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Digestive Diseases and Sciences

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https://read.qxmd.com/read/30903365/diagnostic-and-therapeutic-delays-in-the-management-of-postoperative-crohn-s-disease
#1
LETTER
Vu Q Nguyen, Dario Sorrentino
No abstract text is available yet for this article.
March 22, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30903364/determinants-of-hepatitis-c-treatment-adherence-and-treatment-completion-among-veterans-in-the-direct-acting-antiviral-era
#2
Krupa Patel, Susan L Zickmund, Harleigh Jones, Andrea Reid, Linda Calgaro, Arielle Otero, Tami Coppler, Shari S Rogal
BACKGROUND: Despite the availability of direct acting antiviral medications (DAAs), there are ongoing concerns about adherence to hepatitis C virus (HCV) treatment. We sought to understand the barriers to and facilitators of DAA adherence in the Veteran population. METHODS: Patients completed semi-structured interviews focused on barriers to and facilitators of HCV treatment adherence both pre- and post-DAA treatment. Adherence was assessed via provider pill count and self-report...
March 22, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30895483/living-donor-liver-transplantation-for-hepatocellular-carcinoma-an-asian-perspective
#3
REVIEW
Young-In Yoon, Sung-Gyu Lee
Despite advancements in early diagnosis and medico-surgical treatment, hepatocellular carcinoma (HCC) is still a major cancer that causes substantial mortality in Asian countries. Liver transplantation (LT) has been accepted worldwide as the most effective treatment modality for patients with HCC; however, with the high incidence of HCC and low organ donation rate, Asia has developed distinctive features of indications and strategies for the application of LT. Unlike Western countries, living donor liver transplantation (LDLT) accounts for most LT cases for HCC in Asian countries, and most major transplantation centers perform LDLT for HCC patients with extended criteria...
March 20, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30895482/liver-allocation-policies-in-the-usa-past-present-and-the-future
#4
REVIEW
Anjana Pillai, Thomas Couri, Michael Charlton
Identifying the optimal allocation policy with regard to hepatocellular carcinoma has been a persistent and evolving challenge. The current criteria for LT for HCC endorsed by the United Network of Organ Sharing (UNOS) are based on the Milan Criteria: a solitary tumor < 5 cm, or maximum of three tumors ≤ 3 cm each, without vascular invasion or evidence of extrahepatic spread. Contraindications to HCC exception points include: stage 1 HCC, ruptured HCC, extrahepatic HCC, and main portal or hepatic vein HCC invasion...
March 20, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30887152/multidisciplinary-approach-to-hcc-management-how-can-this-be-done
#5
REVIEW
Melissa M Gadsden, David E Kaplan
Multidisciplinary tumor boards have evolved to address the increasing complexity of cancer care management. Given that hepatocellular carcinoma (HCC) often arises in the setting of underlying cirrhosis, expert input from hepatologists alongside hepatobiliary and transplant surgeons, radiation oncologists, interventional and body radiologists, and medical oncologists has become increasingly important in order to offer patients appropriate cancer treatments. The MDLTB structure has evolved since the early 2000s to bring these specialists together at regularly scheduled meetings to develop a therapeutic treatment plan for HCC management...
March 18, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30887151/biliary-strictures-after-liver-transplantation-with-grafts-from-donors-after-cardiac-death-narrowing-down-the-etiologies
#6
EDITORIAL
Hamzeh Saraireh, Latha Thankam Sundaram, Binu V John
No abstract text is available yet for this article.
March 18, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30887150/systemic-management-for-advanced-hepatocellular-carcinoma-a-review-of-the-molecular-pathways-of-carcinogenesis-current-and-emerging-therapies-and-novel-treatment-strategies
#7
REVIEW
Saad Saffo, Tamar H Taddei
Hepatocellular carcinoma (HCC) arises from a number of cirrhosis-related and non-cirrhosis-related exposures and is one of the leading causes of cancer-related deaths worldwide. Achieving a durable cure currently relies on either resection or transplantation, but since most patients will be diagnosed with inoperable disease, there is great interest in achieving more effective systemic therapies. At a molecular level, HCC is heterogeneous, but initial treatment strategies, including the use of multi-targeted tyrosine kinase inhibitors and checkpoint inhibitors, have been fairly homogenous, depending on general host factors and overall tumor burden rather than specific molecular signatures...
March 18, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30887149/in-the-zone-how-impedance-facilitates-progress-in-functional-dyspepsia-research
#8
EDITORIAL
Simon Keely, Nicholas J Talley
No abstract text is available yet for this article.
March 18, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30879168/improving-anemia-in-inflammatory-bowel-disease-impact-of-the-anemia-care-pathway
#9
Talha Qureshi, T Peter Nguyen, Ruifei Wang, Diana Willis, Rajesh Shah, Jason K Hou
BACKGROUND: Anemia is a common complication of inflammatory bowel disease (IBD). Despite existing guidelines for anemia in IBD, it is frequently under-treated and the prevalence of anemia has remained high. To address this gap, the Crohn's and Colitis Foundation developed the Anemia Care Pathway (ACP). AIMS: To implement the ACP in a managed care setting and identify where it improves practice habits and where barriers remain. METHODS: The ACP was implemented from July 2016 through June 2017 and retrospectively studied...
March 16, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30877610/wdr34-activates-wnt-beta-catenin-signaling-in-hepatocellular-carcinoma
#10
Xiaoling Luo, Yuting Liu, Shijie Ma, Lei Liu, Rui Xie, Shaochuang Wang
BACKGROUND: Wnt ligand binding initiates the interaction between Frizzled and Dvl proteins. However, the regulation of Frizzled-Dvl proteins interaction remains largely unknown. AIMS: The present study aims to elucidate the regulation of Frizzled-Dvl interaction by WDR34. METHODS: The protein levels of WDR34 in hepatocellular carcinoma (HCC) tissues were examined by western blot and immunohistochemistry. The effects of WDR34 on the growth and migration of HCC cells were examined using MTT assay and Boyden chamber assay...
March 15, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30877609/patient-initiated-colonoscopy-scheduling-effectively-increases-colorectal-cancer-screening-adherence
#11
Gautam Mankaney, Maged Rizk, Shashank Sarvepalli, Jeannie Bongorno, Ari Garber, Rocio Lopez, John McMichael, Carol A Burke
BACKGROUND AND AIM: We identified patients without medical record evidence of up-to-date colorectal cancer (CRC) screening and sent an invitation letter to self-schedule a colonoscopy without requiring prior primary care or gastroenterologist consultation. The aim of the study was to evaluate the response rate to the letter and factors associated with colonoscopy completion. METHODS: A computer algorithm invited patients not up to date with CRC screening, with an INR < 1...
March 15, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30874990/coexistence-of-alterations-of-gastrointestinal-function-and-mechanical-allodynia-in-the-reserpine-induced-animal-model-of-fibromyalgia
#12
Masayuki Uchida, Orie Kobayashi, Miku Yoshida, Machiko Miwa, Reina Miura, Hiroko Saito, Yukinori Nagakura
BACKGROUND: Fibromyalgia (FM) is a disorder characterized by widespread chronic pain as core symptom and a broad range of comorbidities. Despite the prevalence of gastrointestinal (GI) comorbidities in patients with FM, GI functions have rarely been investigated in animal models of FM. AIMS: The purpose of the present study is to investigate the coexistence of alterations of GI function in the reserpine-induced myalgia (RIM) rat, a validated FM model associated with disruption of monoamine system...
March 14, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30874989/locostatin-alleviates-liver-fibrosis-induced-by-carbon-tetrachloride-in-mice
#13
Junji Ma, Yuzi Qiu, Min Wang, Ming Zhang, Xiaoyi Zhao, Huiqing Jiang
BACKGROUND AND AIMS: Liver fibrosis is featured with excessive deposition of extracellular matrix and fibrous connective tissue hyperplasia. The specific inhibitor of Raf-1 kinase inhibitor protein, locostatin, inhibits the migration of hepatic stellate cells. In this study, we investigated the effect of locostatin on liver fibrosis and its underlying mechanism. METHODS: Carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and locostatin was injected intraperitoneally...
March 14, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30874988/utilization-of-census-tract-based-neighborhood-poverty-rates-to-predict-non-adherence-to-screening-colonoscopy
#14
Philip Vutien, Rucha Shah, Karen Ma, Nasir Saleem, Joshua Melson
OBJECTIVES: Efforts to improve colorectal cancer (CRC) screening rates include recognizing predictors of colonoscopy non-adherence and identifying these high-risk patient populations. Past studies have focused on individual-level factors but few have evaluated the influence of neighborhood-level predictors. We sought to assess the effect of census tract-based neighborhood poverty rates on scheduled screening colonoscopy non-adherence. METHODS: In this prospective observational cohort study, data from electronic medical records and appointment tracking software were collected in 599 patients scheduled to undergo outpatient CRC screening colonoscopy at two academic endoscopy centers between January 2011 and December 2012...
March 14, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30874987/functional-role-of-basolateral-clc-2-channels-in-the-regulation-of-duodenal-anion-secretion-in-mice
#15
Chao Du, Jingjing Liu, Hanxing Wan, Hui Dong, Xiaoyan Zhao
BACKGROUND: Although ClC-2 channels are important in colonic Cl- secretion, it is unclear about their roles in small intestinal anion secretion. Therefore, we sought to examine whether ClC-2 channels play important roles in anion secretion, particularly duodenal bicarbonate secretion (DBS). METHODS: Duodenal mucosae from mice were stripped of seromuscular layers and mounted in Ussing chambers. Both duodenal short-circuit current (Isc ) and HCO3 - secretion in vitro were simultaneously recorded...
March 14, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30874986/clinical-impact-of-sonographic-transmural-healing-after-anti-tnf-antibody-treatment-in-patients-with-crohn-s-disease
#16
José María Paredes, Nadia Moreno, Patricia Latorre, Tomás Ripollés, María Jesús Martinez, José Vizuete, Eduardo Moreno-Osset
AIM: To assess the clinical benefits of transmural healing (TH) shown on intestinal ultrasound (IUS) after treatment with tumor necrosis factor-alpha antibodies (anti-TNF) in patients with Crohn's disease. MATERIALS AND METHODS: This prospective study included consecutively 36 patients who underwent IUS in the week prior to start anti-TNF treatment, at 12 weeks, and 1 year after starting treatment. The clinical response to treatment was assessed using the Crohn's disease activity index and C-reactive protein (CRP) values...
March 14, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30874985/what-comes-first-treatment-of-viral-hepatitis-or-liver-cancer
#17
REVIEW
Jordan J Feld, Lisette A P Krassenburg
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are the most important underlying causes for the development of hepatocellular carcinoma (HCC) worldwide. Determining the optimal approach for management of the viral infection and the HCC depends on the virus and the stage of the cancer. In patients with HCV-associated HCC, there are multiple reasons to first treat the HCC. Firstly, in case of a curable HCC, the urgency for HCC treatment is important to avoid progression during HCV treatment...
March 14, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30868409/stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma-current-state-and-future-opportunities
#18
REVIEW
Payal D Soni, Manisha Palta
Hepatocellular carcinoma is a rising cause of morbidity and mortality in the USA and around the world. Surgical resection and liver transplantation are the preferred management strategies; however, less than 30% of patients are eligible for surgery. Stereotactic body radiation therapy is a promising local treatment option for non-surgical candidates. Local control rates between 95 and 100% have been reported at 1-2 years post-treatment, and classical radiation-induced liver disease described with conventional radiation is an unlikely complication from stereotactic radiotherapy...
March 14, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30868408/correction-to-hospital-cirrhosis-volume-and-readmission-in-patients-with-cirrhosis-in-california
#19
Mike Wei, Jason Ford, Qihan Li, Donghak Jeong, Allison J Kwong, Mindie H Nguyen, Matthew S Chang
The original version of the article unfortunately contained errors in 'Severity of illness' and 'Hospital characteristics' entries of Table 1. Corrected version of Table 1 is given below.
March 13, 2019: Digestive Diseases and Sciences
https://read.qxmd.com/read/30863955/gut-leakage-of-fungal-derived-inflammatory-mediators-part-of-a-gut-liver-kidney-axis-in-bacterial-sepsis
#20
REVIEW
Panomwat Amornphimoltham, Peter S T Yuen, Robert A Star, Asada Leelahavanichkul
Sepsis is a life-threatening response to systemic infection. In addition to frank gastrointestinal (GI) rupture/puncture, sepsis can also be exacerbated by translocation of pathogen-associated molecular patterns (PAMPs) from the GI tract to the systemic circulation (gut origin of sepsis). In the human gut, Gram-negative bacteria and Candida albicans are abundant, along with their major PAMP components, endotoxin (LPS) and (1 → 3)-β-D-glucan (BG). Whereas the influence of LPS in bacterial sepsis has been studied extensively, exploration of the role of BG in bacterial sepsis is limited...
March 13, 2019: Digestive Diseases and Sciences
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