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Journals Journal of Cancer Research and...

Journal of Cancer Research and Clinical Oncology

https://read.qxmd.com/read/38713284/identification-of-immunogenic-cell-death-related-damage-related-molecular-patterns-damps-to-predict-outcomes-in-patients-with-head-and-neck-squamous-cell-carcinoma
#21
JOURNAL ARTICLE
Jiayi Zhang, Xinzhan Shi, Mengqi Wang, Rundong Zhai, Mengyao Wang, Zizhen Gong, Zihui Ni, Teng Xu, Weiwen Zhu, Laikui Liu
PURPOSE: Head and neck cancer is the sixth most common type of cancer worldwide, wherein the immune responses are closely associated with disease occurrence, development, and prognosis. Investigation of the role of immunogenic cell death-related genes (ICDGs) in adaptive immune response activation may provide cues into the mechanism underlying the outcome of HNSCC immunotherapy. METHODS: ICDGs expression patterns in HNSCC were analyzed, after which consensus clustering in HNSCC cohort conducted...
May 7, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38713256/the-role-of-tumor-associated-macrophages-in-tumor-immune-evasion
#22
REVIEW
Ruizhe Huang, Ting Kang, Siyu Chen
BACKGROUND: Tumor growth is closely linked to the activities of various cells in the tumor microenvironment (TME), particularly immune cells. During tumor progression, circulating monocytes and macrophages are recruited, altering the TME and accelerating growth. These macrophages adjust their functions in response to signals from tumor and stromal cells. Tumor-associated macrophages (TAMs), similar to M2 macrophages, are key regulators in the TME. METHODS: We review the origins, characteristics, and functions of TAMs within the TME...
May 7, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38713252/kif22-promotes-multiple-myeloma-progression-by-regulating-the-cdc25c-cdk1-cyclinb1-pathway
#23
JOURNAL ARTICLE
Meng Zhai, Jiyu Miao, Ru Zhang, Rui Liu, Fangmei Li, Ying Shen, Ting Wang, Xuezhu Xu, Gongzhizi Gao, Jinsong Hu, Aili He, Ju Bai
PURPOSE: Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal proliferation of malignant plasma B cells in bone marrow, and its pathogenesis remains unknown. The aim of this study was to determine the role of kinesin family member 22 (KIF22) in MM and elucidate its molecular mechanism. METHODS: The expression of KIF22 was detected in MM patients based upon the public datasets and clinical samples. Then, in vitro assays were performed to investigate the biological function of KIF22 in MM cell lines, and subcutaneous xenograft models in nude mice were conducted in vivo...
May 7, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38710956/safety-efficacy-and-survival-of-different-transarterial-chemoembolization-techniques-in-the-management-of-unresectable-hepatocellular-carcinoma-a-comparative-single-center-analysis
#24
COMPARATIVE STUDY
Philipp Schindler, Daniel Kaldewey, Florian Rennebaum, Jonel Trebicka, Andreas Pascher, Moritz Wildgruber, Michael Köhler, Max Masthoff
PURPOSE: Transarterial chemoembolization (TACE) has become the standard of care for the treatment of intermediate-stage hepatocellular carcinoma (HCC). However, current clinical practice guidelines lack consensus on the best selection of a specific TACE technique. This study aims to compare safety, tumor response, and progression-free survival (PFS) of conventional TACE (cTACE), drug-eluting bead TACE (DEB-TACE), and degradable starch microsphere TACE (DSM-TACE). METHODS: This retrospective study included n = 192 patients with HCC who underwent first TACE with unbiased follow-up at 4-6 weeks at our center between 2008 and 2021...
May 6, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38710946/total-hysterectomy-versus-radical-hysterectomy-in-neuroendocrine-cervical-cancer-a-seer-database-analysis
#25
COMPARATIVE STUDY
Feitianzhi Zeng, Peng Guo, Meng Xia, Mian He
PURPOSE: We conducted this study to evaluate the efficacy of total hysterectomy versus radical hysterectomy in the treatment of neuroendocrine cervical cancer (NECC). METHODS: Eligible NECC patients were identified from the Surveillance, Epidemiology and End Results (SEER) database. Demographic characteristics, clinical treatment and survival of the patients were collected. The overall survival (OS) and cancer-specific survival (CSS) were estimated by Kaplan-Meier analysis with log-rank test...
May 6, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38710918/modified-lichong-decoction-intervenes-in-colorectal-cancer-by-modulating-the-intestinal-flora-and-the-wnt-%C3%AE-catenin-signaling-pathway
#26
JOURNAL ARTICLE
Longhui Liu, Mengmeng Zhao, Xiaomeng Lang, Sujie Jia, Xin Kang, Yue Liu, Jianping Liu
BACKGROUND: The pathogenesis and treatment of colorectal cancer (CRC) continue to be areas of ongoing research, especially the benefits of traditional Chinese medicine (TCM) in slowing the progression of CRC. This study was conducted to investigate the effectiveness and mechanism of action of modified Lichong decoction (MLCD) in inhibiting CRC progression. METHODS: We established CRC animal models using azoxymethane/dextran sodium sulfate (AOM/DSS) and administered high, medium, or low doses of MLCD or mesalazine (MS) for 9 weeks to observe MLCD alleviation of CRC...
May 6, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38709400/evaluating-the-clinical-efficacy-and-safety-of-concurrent-chemoradiotherapy-with-cisplatin-and-nab-paclitaxel-in-postoperative-early-stage-cervical-cancer
#27
JOURNAL ARTICLE
Ning Zhao, Yunhai Li, Xue Chen, Jinli Ma, Weiming Luo, Yunhai Li
OBJECTIVE: A preclinical study showed that nab-paclitaxel acted as a radiosensitizer and improved tumor radiotherapy in a supra-additive manner. In this study, we aimed to evaluate the clinical efficacy and safety of concurrent chemoradiotherapy (CCRT) with cisplatin and nab-paclitaxel in postoperative early-stage cervical cancer with an unfavorable prognosis. METHODS: Eligible patients with stage IB1-IIA2 (FIGO 2009) cervical carcinoma were recruited retrospectively between August 2018 to May 2021...
May 6, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38703300/lamc2-regulates-the-proliferation-invasion-and-metastasis-of-gastric-cancer-via-pi3k-akt-signaling-pathway
#28
JOURNAL ARTICLE
Lulu Cheng, Xiaofei Li, Wenhui Dong, Jing Yang, Pengmei Li, Xihui Qiang, Jiajun Yin, Lianyi Guo
OBJECTIVES: Gastric cancer (GC) is a prevalent malignant tumor widely distributed globally, exhibiting elevated incidence and fatality rates. The gene LAMC2 encodes the laminin subunit gamma-2 chain and is found specifically in the basement membrane of epithelial cells. Its expression is aberrant in multiple types of malignant tumors. This research elucidated a link between LAMC2 and the clinical characteristics of GC and investigated the potential involvement of LAMC2 in GC proliferation and advancement...
May 4, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38703270/cancer-of-unknown-primary-derived-from-regressed-breast-cancer
#29
LETTER
Maria Pouyiourou, Theresa Mokry, Maximilian Feszler, Andrea Teifke, Andreas Kreft, Alwin Krämer
No abstract text is available yet for this article.
May 4, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38703241/targeting-bmal1-reverses-drug-resistance-of-acute-myeloid-leukemia-cells-and-promotes-ferroptosis-through-hmgb1-gpx4-signaling-pathway
#30
JOURNAL ARTICLE
Hong Zheng, Ting Wu, Zhi Lin, Dan Wang, Jing Zhang, Ting Zeng, Leping Liu, Jie Shen, Mingyi Zhao, Jia-Da Li, Minghua Yang
PURPOSE: Acute myeloid leukemia (AML) is a refractory hematologic malignancy that poses a serious threat to human health. Exploring alternative therapeutic strategies capable of inducing alternative modes of cell death, such as ferroptosis, holds great promise as a viable and effective intervention. METHODS: We analyzed online database data and collected clinical samples to verify the expression and function of BMAL1 in AML. We conducted experiments on AML cell proliferation, cell cycle, ferroptosis, and chemotherapy resistance by overexpressing/knocking down BMAL1 and using assays such as MDA detection and BODIPY 581/591 C11 staining...
May 4, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38703186/effects-of-concurrent-chemoradiotherapy-with-or-without-endostar-on-the-regression-of-retropharyngeal-lymph-node-and-prognosis-of-patients-with-locally-advanced-nasopharyngeal-carcinoma-a-retrospective-study
#31
JOURNAL ARTICLE
Jun-Mei Song, Ning Mo, Yu-Qing Lv, Lu-Lu Huang, Ya-Jing Wen, Ting Liu, Zhi-Ru Li, Ren-Sheng Wang, Ting-Ting Zhang
BACKGROUND AND PURPOSE: To investigate the effect of combining Endostar with concurrent chemoradiotherapy (ECCRT) compared to concurrent chemoradiotherapy (CCRT) on the regression rate of retropharyngeal lymph nodes (RLNs) and the relationship between regression rate of RLNs and prognosis of patients with locally advanced nasopharyngeal carcinoma (LANPC). METHODS: A total of 122 LANPC patients with RLNs metastasis were included. Metastatic RLNs were delineated both before and after treatment slice by slice on the magnetic resonance images cross-section...
May 4, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38700789/germline-findings-in-cancer-predisposing-genes-from-a-small-cohort-of-chordoma-patients
#32
JOURNAL ARTICLE
Margarita Raygada, Liny John, Anne Liu, Julianne Schultz, B J Thomas, Donna Bernstein, Markku Miettinen, Mark Raffeld, Liqiang Xi, Manoj Tyagi, Kenneth Aldape, John Glod, Karlyne M Reilly, Brigitte C Widemann, Mary Frances Wedekind
INTRODUCTION: Chordoma is a rare slow-growing tumor that occurs along the length of the spinal axis and arises from primitive notochordal remnants (Stepanek et al., Am J Med Genet 75:335-336, 1998). Most chordomas are sporadic, but a small percentage of cases are due to hereditary cancer syndromes (HCS) such as tuberous sclerosis 1 and 2 (TSC1/2), or constitutional variants in the gene encoding brachyury T (TBXT) (Pillay et al., Nat Genet 44:1185-1187, 2012; Yang et al., Nat Genet 41:1176-1178, 2009)...
May 3, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38700533/knockdown-of-nadk-promotes-luad-ferroptosis-via-nadph-fsp1-axis
#33
JOURNAL ARTICLE
Xiangpeng Meng, Fang Peng, Shijie Yu, Xinming Chi, Wenchi Wang, Shujuan Shao
BACKGROUND: Lung cancer is a serious threat to human health and is the first leading cause of cancer death. Ferroptosis, a newly discovered form of programmed cell death associated with redox homeostasis, is of particular interest in the lung cancer, given the high oxygen environment of lung cancer. NADPH has reducing properties and therefore holds the potential to resist ferroptosis. Resistance to ferroptosis exists in lung cancer, but the role of NADK in regulating ferroptosis in lung cancer has not been reported yet...
May 3, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38696003/a-perspective-on-tumor-radiation-resistance-following-high-let-radiation-treatment
#34
REVIEW
Yogendra Singh Rajpurohit, Dhirendra Kumar Sharma, Mitu Lal, Ishu Soni
High-linear energy transfer (LET) radiation is a promising alternative to conventional low-LET radiation for therapeutic gain against cancer owing to its ability to induce complex and clustered DNA lesions. However, the development of radiation resistance poses a significant barrier. The potential molecular mechanisms that could confer resistance development are translesion synthesis (TLS), replication gap suppression (RGS) mechanisms, autophagy, epithelial-mesenchymal transition (EMT) activation, release of exosomes, and epigenetic changes...
May 2, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38695944/primary-lung-cancer-in-children-and-adolescents
#35
JOURNAL ARTICLE
Qiuming Chen, Jun Cheng, Luming Wang, Xiayi Lv, Jian Hu
PURPOSE: Primary lung cancer is extremely rare in children and adolescents. The aim of this study is to clarify clinical features and outcomes of primary lung cancer in children and adolescents. METHODS: Young patients (aged ≤ 20 years) diagnosed as primary lung cancer between 2012 and 2023 were retrospective reviewed. According to radiological appearance of the nodules, they were divided into solid nodule (SN) group and ground glass opacity (GGO) group...
May 2, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38693452/effective-bridging-strategies-prior-to-infusion-with-tisagenlecleucel-results-in-high-response-rates-and-long-term-remission-in-relapsed-refractory-large-b-cell-lymphoma-findings-from-a-german-monocentric-study
#36
JOURNAL ARTICLE
Farina Eigendorff, Irina Filimonova, Sebastian Scholl, Anne Sayer-Klink, Silke Rummler, Christa Kunert, Klaus Pietschmann, Andrea Wittig, Andreas Hochhaus, Ulf Schnetzke
BACKGROUND: Incorporating chimeric antigen receptor (CAR)-T cell therapy into relapsed or refractory large B-cell lymphoma (rr LBCL) treatment algorithms has yielded remarkable response rates and durable remissions, yet a substantial portion of patients experience progression or relapse. Variations in outcomes across treatment centers may be attributed to different bridging strategies and remission statuses preceding CAR-T cell therapy. PATIENTS: Twenty-nine consecutive adult patients receiving tisagenlecleucel (tisa-cel) for rr LBCL from December 2019 to February 2023 at Jena University Hospital were analyzed...
May 1, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38691204/predicting-response-of-hepatoblastoma-primary-lesions-to-neoadjuvant-chemotherapy-through-contrast-enhanced-computed-tomography-radiomics
#37
JOURNAL ARTICLE
Yanlin Yang, Haoru Wang, Jiajun Si, Li Zhang, Hao Ding, Fang Wang, Ling He, Xin Chen
OBJECTIVE: To investigate the clinical value of contrast-enhanced computed tomography (CECT) radiomics for predicting the response of primary lesions to neoadjuvant chemotherapy in hepatoblastoma. METHODS: Clinical and CECT imaging data were retrospectively collected from 116 children with hepatoblastoma who received neoadjuvant chemotherapy. Tumor response was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST). Subsequently, they were randomly stratified into a training cohort and a test cohort in a 7:3 ratio...
April 30, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38687357/regulation-of-vegf-a-expression-and-vegf-a-targeted-therapy-in-malignant-tumors
#38
REVIEW
Yan Kang, Huiting Li, Yiping Liu, Zheng Li
Vascular endothelial growth factor A (VEGF-A), a highly conserved dimeric glycoprotein, is a key regulatory gene and a marker molecule of angiogenesis. The upregulation of VEGF-A facilitates the process of tumor vascularization, thereby fostering the initiation and progression of malignant neoplasms. Many genes can adjust the angiogenesis of tumors by changing the expression of VEGF-A. In addition, VEGF-A also exhibits immune regulatory properties, which directly or indirectly suppresses the antitumor activity of immune cells...
April 30, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38687350/dynamic-change-in-the-peritoneal-cancer-index-based-on-ct-after-chemotherapy-in-the-overall-survival-prediction-of-gastric-cancer-patients-with-peritoneal-metastasis
#39
JOURNAL ARTICLE
Yi-Yuan Wei, Jie-Yuan Cai, Lin-Lin Wang, Jie Yang, Yan-Ling Li, Xiao-Ting Li, Xiao-Tian Zhang, Yan-Jie Shi, Lei Tang
PURPOSE: The purpose of this research was to investigate the efficacy of the CT-based peritoneal cancer index (PCI) to predict the overall survival of patients with peritoneal metastasis in gastric cancer (GCPM) after two cycles of chemotherapy. METHODS: This retrospective study registered 112 individuals with peritoneal metastasis in gastric cancer in our hospital. Abdominal and pelvic enhanced CT before and after chemotherapy was independently analyzed by two radiologists...
April 30, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38684578/two-headed-unetefficientnets-for-parallel-execution-of-segmentation-and-classification-of-brain-tumors-incorporating-postprocessing-techniques-with-connected-component-labelling
#40
JOURNAL ARTICLE
Hari Mohan Rai, Joon Yoo, Serhii Dashkevych
PURPOSE: The purpose of this study is to develop accurate and automated detection and segmentation methods for brain tumors, given their significant fatality rates, with aggressive malignant tumors like Glioblastoma Multiforme (GBM) having a five-year survival rate as low as 5 to 10%. This underscores the urgent need to improve diagnosis and treatment outcomes through innovative approaches in medical imaging and deep learning techniques. METHODS: In this work, we propose a novel approach utilizing the two-headed UNetEfficientNets model for simultaneous segmentation and classification of brain tumors from Magnetic Resonance Imaging (MRI) images...
April 29, 2024: Journal of Cancer Research and Clinical Oncology
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