Rahimi
Breast cancer is the most common cancer among women. Need for novel preventive and curative approaches with more safety than the present one seems inevitable. This review is devoted to potentially favorable role of probiotics in prevention and treatment of breast cancer as well as their alleviating role regarding chemotherapy-induced side effects. Literature was searched for human, animal, and in vitro studies about the role of probiotics in breast cancer. In vitro studies showed that probiotic intervention induces cancer cells apoptosis and inhibits their proliferation...
January 26, 2019: Nutrition and Cancer
Takayuki Fujio, Kazuhisa Nakashima, Tateaki Naito, Haruki Kobayashi, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Toshiaki Takahashi
This study aimed to explore the tolerability and safety of platinum combination chemotherapy in malnourished patients with advanced non-small cell lung cancer (NSCLC) and poor performance status (PS). We retrospectively reviewed NSCLC patients with a PS of 2 who received first-line platinum combination chemotherapy at the Shizuoka Cancer Center between December 2009 and December 2014. Nutritional status was classified using the Glasgow Prognostic Score (GPS), which is an indicator of systemic inflammation and malnutrition...
January 26, 2019: Nutrition and Cancer
Bochao Zhao, Jingting Zhang, Jiale Zhang, Shihui Zou, Rui Luo, Huimian Xu, Baojun Huang
OBJECTIVE: In this study, we performed a systematic review and meta-analysis to evaluate the impact of preoperative underweight status on postoperative complications and survival outcome of gastric cancer (GC) patients. METHODS: The related studies were identified by searching PubMed and Embase databases. According to the body mass index (BMI), all patients were classified into underweight group (<18.5 kg/m2 ) and normal weight group (≥18.5 kg/m2 , <25 kg/m2 )...
January 26, 2019: Nutrition and Cancer
Anuradha Deorukhkar, Laxmi Ananthanarayan
Sample urban population was assessed for consumption of legumes. Genistein and daidzein content of commonly consumed legumes was evaluated to estimate the isoflavone intake through the consumption of these legumes by selected population. Total genistein content of all legumes considered for analysis was found to be in the range of 0.60 to 8.65 mg per 100 g whereas total daidzein content was found to be in the range of 1.10 to 30.37 mg per 100 g in selected legumes. Chickpea, kabuli, whole (Cicer arietinum), pigeon pea, split, decorticated (Cajanus cajan), chickpea, split, decorticated (Cicer arietinum) showed a high amount of genistein and daidzein among selected legumes...
January 26, 2019: Nutrition and Cancer
Agata M Gawel, Marlena Godlewska, Marta Grech-Baran, Anna Stachurska, Damian Gawel
Multidrug resistance is one of the key barriers suppressing the effectiveness of drug therapies of malignant tumors. Here, we report a study on the effect of a mix of natural extracts (MIX2) prepared from fresh fruits of Prunus spinosa, Crataegus monogyna, Sorbus aucuparia, and Euonymus europaeus on the classic hallmarks of cancer cells and the expression of multidrug resistance proteins. In the studies, HeLa and T98G cell lines, and classic methods of molecular biology, including RT-qPCR, Western blot, flow cytometry, and confocal imaging, were used...
January 24, 2019: Nutrition and Cancer
Xuexin Wang, Guoping Zhang, Chaohua Zhu, Lei Lin, Zhenshuan Zhao, Xiaoguang Yu, Guobin Liu, Haijing Zhang, Quanhai Li, Wei Dong, Jian Wang
OBJECTIVE: To investigate the protective effects and underlying mechanisms of Vitamin C (VC) on hydrocortisone (HC)-induced cell injury in human microvascular endothelial cells (HMEC). METHODS: Cell viability was measured by CCK-8 assay and the expression of Best-3 was detected by Western blotting assay. The experiment was divided into normal control, HC injury group, VC treatment groups, HC + Best-3 siRNA group, HC + VC + Best-3 siRNA group, HC + pcDNA3...
January 23, 2019: Nutrition and Cancer
Shivakumar Belur, Srikanth Barkeer, Bale M Swamy, Lu-Gang Yu, Shashikala R Inamdar
TF antigen binding lectins from dietary sources PNA, ACA, ABL, JAC, and SRL from Sclerotium rolfsii have been reported to induce diverse effects on cancer cell proliferation by different mechanisms. This study aimed to compare effects of these lectins on growth and cell cycle progression in colon cancer HT29 and SW620 cells. As reported SRL, ABL, and JAC inhibited while PNA and ACA increased cell proliferation. ABL and JAC treated HT29 cells showed increased cell population in G0/G1 phase. PNA, ACA, ABL, and JAC increased SW620 cell population in S and decreased in G2/M phase...
January 23, 2019: Nutrition and Cancer
Sílvia Fernandes Maurício, Simone de Vasconcelos Generoso, Érica Leandro Marciano Vieira, Jingjie Xiao, Carla M Prado, Maria Cristina Gonzalez, Maria Isabel Toulson Davisson Correia
Sarcopenia is a syndrome characterized by loss of muscle mass and strength that impacts clinical outcomes and mortality in cancer patients. Although the molecular pathways involved in sarcopenia are not fully elucidated, the decrease in protein synthesis rate appears to be one of the most important events. The objective of this study was to investigate the relationship between sarcopenia and mTOR signaling pathway in patients undergoing colorectal resection surgery. Three groups of patients were assessed: 1) the control group (no cancer, no sarcopenia), 2) the cancer non-sarcopenic group and 3) the cancer sarcopenic group...
January 20, 2019: Nutrition and Cancer
Nida Suhail, Nayeem Bilal, Shirin Hasan, Naheed Banu
The present study evaluates the topical application of aloe vera (Av) leaf gel as a protective natural product against 7,12-dimethylbenz(a)anthracene (DMBA)-induced skin lesions in Swiss albino mice and as an antioxidant for the systemic toxicity of DMBA in the presence and absence of chronic unpredictable stress (CUS). Animals were randomized into seven groups and sacrificed after 16 weeks of treatment. Av gel application along with DMBA + 12-O-tetradecanoylphorbol-13-acetate (TPA) was found to be effective in reducing tumor incidence, cumulative number of papillomas, tumor burden and tumor yield when compared to untreated groups...
January 20, 2019: Nutrition and Cancer
Qing-Qing Wang, Guo-Qi Zheng, Dong-Liang Yang, Yu-Fei Liang, Wen-Jie Yin, Shan-Shan Su
OBJECTIVE: To investigate the relationships between the Controlling Nutritional Status (CONUT) score and ascites fluid lactate dehydrogenase (LDH) level, and prognosis in patients with malignant peritoneal mesothelioma (MPeM). METHODS: A total of 125 patients with MPeM were selected for the study using a pathological screening method. Once the diagnosis is established, before the treatment their clinical characteristics and nutritional evaluations were recorded including CONUT score and ascites LDH level...
January 20, 2019: Nutrition and Cancer
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