journal
https://read.qxmd.com/read/38622464/engagement-in-gi-behavioral-health-is-associated-with-reduced-portal-messages-phone-calls-and-ed-visits
#1
JOURNAL ARTICLE
Brian J Arizmendi, Meredith R Craven, Pablo Martinez-Camblor, Lauren K Tormey, Jessica K Salwen-Deremer
BACKGROUND AND AIMS: Chronic digestive disorders are associated with increased costs for healthcare systems and often require provision of both urgent care and non-face-to-face (non-F2F) care, such as responding to patient messages. Numerous benefits of integrated gastroenterology (GI) behavioral health have been identified; however, it is unclear if integrated care impacts healthcare utilization, including urgent care and non-F2F contact. We sought to investigate the association between patient engagement with GI behavioral health and healthcare utilization...
April 15, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38622463/cfp-yit-an-inbred-mouse-strain-with-slow-gastrointestinal-transit
#2
JOURNAL ARTICLE
Gaku Wagai, Masao Togao, Takashi Kurakawa, Haruka Nishizaki, Jun Otsuka, Yuki Ohta-Takada, Akinobu Kurita, Tomo Suzuki, Koji Kawakami
BACKGROUND: Gastrointestinal transit (GIT) is influenced by factors including diet, medications, genetics, and gut microbiota, with slow GIT potentially indicating a functional disorder linked to conditions, such as constipation. Although GIT studies have utilized various animal models, few effectively model spontaneous slow GIT. AIMS: We aimed to characterize the GIT phenotype of CFP/Yit (CFP), an inbred mouse strain with suggested slow GIT. METHODS: Female and male CFP mice were compared to Crl:CD1 (ICR) mice in GIT and assessed based on oral gavage of fluorescent-labeled 70-kDa dextran, feed intake, fecal amount, and fecal water content...
April 15, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38622462/differences-between-patients-with-heartburn-refractory-to-vonoprazan-and-those-refractory-to-proton-pump-inhibitors
#3
JOURNAL ARTICLE
Tomoaki Matsumura, Michiko Sonoda, Kenichiro Okimoto, Hang Viet Dao, Satsuki Takahashi, Naoki Akizue, Ryosuke Horio, Chihiro Goto, Akane Kurosugi, Tatsuya Kaneko, Yuki Ohta, Takashi Taida, Atsuko Kikuchi, Mai Fujie, Jun Kato, Naoya Kato
BACKGROUND: Vonoprazan, a potassium-competitive acid blocker, demonstrates more potent acid inhibition than proton pump inhibitors (PPIs). This study aimed to evaluate the effect of vonoprazan in patients with unproven gastroesophageal reflux disease (GERD) by comparing patients with vonoprazan-refractory heartburn with those with PPI-refractory heartburn. METHODS: This study included 104 consecutive patients with vonoprazan- or PPI-refractory heartburn (52 patients each), no erosive esophagitis on endoscopy and who underwent combined multichannel intraluminal impedance-pH (MII-pH) testing with vonoprazan/PPI discontinuation...
April 15, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38622461/ubxn11-predicts-as-a-poor-index-for-colorectal-cancer-and-contributes-to-the-tumorigenesis-by-activating-nf-%C3%AE%C2%BAb-signaling
#4
JOURNAL ARTICLE
Xiangbo Chen, Changxin Chen, Rensong He, Yisen Huang, Yubin Wang
BACKGROUND: The complex mechanisms of colorectal cancer (CRC) pathogenesis and progression remain poorly understood. This study endeavors to unravel the role of UBXN11within the context of CRC. METHODS: UBXN11 expression level in CRC, stomach adenocarcinoma and esophageal carcinoma, and the overall survival in corresponding cancers were analyzed using UALCAN database. Human CRC cell lines and xenograft mouse model with UBXN11 overexpression were established to investigate the pathological role of UBXN11 in CRC progression...
April 15, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38616215/organizational-and-implementation-factors-associated-with-cirrhosis-care-in-the-veterans-health-administration
#5
JOURNAL ARTICLE
Heather McCurdy, Anna Nobbe, Dawn Scott, Heather Patton, Timothy R Morgan, Jasmohan S Bajaj, Vera Yakovchenko, Monica Merante, Sandra Gibson, Carolyn Lamorte, Gyorgy Baffy, George N Ioannou, Tamar H Taddei, Karine Rozenberg-Ben-Dror, Jennifer Anwar, Jason A Dominitz, Shari S Rogal
BACKGROUND: The Veterans Health Administration provides care to more than 100,000 Veterans with cirrhosis. AIMS: This implementation evaluation aimed to understand organizational resources and barriers associated with cirrhosis care. METHODS: Clinicians across 145 Department of Veterans Affairs (VA) medical centers (VAMCs) were surveyed in 2022 about implementing guideline-concordant cirrhosis care. VA Corporate Data Warehouse data were used to assess VAMC performance on two national cirrhosis quality measures: HCC surveillance and esophageal variceal surveillance or treatment (EVST)...
April 14, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38609542/triglycerides-a-sensitizer-but-not-a-trigger-for-hypertriglyceridemic-acute-pancreatitis
#6
JOURNAL ARTICLE
Lu Wang, Yutang Ren, Ting Xu, Jinting Geng, Ning Yang, Ruifeng Wang
BACKGROUND: The incidence of hypertriglyceridemic acute pancreatitis (HTG-AP) is increasing. Although the guideline defines the diagnostic criteria as triglyceride (TG) greater than 11.3 mmol/L, there is actually no specific threshold. Many people with hypertriglyceridemia (HTG) or obvious chyloid blood do not develop acute pancreatitis (AP). AIMS: To explore the role of HTG in the pathogenesis of AP. METHODS: Thirty-six male SD rats were randomly assigned into normal control, AP, HTG, HTG-AP, low-dose fenofibrate and high-dose fenofibrate groups...
April 12, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38602621/acute-pancreatitis-in-pregnancy-a-propensity-score-matching-analysis-and-dynamic-nomogram-for-risk-assessment
#7
JOURNAL ARTICLE
Xiaowei Tang, Yuan Chen, Shu Huang, Jiao Jiang, Bei Luo, Wensen Ren, Xueqin Zhou, Xiaomin Shi, Wei Zhang, Lei Shi, Xiaolin Zhong, Muhan Lü
BACKGROUND: Acute pancreatitis is easily confused with abdominal pain symptoms, and it could lead to serious complications for pregnant women and fetus, the mortality was as high as 3.3% and 11.6-18.7%, respectively. However, there is still lack of sensitive laboratory markers for early diagnosis of APIP and authoritative guidelines to guide treatment. OBJECTIVE: The purpose of this study was to explore the risk factors of acute pancreatitis in pregnancy, establish, and evaluate the dynamic prediction model of risk factors in acute pancreatitis in pregnancy patients...
April 11, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38600412/venous-thrombosis-in-acute-pancreatitis-what-to-and-not-to-do
#8
REVIEW
Jayanta Samanta, Jahnvi Dhar, Pankaj Gupta, Rakesh Kochhar
Acute pancreatitis is an acute inflammatory condition of the pancreas that has not only local but systemic effects as well. Venous thrombosis is one such complication which can give rise to thrombosis of the peripheral vasculature in the form of deep vein thrombosis, pulmonary embolism, and splanchnic vein thrombosis. The prevalence of these complications increases with the severity of the disease and adds to the adverse outcomes profile. With better imaging and awareness, more cases are being detected, although many at times it can be an incidental finding...
April 10, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594437/endoscopic-longitudinal-incision-and-recanalization-in-the-treatment-of-acquired-esophageal-atresia-with-video
#9
JOURNAL ARTICLE
Meng-Nan Xu, Hong-Yu Chen, Bai-Rong Li, Teng Li, Chong-Xi Fan, Shou-Bin Ning
No abstract text is available yet for this article.
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594436/serum-lactate-is-an-indicator-for-short-term-and-long-term-mortality-in-patients-with-acute-pancreatitis
#10
JOURNAL ARTICLE
Zhao Zeng, Rong Huang, Hang Lin, Hongchun Peng, Ju Luo, Ning Ding
BACKGROUND: Serum lactate, as a single and an easily available biomarker, has been applied in various diseases. AIMS: In this study, we aimed to explore the predictive value of serum lactate for short-term and long-term prognosis in acute pancreatitis (AP) admitted in intensive care unit (ICU) based on a large-scale database. METHODS: AP patients admitted in ICU in the MIMIC-IV database were included. We constructed three different models to investigate the relationships between serum lactate and clinical outcomes, including 30-day, 180-day and 1-year mortality in AP...
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594435/a-prediction-model-for-successful-increase-of-adalimumab-dose-intervals-in-patients-with-crohn-s-disease-secondary-analysis-of-the-pragmatic-open-label-randomised-controlled-non-inferiority-ladi-trial
#11
JOURNAL ARTICLE
Reinier C A van Linschoten, Fenna M Jansen, Renske W M Pauwels, Lisa J T Smits, Femke Atsma, Wietske Kievit, Dirk J de Jong, Annemarie C de Vries, Paul J Boekema, Rachel L West, Alexander G L Bodelier, Ingrid A M Gisbertz, Frank H J Wolfhagen, Tessa E H Römkens, Maurice W M D Lutgens, Adriaan A van Bodegraven, Bas Oldenburg, Marieke J Pierik, Maurice G V M Russel, Nanne K de Boer, Rosalie C Mallant-Hent, Pieter C J Ter Borg, Andrea E van der Meulen-de Jong, Jeroen M Jansen, Sita V Jansen, Adrianus C I T L Tan, C Janneke van der Woude, Frank Hoentjen
BACKGROUND: In the pragmatic open-label randomised controlled non-inferiority LADI trial we showed that increasing adalimumab (ADA) dose intervals was non-inferior to conventional dosing for persistent flares in patients with Crohn's disease (CD) in clinical and biochemical remission. AIMS: To develop a prediction model to identify patients who can successfully increase their ADA dose interval based on secondary analysis of trial data. METHODS: Patients in the intervention group of the LADI trial increased ADA intervals to 3 and then to 4 weeks...
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594434/ges-what-patients-with-gastroparesis-may-have-cyclical-vs-non-cyclical-symptom-patterns
#12
EDITORIAL
Saranya Arumugam, Thangam Venkatesan
No abstract text is available yet for this article.
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594433/transpancreatic-sphincterotomy-after-double-guidewire-technique-was-noninferior-to-primary-transpancreatic-sphincterotomy-in-difficult-biliary-cannulation
#13
JOURNAL ARTICLE
Shaofei Wang, Bingqing Bai, Sisi Liu, Yuanyuan Fang, Chenyu Zhang, Xinwen Chen, Qiming Huang, Jiren Wang, Jianglong Hong, Yang Li, Zhangwei Xu, Xiaochang Liu, Junjun Bao, Qiao Mei, Rutao Hong
BACKGROUND: When unintentional pancreatic duct access occurs during difficult biliary cannulation, the double guidewire (DGW) or transpancreatic sphincterotomy (TPS) may be utilized. DGW can be easily switched to TPS due to the existing guidewire in the pancreatic duct. However, the efficacy of TPS after DGW, named sequential DGW-TPS technique, versus primary TPS has not been assessed. AIMS: Our aim was to compare the benefits and adverse events of sequential DGW-TPS technique and primary TPS...
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594432/difference-in-cyclic-versus-non-cyclic-symptom-patterns-in-patients-with-the-symptoms-of-gastroparesis-undergoing-bioelectric-therapy
#14
JOURNAL ARTICLE
Scott Bills, Amal Shine, Jane Claire Williams, Prateek Mathur, Archana Kedar, Michael Daniels, Thomas L Abell
INTRODUCTION: Patients with gastroparesis (Gp) have symptoms with or without a cyclic pattern. This retrospective study evaluates differences in cyclic vs. non-cyclic symptoms of Gp by analyzing mucosal electrogastrogram (mEG), familial dysautonomias, and response to gastric stimulation. METHODS: 37 patients with drug refractory Gp, 7 male and 30 female, with a mean age of 41.4 years, were studied. 18 had diabetes mellitus, 25 had cyclic (Cyc), and 12 had a non-cyclic (NoCyc) pattern of symptoms...
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594431/prediction-of-the-severity-of-gastrointestinal-bleeding-reassessing-dominant-wisdom
#15
EDITORIAL
Junya Arai, Ryota Niikura, Takao Itoi, Takashi Kawai
No abstract text is available yet for this article.
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594430/red-blood-cell-distribution-width-as-a-risk-factor-for-30-90-day-mortality-in-patients-with-gastrointestinal-bleeding-analysis-of-the-mimic-iv-database
#16
JOURNAL ARTICLE
Yu Chen, Yang Chen, Li Ming, Tan Shiyun
PURPOSE: The purpose of this research was to assess the relationship between red blood cell distribution width (RDW) and mortality in patients with gastrointestinal (GIB) bleeding in the intensive care unit (ICU). METHODS: The information of the participants was obtained from the Medical Information Mart for Intensive Care IV database. The main outcome of this research was 30/90-day mortality, with ICU mortality and in-hospital mortality as secondary outcomes...
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594429/plecanatide-improves-abdominal-bloating-and-bowel-symptoms-of-irritable-bowel-syndrome-with-constipation
#17
JOURNAL ARTICLE
Darren M Brenner, Amol Sharma, Satish S C Rao, Adam P Laitman, Zeev Heimanson, Christopher Allen, Gregory S Sayuk
BACKGROUND: Bloating is a bothersome symptom in irritable bowel syndrome with constipation (IBS-C). AIM: To evaluate plecanatide efficacy in patients with IBS-C stratified by bloating intensity. METHODS: Pooled phase 3 data (2 randomized, controlled IBS-C trials) from adults treated with plecanatide 3 mg or placebo for 12 weeks were analyzed. Patients were stratified post-hoc by baseline bloating severity (11-point scale: mild [≤ 5] and moderate-to-severe [> 5])...
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38594428/concise-commentary-bloating-in-ibs-can-we-burst-the-bubble
#18
EDITORIAL
Will Takakura, Prashant Singh
No abstract text is available yet for this article.
April 9, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38580888/correlation-between-serum-and-fecal-biomarkers-and-patient-reported-outcomes-in-patients-with-crohn-s-disease-and-ulcerative-colitis
#19
JOURNAL ARTICLE
Kiran K Motwani, Madeline Alizadeh, Ameer Abutaleb, Jennifer Grossman, Jennifer Wellington, Raymond K Cross
BACKGROUND: Patient-reported outcomes (PROs), such as the short CD activity index (sCDAI) and partial Mayo Score (PMS), are used to define clinical remission in IBD, but may not represent the true degree of inflammation and endoscopy is invasive. Non-invasive testing options include c-reactive protein (CRP) and fecal calprotectin (FCP). AIM: The aim of this study was to assess the degree of correlation of non-invasive biomarkers with PROs and the impact other clinical variables can have on their levels...
April 5, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38580887/adverse-events-and-device-failures-associated-with-pancreatic-stents-a-comprehensive-analysis-using-the-fda-s-maude-database
#20
JOURNAL ARTICLE
Fouad Jaber, Saqr Alsakarneh, Tala Alsharaeh, Ahmed-Jordan Salahat, Mohammad Jaber, Yazan Abboud, Mohammad Aldiabat, Khalid Ahmed, Mohamed Abdallah, Ala Abdel-Jalil, Mohammad Bilal, Monique Barakat, Douglas G Adler
INTRODUCTION: Pancreatic duct stents (PDS) are widely used for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. However, there is a paucity of data regarding the adverse events associated with PDS placement. This study aims to investigate the reported adverse events and device failures related to PDS, utilizing the Manufacturer and User Facility Device Experience (MAUDE) database maintained by the U.S. Food and Drug Administration (FDA). METHODS: Post-marketing surveillance data from January 2013 to December 8, 2023, were extracted from the FDA's MAUDE database to analyze the reports pertaining to the use of commonly used PDS...
April 5, 2024: Digestive Diseases and Sciences
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