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International Ophthalmology

Andrea Passani, Angela Tindara Sframeli, Chiara Posarelli, Domenico Lisi, Gianluca Guidi, Giamberto Casini, Antonio Ferreras, Michele Figus
PURPOSE: The aim of this study is to investigate potential correlations between age, gender, spherical equivalent and optical coherence tomography (OCT) retinal parameters among healthy children. METHODS: A macular spectral-domain OCT was performed in all patients using a Spectralis® OCT device, and the macular thickness and volume of each of the early treatment diabetic retinopathy study (ETDRS) subfields were analysed. RESULTS: Ninety-four children were enrolled...
February 19, 2019: International Ophthalmology
Cristina Calvo-Gonzalez, Juan Reche-Frutos, José Ignacio Fernández-Vigo, Juan Donate-López, Irene Serrano-García, Cristina Fernández-Pérez
PURPOSE: To describe indocyanine green angiography (ICGA) and visual acuity (VA) results in patients with neovascular age-related macular degeneration (nAMD) refractory to ranibizumab switched to aflibercept. METHODS: This study is a prospective interventional case series. Thirty-two eyes of 32 patients with nAMD showing a poor response after at least 24 months of ranibizumab were switched to aflibercept. Twenty eyes had type I choroidal neovascularization (CNV group), and 12 eyes had polypoidal choroidal vasculopathy (PCV group)...
February 14, 2019: International Ophthalmology
Thiago Gonçalves Dos Santos Martins, Ana Luiza Fontes de Azevedo Costa, Karina Mie Furuzawa, Roger Chammas, Milton Ruiz Alves
PURPOSE: To evaluate the influence of preoperative mitomycin C (MMC) on the proliferative behavior of fibroblasts and fibrovascular tissue derived from the primary pterygium using the immunohistochemical method (Ki67 and CD34). DESIGN: Randomized clinical trial. SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Sixty-five patients with primary pterygium were randomly selected and divided into one of three groups. The control group had 29 patients that were only submitted to pterygium removal...
February 13, 2019: International Ophthalmology
Homa Hassankarimi, Seyed Mohammad Reza Noori, Ebrahim Jafarzadehpour, Shahin Yazdani, Fatemeh Radinmehr
PURPOSE: To evaluate discrete wavelet transform coefficients and identify descriptors of pattern electroretinogram (PERG) waveforms in order to determine PERG characteristics for optimizing the diagnosis of early primary open-angle glaucoma (POAG). METHODS: Pattern electroretinogram was performed in 30 normal eyes and 30 eyes with primary open-angle glaucoma according to the ISCEV protocol. The check size was 0.8° and 16°, and the color was black/white in both groups...
February 6, 2019: International Ophthalmology
Sinan Emre, Suzan Güven-Yılmaz, Mahmut Oğuz Ulusoy, Halil Ateş
PURPOSE: Retinal vasculitis and vein occlusions are common causes of serious visual loss in Behçet's disease. We aimed to evaluate the optical coherence tomography angiography (OCTA) findings of Behcet uveitis (BU) patients. METHODS: We evaluated 32 eyes of 16 patients with BU and 30 eyes of 15 healthy controls. Superficial capillary plexus (SCP) and deeper capillary plexuses (DCP) were evaluated using OCTA RTVue XR AVANTI. RESULTS: On SCP, nonperfusion/hypoperfusion areas (NPA) were seen in 10 eyes, perifoveal capillary arcade disruption (PCAD) was seen in 10 eyes, capillary network disorganization (CND) was seen in 7 eyes and intraretinal cystoid spaces (ICS) were seen in 2 eyes...
February 1, 2019: International Ophthalmology
S N Onwubiko, N N Udeh, O Nkwegu, D O Ukwu, N Z Nwachukwu
PURPOSE: To investigate the current practice on glaucoma care with the aim of highlighting its poise to tackle this emerging sight-threatening disease in Nigeria. METHODS: This was a cross-sectional, descriptive, population-based survey involving 88 ophthalmologists. Information on their demographic characteristics, practice profile, challenges and prospects on glaucoma care was collected using a semi-structured, self-administered questionnaire in August 2016. Data were analysed using SPSS 20...
February 1, 2019: International Ophthalmology
Gilad Allon, Yinon Shapira, Itzchak Beiran, Eytan Z Blumenthal
PURPOSE: To describe a new technique for sealing small corneal perforations after penetrating trauma. METHODS: Corneal perforations in six eyes were sealed using a stromal cefuroxime hydration technique. This technique is identical to the current method used to seal leaking incisions upon completion of cataract surgery except for the use of cefuroxime instead of balanced salt solution. Additionally, cefuroxime was intentionally injected into the anterior chamber...
February 1, 2019: International Ophthalmology
Chengguo Zuo, Shufen Lin, Keling Wu, Ruowen Gong, Yafen Liu, Mingkai Lin, Jian Ge
PURPOSE: To investigate the predictors of long-term intraocular pressure (IOP) in chronic primary angle-closure glaucoma (CPACG) treated with primary trabeculectomy. METHODS: This study systematically reviewed cases of CPACG treated with primary trabeculectomy. The scleral flaps in all cases were sutured with two stitches in situ and two releasable sutures to ensure watertight under normal IOP conditions during surgery. Mitomycin C was used in all eyes. All patients were followed for 2 years...
January 24, 2019: International Ophthalmology
Renato Menezes Palácios, Andre Maia, Michel Eid Farah, Mauricio Maia
PURPOSES: To compare surgeons' opinions regarding idiopathic full-thickness macular hole (MH) surgery by using traditional microscopy and three-dimensional (3-D) visualization system. To analyze the required time for pars plana vitrectomy (PPV) and for internal limiting membrane (ILM) rhexis by using both visualization methods. To evaluate anatomical surgical results. METHODS: Four surgeons (surgeon 1, fellows 1, 2, 3) performed the total of 40 surgeries for treating MHs...
January 23, 2019: International Ophthalmology
Ivo Guber, Ciara Bergin, Shruti Malde, Josef Guber, Samer Hamada, Damian Lake
BACKGROUND: To investigate response of dissolving collagen contact lenses as an alternative for bandage contact lenses, for the post-interventional care of epithelial defects after corneal cross-linking (CXL) treatment for keratoconus. PATIENTS AND METHODS: Follow-up visits were performed at day 1, 4 and 1 month after the intervention. We reviewed notes for re-epithelialization, comfort/pain and any untoward effects of Collagen SOFT SHIELD® . Assessment included visual acuity (VA), refraction (SE); corneal haze, epithelial erosion and pain status were assessed subjectively on a 4-point scale, from 0 (none) to 3 (severe)...
January 18, 2019: International Ophthalmology
Reza Ghaffari, Hamed Ghassemi, Golshan Latifi, Mahmood Jabbarvand, Alireza Zamzam, Hassan Hashemi
PURPOSE: The purpose of this article was to introduce a novel surgical technique for the management of peripheral Descemet's membrane perforation during deep anterior lamellar keratoplasty (DALK). METHODS: First, a thin stromal patch was prepared either from the anterior stromal lamella cut during DALK or from the anterior stroma of a Descemet's stripping automated endothelial keratoplasty button. The stromal patch was secured in a stromal pocket dissected deep in the trephination edge along the perforation site...
January 17, 2019: International Ophthalmology
Ali Mostafaei, Nazli Taheri, Morteza Ghojazadeh, Atena Latifi, Neda Moghaddam
PURPOSE: Comparison of the effect of mitomycin C (MMC) versus bevacizumab-methylcellulose mixture (BMM) on combined phacoemulsification and non-penetrating deep sclerectomy surgery on the intraocular pressure in patients with open-angle glaucoma was made. METHODS: The current study is a controlled, randomized, double-blind clinical trial. Thirty-eight patients were enrolled, with a total of 40 eyes, and underwent a combined phacoemulsification and non-penetrating deep sclerectomy surgery from 2016 to 2017...
January 17, 2019: International Ophthalmology
Jaime D Martinez, Anat Galor, Guillermo Amescua, Nallely Ramos-Betancourt, Francisco Beltrán, Alejandro Babayán Sosa, Concepción Santacruz Valdés, Cecilia Ramírez-Assad, Elsa Mora Juárez, Everardo Hernández-Quintela
PURPOSE: To translate and validate a Spanish-language adaptation of the 5-Item Dry Eye Questionnaire for the Mexican population. METHODS: Based on the MAPI Institute guidelines, the linguistic validation procedures consisted of four steps. Every step was reviewed by the committee. The translated validated questionnaire was applied to 25 Mexican subjects. The questionnaires were completed by the same subjects at three time points, 8 h apart on the same day and then 3 days later...
January 14, 2019: International Ophthalmology
Xue Wang, Zhi-Lan Yuan
OBJECTIVE: The objective of this work was to find out the effects of nuclear factor erythroid 2-related factor/heme oxygenase-1 (Nrf2/HO-1) pathway on retinal ganglion cell (RGC) injury in glaucoma. METHODS: The chronic ocular hypertension (COH) rat models of glaucoma were constructed, and intraocular pressure (IOP) and RGC numbers were detected at different time points. Additionally, rats were divided into normal group (normal control rats), model group (COH model rats), and model + tBHQ group (COH model rats treated with Nrf activator, tBHQ)...
January 12, 2019: International Ophthalmology
Ankita, Jana Stefanickova, Sandeep Saxena, Dwividendra K Nim, Kaleem Ahmad, Abbas A Mahdi, Apjit Kaur, Shashi K Bhasker, Jela Valaskova, Peter Kruzliak
PURPOSE: To study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR). METHODS: This is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included...
January 9, 2019: International Ophthalmology
Ayhan Saglik, Ismail Koyuncu, Ataman Gonel, Hamza Yalcin, Fatih Mehmet Adibelli, Muslum Toptan
PURPOSE: The aim of the study was to measure amino acid levels with the metabolomics analysis in pterygium tissue and normal conjunctiva tissue. MATERIALS AND METHODS: In this prospective, randomized, clinical study, a comparison of the amino acid profile of pterygium tissue and normal conjunctiva tissue taken during autograft pterygium surgery was made. After homogenization of the tissues, amino acid levels were measured with chromatography-mass spectrometry (LC-MS/MS) in the biochemistry laboratory...
January 8, 2019: International Ophthalmology
Annekatrin Rickmann, Silke Wahl, Alisa Katsen-Globa, Peter Szurman
PURPOSE: The aim of this study was to investigate the clinical outcome after standardized DMEK using a glass injector. METHODS: A total of 254 patients undergoing DMEK surgery using a disposable DMEK borosilicate glass cartridge system were included in this retrospective study. The mean follow-up time was 13.2 months (SD ± 8.1, range 6-36 months). The used glass cartridge system has an aperture diameter of 1.6 mm and a posterior loading orifice of 4.29 mm...
January 4, 2019: International Ophthalmology
Yan-Ni Zhu, Guo-Jin Zuo, Qi Wang, Xiao-Ming Chen, Jin-Kui Cheng, Shu Zhang
OBJECTIVE: To understand the involvement of the mGluR5-mediated JNK signaling pathway in rats with diabetic retinopathy (DR). METHODS: This study established rat models of diabetes mellitus (DM), which were divided into Normal, DM, DM + CHPG (mGluR5 agonist CHPG), and DM + MTEP (mGluR5 antagonist MTEP) groups. The blood glucose and weight of rats were recorded. EB staining was used for observation of blood-retinal barrier (BRB) damage. Neural retina function was measured by pattern electroretinogram (ERG)...
January 3, 2019: International Ophthalmology
Xiao-Wei Gao, Xiao-Min Zhang, Hai-Yan Liu, Shan-Shan Wang, Hua-Jiang Dong
PURPOSE: The mechanisms of naso-ocular interaction in allergic rhinoconjunctivitis are not well understood. Neurogenic inflammation affects both eyes and nose via the same neurogenic factors. The purpose of this study was to investigate the effects of neurogenic inflammation on conjunctival inflammation following nasal allergen provocation. METHODS: Sensitized rats were exposed to ovalbumin (OVA) via the nose. Parts of the nasal mucosa and conjunctivae were sliced and used for hematoxylin-eosin staining, immunohistochemical analysis, western blotting, and real-time polymerase chain reaction...
January 3, 2019: International Ophthalmology
Berna Dogan, Muhammet Kazim Erol, Melih Akidan, Elcin Suren, Yusuf Akar
PURPOSE: To evaluate the retinal and choroidal vascular changes through optical coherence tomography angiography (OCTA) in patients with macular telangiectasia type 2 (MacTel 2). METHODS: Our study included 20 patients (40 eyes) with MacTel 2, and age-matched and sex-matched 18 subjects (36 eyes) in the control group. Fundus color photographs, fundus autofluorescence, fundus fluorescein angiography, spectral-domain optical coherence tomography and OCTA were performed...
January 3, 2019: International Ophthalmology
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