journal
Journals Journal of Cancer Research and...

Journal of Cancer Research and Clinical Oncology

https://read.qxmd.com/read/38796605/low-skeletal-muscle-mass-predicts-melanoma-specific-survival-in-melanoma-patients-treated-with-adjuvant-immune-checkpoint-blockade
#1
JOURNAL ARTICLE
Miriam Mengoni, Andreas Dominik Braun, Mattes Simon Hinnerichs, Anar Aghayev, Thomas Tüting, Alexey Surov
PURPOSE: Adjuvant immunotherapy with immune checkpoint blockade(ICB) has greatly reduced the risk of recurrence and metastatic spread in early and advanced melanoma. However, not all patients benefit from adjuvant treatment: many patients show disease recurrence despite therapy, while those without recurrence harbor the risk for potentially irreversible adverse events. Biomarkers to select patients benefitting most from adjuvant therapy are currently lacking. As body composition assessment using CT images has shown promising results as a prognostic biomarker in stage IV melanoma, we aim to study the applicability of body composition parameters also in adjuvant melanoma treatment...
May 25, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38795250/outcome-prediction-of-sstr-rads-3a-and-sstr-rads-3b-lesions-in-patients-with-neuroendocrine-tumors-based-on-68-ga-dotatate-pet-mr
#2
JOURNAL ARTICLE
Jing Gao, Jinxin Zhou, Chang Liu, Yu Pan, Xiaozhu Lin, Yifan Zhang
PURPOSE: Somatostatin receptor (SSTR)-targeted PET imaging has emerged as a common approach to evaluating those patients with well-differentiated neuroendocrine tumors (NETs). The SSTR reporting and data system (SSTR-RADS) version 1.0 provides a means of categorizing lesions from 1 to 5 according to the likelihood of NET involvement, with SSTR-RADS-3A (soft-tissue) and SSTR-RADS-3B (bone) lesions being those suggestive of but without definitive NET involvement. The goal of the present study was to assess the ability of 68 Ga-DOTATATE PET/MR imaging data to predict outcomes for indeterminate SSTR-RADS-3A and 3B lesions...
May 25, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38795238/fluorescein-guided-surgery-in-high-grade-gliomas-focusing-on-the-eloquent-and-deep-seated-areas
#3
JOURNAL ARTICLE
Yao Xiao, Mingrui Li, Xiangyu Wang, Jun Tan, Chaoying Qin, Qing Liu
PURPOSE: The vital function of eloquent and deep brain areas necessitates precise treatment for tumors located in these regions. Fluorescein-guided surgery (FGS) has been widely used for high-grade gliomas (HGGs) resection. Nevertheless, the safety and efficacy of utilizing this technique for resecting brain tumors located in eloquent and deep-seated areas remain uncertain. This study aims to assess the safety and extent of resection of HGGs in these challenging tumors with fluorescein and explore its impact on patient survival...
May 25, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38795230/study-on-carotid-artery-stenosis-after-radiotherapy-for-nasopharyngeal-carcinoma
#4
JOURNAL ARTICLE
JunMei Song, Luo Lan, YuQing Lv, YaJing Wen, Min Kang, RenSheng Wang
OBJECTIVE: This study investigated carotid artery stenosis (CAS) and associated risk factors in patients with nasopharyngeal carcinoma (NPC) post-radiotherapy. MATERIALS AND METHODS: The observation group comprised 86 reexamined patients with NPC, divided into Group 1 and Group 2 based on post-radiotherapy duration, alongside 34 newly diagnosed patients with NPC (Group 0). Carotid artery ultrasonography and chi-square analysis were performed. RESULTS: Moderate-to-severe vascular abnormalities were exclusively in Group 2...
May 25, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38780840/the-efficiency-and-safety-of-temozolomide-and-pd-1-l1-inhibitors-in-pretreated-nsclc-with-brain-metastasis-a-retrospective-cohort
#5
JOURNAL ARTICLE
Xiaobing Li, De Wu, Jing Tang, Yuebing Wu
OBJECTIVE: Previous research has shown that both temozolomide (TMZ) and PD-1/L1 inhibitors (PD-1/L1) alone exhibit certain potential in the treatment of non-small cell lung cancer (NSCLC) with brain metastases (BM), in this study, we will explore combining the two in order to seek new effective treatment options for NSCLC with BM. MATERIAL AND METHODS: During 2021.1 to 2023.12, we collected the date of these pretreated-NSCLC with BM who accept the treatment of TMZ and PD-1/L1, the objective response ratio (ORR), progression-free survival (PFS) and overall survival (OS) were set as the primary endpoint, meanwhile, the toxicity of such regimen was also recorded...
May 23, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38780656/combined-hepatocellular-cholangiocarcinoma-from-genesis-to-molecular-pathways-and-therapeutic-strategies
#6
REVIEW
Simona Gurzu, Rita Szodorai, Ioan Jung, Laura Banias
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common primary liver cancers. Little is known about the combined hepatocellular-cholangiocarcinoma (cHCC-ICC) variant and the proper therapeutic strategies. Out of over 1200 available studies about cHCC-ICC, we selected the most representative ones that reflected updated information with application to individualized therapy. Based on literature data and own experience, we hypothesize that two molecular groups of cHCC-ICC can be identified...
May 23, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38777866/a-novel-subtype-based-on-driver-methylation-transcription-in-lung-adenocarcinoma
#7
JOURNAL ARTICLE
Xin Wang, Zhenyi Xu, Shuang Zhao, Jiali Song, Yipei Yu, Han Yang, Yan Hou
AIMS: To identify driver methylation genes and a novel subtype of lung adenocarcinoma (LUAD) by multi-omics and elucidate its molecular features and clinical significance. METHODS: We collected LUAD patients from public databases, and identified driver methylation genes (DMGs) by MethSig and MethylMix algrothms. And novel driver methylation multi-omics subtypes were identified by similarity network fusion (SNF). Furthermore, the prognosis, tumor microenvironment (TME), molecular features and therapy efficiency among subtypes were comprehensively evaluated...
May 22, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38772976/use-superb-microvascular-imaging-to-diagnose-and-predict-metastatic-cervical-lymph-nodes-in-patients-with-papillary-thyroid-carcinoma
#8
JOURNAL ARTICLE
Ting Huang, Pin-Tong Huang, Zhi-Yan Luo, Ji-Fang Lv, Pei-Le Jin, Tao Zhang, Yu-Lan Zhao, Yong Wang, Yu-Rong Hong
PURPOSE: Papillary thyroid carcinoma (PTC) with metastatic lymph nodes (LNs) is closely associated with disease recurrence. This study accessed the value of superb microvascular imaging (SMI) in the diagnosis and prediction of metastatic cervical LNs in patients with PTC. METHODS: A total of 183 cervical LNs (103 metastatic and 80 reactive) from 116 patients with PTC were analysed. Metastatic cervical LNs were confirmed by pathology or/and cytology; reactive cervical LNs were confirmed by pathology or clinical features...
May 21, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38769118/primary-ewing-s-sarcoma-of-the-uterine-cervix-a-case-report-and-review-of-the-literature
#9
REVIEW
Yuhang Xiao, Yong Zhi, Guangxu Cao, Heling Ma, Jinli Gao, Fang Li
BACKGROUND: Ewing's sarcoma (ES) is an aggressive cancer of bone and soft tissue, most of which tend to occur in the bone. Extraosseous Ewing's sarcoma (EES) of the cervix is extremely rare. CASE PRESENTATION: In the present work, we reported a 39-year-old cervical EES patient with a 2.5*2.1*1.8 cm tumor mass. According to previous literatures, our case is the smallest tumor found in primary cervical ES ever. The patient initially came to our hospital due to vaginal bleeding, and then the gynecological examination found a neoplasm between the cervical canal and partially in the external cervical orifice...
May 21, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38769201/clinical-significance-of-18-f-fdg-pet-ct-for-detection-of-incidental-pre-malignant-and-malignant-colonic-lesions-correlation-with-colonoscopic-and-histopathological-results
#10
JOURNAL ARTICLE
Yingying Zhang, Jiangqin Han, Junpeng Li, Jinming Cao, Yeye Zhou, Shengming Deng, Bin Zhang, Yi Yang
BACKGROUND: Incidental colorectal fluorodeoxyglucose (FDG) uptake, observed during positron emission tomography/computed tomography (PET/CT) scans, attracts particular attention due to its potential to represent both benign and pre-malignant/malignant lesions. Early detection and excision of these lesions are crucial for preventing cancer development and reducing mortality. This research aims to evaluate the correlation between incidental colorectal FDG uptake on PET/CT with colonoscopic and histopathological results...
May 20, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38769166/target-trial-emulation-of-carfilzomib-safety-among-patients-with-relapsed-refractory-multiple-myeloma-using-a-nationwide-observational-data-in-korea
#11
JOURNAL ARTICLE
Hyun Kyung Lee, Ha Young Jang, In-Wha Kim, Jung Mi Oh
PURPOSE: Carfilzomib, commonly used for relapsed/refractory multiple myeloma (RRMM), has been associated with various adverse events in randomized controlled trials (RCTs). However, real-world safety data for a more diverse population are needed, as carfilzomib received expedited approval. This study aimed to evaluate carfilzomib's safety in Korea by comparing new users of KRd (carfilzomib, lenalidomide, and dexamethasone) to Rd (lenalidomide and dexamethasone) using a nationwide administrative claims database...
May 20, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38767747/machine-learning-identifies-the-role-of-smad6-in-the-prognosis-and-drug-susceptibility-in-bladder-cancer
#12
JOURNAL ARTICLE
Ziang Chen, Yuxi Ou, Fangdie Ye, Weijian Li, Haowen Jiang, Shenghua Liu
BACKGROUND: Bladder cancer (BCa) is among the most prevalent malignant tumors affecting the urinary system. Due to its highly recurrent nature, standard treatments such as surgery often fail to significantly improve patient prognosis. Our research aims to predict prognosis and identify precise therapeutic targets for novel treatment interventions. METHODS: We collected and screened genes related to the TGF-β signaling pathway and performed unsupervised clustering analysis on TCGA-BLCA samples based on these genes...
May 20, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38767702/a-novel-trna-derived-fragment-trf-17-18vby9m-works-as-a-potential-diagnostic-biomarker-for-gastric-cancer
#13
JOURNAL ARTICLE
Chunyan Mao, Zhihan Zhang, Ronghua Fang, Wentao Yuan, Yi Wu, Hui Cong
BACKGROUND: Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide. The low effectiveness of common biomarkers for the detection of early GC makes it essential to seek new biomarkers to improve diagnostic efficacy. tsRNAs (transfer RNA-derived small RNAs) are related to the growth of malignant tumors. In this article, we focused on whether tsRNAs may be employed as biomarkers for GC. METHODS: tRF-17-18VBY9M was screened in the tsRFun database as a research object...
May 20, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38762825/tumor-infiltrating-b-lymphocytes-tibs-associate-with-poor-clinical-outcomes-unfavorable-therapeutic-benefit-and-immunosuppressive-context-in-metastatic-clear-cell-renal-cell-carcinoma-mccrcc-patients-treated-with-anti-pd-1-antibody-plus-axitinib
#14
JOURNAL ARTICLE
Zhiyuan Lin, Shuxiu Xiao, Yu Qi, Jianming Guo, Lili Lu
PURPOSE: Immune checkpoint inhibitors (ICIs) plus tyrosine kinase inhibitors (TKIs) has become first-line therapy for metastatic renal cell carcinoma patients. This study aims to investigate the effect of tumor infiltrating B lymphocytes (TIBs) on the combination therapy. METHODS: The retrospective analysis was conducted on the clinical records of 115 metastatic clear cell renal cell carcinoma (mccRCC) patients treated with anti-PD-1 antibody plus Axitinib between March 2020 and June 2023...
May 19, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38761291/genome-wide-investigation-of-lncrnas-revealed-their-tight-association-with-gastric-cancer
#15
JOURNAL ARTICLE
Tong Liu, Yuedong Ma, Shuo Han, Pengda Sun
BACKGROUND: Gastric cancer (GC) is a significant health issue globally, ranking as the fifth most common cancer with over 10,000 new cases reported annually. Long non-coding RNA (lncRNA) has emerged as a critical player in cellular functions, influencing GC's development, growth, metastasis, and prognosis. However, our understanding of lncRNA's role in the pathogenesis of GC remains limited. Therefore, it is particularly important to explore the relationship between lncRNA and gastric cancer...
May 18, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38760614/survival-outcomes-of-neoadjuvant-immunochemotherapy-versus-chemotherapy-for-locally-advanced-esophageal-squamous-cell-carcinoma
#16
COMPARATIVE STUDY
Huilai Lv, Fan Zhang, Chao Huang, Shi Xu, Jiachen Li, Bokang Sun, Chunyue Gai, Zhao Liu, Mingbo Wang, Zhenhua Li, Ziqiang Tian
PURPOSE: Neoadjuvant chemotherapy (NCT) is the standard preoperative treatment for resectable locally advanced esophageal squamous cell carcinoma (ESCC). Some studies reported neoadjuvant immunochemotherapy (NICT) could improve pathological response with manageable safety. However, few studies have compared the efficacy and safety of NICT and NCT, especially survival outcomes. In this study, we compared the efficacy and safety of NICT and NCT after a median follow-up of 36.0 months...
May 17, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38753184/evaluating-the-effects-of-various-ethanolic-medicinal-plant-extracts-on-metastatic-breast-cancer-proliferation-invasion-and-expression-of-a-novel-potential-drug-target-cd82-metastatic-suppressor-protein-and-on-in-vivo-angiogenesis-using-the-ex-ovo-yolk-sac
#17
JOURNAL ARTICLE
Samantha Loggenberg, Danielle Twilley, Namrita Lall
PURPOSE: Breast cancer metastasis relies on cellular invasion and angiogenesis facilitated by the downregulation of metastatic suppressor proteins like Cluster of Differentiation 82 (CD82). Currently, no medicines target multiple systems to prevent metastatic progression through CD82 upregulation. This study screened for plant extracts displaying effects on cell proliferation, invasion, and CD82 expression in breast cancer cells, and in vivo angiogenesis, and further correlated between the biological activities and effect on CD82 expression...
May 16, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38753091/risk-assessment-model-based-on-nucleotide-metabolism-related-genes-highlights-slc27a2-as-a-potential-therapeutic-target-in-breast-cancer
#18
JOURNAL ARTICLE
Bo Zhang, Yunjiao Zhang, Kexin Chang, Niuniu Hou, Pengyu Fan, Cheng Ji, Liuyin Liu, Zhe Wang, Ruolei Li, Yaping Wang, Jian Zhang, Rui Ling
PURPOSE: Breast cancer (BC) is the most prevalent malignant tumor worldwide among women, with the highest incidence rate. The mechanisms underlying nucleotide metabolism on biological functions in BC remain incompletely elucidated. MATERIALS AND METHODS: We harnessed differentially expressed nucleotide metabolism-related genes from The Cancer Genome Atlas-BRCA, constructing a prognostic risk model through univariate Cox regression and LASSO regression analyses. A validation set and the GSE7390 dataset were used to validate the risk model...
May 16, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38753081/the-emerging-role-and-mechanism-of-hmga2-in-breast-cancer
#19
REVIEW
Qing Ma, Sisi Ye, Hong Liu, Yu Zhao, Wei Zhang
High mobility group AT-hook 2 (HMGA2) is a member of the non-histone chromosomal high mobility group (HMG) protein family, which participate in embryonic development and other biological processes. HMGA2 overexpression is associated with breast cancer (BC) cell growth, proliferation, metastasis, and drug resistance. Furthermore, HMGA2 expression is positively associated with poor prognosis of patients with BC, and inhibiting HMGA2 signaling can stimulate BC cell progression and metastasis. In this review, we focus on HMGA2 expression changes in BC tissues and multiple BC cell lines...
May 16, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38750402/clinicopathologic-features-and-genomic-profiling-of-female-axillary-lymph-node-metastases-from-adenocarcinoma-or-poorly-differentiated-carcinoma-of-unknown-primary
#20
JOURNAL ARTICLE
Liansha Tang, Yueting Zhu, Yang Du, Xiangyu Long, Yixiu Long, Yuan Tang, Jiyan Liu
PURPOSE: Axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary (CUPAx) is a rare disease in women. This retrospective study intended to examine the clinicopathological features of CUPAx and compared CUPAx genetically with axillary lymph node metastases from breast cancer (BCAx), investigating differences in their biological behavior. METHODS: We conducted the clinical and prognostic analysis of 58 CUPAx patients in West China Hospital spanning from 2009 to 2021...
May 15, 2024: Journal of Cancer Research and Clinical Oncology
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