Liang Shi, Muhong Guo, Cuixiao Shi, Gu Gao, Xianghong Xu, Chuan Zhang, Jingjing Fu, Yudan Ni, Feng Wang, Xue Xue, Fei Yu
PURPOSE: Trimethylamine N-oxide (TMAO), a gut microbiome-derived metabolite, and its precursors (carnitine, choline, betaine) have not been fully examined in relation to thyroid cancer (TC) risk. The aim of this study was to assess the value of TMAO and its precursors in diagnosis of benign and malignant thyroid nodules. METHODS: In this study, high-performance liquid chromatography-tandem mass spectrometry was utilized to measure the levels of plasma TMAO and its precursors (choline, carnitine, and betaine) in 215 TC patients, 63 benign thyroid nodules (BTN) patients and 148 healthy controls (HC)...
March 20, 2024: Journal of Cancer Research and Clinical Oncology