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Journal of Cancer Research and Clinical Oncology

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https://read.qxmd.com/read/30783814/first-line-afatinib-vs-gefitinib-for-patients-with-egfr-mutation-positive-nsclc-lux-lung-7-impact-of-afatinib-dose-adjustment-and-analysis-of-mode-of-initial-progression-for-patients-who-continued-treatment-beyond-progression
#1
Martin Schuler, Eng-Huat Tan, Kenneth O'Byrne, Li Zhang, Michael Boyer, Tony Mok, Vera Hirsh, James Chih-Hsin Yang, Ki Hyeong Lee, Shun Lu, Yuankai Shi, Sang-We Kim, Janessa Laskin, Dong-Wan Kim, Catherine Dubos Arvis, Karl Kölbeck, Dan Massey, Angela Märten, Luis Paz-Ares, Keunchil Park
PURPOSE: In the randomized phase IIb LUX-Lung 7 trial, afatinib significantly improved progression-free survival (PFS) and time-to-treatment failure vs gefitinib in patients with treatment-naïve epidermal growth factor receptor mutation-positive non-small cell lung cancer. We report post hoc analyses of tolerability-guided dose adjustment for afatinib and summarize the clinical characteristics of patients who continued afatinib/gefitinib beyond initial radiological progression in LUX-Lung 7...
February 19, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30778749/cd24-targeting-bi-specific-antibody-that-simultaneously-stimulates-nkg2d-enhances-the-efficacy-of-cancer-immunotherapy
#2
Yue Han, Fumou Sun, Xinrong Zhang, Tong Wang, Jiahao Jiang, Jialing Cai, Qi Gao, Kamal Hezam, Yali Liu, Jiajun Xie, Min Wang, Juan Zhang
PURPOSE: Bi-specific antibody (BsAb) is an emerging novel format of antibody. We aimed to develop the natural killer (NK) cell receptor NK group 2, member D (NKG2D)-mediated, immune surveillance system. In this system, the NKG2D ligand MHC class I-related chain A (MICA) was fused with BsAb, which targeted a cluster of differentiation 24 (CD24), a tumor-initiating cell marker that is over-expressed on hepatocellular carcinoma (HCC). METHODS: The Homo MICA extracellular domains (hMICA) were fused to the end of the heavy chain of cG7 with the flexible pentapeptide (Gly-Gly-Gly-Gly-Ser; G4S), which formed the cG7-MICA that was further identified using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting (WB)...
February 18, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30778748/clinical-impact-of-circulating-laptm4b-35-in-pancreatic-ductal-adenocarcinoma
#3
Zixuan Yang, Norbert Senninger, Isabelle Flammang, Qifa Ye, Sameer A Dhayat
PURPOSE: LAPTM4B is upregulated in a wide range of cancers associated with poor prognosis. However, the clinical impact of LAPTM4B as diagnostic and prognostic marker in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Thus, the aim of the present study was to investigate the expression of LAPTM4B as circulating marker in PDAC. METHODS: Expression analysis of LAPTM4B-35 in pancreatic tissue and preoperative blood serum samples of 169 patients with PDAC UICC Stages I-IV (n = 98), chronic pancreatitis (n = 41), and healthy controls (n = 30) by immunohistochemistry, Western blot, and ELISA...
February 18, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30770989/cd110-promotes-pancreatic-cancer-progression-and-its-expression-is-correlated-with-poor-prognosis
#4
Zilong Yan, Kenoki Ohuchida, Biao Zheng, Takashi Okumura, Shin Takesue, Hiromichi Nakayama, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura
PURPOSE: This study aimed at investigating the function and significance of CD110 expression in pancreatic cancer. METHODS: We performed immunohistochemical staining for CD110 expression in tumor samples from 86 patients with pancreatic cancer. We evaluated clinical outcomes and other clinicopathological factors to determine the significance of CD110 on survival and liver metastasis. We examine thrombopoietin-CD110 signaling in cancer cell extravasation in vitro and in vivo...
February 15, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30758671/preoperative-controlling-nutritional-status-conut-score-as-a-novel-immune-nutritional-predictor-of-survival-in-non-metastatic-clear-cell-renal-cell-carcinoma-of-%C3%A2-7-cm-on-preoperative-imaging
#5
Ahmed Elghiaty, Jongchan Kim, Won Sik Jang, Jee Soo Park, Ji Eun Heo, Koon Ho Rha, Young Deuk Choi, Won Sik Ham
PURPOSE: This study aimed at investigating the prognostic value of Preoperative controlling nutritional status (CONUT) score in non-metastatic clear-cell renal cell carcinoma of ≤ 7 cm on preoperative imaging. METHODS: We retrospectively included 1046 among 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤ 7 cm (2005-2014) after excluding other pathology, conditions affecting CONUT score components, metastasis, regional lymphadenopathy, positive margin, and follow-up < 12 months...
February 13, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30758670/prevalence-and-clinical-significance-of-rbm3-immunostaining-in-non-small-cell-lung-cancers
#6
Nathaniel Melling, Kai Bachmann, Bianca Hofmann, Alexander Tarek El Gammal, Matthias Reeh, Oliver Mann, Christoph Moebius, Marco Blessmann, Jakob Robert Izbicki, Katharina Grupp
INTRODUCTION: Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies. MATERIALS AND METHODS: This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers (NSCLCs). Therefore, we took advantage of our tissue microarray (TMA) containing more than 600 NSCLC specimens. RESULTS: While nuclear RBM3 staining was always high in normal lung tissue, high RBM3 staining was only seen in 77...
February 13, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30756189/does-fdg-pet-ct-have-a-role-in-determining-adjuvant-chemotherapy-in-surgical-margin-negative-stage-ia-non-small-cell-lung-cancer-patients
#7
Hye Lim Park, Ie Ryung Yoo, Sun Ha Boo, Sonya Youngju Park, Jae Kil Park, Sook Whan Sung, Seok Whan Moon
PURPOSE: To evaluate the prognostic value of FDG PET/CT metabolic parameter compared to clinico-pathological risk factors in surgical margin-negative stage IA non-small cell lung cancer (NSCLC) patients. METHODS: 167 patients with consecutive FDG PET/CT scans from 2009 to 2015 performed for staging of NSCLC stage IA with plans for curative surgery were retrospectively reviewed. Maximum standardized uptake value (SUVmax) of primary tumor and mean SUV of liver were acquired from PET/CT...
February 13, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30739168/cancer-risk-in-stroke-survivors-followed-for-up-to-10-years-in-general-practices-in-germany
#8
Louis Jacob, Karel Kostev
AIMS: The goal of this study was to analyze cancer risk in stroke survivors followed for up to 10 years in general practices in Germany. METHODS: The current study sample included patients who received an initial stroke diagnosis in one of 1262 general practices in Germany between 2006 and 2015 (index date). Patients without stroke were matched (1:1) to patients with stroke by age, gender, index year, and 16 comorbidities diagnosed in the 12 months prior to the index date using a propensity score method...
February 9, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30737623/expression-of-syk-and-map4-proteins-in-ovarian-cancer
#9
Siwei Zhang, Suha Deen, Sarah J Storr, Anqi Yao, Stewart G Martin
PURPOSE: We have previously reported on the prognostic importance of the calpain family of proteins in ovarian cancer, especially calpain-2. Spleen tyrosine kinase (Syk) phosphorylates a variety of cytoskeletal proteins with studies suggesting potential interactions between Syk and conventional calpains. Microtubule-associated protein 4 (MAP4) has been reported to be regulated by Syk. METHODS: The current study assessed Syk and MAP4 protein expression, by immunohistochemistry on a tissue microarray comprised of cores from primary ovarian carcinomas (n = 575), to evaluate associations with patient clinical outcomes and other clinicopathological factors and sought to determine whether there were any correlations between the expression of Syk, MAP4 and the calpain system...
February 8, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30719536/radiomics-based-machine-learning-methods-for-isocitrate-dehydrogenase-genotype-prediction-of-diffuse-gliomas
#10
Shuang Wu, Jin Meng, Qi Yu, Ping Li, Shen Fu
PURPOSE: Reliable and accurate predictive models are necessary to drive the success of radiomics. Our aim was to identify the optimal radiomics-based machine learning method for isocitrate dehydrogenase (IDH) genotype prediction in diffuse gliomas. METHODS: Eight classical machine learning methods were evaluated in terms of their stability and performance for pre-operative IDH genotype prediction. A total of 126 patients were enrolled for analysis. Overall, 704 radiomic features extracted from the pre-operative MRI images were analyzed...
February 4, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30706130/serum-mir-16-as-a-potential-biomarker-for-human-cancer-diagnosis-results-from-a-large-scale-population
#11
Zebo Huang, Wenjiao Chen, Yiping Du, Qin Guo, Yong Mao, Xin Zhou, Dong Hua
BACKGROUND: Cancer is a serious public health problem worldwide, and difficulty in early diagnosis has been the chief obstacle to improve the prognosis of patients. Recently, microRNAs (miRNAs) were widely studied to be potential biomarkers for cancer detection. miR-16 is a prevalent but sophisticated one. In the current study, we aimed to assess the diagnostic value of serum miR-16 for cancer detection. METHODS: A total of 1458 cancer patients, containing ten types of cancers, and 1457 non-cancer controls were recruited in this study...
January 31, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30701326/nrf2-orchestrates-the-redox-regulation-induced-by-radiation-therapy-sustaining-embryonal-and-alveolar-rhabdomyosarcoma-cells-radioresistance
#12
Francesco Marampon, Silvia Codenotti, Francesca Megiorni, Andrea Del Fattore, Simona Camero, Giovanni Luca Gravina, Claudio Festuccia, Daniela Musio, Francesca De Felice, Valerio Nardone, Anna Natalizia Santoro, Carlo Dominici, Alessandro Fanzani, Luigi Pirtoli, Antonella Fioravanti, Vincenzo Tombolini, Sara Cheleschi, Paolo Tini
PURPOSE: Tumor cells generally exhibit higher levels of reactive oxygen species (ROS), however, when stressed, tumor cells can undergo a process of 'Redox Resetting' to acquire a new redox balance with stronger antioxidant systems that enable cancer cells to become resistant to radiation therapy (RT). Here, we describe how RT affects the oxidant/antioxidant balance in human embryonal (RD) and alveolar (RH30) rhabdomyosarcoma (RMS) cell lines, investigating on the molecular mechanisms involved...
January 30, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30673873/mistletoe-in-oncological-treatment-a-systematic-review-part-1-survival-and-safety
#13
REVIEW
M Freuding, C Keinki, O Micke, J Buentzel, Jutta Huebner
PURPOSE: Mistletoe treatment of cancer patients is discussed highly controversial in the scientific literature. Aim of this systematic review is to give an extensive overview about current state of research concerning mistletoe therapy of oncologic patients regarding survival, quality of life and safety. METHODS: In September and October 2017 Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, CINAHL and "Science Citation Index Expanded" (Web of Science) were systematically searched...
January 23, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30673872/mistletoe-in-oncological-treatment-a-systematic-review-part-2-quality-of-life-and-toxicity-of-cancer-treatment
#14
REVIEW
M Freuding, C Keinki, S Kutschan, O Micke, J Buentzel, Jutta Huebner
PURPOSE: One important goal of any cancer therapy is to improve or maintain quality of life. In this context, mistletoe treatment is discussed to be highly controversial. The aim of this systematic review is to give an extensive overview about the current state of evidence concerning mistletoe therapy of oncologic patients regarding quality of life and side effects of cancer treatments. METHODS: In September and October 2017, Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, CINAHL and "Science Citation Index Expanded" (Web of Science) were systematically searched...
January 23, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30673871/comparative-analysis-of-co-occurring-mutations-of-specific-tumor-suppressor-genes-in-lung-adenocarcinoma-between-asian-and-caucasian-populations
#15
Yiliang Zhang, Yuan Ma, Yuan Li, Xuxia Shen, Yongfu Yu, Yunjian Pan, Yang Zhang, Difan Zheng, Yue Zhao, Ting Ye, Bin Li, Hong Hu, Yihua Sun, Yawei Zhang, Jiaqing Xiang, Haiquan Chen
INTRODUCTION: Mutated tumor suppressor genes (TSG) such as TP53, STK11, and MGA are widely-reported. We hypothesized the presence of single mutation or co-occurring mutations in these specific genes may represent a significant therapeutic target for lung adenocarcinoma. METHODS: We sequenced lung adenocarcinoma samples from 677 East-Asian patients, combined them with those from cBioPortal public database (including TCGA) and performed a comparative analysis between Asian and Caucasian populations...
January 23, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30673870/combining-immunotherapy-and-natural-immune-stimulants-mechanisms-and-clinical-implications
#16
LETTER
Khara Lucius, Jacob Hill
No abstract text is available yet for this article.
January 23, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30666409/epros-in-the-follow-up-of-cancer-patients-treated-with-immune-checkpoint-inhibitors-a-retrospective-study
#17
Sanna Iivanainen, Tuomo Alanko, Katriina Peltola, Teemu Konkola, Jussi Ekström, Henri Virtanen, Jussi P Koivunen
PURPOSE: Patient-reported outcome (PRO) follow-up has been shown to improve quality of life (QoL) and survival of cancer patients receiving chemotherapy. Kaiku Health application is a web-based electronic PRO (ePRO) tool which is designed for follow-up of cancer patients receiving immune checkpoint inhibitors (ICI). Purpose of the current study is to investigate whether symptoms collected by Kaiku Health ePRO tool on cancer patients receiving immune checkpoint inhibitors (ICI) follows to symptoms reported in clinical trials and whether coupling of specific symptoms does occur...
January 21, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30661098/glrx-inhibition-enhances-the-effects-of-geftinib-in-egfr-tki-resistant-nsclc-cells-through-foxm1-signaling-pathway
#18
Linlin Wang, Jing Liu, Jinguo Liu, Xiaoyan Chen, Meijia Chang, Jing Li, Yuanlin Song, Chunxue Bai, Jian Zhou
PURPOSE: Non-small-cell lung cancer (NSCLC) is the most common form of lung cancer. Gefitinib is one of the most accepted therapies against NSCLC in those carrying EGFR mutations, but it is only effective in approximately 20% of patients with NSCLC. Thus, alternative therapeutic interventions are urgently needed to overcome gefitinib resistance. Glutaredoxin (GLRX) plays a key role in oxidative stress. However, whether GLRX inhibition could enhance gefitinib efficacy in the gefitinib-resistant NSCLC cells is unknown...
January 19, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30656409/expression-of-cancer-testis-antigens-in-esophageal-cancer-and-their-progress-in-immunotherapy
#19
REVIEW
Yujie Zhang, Yuxin Zhang, Li Zhang
PURPOSE: Esophageal cancer is a common disease in China with low survival rate due to no obvious early symptoms and lack of effective screening strategies. Traditional treatments usually do not produce desirable results in patients with advanced esophageal cancer, so immunotherapy which relies on tumor-related antigens is needed to combat low survival rates effectively. Cancer-testis antigens (CTA), a large family of tumor-related antigens, have a strong in vivo immunogenicity and tumor-restricted expressing patterns in normal adult tissues...
January 17, 2019: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/30656408/effects-of-metabolic-syndrome-on-the-prevalence-of-prostate-cancer-historical-cohort-study-using-the-national-health-insurance-service-database
#20
Sangjun Yoo, Sohee Oh, Juhyun Park, Sung Yong Cho, Min Chul Cho, Hwancheol Son, Hyeon Jeong
PURPOSE: To estimate the effect of metabolic syndrome (MetS) on the prevalence of prostate cancer using a large retrospective cohort with a 5-year follow-up duration. METHODS: National Health Insurance Service health checkup cohort was used for the study. In total, 130,342 men included in the health checkup cohort in 2009 were divided into two groups according to the presence of prostate cancer. The prevalence of prostate cancer from 2009 to 2013 was cumulatively calculated from 2003...
January 17, 2019: Journal of Cancer Research and Clinical Oncology
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