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Journals Journal of Cancer Research and...

Journal of Cancer Research and Clinical Oncology

https://read.qxmd.com/read/37253947/short-and-long-term-outcomes-of-robotic-assisted-versus-video-assisted-thoracoscopic-lobectomy-in-non-small-cell-lung-cancer-patients-aged-35-years-or-younger-a-real-world-study-with-propensity-score-matched-analysis
#21
JOURNAL ARTICLE
Hanbo Pan, Jiaqi Zhang, Yu Tian, Ningyuan Zou, Hongda Zhu, Zenan Gu, Weiqiu Jin, Junwei Ning, Long Jiang, Jia Huang, Qingquan Luo
PURPOSE: This study compared short- and long-term outcomes of robotic-assisted thoracoscopic surgery (RATS) versus video-assisted thoracoscopic surgery (VATS) for lobectomy in young adults aged ≤ 35 years with non-small cell lung cancer (NSCLC), aiming to assess the superiority of RATS over VATS for this special group of patients. METHODS: A total of 1355 consecutive NSCLC cases aged 18-35 years undergoing RATS (n = 105) or VATS (n = 1250) between 2014 and 2021 were retrospectively identified from a prospectively maintained database...
May 30, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37249648/competing-risks-analysis-of-external-versus-internal-radiation-in-patients-with-hepatocellular-carcinoma-after-controlling-for-immortal-time-bias
#22
JOURNAL ARTICLE
Chao-Yue Ku, Xue-Ke Yang, Li-Jing Xi, Rui-Zhe Wang, Bin-Bin Wu, Man Dai, Li Liu, Zhi-Guang Ping
PURPOSE: In cohort studies on liver cancer, there are often immortal time bias and interference of competing risk events. This study proposes to explore the role of internal and external radiotherapy for hepatocellular carcinoma using SEER data, using a competing risk model and controlling immortal time bias. METHODS: Data of SEER from 2004 till 2015 was included. To analyze whether there was a difference in survival between HCC (hepatocellular carcinoma) patients receiving external radiation and internal radiation, we used a competing risk analysis after excluding immortal time bias, and created a nomogram to assess the risk of cancer-specific death (CSD) in hepatocellular carcinoma patients receiving radiotherapy...
May 30, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37249647/fusion-protein-and-hemagglutinin-of-canine-distemper-virus-co-induce-apoptosis-in-canine-mammary-tumor-cells
#23
JOURNAL ARTICLE
Chenchen Gu, Jun Su, Jigui Wang, Qianqian Xie, Jing Wu, Jun Xiao, Weiquan Liu
BACKGROUND: Canine distemper virus (CDV) has been shown to have oncolytic activity against primary canine tumors. Previous studies from this laboratory had confirmed that CDV induces apoptosis in canine mammary tumor (CMT) cells, although the molecular mechanism remains unknown. METHODS: The CDV N, P, M, F, H, L, C, and V genes were identified in CDV-L and cloned separately. Mutants with deletions in the 5' region (pCMV-F L △60, pCMV-FL △107, and pCMV-FL △114) or with site-directed mutagenesis in the 3' region (pCMV-FL A602-610) of the F gene were generated...
May 30, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37249646/the-long-term-course-and-relationship-with-survival-of-multidimensional-fatigue-in-patients-with-brain-metastases-after-gamma-knife-radiosurgery
#24
JOURNAL ARTICLE
Eline Verhaak, Wietske C M Schimmel, Margriet M Sitskoorn, Patrick E J Hanssens, Elke Butterbrod, Karin Gehring
PURPOSE: The aims of this study were to evaluate long-term multidimensional fatigue in patients with brain metastases (BM) up to 21 months after Gamma Knife radiosurgery (GKRS) and (change in) fatigue as predictor of survival. METHODS: Patients with 1 to 10 BM, expected survival > 3 months, and Karnofsky Performance Status ≥ 70, and Dutch non-cancer controls were included. Fatigue was measured with the Multidimensional Fatigue Inventory...
May 30, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37249645/survival-benefit-of-radiotherapy-and-nomogram-for-patients-with-primary-tracheal-malignant-tumors-a-propensity-score-matched-seer-database-analysis
#25
JOURNAL ARTICLE
Zhen Zheng, Zhennan Du, Zhongjie Fang, Yunbin Shi, Xue Chen, Ming Jin, Kaitai Liu
PURPOSE: The purpose of this study was to conduct a matched-pair analysis to assess the impact of radiotherapy (RT) on patients with malignant tracheal tumors using the surveillance, epidemiology, and end results database. Additionally, a predictive nomogram was developed for patients with malignant tracheal tumors. METHODS: Propensity score matching (PSM) was used to minimize bias between the RT and no-RT groups. We utilized both univariate and multivariate Cox proportional hazards regression analyses to identify independent prognostic factors for patients and subgroups...
May 30, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37249644/growth-assessment-of-pure-ground-glass-nodules-on-ct-comparison-of-density-and-size-measurement-methods
#26
JOURNAL ARTICLE
Yifan He, Ziqi Xiong, Jingyu Zhang, Jiayue Xie, Wen Zhu, Min Zhao, Zhiyong Li
PURPOSE: To investigate the differences of size and density measurements in assessing pure ground-glass nodules (pGGNs) growth, and compare the growth rates and growth proportions of the two methods during follow-up period. METHODS: Ninety patients with at least 3 consecutive thin-section chest CTs and confirmed 103 pGGNs on baseline CT were enrolled retrospectively. Using the two definitions of size and density to evaluate pGGNs growth with semi-automated segmentation...
May 30, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37248320/grade-scoring-system-reveals-distinct-molecular-subtypes-and-identifies-kif20a-as-a-novel-biomarker-for-predicting-temozolomide-treatment-efficiency-in-gliomas
#27
JOURNAL ARTICLE
Liguo Ye, Shi'ao Tong, Yaning Wang, Yu Wang, Wenbin Ma
BACKGROUND: The importance of molecular diagnostics is increasingly emphasized in the 2021 WHO guidelines for gliomas. There is considerable variability in molecular features and prognosis among glioma patients with the same pathological WHO grade. METHODS: mRNA data and clinical information of human glioma patients were obtained from TCGA and CGGA databases, while expression profiles and TMZ resistance phenotypes of human glioma stem cells were acquired from the GEO database...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37248319/model-for-predicting-prognosis-and-immunotherapy-based-on-cd-8%C3%A2-t-cells-infiltration-in-neuroblastoma
#28
JOURNAL ARTICLE
Wei Bao, Zhiping Song, Hao Wan, Xiaoping Yu, Zhaoyan Chen, Yaqing Jiang, Xiao Chen, Kai Le
BACKGROUND: Neuroblastoma (NBL) is an extracranial malignant tumor in children deriving from the neural crest in the sympathetic nervous system. Although various immunotherapy interventions have made significant breakthroughs in many adult cancers, the efficacy of these immunotherapies was still limited in NBL. NBL has low immunogenicity which results in a lack of tumor-infiltrating T lymphocytes in the tumor microenvironment (TME). Moreover, tumor cells can wield many immune evasion strategies both in the TME and systemically to impede lymphocyte infiltration and activation...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37247083/a-robust-gene-prognostic-index-composed-of-gzmb-irf1-and-tp63-can-stratify-the-risk-of-two-metastatic-urothelial-carcinoma-cohorts-based-on-immune-checkpoint-blockade-therapy
#29
JOURNAL ARTICLE
Jiaxing Lin, Mengting Ding, Caipeng Qin, Yuxuan Song, Wenbo Yang, Yiqing Du, Tao Xu
BACKGROUND: Immune checkpoint blockade (ICB) therapy has become a first-line treatment option for metastatic urothelial carcinoma (mUC) patients who do not meet the criteria of cisplatin. Still, only a few people can benefit from it, so useful predictive markers are needed. METHODS: Download the ICB-based mUC and chemotherapy-based bladder cancer cohorts, and extract the expression data of pyroptosis-related genes (PRG). The LASSO algorithm was used to construct the PRG prognostic index (PRGPI) in the mUC cohort, and we verified the prognostic ability of PRGPI in two mUC and two bladder cancer cohorts...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37247082/a-new-nomogram-for-assessing-complete-response-cr-in-gastric-diffuse-large-b-cell-lymphoma-dlbcl-patients-after-chemotherapy
#30
JOURNAL ARTICLE
Ping Wang, Kaige Chen, Jiayang Wang, Zihao Ni, Naijian Shang, Wei Meng
PURPOSE: Achieving complete response (CR) after first-line chemotherapy in gastric DLBCL patients often results in longer disease-free survival. We explored whether a model based on imaging features combined with clinicopathological factors could assess the CR to chemotherapy in patients with gastric DLBCL. METHODS: Univariate (P < 0.10) and multivariate (P < 0.05) analyses were used to identify factors associated with a CR to treatment...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37247081/based-on-disulfidptosis-revealing-the-prognostic-and-immunological-characteristics-of-renal-cell-carcinoma-with-tumor-thrombus-of-vena-cava-and-identifying-potential-therapeutic-target-ajap1
#31
JOURNAL ARTICLE
Lin Yang, Jiahao Liu, Sheng Li, Xiaoqiang Liu, Fuchun Zheng, Songhui Xu, Bin Fu, Jing Xiong
BACKGROUND: Patients with clear cell renal cell carcinoma (ccRCC) with venous tumor thrombus have a poor prognosis, high surgical risk, and lack of targeted therapeutic agents. METHODS: Genes with consistent differential expression trends in tumor tissues and VTT groups were first screened, and then differential genes associated with disulfidptosis were found by correlation analysis. Subsequently, identifying ccRCC subtypes and constructing risk models to compare the differences in prognosis and the tumor microenvironment in different subgroups...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37247080/single-cell-rna-seq-and-bulk-rna-seq-reveal-reliable-diagnostic-and-prognostic-biomarkers-for-crc
#32
JOURNAL ARTICLE
Xing Zhang, Longkun Yang, Ying Deng, Zhicong Huang, Hao Huang, Yuying Wu, Baochang He, Fulan Hu
PURPOSE: The potential role of epithelium-specific genes through the adenoma-carcinoma sequence in the development of colorectal cancer (CRC) remains unknown. Therefore, we integrated single-cell RNA sequencing and bulk RNA sequencing data to select diagnosis and prognosis biomarkers for CRC. METHODS: The CRC scRNA-seq dataset was used to describe the cellular landscape of normal intestinal mucosa, adenoma and CRC and to further select epithelium-specific clusters...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37247079/intraoperative-frozen-section-in-gynaecology-cancers-with-special-reference-to-ovarian-tumours-time-to-unfreeze-the-pitfalls-in-the-path-of-the-derby-horse-of-oncology
#33
JOURNAL ARTICLE
Dimpy Begum, Debabrata Barmon, Upasana Baruah, Shiraj Ahmed, Sakshi Gupta, Karthik Chandra Bassetty
PURPOSE: In an oncological set up the role of frozen section biopsy is undeniable. They serve as an important tool for surgeon's intraoperative decision making but the diagnostic reliability of intraoperative frozen section may vary from institute to institute. The surgeon should be well aware of the accuracy of the frozen section reports in their setup to enable them to take decisions based on the report. This is why we had conducted a retrospective study at Dr B. Borooah Cancer Institute, Guwahati, Assam, India to find out our institutional frozen section accuracy...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37247078/peripheral-blood-based-cell-signature-indicates-response-to-interstitial-brachytherapy-in-primary-liver-cancer
#34
JOURNAL ARTICLE
Sophia Kästle, Matthias R Stechele, Lisa Richter, Regina Schinner, Elif Öcal, Marianna Alunni-Fabbroni, Enrico De Toni, Stefanie Corradini, Max Seidensticker, S Nahum Goldberg, Jens Ricke, Moritz Wildgruber, Melanie A Kimm
PURPOSE: Biomarkers are essential to implement personalized therapies in cancer treatment options. As primary liver tumors are increasing and treatment is coupled to liver function and activation of systemic cells of the immune system, we investigated blood-based cells for their ability to predict response to local ablative therapy. METHODS: We analyzed peripheral blood cells in 20 patients with primary liver cancer at baseline and following brachytherapy. In addition to platelets, leukocytes, lymphocytes, monocytes, neutrophils and most common ratios PLR, LMR, NMR and NLR, we investigated T cell and NKT cell populations of 11 responders and 9 non-responders using flow cytometry...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37246189/network-meta-analysis-of-8-types-of-traditional-chinese-medicine-injection-combined-with-chemotherapy-in-colorectal-cancer-treatment
#35
REVIEW
Wenguang Gao, Kun Zhang
OBJECTIVE: This study conducted a network meta-analysis to comprehensively compare the efficacy and safety of 8 types of traditional Chinese medicine injection combined with chemotherapy in colorectal cancer treatment. METHODS: We searched relevant previous studies from databases including Pubmed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Service System (SinMed), VIP, and Wanfang Database...
May 29, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37245170/clinicopathologic-and-prognostic-factors-of-patients-with-t3-t4-colorectal-signet-ring-cell-carcinoma-a-population-based-study
#36
JOURNAL ARTICLE
Fan Zhang, Boqi Xu, Yao Peng, Zhongqi Mao
BACKGROUND: To evaluate cancer-specific survival (CSS) and construct a nomogram to predict the CSS of patients with colorectal signet ring cell carcinoma (SRCC). METHODS: The data for patients with colorectal SRCC from 2000 to 2019 was identified from Surveillance, Epidemiology, and End Results (SEER) database. Propensity Score Matching (PSM) was used to minimize bias between SRCC and adenocarcinoma patients. Kaplan-Meier method and log-rank test were used to estimate the CSS...
May 28, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37244876/integrated-analysis-of-single-cell-and-bulk-rna-sequencing-identifies-a-signature-based-on-t-cell-marker-genes-to-predict-prognosis-and-immunotherapy-response-in-bladder-cancer
#37
JOURNAL ARTICLE
Xuezhong Shi, Ani Dong, Yongli Yang, Guowei Zheng, Nana Wang, Chaojun Yang, Yuping Wang, Jie Lu, Xiaocan Jia
BACKGROUND: T cells have been proven to play important roles in anti-tumor and tumor microenvironment shaping, while these roles have not been explained in bladder cancer (BLCA). METHODS: Single-cell RNA-sequencing (scRNA-seq) data were downloaded from the gene expression omnibus (GEO) database to screen T-cell marker genes. Bulk RNA-sequencing data and clinical information from BLCA patients were downloaded from the cancer genome atlas (TCGA) database to develop a prognosis signature...
May 27, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37244875/involvement-of-spleen-is-associated-with-shorter-survival-in-patients-with-angioimmunoblastic-t-cell-lymphoma
#38
JOURNAL ARTICLE
Yingdan Huang, Ruolan Zeng, Chang Xue, Qing Huang, Ding Yu, Liang Shao, Hui Zhou, Huijing Wu
BACKGROUND: The prognosis of patients with angioimmunoblastic T cell lymphoma (AITL) remains dismal, with their 5-year overall survival (OS) and progression-free survival (PFS) rates of 32-41% and 18-38%, respectively. Spleen involvement occurs in a proportion of patients with AITL. But still, it is unclear whether spleen involvement impacts the prognosis of AITL patients. In this study, we aim to establish new prognostic indicators for the identification of high-risk patients to draft optimal treatment regimens...
May 27, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37243817/efficacy-of-adjuvant-radiation-in-early-stage-cancers-of-buccal-mucosa-an-institutional-experience
#39
JOURNAL ARTICLE
Surekha Goyal, Vedamanasa Ikkurthi, S N Geeta
PURPOSE: The purpose of this study is to determine if depth of infiltration is the only risk factor that will determine the outcomes in early-stage buccal mucosa patients or do the other minor risk factors have an impact too. METHODS: It is a retrospective analysis of 226 patients with early-stage buccal mucosa cancer who were treated with curative intent from 2010 to 2020. These patients were grouped in two arms, surgery alone (n = 111) and surgery followed by adjuvant radiotherapy (n = 115)...
May 27, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37237167/the-distribution-pattern-of-pelvic-lymph-nodal-metastases-in-cervical-cancer
#40
JOURNAL ARTICLE
Shangdan Xie, Jing Zhao, Xintao Wang, Yan Hu, Guannan Feng, Haiyan Zhu, Chao Wang
PURPOSE: Depiction of pelvic lymph node metastasis (LNM) sites among patients with cervical cancer facilitates accurate determination of the extent of dissection and radiotherapy regimens. METHODS: A retrospective study of 1182 cervical cancer patients who underwent radical hysterectomy and pelvic lymph node dissection between 2008 and 2018 was performed. The number of removed pelvic lymph nodes and metastasis status in different anatomical regions was analyzed...
May 26, 2023: Journal of Cancer Research and Clinical Oncology
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