journal
https://read.qxmd.com/read/38625618/changes-in-ocular-blood-flow-in-patients-with-neovascular-age-related-macular-degeneration-after-intravitreal-injection-of-ranibizumab-biosimilar-and-brolucizumab
#1
JOURNAL ARTICLE
Hiroki Takizawa, Masayuki Yasuda, Keisuke Hoshi, Tatsu Okabe, Hiroshi Kunikata, Toru Nakazawa
PURPOSE: To assess ocular blood flow (OBF) changes in patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal injections of ranibizumab biosimilar (IVRbs) or brolucizumab (IVBr). METHODS: This retrospective longitudinal study included 43 eyes of 43 patients (74.5 ± 9.8 years old, male to female ratio 31:12) with nAMD treated with IVBr (29 eyes) or IVRbs (14 eyes). OBF in the optic nerve head (ONH) and choroid (Ch) was measured with laser speckle flowgraphy (Softcare Co...
April 16, 2024: International Ophthalmology
https://read.qxmd.com/read/38625598/macular-hole-surgery-follow-up-with-spectral-domain-optical-coherence-tomography-guided-facedown-posturing
#2
JOURNAL ARTICLE
Zeynep Eylul Ercan, Sezin Akca Bayar, Rengin Aslihan Kurt, Imren Akkoyun, Gursel Yilmaz
PURPOSE: The main treatment for macular hole (MH) is pars plana vitrectomy, with or without internal limiting membrane (ILM) peeling, followed by gas tamponade and face-down positioning (FDP). This study aims to present the anatomical and visual outcomes following MH repair with optical coherence tomography (OCT)-guided FDP. METHODS: Thirty-two patients who underwent surgery for idiopathic MH were enrolled. The requirement for the prone position was lifted for those with MH closure observed under gas on postoperative day one OCT...
April 16, 2024: International Ophthalmology
https://read.qxmd.com/read/38625418/susceptibility-of-optic-nerve-head-in-children-with-posture-related-elevation-of-intraocular-pressure
#3
JOURNAL ARTICLE
Jan Niklas Lüke, Caroline Gietzelt, Philip Enders, Johanna Dietlein, Alexandra Lappa, Vincent Lüke, Randolf Alexander Widder, Thomas S Dietlein
BACKGROUND/AIMS: This work aimed to investigate changes in optic nerve head (ONH) morphometry based on Bruch membrane opening in children with extensive nocturnal intraocular pressure (IOP) elevations. METHODS: The course of Bruch membrane opening-based optic nerve head (ONH) morphometry was analysed in thirty-two patients younger than 18 years with evaluable SD-OCT examinations of the ONH and nocturnal posture-dependent IOP elevation above 25 mmHg. Longitudinal changes in neuroretinal rim tissue, as measured by Bruch Membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness, were assessed...
April 16, 2024: International Ophthalmology
https://read.qxmd.com/read/38622479/efficacy-of-tocilizumab-in-patients-with-moderate-to-severe-corticosteroid-resistant-thyroid-eye-disease-a-prospective-study
#4
JOURNAL ARTICLE
Chaeyeon Lee, Ji Woong Park, Yoon-Duck Kim, Kyung In Woo
PURPOSE: To evaluate the clinical outcomes of intravenous tocilizumab (TCZ) injection in patients with moderate-to-severe active thyroid eye disease (TED). METHODS: Patients with active and moderate-to-severe TED who did not respond to conventional therapies were treated with TCZ from June 2019 to January 2021. The medical records of the patients were evaluated before the treatment. We analyzed patient demographics, including the duration of Graves' disease and TED, and assessed subjective symptoms, such as diplopia and ocular movement, clinical activity score (CAS), modified NOSPECS score, and exophthalmos before treatment and at 4, 8, 12, and 16 weeks after the first drug injection...
April 16, 2024: International Ophthalmology
https://read.qxmd.com/read/38622472/comparison-of-macular-and-optic-disc-vessel-density-in-thyroid-orbitopathy-a-comparative-octa-study
#5
JOURNAL ARTICLE
Izlem Yildiz, Senay Asik Nacaroglu, Gamze Ozturk Karabulut, Korhan Fazil, Cigdem Altan
PURPOSE: To determine the microvascular and structural changes in the peripapillary and macular areas observed in patients with active thyroid orbitopathy(TO) before and after steroid treatment and compare with inactive TO and the control group by optical coherence tomography angiography (OCTA). MATERIAL AND METHOD: This cross-sectional study included 34 eyes of 17 active TO patients, 108 eyes of 54 inactive TO patients, and 60 eyes of 30 healthy controls. Central macular thickness (CMT), ganglion cell layer-inner plexiform layer (GCL-IPL) thickness, central choroidal thickness (CCT), retinal nerve fiber layer (RNFL) thickness, choroidal thickness in the peripapillary region, superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris vessel densities were determined by OCTA in before and after 12-week steroid treatment of active TO cases, inactive TO and control groups...
April 15, 2024: International Ophthalmology
https://read.qxmd.com/read/38622271/ocular-manifestations-of-liver-disease-an-important-diagnostic-aid
#6
REVIEW
Riya Patel, Smriti Nair, Hassaam Choudhry, Mustafa Jaffry, Mohammad Dastjerdi
PURPOSE: This review examined existing literature to determine various ocular manifestations of liver pathologies, with a focus on metabolic deficiencies as well as viral and immune liver conditions. METHODS: Recent data were compiled from PubMed from 2000 to 2020 using keywords that were relevant to the assessed pathologies. Ocular presentations of several liver pathologies were researched and then summarized in a comprehensive form. RESULTS: Several ocular manifestations of liver disease were related to vitamin A deficiency, as liver disease is associated with impaired vitamin A homeostasis...
April 15, 2024: International Ophthalmology
https://read.qxmd.com/read/38619629/identification-of-a-circulating-three-mirna-panel-for-the-diagnosis-of-primary-open-angle-glaucoma
#7
JOURNAL ARTICLE
Bo Qin, Li-Ping Li, Qing-Dan Xu, Yuan Lei, Yu-Hong Chen
PURPOSE: Conventional diagnosis of primary open angle glaucoma (POAG) needs a combination of ophthalmic examinations. An efficient assay is urgently needed for a timely POAG diagnosis. We aim to explore differential expressions of circulating microRNAs (miRNA) and provide novel miRNA biomarkers for POAG diagnosis. METHODS: A total of 180 POAG patients and 210 age-related cataract (ARC) patients were enrolled. We collected aqueous humor (AH) and plasma samples from the recruited patients...
April 15, 2024: International Ophthalmology
https://read.qxmd.com/read/38615085/efficacy-of%C3%A2-hydroxypropyl-guar-drops%C3%A2-in-improving-tear-film-index-and-ocular-surface-dynamics%C3%A2-using-two-treatment-methods-under-a-controlled-desiccating-environment
#8
JOURNAL ARTICLE
Ali Abusharha, E Ian Pearce, Ali Alsaqar, Raied Fagehi, Tayyaba Afsar, Suhail Razak
AIM: This study aimed to assess the efficacy of hp-guar eye drops on tear film index and ocular surface dynamics under desiccating conditions using protection and relief treatment modalities. METHODOLOGY: The 12 normal, non-dry eye participants were subjected to adverse environmental conditions using a Controlled Environment Chamber (CEC) where the relative humidity (RH) was 5% and the ambient temperature was 21 °C. The participants were screened for ocular symptoms, tear osmolarity, ocular surface temperature (OST), tear production using the Ocular Surface Disease Index questionnaire (OSDI), OcuSense TearLab Osmometer, FLIR System ThermaCAM P620, and Schirmer strips...
April 14, 2024: International Ophthalmology
https://read.qxmd.com/read/38613630/diagnosis-of-retinal-damage-using-resnet-rescaling-and-support-vector-machine-resnet-rs-svm-a-case-study-from-an-indian-hospital
#9
JOURNAL ARTICLE
Santi Kumari Behera, Rina Mahakud, Millee Panigrahi, Prabira Kumar Sethy, Rasmikanta Pati
PURPOSE: This study aims to address the challenge of identifying retinal damage in medical applications through a computer-aided diagnosis (CAD) approach. Data was collected from four prominent eye hospitals in India for analysis and model development. METHODS: Data was collected from Silchar Medical College and Hospital (SMCH), Aravind Eye Hospital (Tamil Nadu), LV Prasad Eye Hospital (Hyderabad), and Medanta (Gurugram). A modified version of the ResNet-101 architecture, named ResNet-RS, was utilized for retinal damage identification...
April 13, 2024: International Ophthalmology
https://read.qxmd.com/read/38598101/axonal-protection-by-combination-of-ripasudil-and-brimonidine-with-upregulation-of-p-ampk-in-tnf-induced-optic-nerve-degeneration
#10
JOURNAL ARTICLE
Mizuki Otsubo, Kana Sase, Chihiro Tsukahara, Naoki Fujita, Ibuki Arizono, Naoto Tokuda, Yasushi Kitaoka
PURPOSE: The ROCK inhibitor ripasudil hydrochloride hydrate was shown to have axonal protective effects in TNF-induced optic nerve degeneration. The α2-adrenoreceptor agonist brimonidine was also shown to exert axonal protection. The current study aimed to elucidate whether additive axonal protection was achieved by the simultaneous injection of ripasudil and brimonidine and examine the association with AMPK activation. METHODS: Intravitreal administration was performed in the following groups: PBS, TNF, or TNF with ripasudil, with brimonidine, or with a combination of ripasudil and brimonidine...
April 10, 2024: International Ophthalmology
https://read.qxmd.com/read/38594548/higher-order-aberrations-in-keratoconus%C3%A2
#11
REVIEW
Nir Erdinest, Naomi London, David Landau, Ramez Barbara, Adel Barbara, Shehzad A Naroo
INTRODUCTION: Keratoconus is a progressive disorder of the cornea that causes thinning (Sedaghat et al. in Sci Rep 11(1):11971, 2021), ectasia, and irregular astigmatism, resulting in poor visual acuity that cannot be corrected with standard sphero-cylindrical spectacle lenses. One feature distinguishing keratoconic corneas is ocular aberrations, manifesting up to five or six times the amount of higher-order aberrations than a normal, healthy eye. These aberrations can cause visual disturbances even at the very early stages of the disease...
April 10, 2024: International Ophthalmology
https://read.qxmd.com/read/38587686/dynamic-viscosity-of-the-wall-of-the-lacrimal-sac-in-disorders-of-the-patency-of-the-lacrimal-ducts
#12
JOURNAL ARTICLE
V D Yartsev, I A Novikov, E L Atkova, M A Ekaterinchev
PURPOSE: To assess the dynamic viscosity of the lacrimal sac wall in patients with various origins of lacrimal duct obstruction. METHODS: The study was performed in 35 cases: 21 cases with primary nasolacrimal duct obstruction (PANDO) and 14 cases with secondary nasolacrimal duct obstruction after radioiodine therapy (SALDO). The study of biomechanical properties of the lacrimal sac was carried out using a test bench. The principle of the study was to indent the sample at a given speed and record the data obtained from the sensor of the force transmitted to the sample...
April 8, 2024: International Ophthalmology
https://read.qxmd.com/read/38587685/the-association-in-diabetic-retinopathy-and-stroke-finding-from-nhanes-evidence
#13
JOURNAL ARTICLE
Jing Tang, Ping Huang
PURPOSE: Diabetic retinopathy and stroke are both vascular pathologies, and this study intends to investigate the relationship between diabetic retinopathy and stroke. METHODS: The NHANES database was used to find the relationship between diabetic retinopathy and stroke with 1948 individuals aged 40 years or older. The sensitivity of the data was verified by multiple interpolation, further analysis was done by subgroup analyses, and possible links were investigated with mediation studies...
April 8, 2024: International Ophthalmology
https://read.qxmd.com/read/38587565/corneal-endothelial-changes-seven-years-after-phacoemulsification-cataract-surgery
#14
JOURNAL ARTICLE
Björn Lundberg
PURPOSE: To evaluate long-term postoperative corneal changes after phacoemulsification cataract surgery. METHODS: Twenty patients who participated in a previous study regarding corneal endothelial changes after phacoemulsification cataract surgery were examined after 7 years. The patients were divided in three groups based on their initial increase in central corneal thickness day one after the surgery: < 5% increase, 6-20% increase and ≥ 20% increase...
April 8, 2024: International Ophthalmology
https://read.qxmd.com/read/38573375/the-protective-effect-of-vitamin-a-palmitate-eye-gel-on-the-ocular-surface-during-general-anaesthesia-surgery-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Siyuan Li, Guiyu Lei, Ying Liu, Lei Tian, Ying Jie, Guyan Wang
PURPOSE: To investigate the change in tear production associated with general anesthesia and the protective effect of vitamin A palmitate eye gel on the ocular surface during general anesthesia. METHODS: This double-blind, randomized clinical trial included patients undergoing non-ophthalmic surgery under general anesthesia who randomly received vitamin A palmitate eye gel and taping for one eye (Group A, n = 60) or taping alone for the other eye (Group B, n = 60)...
April 4, 2024: International Ophthalmology
https://read.qxmd.com/read/38565753/impact-of-duration-of-silicone-oil-tamponade-on-foveal-and-parafoveal-thickness-in-rhegmatogenous-retinal-detachment-a-retrospective-cohort-study
#16
JOURNAL ARTICLE
Wael Ahmed Ewais, Lamia Samy Ali, Fayrouz M Aboalazayem
PURPOSE: To detect and analyze the influence of the duration of tamponade with silicone oil on the foveal and parafoveal thickness in cases of rhegmatogenous retinal detachment. METHODS: This is a retrospective cohort study of 64 eyes with rhegmatogenous retinal detachment in one eye who underwent pars plana vitrectomy (PPV) with silicone oil injection during the period between January 2019 and December 2021. The patients were divided into 2 groups. Group A with early removal of the silicone oil after 3-4 months and Group B with late removal of the silicone oil (SOR) after 6-8 months...
April 2, 2024: International Ophthalmology
https://read.qxmd.com/read/38557801/management-after-cataract-surgery-for-patients-with-diabetic-retinopathy-a-systematic-review-and-meta-analysis
#17
REVIEW
Jiahui Wu, Yongwei Zhou, Fangyuan Zhen, Shasha Wang, Qiuming Li, Shuqian Dong
PURPOSE: To evaluate the safety and effectiveness of various treatment modalities in patients with diabetic retinopathy (DR) who underwent cataract surgery. METHODS: A comprehensive search for randomized controlled trials (RCTs) was conducted using the PubMed, Embase, Cochrane Library, and CNKI databases up to December 22, 2021. The safety and efficacy of treatment modalities were assessed using the risk ratio (RR) to compare the progression of DR and the mean difference to evaluate the best corrected visual acuity (BCVA) and macular thickness (MT)...
April 1, 2024: International Ophthalmology
https://read.qxmd.com/read/38554176/dancing-in-the-eye-dynamic-optical-coherence-tomography-to-distinguish-different-retinal-microglia-populations
#18
EDITORIAL
Francesco Pichi, Piergiorgio Neri, Laura Moreno-Rodriguez, Ester Carreño
No abstract text is available yet for this article.
March 30, 2024: International Ophthalmology
https://read.qxmd.com/read/38551696/pro-re-nata-anti-vegf-treatment-in-pachychoroid-neovasculopathy-compared-with-age-related-macular-degeneration-based-on-optical-coherence-tomography
#19
JOURNAL ARTICLE
Güner Üney, Dicle Hazırolan, Nurten Ünlü, Özlem Candan
PURPOSE: To compare anti-vascular endothelial growth factor (anti-VEGF) treatment in pachychoroid neovasculopathy (PNV) and age related macular degeneration (AMD). METHODS: Cases having pro re nata (PRN) anti-VEGF treatment for choroidal neovascularization were reviewed and grouped as PNV and AMD. Groups were compared according to central foveal thickness (CFT), best corrected visual acuity (BCVA), and total injection over 12 months. The correlation of beginning choroidal thickness, CFT, and BCVA with final BCVA was analyzed...
March 29, 2024: International Ophthalmology
https://read.qxmd.com/read/38551693/is-there-a-relationship-between-the-severity-of-disease-in-major-depressive-disorder-patients-and-dry-eye-disease
#20
JOURNAL ARTICLE
Gizem Doğan Gökçe, Merve Metin
PURPOSE: To investigate dry eye disease (DED) in newly diagnosed patients with depressive disorder (MDD). METHOD: This observational study included 48 MDD patients in Group 1 and 20 healthy controls in Group 2. Psychiatric and ophthalmic examinations, Beck Depression Inventory (BDI), Ocular Surface Disease Index (OSDI), Schirmer's test, tear breakup time (TBUT), Meibomian gland dysfunction (MGD), and ocular staining were conducted. The results were statistically compared...
March 29, 2024: International Ophthalmology
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