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Clinical Cardiology

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https://read.qxmd.com/read/31099039/dysbiotic-gut-microbes-may-contribute-to-hypertension-by-limiting-vitamin-d-production
#1
Kun Zuo, Jing Li, Qiuhua Xu, Chaowei Hu, Yuanfeng Gao, Mulei Chen, Roumu Hu, Ye Liu, Hongjie Chi, Qing Yin, Yudan Cao, Pan Wang, Yanwen Qin, Xiaoyan Liu, Jiuchang Zhong, Jun Cai, Kuibao Li, Xinchun Yang
BACKGROUND: Accumulating studies have suggested that gut microbiota (GM) dysbiosis and vitamin D3 deficiency each play an important role during the progression of hypertension (HTN). However, few studies have characterized the underlying interaction between gut microbiota shift and vitamin D3 deficiency in HTN patients. HYPOTHESIS: This study aimed to evaluate the possible crosstalk between GM dysbiosis and vitamin D deficiency in the pathogenesis of HTN METHODS: In a cohort of 34 HTN patients and 15 healthy controls, we analyzed the fecal microbiota products, GM composition, and the interaction between GM and vitamin D3...
May 17, 2019: Clinical Cardiology
https://read.qxmd.com/read/31073996/the-non-genetic-paternal-factors-for-congenital-heart-defects-a-systematic-review-and-meta-analysis
#2
Jiayu Peng, Zhuo Meng, Shuang Zhou, Yue Zhou, Yujian Wu, Qingjie Wang, Jian Wang, Kun Sun
BACKGROUND: Advances have been made in identifying genetic etiologies and maternal risk factors of congenital heart defects (CHDs), while few literatures are available regarding paternal risk factors for CHDs. Thus, we aim to conduct a meta-analysis and systematic review about the non-genetic paternal risk factors for CHDs. METHODS: We searched the PubMed, MEDLINE, and Cochrane Library online databases and identified 31 studies published between 1990 and 2018 according to the inclusion criteria...
May 10, 2019: Clinical Cardiology
https://read.qxmd.com/read/31056764/the-clinical-outcomes-of-patients-who-developed-typical-atrial-flutter-on-class-1c-anti-arrhythmic-medications-treated-with-hybrid-approach
#3
Lior Grossman, Moshe Katz, Roy Beinart, Eyal Nof
INTRODUCTION: A common approach to patients, who developed atrial flutter secondary to treatment with class Ic anti-arrhythmic drugs for atrial fibrillation (AF) (Ic flutter), is a hybrid approach: ablation of the Cavo-Tricuspid isthmus (CTI) and continuation Ic medical treatment to prevent recurrence of AF. We aim to explore the clinical outcome of patients treated in this approach. METHODS AND RESULTS: Two hundred and four consecutive patients who underwent ablation for typical AFL at a tertiary medical center between 2010 and 2016 were enrolled and followed up...
May 6, 2019: Clinical Cardiology
https://read.qxmd.com/read/31056759/association-left-ventricular-lead-and-ventricular-arrhythmias-after-upgrade-to-cardiac-resynchronization-therapy-in-patients-with-implantable-cardioverter-defibrillators
#4
Mitsuharu Kawamura, Shuhei Arai, Kosuke Yoshikawa, Toshihiko Gokan, Ko Ogawa, Akinori Ochi, Yoshimi Onishi, Yumi Munetsugu, Hiroyuki Ito, Tatsuya Onuki, Youichi Kobayashi, Toshiro Shinke
BACKGROUND: There are some controversial reports related to the pro-arrhythmic or anti-arrhythmic potential of cardiac resynchronization therapy (CRT) and little is known about the relationship between ventricular arrhythmia (VA) and left ventricular (LV)-lead threshold. HYPOTHESIS: Upgrade CRT is anti-arrhythmic effect of VA with implantable cardioverter-defibrillator (ICD) patients and has a relationship the incident of VA and LV-lead threshold. METHODS: Among 384 patients with the implantation of CRT-defibrillator (CRT-D), 102 patients underwent an upgrade from ICD to CRT-D...
May 5, 2019: Clinical Cardiology
https://read.qxmd.com/read/31039274/cardiac-prostheses-related-hemolytic-anemia
#5
REVIEW
Mohamad Alkhouli, Ali Farooq, Ronald Go, Sudarshan Balla, Chalak Berzingi
Hemolysis is an unintended sequel of temporary or permanent intracardiac devices. However, limited data exist on the characteristics and treatment of hemolysis in patients with cardiac prostheses. This entity, albeit uncommon, often poses significant diagnostic and management challenges to the clinical cardiologist. In this manuscript, we aim to provide a contemporary overview of the incidence, mechanisms, diagnosis and management of cardiac prosthesis related hemolysis. This article is protected by copyright...
April 30, 2019: Clinical Cardiology
https://read.qxmd.com/read/31038759/the-cardiac-autonomic-nervous-system-a-target-for-modulation-of-atrial-fibrillation
#6
REVIEW
Mu Qin, Cong Zeng, Xu Liu
The cardiac autonomic nerve system (CANS) is a potentially potent modulator of the initiation and perpetuation of atrial fibrillation (AF). In this review, we focus on the relationship between the ANS and the pathophysiology of AF and the potential benefit and limitations of neuromodulation in the management of this arrhythmia from eight aspects. We conclude that Activation and Remodeling of CANS involved in the initiation and maintenance of AF. The network control mechanism, innervation regions and sympathetic/parasympathetic balance play an important role in AF substrate...
April 30, 2019: Clinical Cardiology
https://read.qxmd.com/read/31020672/association-of-crp-and-vitamin-d-deficiency-with-cardiovascular-disease-a-nationwide-cross-sectional-study-from-nhanes-2007-2008
#7
Qian Li, Zhenguo Dai, Yuze Cao, Lihua Wang
OBJECTIVES: The association of C-reactive protein (CRP) and serum 25-hydroxyvitamin D [25(OH)D] and cardiovascular disease (CVD) remains unknown. METHODS: We performed a cross-sectional analysis on 3,848 participants by using the data from the National Health and Nutrition Examination Surveys (2007-2008). CVD was defined as a compromise of stroke, myocardial infarction, heart failure and coronary heart disease. High CRP was defined as ≥0.2 mg/dL, and vitamin D status were categorized as severe deficiency, <25 nmol/mL; deficiency, 25-49...
April 24, 2019: Clinical Cardiology
https://read.qxmd.com/read/31020665/ankle-brachial-index-arterial-stiffness-and-biomarkers-in-the-prediction-of-mortality-and-outcomes-in-patients-with-end-stage-kidney-disease
#8
Kenichiro Otsuka, Koki Nakanishi, Kenei Shimada, Haruo Nakamura, Hitoshi Inanami, Hiroki Nishioka, Kohei Fujimoto, Noriaki Kasayuki, Minoru Yoshiyama
BACKGROUND: Although ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) are significant predictors of major adverse cardiovascular event (MACE), their prognostic value in association with biomarkers has not been fully evaluated in patients with end-stage kidney disease (ESKD). HYPOTHESIS: We hypothesized that ABI/baPWV would provide better prognostic value independent of biomarkers in ESKD patients. METHODS: This study included 104 ESKD patients treated with maintenance hemodialysis who underwent ABI and baPWV examinations and laboratory tests, including brain-natriuretic peptide, high-sensitive cardiac troponin T (hs-cTnT), and high-sensitive C-reactive protein (hs-CRP)...
April 24, 2019: Clinical Cardiology
https://read.qxmd.com/read/31017303/depressive-symptoms-in-asymptomatic-stage-b-heart-failure-with-type-ii-diabetic-mellitus
#9
Paul J Mills, Pam R Taub, Ottar Lunde, Meredith A Pung, Kathleen Wilson, Christopher Pruitt, Thomas Rutledge, Alan Maisel, Barry H Greenberg
BACKGROUND: The presence of concomitant Type II diabetic mellitus (T2DM) and depressive symptoms adversely affects individuals with symptomatic heart failure (HF). Hypothesis In presymptomatic Stage B HF, this study hypothesized the presence of greater inflammation and depressive symptoms in T2DM as compared to non-T2DM Stage B patients. METHODS: This cross-sectional study examined clinical parameters, inflammatory biomarkers, and depressive symptoms in 349 T2DM and non-T2DM men with asymptomatic stage B HF (mean age 66...
April 24, 2019: Clinical Cardiology
https://read.qxmd.com/read/31017298/unmet-medical-needs-in-intermittent-claudicantion-with-diabetes-and-coronary-artery-disease-a-real-world-analysis-on-21-197-pad-patients
#10
Philipp Stalling, Christiane Engelbertz, Florian Lüders, Matthias Meyborg, Katrin Gebauer, Johannes Waltenberger, Holger Reinecke, Eva Freisinger
BACKGROUND: Peripheral artery disease (PAD) is frequently co-prevalent with coronary artery disease (CAD) and diabetes (DM). The study aims to define the burden of CAD and/ or DM in PAD patients at moderate stages and further to evaluate its impact on therapy and outcome. METHODS: Study is based on health insurance claims data of the BARMER reflecting an unselected "real-world" scenario. Retrospective analyses were based on 21,197 patients hospitalized for PAD Rutherford 1-3 between Jan 1st, 2009 - Dec 31st, 2011, including a 4-year follow-up (median 775 days)...
April 24, 2019: Clinical Cardiology
https://read.qxmd.com/read/30993750/eicosapentaenoic-acid-therapy-is-associated-with-decreased-coronary-plaque-instability-assessed-using-optical-frequency-domain-imaging
#11
Takao Konishi, Daisuke Sunaga, Naohiro Funayama, Tadashi Yamamoto, Hironori Murakami, Daisuke Hotta, Masanori Nojima, Shinya Tanaka
BACKGROUND: The relationship between eicosapentaenoic acid (EPA) therapy and coronary plaque stability assessed by optical frequency domain imaging (OFDI) has not been thoroughly described. HYPOTHESIS: EPA therapy is associated with decreased plaque instability in patients undergoing percutaneous coronary intervention (PCI) using OFDI. METHODS: Data on coronary artery plaques from 121 patients who consecutively underwent PCI between October 2015 and July 2018 were retrospectively analyzed...
April 17, 2019: Clinical Cardiology
https://read.qxmd.com/read/30989700/long-term-outcomes-in-japanese-nonagenarians-undergoing-transcatheter-aortic-valve-implantation-a-multi-center-analysis
#12
Hiroaki Yokoyama, Tetsuya Tobaru, Yuki Muto, Kenichi Hagiya, Ryosuke Higuchi, Mike Saji, Itaru Takamisawa, Jun Shimizu, Shuichiro Takanashi, Morimasa Takayama, Hirofumi Tomita, Harutoshi Tamura, Shinichiro Doi, Shinya Okazaki, Mitsuaki Isobe
BACKGROUND: Japan is an aging society and the number of nonagenarians with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) is increasing, but their outcomes have not been determined fully. METHODS: We prospectively enrolled 767 consecutive patients who underwent TAVI in three Japanese institutions. Clinical characteristics and outcomes of nonagenarians (n=94) were evaluated and compared with those of patients aged <90 years (n=673)...
April 16, 2019: Clinical Cardiology
https://read.qxmd.com/read/30989668/successful-defibrillation-verification-in-subcutaneous-implantable-cardioverter-defibrillator-recipients-by-low-energy-shocks
#13
Mauro Biffi, Matteo Ziacchi, Andrea Angeletti, Andrea Castelli, Giulia Massaro, Cristian Martignani, Mariolina Lovecchio, Sergio Valsecchi, Igor Diemberger
BACKGROUND: The S-ICD is an effective alternative to the transvenous one. Defibrillation efficacy depends on maximum device output and on the optimal device location at device implantation. Little is known about the real safety margin in real life clinical practice. METHODS: We sought to understand what is the efficacy of induced VF termination at S-ICD implantation using lower energies than the recommended 65J. RESULTS: 64 consecutive S-ICD recipients underwent VF termination attempts at implantation with energies ranging from 20 to 50 J...
April 16, 2019: Clinical Cardiology
https://read.qxmd.com/read/30941774/wake-forest-university-long-term-follow-up-of-type-2-myocardial-infarction-the-wake-up-t2mi-registry
#14
Hanumantha R Jogu, Sameer Arora, Muthiah Vaduganathan, Arman Qamar, Ambarish Pandey, Parag A Chevli, Tusharkumar H Pansuriya, Muhammad I Ahmad, Abhishek Dutta, Padageshwar R Sunkara, Waqas Qureshi, Sujethra Vasu, Bharathi Upadhya, Deepak L Bhatt, James L Januzzi, David Herrington
BACKGROUND: The Wake-Up T2MI Registry is a retrospective cohort study investigating patients with type 2 myocardial infarction (T2MI), acute myocardial injury, and chronic myocardial injury. We aim to explore risk stratification strategies and investigate clinical characteristics, management, and short- and long-term outcomes in this high-risk, understudied population. METHODS: From 1 January 2009 to 31 December 2010, 2846 patients were identified with T2MI or myocardial injury defined as elevated cardiac troponin I with at least one value above the 99th percentile upper reference limit and coefficient of variation of 10% (>40 ng/L) and meeting our inclusion criteria...
April 2, 2019: Clinical Cardiology
https://read.qxmd.com/read/30937935/rationale-and-design-of-the-impact-of-anticoagulation-therapy-on-the-cognitive-decline-and-dementia-in-patients-with-non-valvular-atrial-fibrillation-caf-trial-a-vanguard-study
#15
T Jared Bunch, Victoria Jacobs, Heidi May, Scott M Stevens, Brian Crandall, Michael Cutler, John D Day, Charles Mallender, Jeff Olson, Jeffrey Osborn, J Peter Weiss, Scott C Woller
BACKGROUND: Atrial fibrillation (AF) is associated with a risk for cognitive impairment and dementia, which is more pronounced in patients with a history of clinical stroke. Observational trials suggest that the implementation and quality of long-term anticoagulation impact dementia risk. Emerging evidence suggests that direct oral anticoagulants may improve long-term risk of dementia in AF patients. METHODS: This manuscript describes the rational and trial design of the the Cognitive Decline and Dementia in Atrial Fibrillation Patients (CAF) Trial...
April 1, 2019: Clinical Cardiology
https://read.qxmd.com/read/30907013/left-atrial-function-in-elite-athletes-a-meta-analysis-of-2d-speckle-tracking-echocardiographic-studies
#16
REVIEW
Cesare Cuspidi, Marijana Tadic, Carla Sala, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
BACKGROUND: We sought to investigate left atrial (LA) volume, function and strain in elite athletes by a meta-analysis including echocardiographic studies that provided volumetric and strain analysis of LA phasic function. METHODS: The OVID-MEDLINE, PubMed and Cochrane CENTRAL databases were searched for English-language articles without time restriction up to February 2018 through focused and high sensitive search strategies. Studies were identified by crossing the following search terms: "athletes", "left atrial size", "left atrial volume", "atrial function", "atrial strain", "atrial strain rate", "echocardiography", "2D speckle echocardiography" RESULTS: Meta-analysis included 403 athletes and 314 active but not trained healthy controls from 9 studies...
March 24, 2019: Clinical Cardiology
https://read.qxmd.com/read/30907012/high-cystatin-c-levels-predict-long-term-mortality-in-patients-with-st-segment-elevation-myocardial-infraction-undergoing-late-percutaneous-coronary-intervention-a-retrospective-study
#17
Yuewu Chen, Yan Fan, Min Men, Guidong Shen, Aiqun Ma
OBJECTIVES: Late percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infraction (STEMI), defined as time of PCI > 7 days from symptom onset, is a common practice with clinical benefits. This study aimed to evaluate the predictive value of admission cystatin C level on long-term mortality in STEMI patients receiving late PCI. METHODS: Medical records of STEMI patients who were hospitalized between 2009 and 2011 from eight PCI-capable hospitals in Northwest China were retrospectively analyzed...
March 24, 2019: Clinical Cardiology
https://read.qxmd.com/read/30907005/efficacy-and-safety-of-apixaban-versus-warfarin-in-patients-with-atrial-fibrillation-and-prior-bioprosthetic-valve-replacement-or-valve-repair-insights-from-the-aristotle-trial
#18
Patricia O Guimarães, Sean D Pokorney, Renato D Lopes, Daniel M Wojdyla, Bernard J Gersh, Anna Giczewska, Anthony Carnicelli, Basil S Lewis, Michael Hanna, Lars Wallentin, Dragos Vinereanu, John H Alexander, Christopher B Granger
BACKGROUND: The optimal anticoagulation strategy for patients with atrial fibrillation (AF) and bioprosthetic valve (BPV) replacement or native valve repair remains uncertain. HYPOTHESIS: We evaluated the safety and efficacy of apixaban versus warfarin in patients with AF and a history of BPV replacement or native valve repair. METHODS: Using data from ARISTOTLE (n=18,201), a randomized trial comparing apixaban with warfarin in patients with AF, we analyzed the subgroup of patients (n=251) with prior valve surgery...
March 24, 2019: Clinical Cardiology
https://read.qxmd.com/read/30895632/prognostic-implications-of-troponin-i-elevation-in-emergency-department-patients-with-tachyarrhythmia
#19
Maribel González-Del-Hoyo, Germán Cediel, Anna Carrasquer, Gil Bonet, Karla Vásquez-Nuñez, Carme Boqué, Samuel Alí, Alfredo Bardají
BACKGROUND: Tachyarrhythmias are very common in emergency medicine, and little is known about the long-term prognostic implications of troponin I levels in these patients. HYPOTHESIS: This study aimed to investigate the correlation of cardiac troponin I (cTnI) levels and long-term prognosis in patients admitted to the emergency department with a primary diagnosis of tachyarrhythmia. METHODS: A retrospective cohort study was conducted between January 2012 and December 2013, enrolling patients admitted to the emergency department with a primary diagnosis of tachyarrhythmia and having documented cTnI measurements...
March 20, 2019: Clinical Cardiology
https://read.qxmd.com/read/30887538/clinical-impact-of-using-a-more-sensitive-troponin-assay-in-patients-with-acute-chest-pain
#20
Guangmei Wang, Jiali Wang, Shuo Wu, Wen Zheng, He Zhang, Jingjing Ma, Jiaqi Zheng, Feng Xu, Yuguo Chen
BACKGROUND: More sensitive troponin assays have the potential to better evaluate the patients with suspected acute coronary syndrome (ACS). Meanwhile, they may result in avoidable diagnostic testing. HYPOTHESIS: Our aim was to determine the clinical impact of implementing a more sensitive cardiac troponin I (cTnI) assay in patients with acute non-traumatic chest pain presenting to the emergency department (ED). METHODS: This is a pre-post cohort study...
March 19, 2019: Clinical Cardiology
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