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Journals Journal of Cancer Research and...

Journal of Cancer Research and Clinical Oncology

https://read.qxmd.com/read/37736789/construction-of-an-anoikis%C3%A2-related-prognostic-signature-to-predict-immunotherapeutic-response-and-prognosis-in-hepatocellular-carcinoma
#1
JOURNAL ARTICLE
Chen Xiong, Guoqiang Pan, Hanchao Wang, Guangxiao Meng, Lunjie Yan, Ruizhe Li, Yuchuan Yan, Yafei Yang, Xiao Zhang, Chuncheng Yang, Zhaoru Dong, Tao Li
PURPOSE: Anoikis resistance is an important inducer of tumor metastasis. The role of anoikis-related genes (ARGs) in hepatocellular carcinoma (HCC) remains unclear. METHODS: A list of ARGs was obtained and regression analysis was employed to assemble an anoikis-related prognostic signature and risk score formula from mRNA data and clinical prognostic data downloaded from The Cancer Genome Atlas database. Quantitative real-time PCR (qRT-PCR) was performed on clinical samples to validate the selected ARGs expressions...
September 22, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37736788/integrative-landscape-analysis-of-prognostic-model-biomarkers-and-immunogenomics-of-disulfidptosis-related-genes-in-breast-cancer-based-on-lasso-and-wgcna-analyses
#2
JOURNAL ARTICLE
Shuyan Liu, Yiwen Zheng, Shujin Li, Yaoqiang Du, Xiaozhen Liu, Hongchao Tang, Xuli Meng, Qinghui Zheng
BACKGROUND: Disulfidptosis is a novel type of programmed cell death. However, the value of disulfidptosis-related genes (DRGs) in the prediction of breast cancer prognosis is unclear. METHODS: RNA-seq data of 1231 patients, together with information on patient clinical characteristics and prognosis, were downloaded from TCGA. DRGs were identified between cancerous and non-cancerous tissues. The LASSO algorithm was used to assign half of the samples to the training set...
September 22, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37733242/identification-of-a-trp-channel-related-risk-model-for-predicting-prognosis-and-therapeutic-effects-of-patients-with-hepatocellular-carcinoma
#3
JOURNAL ARTICLE
Chong Pang, Zhe Xu, Jilong Han, Fujun Li, Hongyan Zhu, Jiaqi Zhang, Dong Wang, Xundi Xu
PURPOSE: TRP channels have been implicated in cancer progression. Our study seeks to establish a prognostic model for hepatocellular carcinoma (HCC) by utilizing genes related to TRP channels. METHODS: We used the TCGA and ICGC databases as training and validation cohorts, respectively. We calculated the risk scores using Lasso-Cox regression analysis based on the expression levels of prognostic genes and performed survival analysis to compare overall survival between high- and low-risk groups...
September 21, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37733241/integrated-analysis-of-tumor-microenvironment-features-to-establish-a-diagnostic-model-for-papillary-thyroid-cancer-using-bulk-and-single-cell-rna-sequencing-technology
#4
JOURNAL ARTICLE
Yizeng Wang, Wenbin Song, Yingxi Li, Zhaoyi Liu, Ke Zhao, Lanning Jia, Xiaoning Wang, Ruoyu Jiang, Yao Tian, Xianghui He
BACKGROUND: Characterizing tumor microenvironment using single-cell RNA sequencing has been a promising strategy for cancer diagnosis and treatment. However, a few studies have focused on diagnosing papillary thyroid cancer (PTC) through this technology. Therefore, our study explored tumor microenvironment (TME) features and identified potential biomarkers to establish a diagnostic model for papillary thyroid cancer. METHODS: The cell types were identified using the markers from the CellMarker database and published research...
September 21, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37733240/cd4-levels-and-nsclc-metastasis-the-benefits-of-maintaining-moderate-levels
#5
JOURNAL ARTICLE
Ying Bai, Yafeng Liu, Jing Wu, Rui Miao, Zhi Xu, Chunxiao Hu, Jiawei Zhou, Jianqiang Guo, Jun Xie, Zilun Shi, Xuansheng Ding, Yingru Xing, Dong Hu
OBJECTIVES: Prior researches indicate that peripheral blood CD4 levels have an inverse correlation with distant tumor metastasis in non-small cell lung cancer (NSCLC). However, the linear relationship between CD4 and distant metastasis lacks clarity. Hence, the objective of this study was to ascertain the linear relationship between CD4 and distant metastasis in NSCLC patients. METHODS: This retrospective study analyzed clinical and laboratory data of NSCLC patients between March 2016 and July 2022 at the Cancer Hospital of Anhui University of Technology...
September 21, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37730912/albendazole-induces-an-anti-tumor-effect-and-potentiates-pd-l1-blockade-immunotherapy
#6
JOURNAL ARTICLE
Weinan Zhang, Zhiqiang He, Fucheng Liang, Jie Gong, Liuchang Tan, Juan Yang, Siji Song, Luoyingzi Xie, Yuangang Lu
BACKGROUND: Previously, albendazole (ABZ) has been reported as an anti-parasitic drug rather than anti-tumor drug. Our study aim to investigate whether ABZ also has a potential anti-tumor effect by shaping the tumor immune microenvironment and interrogate whether ABZ could synergize with the PD-L1 blockade. METHODS: C57BL/6 mice (C57) were intravenously injected with B16F10-luciferase (B16-luc) cells to establish a lung metastatic melanoma model and subcutaneously inoculated with B16-luc cells to establish a subcutaneous tumor model...
September 20, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37728703/identification-of-a-novel-five-ferroptosis-related-gene-signature-as-a-promising-prognostic-model-for-breast-cancer
#7
JOURNAL ARTICLE
Tian- Cheng Cheng, Jia-Hao Wu, Bei Zhu, Hai-Yan Gao, Lin Zheng, Wei-Xian Chen
BACKGROUND: Breast cancer (BCa) is a major challenge for women's health worldwide. Ferroptosis is closely related to tumorigenesis and cancer progression. However, the prognostic value of ferroptosis-related genes in BCa remains unclear, and more accurate prognostic models are urgently needed. METHODS: Gene expression profiles and clinical information of BCa patients were collected from public databases. LASSO and multivariate Cox regression analysis were utilized to construct the prognostic gene signature...
September 20, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37728702/downregulated-birc5-inhibits-proliferation-and-metastasis-of-melanoma-through-the-%C3%AE-catenin-hif-1%C3%AE-vegf-mmps-pathway
#8
JOURNAL ARTICLE
Qingqing He, Yijing He, Changqiang Li, Jianv Wang, Tong Xia, Xia Xiong, Jixiang Xu, Li Liu
PURPOSE: Melanoma is a malignant skin tumor caused by melanocytes and associated with high mortality rates. This study aims to investigate the specific mechanism of ZWZ-3 in melanoma proliferation and metastasis. METHODS: RNA sequencing was performed to identify the effect of ZWZ-3 on gene expression. siRNA was used to inhibit BIRC5 gene expression in the B16F10 cell line. A zebrafish tumor model was used to assess the therapeutic effect of ZWZ-3 in vivo. Mechanistic insights into the inhibition of tumor metastasis by ZWZ-3 were obtained through analysis of tumor tissue sections in mice...
September 20, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37728701/the-mortality-of-oral-cancer-attributable-to-tobacco-in-china-the-us-and-india
#9
JOURNAL ARTICLE
Jiefan Qiu, Haoyu Wen, Jianjun Bai, Chuanhua Yu
PURPOSE: Assessing the mortality rates associated with tobacco-related oral cancer (OC) is crucial for effective allocation of resources within healthcare and economic systems. METHODS: In this study, data from the Global Burden of Disease Study (GBD) 2019 were utilized to analyze the burden of tobacco-attributable OC in China, the United States (US), and India from 1990 to 2019. Descriptive statistics and an age-period-cohort model were employed to examine and compare the effects on OC mortality...
September 20, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37728700/microrna-biomarkers-and-their-use-in-evaluating-the-prognosis-of-lung-cancer
#10
JOURNAL ARTICLE
Ruijie Wu, Bohan Zhang, Mengju He, Yani Kang, Gong Zhang
OBJECTIVE: We aim to use the microRNA (miRNA, micro-ribonucleic acid) data of lung cancer tissues to establish a miRNA biomarker database for lung cancer that can be used for marker screening and analysis of lung cancer prognosis. METHODS: We obtained lung cancer-related data from The Cancer Genome Atlas (TCGA) and analyzed the miRNA expression profiles of lung cancer tissues and normal tissues using bioinformatics techniques to develop a new composite miRNA-based model for the prognostic assessment of lung cancer...
September 20, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37726557/cost-effectiveness-of-open-pancreaticoduodenectomy-with-or-without-heidelberg-triangle-operation-for-pancreatic-cancer-in-china
#11
JOURNAL ARTICLE
Yuwen Bao, Mengdie Zhang, Pengfei Wu, Yingpeng Wang, Bin Wan, Xin Li, Haixia Ding
OBJECTIVE: Pancreatic cancer is a digestive malignancy with dismal prognosis. The advent of Heidelberg TRIANGLE dissection technique brings a turning point to improve the chance of survival. Our study aimed to evaluated the cost-effectiveness of open pancreaticoduodenectomy (OPD) versus OPD combined with TRIANGLE operation (OPD-TRIANGLE) for patients with pancreatic cancer from the perspective of healthcare system in China. METHODS: Two hundred forty-six patients with pancreatic cancer who underwent OPD or OPD-TRIANGLE from January to September 2022 were enrolled in this study...
September 19, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37725244/multi-omics-approaches-identify-novel-prognostic-biomarkers-of-autophagy-in-uveal-melanoma
#12
JOURNAL ARTICLE
Wenke Jin, Lifeng Wu, Lei Hu, Yuqi Fu, Zhichao Fan, Yi Mou, Ke Ma
PURPOSE: Uveal melanoma (UVM) is a rare yet malignant ocular tumor that metastases in approximately half of all patients, with the majority of those developing metastasis typically succumbing to the disease within a year. Hitherto, no effective treatment for UVM has been identified. Autophagy is a cellular mechanism that has been suggested as an emerging regulatory process for cancer-targeted therapy. Thus, identifying novel prognostic biomarkers of autophagy may help improve future treatment...
September 19, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37725243/lobar-or-sublobar-resection-for-early-stage-second-primary-lung-cancer%C3%A2-%C3%A2-%C3%A2-3%C3%A2-cm-in-size-a-seer-population-based-study
#13
JOURNAL ARTICLE
Ke Zhao, Chunqiu Xia, Minghan Qiu, Zhen Yang, Tingkai Cui, Teng Song, Shuping Li, Hanwei Mei, Yang Zheng, Huaqing Wang
PURPOSE: Surgical strategy for second primary lung cancer (SPLC) may be more conservative due to influence of first primary lung cancer (FPLC). The optimal surgical method for SPLC warrants discussion. We aimed to explore a more suitable surgical approach for early-stage (T1-T2N0, ≤ 3 cm) SPLC and provide insights for clinical practice. METHODS: A retrospective study was conducted using data from the Surveillance, Epidemiology and End Results database between 2004 and 2018, and data of patients with early-stage SPLC who underwent secondary surgery were collected...
September 19, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37725242/slc12a8-mediates-tki-resistance-in-egfr-mutant-lung-cancer-via-pdk1-akt-axis
#14
JOURNAL ARTICLE
Fang Huang, Jian Cui, Jingxuan Wan, Xue Yuan, Yuanzhe Zhu, Xiangxiang Wu, Wei Zuo, Tiantian Zhao
PURPOSE: Epidermal growth factor receptor (EGFR) mutation is a prominent driver of lung cancer. Tyrosine kinase inhibitors (TKIs) have shown efficacy in treating EGFR-mutant lung cancer, but the emergence of drug resistance poses a significant challenge. Recent research has highlighted solute carrier family 12 member 8 (SLC12A8) as one of the highly upregulated genes in various cancer types. However, its oncogenic function remains largely unexplored. METHODS: 343 consecutive lung cancer patients were prospectively recruited and were followed for over 10 years...
September 19, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37725241/identification-of-ferroptosis-related-proteins-in-ameloblastoma-based-on-proteomics-analysis
#15
JOURNAL ARTICLE
Haiyang Li, Xingyue Ma, Ruisi Yang, Shuang Mei, Xudong Zhang, Xiangjun Li
PURPOSE: We used proteomic sequencing and experimental verification to identify the potential ferroptosis-related proteins in ameloblastoma. METHODS: Samples of ameloblastoma (n = 14) and normal gingival tissues (n = 5) were collected for proteomic sequencing to identify differentially expressed proteins (DEPs) in ameloblastoma. Ferroptosis-related genes were downloaded from FerrDb V2, which were then compared with DEPs to obtain ferroptosis-related DEPs (FR-DEPs)...
September 19, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37721570/identification-and-characterization-of-colorectal-cancer-associated-snps-on-the-smad7-locus
#16
JOURNAL ARTICLE
Zhao Liu, Yihan Zhao, Hongli Song, Huaxue Miao, Yingying Wang, Chuntian Tu, Tianyun Fu, Juliang Qin, Bing Du, Min Qian, Hua Ren
PURPOSE: Genome-wide association studies have identified SMAD7 as a colorectal cancer (CRC) susceptibility gene. However, its underlying mechanism has not yet been characterized. This study screened functional SNPs (fSNPs) related to colorectal cancer through Reel-seq and obtained regulatory proteins on functional SNPs. METHODS: The candidate fSNPs on the SMAD7 locus were screened by Reel-seq method. Eight SNPs such as rs8085824 were identified as functional SNPs by luciferase reporter assay and EMSA, SDCP-MS and AIDP-WB revealed that HNRNPK can specifically bind to the rs8085824-C allele...
September 18, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37716922/the-role-of-potassium-in-depth-profiling-of-the-tumor-border-in-bone-invasive-oral-cancer-using-laser-induced-breakdown-spectroscopy-libs-a-pilot-study
#17
JOURNAL ARTICLE
Philipp Winnand, K Olaf Boernsen, Mark Ooms, Marius Heitzer, Matthias Lammert, Jörg Eschweiler, Frank Hölzle, Ali Modabber
PURPOSE: Microscopic tumor spread beyond the macroscopically visible tumor mass in bone represents a major risk in surgical oncology, where the spatial complexity of bony resection margins cannot be countered with rapid bone analysis techniques. Laser-induced breakdown spectroscopy (LIBS) has recently been introduced as a promising option for rapid bone analysis. The present study aimed to use LIBS-based depth profiling based on electrolyte disturbance tracking to evaluate the detection of microscopic tumor spread in bone...
September 16, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37715833/the-prognostic-and-immunological-role-of-fkbp1a-in-an-integrated-muti-omics-cancers-analysis-especially%C3%A2-lung-cancer
#18
JOURNAL ARTICLE
Yi Zhang, Haifeng Xu, Sainan Pi, Huiqian Tan, Bihui Huang, Youpeng Chen
BACKGROUND AND AIM: FKBP1A, a gene encoding the FK506-binding protein 1A, has emerged as a significant player in cancer progression and prognosis. This study aimed to comprehensively investigate the multifaceted role of FKBP1A in cancer, focusing on its differential expression patterns, prognostic implications, genetic alterations, and associations with the tumor microenvironment. METHODS AND RESULTS: Using large-scale datasets, including GTEx, TCGA, HPA, and cBioPortal, we analyzed FKBP1A expression across normal tissues and various cancer types...
September 16, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37715832/prognosis-of-carcinoembryonic-antigen-cea-in-stage-i-colorectal-adenocarcinoma-and-development-of-a-prediction-model-a-retrospective-study-based-on-the-seer-database
#19
JOURNAL ARTICLE
Zhongbiao Chen, Zhimin Lin
BACKGROUND: To investigate the prognostic significance of preoperative carcinoembryonic antigen (CEA) status in stage I colorectal classical adenocarcinoma (CCA) and mucinous adenocarcinoma (MUC), and to construct a nomogram model of stage I CCA. METHODS: The SEER database was used to collect 14,226 patients diagnosed with stage I colorectal adenocarcinoma (CA) from 2010 to 2015. The prognostic significance of preoperative CEA status in stage I CA and MUC was examined by propensity-matching score (PSM)...
September 16, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37715831/introducing-a-standardized-assessment-of-patients-interest-in-and-usage-of-cam-in-routine-cancer-care-chances-and-risks-from-patients-and-physicians-point-of-view
#20
JOURNAL ARTICLE
M Shalgouny, J Bertz-Lepel, L Fischer V Weikersthal, J Herbin, M Meier-Höfig, R Mücke, U Rohe, T Stauch, C Stoll, D Troeltzsch, S Wittmann, O Kurz, R Naumann, J Huebner
BACKGROUND: Cancer patients often use complementary and alternative medicine (CAM), however, standardized assessment in clinical routine is missing. The aim of this study was to evaluate a screening questionnaire on CAM usage that was published in the S3 Guideline Complementary Medicine in the Treatment of Oncological Patients. METHODS: We developed a survey questionnaire to assess the practicability of the guideline questionnaire and communication on CAM between health care providers (HCPs) and patients...
September 16, 2023: Journal of Cancer Research and Clinical Oncology
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